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Protein

Retinal dehydrogenase 2

Gene

Aldh1a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).By similarity

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei187 – 1871Transition state stabilizerBy similarity
Active sitei286 – 2861Proton acceptorPROSITE-ProRule annotation
Active sitei320 – 3201NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi263 – 2686NADBy similarity

GO - Molecular functioni

  • 3-chloroallyl aldehyde dehydrogenase activity Source: MGI
  • aldehyde dehydrogenase (NAD) activity Source: GO_Central
  • retinal binding Source: Ensembl
  • retinal dehydrogenase activity Source: MGI

GO - Biological processi

  • 9-cis-retinoic acid biosynthetic process Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • blood vessel development Source: MGI
  • camera-type eye development Source: MGI
  • cardiac muscle tissue development Source: MGI
  • cellular response to retinoic acid Source: UniProtKB
  • determination of bilateral symmetry Source: MGI
  • embryonic camera-type eye development Source: MGI
  • embryonic digestive tract development Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • face development Source: MGI
  • forebrain development Source: MGI
  • heart development Source: DFLAT
  • heart looping Source: DFLAT
  • heart morphogenesis Source: MGI
  • hindbrain development Source: MGI
  • kidney development Source: Ensembl
  • liver development Source: Ensembl
  • lung development Source: MGI
  • midgut development Source: Ensembl
  • morphogenesis of embryonic epithelium Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • neural crest cell development Source: MGI
  • neural tube development Source: MGI
  • neuron differentiation Source: MGI
  • pancreas development Source: MGI
  • pituitary gland development Source: Ensembl
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of gene expression Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of endothelial cell proliferation Source: MGI
  • response to cytokine Source: MGI
  • response to estradiol Source: Ensembl
  • response to vitamin A Source: Ensembl
  • retinal metabolic process Source: MGI
  • retinoic acid metabolic process Source: MGI
  • retinoic acid receptor signaling pathway Source: MGI
  • retinoid metabolic process Source: DFLAT
  • retinol metabolic process Source: UniProtKB-UniPathway
  • ureter maturation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 2 (EC:1.2.1.36)
Short name:
RALDH 2
Short name:
RalDH2
Alternative name(s):
Aldehyde dehydrogenase family 1 member A2
Retinaldehyde-specific dehydrogenase type 2
Short name:
RALDH(II)
Gene namesi
Name:Aldh1a2
Synonyms:Aldh1a7, Raldh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107928. Aldh1a2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Retinal dehydrogenase 2PRO_0000056423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681PhosphotyrosineBy similarity
Modified residuei351 – 3511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62148.
PaxDbiQ62148.
PeptideAtlasiQ62148.
PRIDEiQ62148.

2D gel databases

REPRODUCTION-2DPAGEIPI00122212.
Q62148.

PTM databases

iPTMnetiQ62148.
PhosphoSiteiQ62148.

Expressioni

Gene expression databases

BgeeiENSMUSG00000013584.
CleanExiMM_ALDH1A2.
MM_ALDH1A7.
GenevisibleiQ62148. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ62148. 1 interaction.
MINTiMINT-4087503.
STRINGi10090.ENSMUSP00000034723.

Structurei

3D structure databases

ProteinModelPortaliQ62148.
SMRiQ62148. Positions 20-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ62148.
KOiK07249.
OMAiKPIANAY.
OrthoDBiEOG091G05E8.
PhylomeDBiQ62148.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSEIAMPG EVKADPAALM ASLQLLPSPT PNLEIKYTKI FINNEWQNSE
60 70 80 90 100
SGRVFPVCNP ATGEQVCEVQ EADKVDIDKA VQAARLAFSL GSVWRRMDAS
110 120 130 140 150
ERGRLLDKLA DLVERDRATL ATMESLNGGK PFLQAFYIDL QGVIKTLRYY
160 170 180 190 200
AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFTWKIAPA
210 220 230 240 250
LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP GYGPTAGAAI
260 270 280 290 300
ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD
310 320 330 340 350
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVKRS VERAKRRIVG
360 370 380 390 400
SPFDPTTEQG PQIDKKQYNK VLELIQSGVA EGAKLECGGK GLGRKGFFIE
410 420 430 440 450
PTVFSNVTDD MRIAKEEIFG PVQEILRFKT MDEVIERANN SDFGLVAAVF
460 470 480 490 500
TNDINKALMV SSAMQAGTVW INCYNALNAQ SPFGGFKMSG NGREMGEFGL
510
REYSEVKTVT VKIPQKNS
Length:518
Mass (Da):56,626
Last modified:March 7, 2006 - v2
Checksum:i2BC35B5C90046ABC
GO

Sequence cautioni

The sequence BAC37332 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA67666 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99273 mRNA. Translation: CAA67666.1. Different initiation.
BC075704 mRNA. Translation: AAH75704.1.
AK078553 mRNA. Translation: BAC37332.1. Different initiation.
CCDSiCCDS52852.1.
PIRiS74224.
RefSeqiNP_033048.2. NM_009022.4.
UniGeneiMm.42016.

Genome annotation databases

EnsembliENSMUST00000034723; ENSMUSP00000034723; ENSMUSG00000013584.
GeneIDi19378.
KEGGimmu:19378.
UCSCiuc009qox.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99273 mRNA. Translation: CAA67666.1. Different initiation.
BC075704 mRNA. Translation: AAH75704.1.
AK078553 mRNA. Translation: BAC37332.1. Different initiation.
CCDSiCCDS52852.1.
PIRiS74224.
RefSeqiNP_033048.2. NM_009022.4.
UniGeneiMm.42016.

3D structure databases

ProteinModelPortaliQ62148.
SMRiQ62148. Positions 20-518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62148. 1 interaction.
MINTiMINT-4087503.
STRINGi10090.ENSMUSP00000034723.

PTM databases

iPTMnetiQ62148.
PhosphoSiteiQ62148.

2D gel databases

REPRODUCTION-2DPAGEIPI00122212.
Q62148.

Proteomic databases

MaxQBiQ62148.
PaxDbiQ62148.
PeptideAtlasiQ62148.
PRIDEiQ62148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034723; ENSMUSP00000034723; ENSMUSG00000013584.
GeneIDi19378.
KEGGimmu:19378.
UCSCiuc009qox.2. mouse.

Organism-specific databases

CTDi8854.
MGIiMGI:107928. Aldh1a2.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ62148.
KOiK07249.
OMAiKPIANAY.
OrthoDBiEOG091G05E8.
PhylomeDBiQ62148.
TreeFamiTF300455.

Enzyme and pathway databases

UniPathwayiUPA00912.
BRENDAi1.2.1.36. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Miscellaneous databases

PROiQ62148.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013584.
CleanExiMM_ALDH1A2.
MM_ALDH1A7.
GenevisibleiQ62148. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1A2_MOUSE
AccessioniPrimary (citable) accession number: Q62148
Secondary accession number(s): Q6DI79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.