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Protein

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation, amyloid accumulation, and impaired learning/memory in a mouse model of Alzheimer disease.4 Publications
Isoform 2: Is able to advanced glycosylation end product (AGE)-induce nuclear factor NF-kappa-B activation.1 Publication
Isoform 10: Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro.1 Publication

GO - Molecular functioni

  • advanced glycation end-product binding Source: MGI
  • heparin binding Source: MGI
  • identical protein binding Source: MGI
  • S100 protein binding Source: UniProtKB

GO - Biological processi

  • astrocyte development Source: MGI
  • induction of positive chemotaxis Source: MGI
  • inflammatory response Source: MGI
  • negative regulation of advanced glycation end-product receptor activity Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing Source: MGI
  • negative regulation of interleukin-10 production Source: MGI
  • negative regulation of signaling Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of activated T cell proliferation Source: MGI
  • positive regulation of advanced glycation end-product receptor activity Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of dendritic cell differentiation Source: MGI
  • positive regulation of interleukin-12 production Source: MGI
  • positive regulation of JUN kinase activity Source: MGI
  • positive regulation of monocyte chemotactic protein-1 production Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of signaling Source: MGI
  • protein localization to membrane Source: MGI
  • regulation of CD4-positive, alpha-beta T cell activation Source: MGI
  • regulation of DNA binding Source: MGI
  • regulation of inflammatory response Source: UniProtKB
  • regulation of T cell mediated cytotoxicity Source: MGI
  • response to hypoxia Source: MGI
Complete GO annotation...

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-879415. Advanced glycosylation endproduct receptor signaling.
R-MMU-933542. TRAF6 mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
Gene namesi
Name:Ager
Synonyms:Rage
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:893592. Ager.

Subcellular locationi

Isoform 2 :
Isoform 10 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 340318ExtracellularSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 40241CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2189161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 402380Advanced glycosylation end product-specific receptorPRO_0000014924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi38 ↔ 98PROSITE-ProRule annotation
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Disulfide bondi143 ↔ 206PROSITE-ProRule annotation
Disulfide bondi257 – 257InterchainPROSITE-ProRule annotation
Disulfide bondi299 – 299InterchainPROSITE-ProRule annotation
Modified residuei376 – 3761PhosphoserineCombined sources
Modified residuei389 – 3891PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ62151.
PaxDbiQ62151.

PTM databases

iPTMnetiQ62151.
PhosphoSiteiQ62151.

Expressioni

Tissue specificityi

Isoform 1: Expressed at higher levels in the coronary arterioles in type 2 diabetic mice (at protein level). Endothelial cells (PubMed:18539754). Expressed in lung, kidney, brain and heart. Most prevalent isoform with the highest level in heart (PubMed:19164451). Isoform 2: Expressed in brain, lung, kidney and small intestine with the highest level in lung. Expressed in brain, lung, kidney and small intestine with the highest level in small intestine (at protein level). Detected in neurons of the cerebrum, bronchial epithelium, endothelial cells, tubular cells of kidney and epithelial cells of small intestine (at protein level). Expression is increased in the kidney of diabetic wild-type mice (at protein level), but not in the other tissues (PubMed:16503878). Expressed only in kidney. Expression is increased in the kidney of diabetic mice (PubMed:19164451). Isoform 3: Expressed in lung, kidney and heart. The second most prevalent isoform with the highest level in lung. Not expressed in brain (PubMed:19164451). Isoform 4: Expressed at very low level in lung only (PubMed:19164451). Isoform 5: Expressed at very low level in lung only (PubMed:19164451). Isoform 6: Expressed at very low level in lung only (PubMed:19164451). Isoform 7: Expressed at very low level in heart only (PubMed:19164451). Isoform 8: Expressed at very low level in lung only (PubMed:19164451). Isoform 9: Expressed at very low level in heart only (PubMed:19164451). Isoform 10: Expressed in lung, brain, heart and kidney with a very high level in kidney (PubMed:24260107). Isoform 11: Expressed in brain, kidney and heart. Not expressed in lung (PubMed:19164451). Isoform 12: Expressed at very low level in lung and kidney (PubMed:19164451). Isoform 13: Expressed at very low level in lung only (PubMed:19164451).4 Publications

Gene expression databases

BgeeiENSMUSG00000015452.
CleanExiMM_RAGE.

Interactioni

Subunit structurei

Interacts with S100B, S100A1 and S100A14. Constitutive homodimer; disulfide-linked (By similarity). Interacts with S100A12 and APP.By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: MGI
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ62151. 2 interactions.
MINTiMINT-4131696.
STRINGi10090.ENSMUSP00000015596.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IM8X-ray3.50A23-230[»]
ProteinModelPortaliQ62151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 10987Ig-like V-typeAdd
BLAST
Domaini123 – 21997Ig-like C2-type 1Add
BLAST
Domaini233 – 31583Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000232122.
HOVERGENiHBG004350.
InParanoidiQ62151.
KOiK19722.
OMAiPNKVGTC.
OrthoDBiEOG091G0BCY.
TreeFamiTF337155.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62151-1) [UniParc]FASTAAdd to basket
Also known as: mRAGE1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA
110 120 130 140 150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT
210 220 230 240 250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV
310 320 330 340 350
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGS VGESGLGTLA LALGILGGLG
360 370 380 390 400
VVALLVGAIL WRKRQPRREE RKAPESQEDE EERAELNQSE EAEMPENGAG

GP
Length:402
Mass (Da):42,654
Last modified:February 17, 2016 - v2
Checksum:iDBFDC50A6C8CB902
GO
Isoform 2 (identifier: Q62151-2) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v11 Publication, mRAGE_v31 Publication, endogenous secretory receptor for AGE (esRAGE)1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     330-333: SVGE → EGLD
     334-402: Missing.

Show »
Length:333
Mass (Da):35,362
Checksum:i7AC9E992F2DDF3F3
GO
Isoform 3 (identifier: Q62151-3) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     320-328: Missing.

Show »
Length:393
Mass (Da):41,768
Checksum:iDB2B868448D060AA
GO
Isoform 4 (identifier: Q62151-4) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v151 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     54-62: Missing.
     320-328: Missing.

Show »
Length:384
Mass (Da):40,724
Checksum:iAB3C4E0FB1DF2B78
GO
Isoform 5 (identifier: Q62151-5) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v141 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     188-382: Missing.

Show »
Length:207
Mass (Da):22,225
Checksum:iE404D4E72999C51F
GO
Isoform 6 (identifier: Q62151-6) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: T → G
     154-402: Missing.

Show »
Length:153
Mass (Da):16,201
Checksum:i565D39235B4282B3
GO
Isoform 7 (identifier: Q62151-7) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-138: QIPGKPEIVDPASELTASVPN → RKGPRLSHFAFIKKPSCTPNP
     139-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:138
Mass (Da):15,027
Checksum:i007981C1151AA802
GO
Isoform 8 (identifier: Q62151-8) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v111 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     119-137: IPGKPEIVDPASELTASVP → KPAMRGQLKALWVSLGWVR
     138-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:137
Mass (Da):14,970
Checksum:iF137773B18869E4E
GO
Isoform 9 (identifier: Q62151-9) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v91 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     27-85: TARIGEPLVL...RILPNGSLLL → PALCCSSLRW...ALWVSLGWVR
     86-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:85
Mass (Da):9,010
Checksum:i2F781505A35E6E69
GO
Isoform 10 (identifier: Q62151-10) [UniParc]FASTAAdd to basket
Also known as: RAGE deletion of intracellular domain1 Publication, RAGEdeltaICD1 Publication, mRAGE_v201 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     372-384: KAPESQEDEEERA → PRKARRMRRNVQS
     385-402: Missing.

Show »
Length:384
Mass (Da):40,950
Checksum:iEBC66DBB542FEE24
GO
Isoform 11 (identifier: Q62151-11) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v21 Publication, mRAGE_v51 Publication, mRAGE_v61 Publication, mRAGE_v81 Publication, mRAGE_v161 Publication, mRAGE_v171 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     19-77: AVAGGQNITA...GGPWDSVARI → ETLPAPTLPL...PHLSPSTLPQ
     78-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:77
Mass (Da):8,113
Checksum:iD56C8B05BECF7981
GO
Isoform 12 (identifier: Q62151-12) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v131 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     30-40: IGEPLVLSCKG → KARRMRRNVQS
     41-402: Missing.

Show »
Length:40
Mass (Da):4,306
Checksum:i9669BDD4B4668380
GO
Isoform 13 (identifier: Q62151-13) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v121 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     31-402: Missing.

Show »
Length:30
Mass (Da):3,036
Checksum:i97EE921F1AAD78B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 303ARI → TQA in ACK28146 (PubMed:19164451).Curated
Sequence conflicti76 – 761R → Q in AAA40040 (PubMed:9224812).Curated
Sequence conflicti76 – 761R → Q in BAE72665 (PubMed:16503878).Curated
Sequence conflicti199 – 1991G → GT in AAA40040 (PubMed:9224812).Curated
Sequence conflicti199 – 1991G → GT in BAE72665 (PubMed:16503878).Curated
Sequence conflicti292 – 2921E → A in AAA40040 (PubMed:9224812).Curated
Sequence conflicti292 – 2921E → A in BAE72665 (PubMed:16503878).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 7759AVAGG…SVARI → ETLPAPTLPLSSPAPTPPPV PPCPLEIPLNLGTTFQRPSP TLSYTRTPQPHLSPSTLPQ in isoform 11. 1 PublicationVSP_058075Add
BLAST
Alternative sequencei27 – 8559TARIG…GSLLL → PALCCSSLRWGTRMRAPIAA WPPTLATDLRKALLSASGSQ KPAMRGQLKALWVSLGWVR in isoform 9. 1 PublicationVSP_058076Add
BLAST
Alternative sequencei30 – 4011IGEPLVLSCKG → KARRMRRNVQS in isoform 12. 1 PublicationVSP_058077Add
BLAST
Alternative sequencei31 – 402372Missing in isoform 13. VSP_058078Add
BLAST
Alternative sequencei41 – 402362Missing in isoform 12. 1 PublicationVSP_058079Add
BLAST
Alternative sequencei54 – 629Missing in isoform 4. 1 PublicationVSP_058080
Alternative sequencei78 – 402325Missing in isoform 11. 1 PublicationVSP_058081Add
BLAST
Alternative sequencei86 – 402317Missing in isoform 9. 1 PublicationVSP_058082Add
BLAST
Alternative sequencei118 – 13821QIPGK…ASVPN → RKGPRLSHFAFIKKPSCTPN P in isoform 7. 1 PublicationVSP_058083Add
BLAST
Alternative sequencei119 – 13719IPGKP…TASVP → KPAMRGQLKALWVSLGWVR in isoform 8. 1 PublicationVSP_058084Add
BLAST
Alternative sequencei138 – 402265Missing in isoform 8. 1 PublicationVSP_058085Add
BLAST
Alternative sequencei139 – 402264Missing in isoform 7. 1 PublicationVSP_058086Add
BLAST
Alternative sequencei153 – 1531T → G in isoform 6. 1 PublicationVSP_058087
Alternative sequencei154 – 402249Missing in isoform 6. 1 PublicationVSP_058088Add
BLAST
Alternative sequencei188 – 382195Missing in isoform 5. 1 PublicationVSP_058089Add
BLAST
Alternative sequencei320 – 3289Missing in isoform 3 and isoform 4. 1 PublicationVSP_058090
Alternative sequencei330 – 3334SVGE → EGLD in isoform 2. 2 PublicationsVSP_058091
Alternative sequencei334 – 40269Missing in isoform 2. 2 PublicationsVSP_058092Add
BLAST
Alternative sequencei372 – 38413KAPES…EEERA → PRKARRMRRNVQS in isoform 10. 1 PublicationVSP_058093Add
BLAST
Alternative sequencei385 – 40218Missing in isoform 10. 1 PublicationVSP_058094Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33412 mRNA. Translation: AAA40040.1.
AB207883 mRNA. Translation: BAE72665.1.
EU520325 mRNA. Translation: ACD35949.1.
EU570240 mRNA. Translation: ACE63492.1.
EU570241 mRNA. Translation: ACE63493.1.
EU570242 mRNA. Translation: ACE63494.1.
EU570243 mRNA. Translation: ACE63495.1.
EU570244 mRNA. Translation: ACE63496.1.
EU570245 mRNA. Translation: ACE63497.1.
EU570246 mRNA. Translation: ACE63498.1.
EU570247 mRNA. Translation: ACE63499.1.
EU906857 mRNA. Translation: ACK28143.1.
EU906858 mRNA. Translation: ACK28144.1.
EU906859 mRNA. Translation: ACK28145.1.
EU906860 mRNA. Translation: ACK28146.1.
EU906861 mRNA. Translation: ACK28147.1.
EU906862 mRNA. Translation: ACK28148.1.
EU906863 mRNA. Translation: ACK28149.1.
EU906864 mRNA. Translation: ACK28150.1.
EU906865 mRNA. Translation: ACK28151.1.
KC692918 mRNA. Translation: AHB30242.1.
AF030001 Genomic DNA. Translation: AAB82007.1.
CT009767 Genomic DNA. No translation available.
CH466666 Genomic DNA. Translation: EDL26799.1.
CH466666 Genomic DNA. Translation: EDL26800.1.
BC061182 mRNA. Translation: AAH61182.1.
CCDSiCCDS28649.1. [Q62151-1]
CCDS70795.1. [Q62151-3]
CCDS70796.1. [Q62151-4]
PIRiT09062.
RefSeqiNP_001258351.1. NM_001271422.1. [Q62151-3]
NP_001258352.1. NM_001271423.1. [Q62151-4]
NP_031451.2. NM_007425.3. [Q62151-1]
UniGeneiMm.3383.

Genome annotation databases

EnsembliENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452. [Q62151-1]
ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452. [Q62151-4]
ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452. [Q62151-2]
ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452. [Q62151-3]
GeneIDi11596.
KEGGimmu:11596.
UCSCiuc008ccw.3. mouse.
uc008ccx.2. mouse.
uc012aqf.2. mouse.
uc012aqg.2. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33412 mRNA. Translation: AAA40040.1.
AB207883 mRNA. Translation: BAE72665.1.
EU520325 mRNA. Translation: ACD35949.1.
EU570240 mRNA. Translation: ACE63492.1.
EU570241 mRNA. Translation: ACE63493.1.
EU570242 mRNA. Translation: ACE63494.1.
EU570243 mRNA. Translation: ACE63495.1.
EU570244 mRNA. Translation: ACE63496.1.
EU570245 mRNA. Translation: ACE63497.1.
EU570246 mRNA. Translation: ACE63498.1.
EU570247 mRNA. Translation: ACE63499.1.
EU906857 mRNA. Translation: ACK28143.1.
EU906858 mRNA. Translation: ACK28144.1.
EU906859 mRNA. Translation: ACK28145.1.
EU906860 mRNA. Translation: ACK28146.1.
EU906861 mRNA. Translation: ACK28147.1.
EU906862 mRNA. Translation: ACK28148.1.
EU906863 mRNA. Translation: ACK28149.1.
EU906864 mRNA. Translation: ACK28150.1.
EU906865 mRNA. Translation: ACK28151.1.
KC692918 mRNA. Translation: AHB30242.1.
AF030001 Genomic DNA. Translation: AAB82007.1.
CT009767 Genomic DNA. No translation available.
CH466666 Genomic DNA. Translation: EDL26799.1.
CH466666 Genomic DNA. Translation: EDL26800.1.
BC061182 mRNA. Translation: AAH61182.1.
CCDSiCCDS28649.1. [Q62151-1]
CCDS70795.1. [Q62151-3]
CCDS70796.1. [Q62151-4]
PIRiT09062.
RefSeqiNP_001258351.1. NM_001271422.1. [Q62151-3]
NP_001258352.1. NM_001271423.1. [Q62151-4]
NP_031451.2. NM_007425.3. [Q62151-1]
UniGeneiMm.3383.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IM8X-ray3.50A23-230[»]
ProteinModelPortaliQ62151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62151. 2 interactions.
MINTiMINT-4131696.
STRINGi10090.ENSMUSP00000015596.

Chemistry

ChEMBLiCHEMBL2189161.

PTM databases

iPTMnetiQ62151.
PhosphoSiteiQ62151.

Proteomic databases

MaxQBiQ62151.
PaxDbiQ62151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452. [Q62151-1]
ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452. [Q62151-4]
ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452. [Q62151-2]
ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452. [Q62151-3]
GeneIDi11596.
KEGGimmu:11596.
UCSCiuc008ccw.3. mouse.
uc008ccx.2. mouse.
uc012aqf.2. mouse.
uc012aqg.2. mouse.

Organism-specific databases

CTDi177.
MGIiMGI:893592. Ager.

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000232122.
HOVERGENiHBG004350.
InParanoidiQ62151.
KOiK19722.
OMAiPNKVGTC.
OrthoDBiEOG091G0BCY.
TreeFamiTF337155.

Enzyme and pathway databases

ReactomeiR-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-879415. Advanced glycosylation endproduct receptor signaling.
R-MMU-933542. TRAF6 mediated NF-kB activation.

Miscellaneous databases

PROiQ62151.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015452.
CleanExiMM_RAGE.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAGE_MOUSE
AccessioniPrimary (citable) accession number: Q62151
Secondary accession number(s): C5H3H4
, C5H3H5, C5H3H7, C5H3I0, C5H7W3, C5H7W4, C5H7W5, C5H7W6, C5H7W7, C5H7W8, C5H7W9, O35444, Q2PGG1, V5R4Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 17, 2016
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.