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Q62137

- JAK3_MOUSE

UniProt

Q62137 - JAK3_MOUSE

Protein

Tyrosine-protein kinase JAK3

Gene

Jak3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei851 – 8511ATPPROSITE-ProRule annotation
    Active sitei945 – 9451Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi824 – 8329ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    3. protein binding Source: MGI
    4. protein tyrosine kinase activity Source: MGI

    GO - Biological processi

    1. B cell differentiation Source: BHF-UCL
    2. cytokine-mediated signaling pathway Source: MGI
    3. enzyme linked receptor protein signaling pathway Source: MGI
    4. innate immune response Source: UniProtKB-KW
    5. interleukin-4-mediated signaling pathway Source: Ensembl
    6. intracellular signal transduction Source: MGI
    7. lymph node development Source: MGI
    8. negative regulation of dendritic cell cytokine production Source: BHF-UCL
    9. negative regulation of FasL biosynthetic process Source: BHF-UCL
    10. negative regulation of interleukin-10 production Source: BHF-UCL
    11. negative regulation of interleukin-12 production Source: BHF-UCL
    12. negative regulation of T cell activation Source: BHF-UCL
    13. negative regulation of T-helper 1 cell differentiation Source: BHF-UCL
    14. negative regulation of thymocyte apoptotic process Source: BHF-UCL
    15. peptidyl-tyrosine phosphorylation Source: MGI
    16. positive regulation of activated T cell proliferation Source: BHF-UCL
    17. positive regulation of calcium ion transport Source: BHF-UCL
    18. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
    19. positive regulation of dendritic cell apoptotic process Source: BHF-UCL
    20. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
    21. positive regulation of immune response Source: BHF-UCL
    22. positive regulation of T cell proliferation Source: BHF-UCL
    23. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    24. protein autophosphorylation Source: BHF-UCL
    25. regulation of T cell apoptotic process Source: BHF-UCL
    26. response to interleukin-15 Source: BHF-UCL
    27. response to interleukin-2 Source: BHF-UCL
    28. response to interleukin-4 Source: BHF-UCL
    29. response to interleukin-9 Source: BHF-UCL
    30. T cell homeostasis Source: BHF-UCL
    31. tyrosine phosphorylation of Stat5 protein Source: BHF-UCL

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Adaptive immunity, Immunity, Innate immunity

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.
    ReactomeiREACT_198701. Interleukin-7 signaling.
    REACT_210793. Interleukin receptor SHC signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase JAK3 (EC:2.7.10.2)
    Alternative name(s):
    Janus kinase 3
    Short name:
    JAK-3
    Gene namesi
    Name:Jak3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:99928. Jak3.

    Subcellular locationi

    Endomembrane system By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytoskeleton Source: InterPro
    3. cytosol Source: Reactome
    4. endomembrane system Source: UniProtKB-SubCell
    5. intracellular Source: BHF-UCL
    6. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice show a severe block in B-cell development at the pre-B stage in the bone marrow. Additionally, they possesses small thymuses revealing a defect in T-cell development. The distribution of developmental subsets is relatively normal, suggesting a block in the expansion of early T-cell progenitors. Peripheral T-cells are present at normal or increased numbers but are functionally incompetent.3 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi853 – 8531L → R: Loss of activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11001100Tyrosine-protein kinase JAK3PRO_0000088116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei781 – 7811Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei900 – 9001PhosphotyrosineBy similarity
    Modified residuei935 – 9351PhosphotyrosineBy similarity
    Modified residuei976 – 9761Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei977 – 9771Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated, leading to regulate its activity. IL2 promotes phosphorylation on tyrosine residues, including autophosphorylation on Tyr-781 By similarity. Dephosphorylation of Tyr-976 and Tyr-977 by PTPN2 negatively regulates cytokine-mediated signaling By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ62137.

    PTM databases

    PhosphoSiteiQ62137.

    Expressioni

    Tissue specificityi

    In contrast with the ubiquitous expression of the other JAKs, JAK3 is predominantly expressed in hematopoietic tissues.1 Publication

    Gene expression databases

    BgeeiQ62137.
    CleanExiMM_JAK3.
    GenevestigatoriQ62137.

    Interactioni

    Subunit structurei

    Interacts with STAM2 and MYO18A. Interacts with SHB By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200858. 5 interactions.
    IntActiQ62137. 2 interactions.
    MINTiMINT-1523453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62137.
    SMRiQ62137. Positions 24-1094.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 353330FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini372 – 472101SH2; atypicalAdd
    BLAST
    Domaini517 – 777261Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini818 – 1100283Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 223223Interaction with cytokine/interferon/growth hormone receptorsBy similarityAdd
    BLAST

    Domaini

    Possesses two phosphotransferase domains. The second one contains the catalytic domain, while the presence of a pseudokinase domain is required for suppression of basal activity of JAK3.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 1 SH2 domain.Curated

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00710000106680.
    HOVERGENiHBG006195.
    KOiK11218.
    OrthoDBiEOG7BW0HM.
    PhylomeDBiQ62137.
    TreeFamiTF327041.

    Family and domain databases

    InterProiIPR019749. Band_41_domain.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR020775. Tyr_kinase_non-rcpt_Jak3.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSiPR01823. JANUSKINASE.
    PR01826. JANUSKINASE3.
    PR00109. TYRKINASE.
    SMARTiSM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q62137-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPPSEETPL IPQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDYLA     50
    EDLCVRAAKA CGILPVYHSL FALATEDFSC WFPPSHIFCI EDVDTQVLVY 100
    RLRFYFPDWF GLETCHRFGL RKDLTSAILD LHVLEHLFAQ HRSDLVSGRL 150
    PVGLSMKEQG EFLSLAVLDL AQMAREQAQR PGELLKTVSY KACLPPSLRD 200
    VIQGQNFVTR RRIRRTVVLA LRRVVACQAD RYALMAKYIL DLERLHPAAT 250
    TETFRVGLPG AQEEPGLLRV AGDNGISWSS GDQELFQTFC DFPEIVDVSI 300
    KQAPRVGPAG EHRLVTVTRM DGHILEAEFP GLPEALSFVA LVDGYFRLIC 350
    DSRHYFCKEV APPRLLEEEA ELCHGPITLD FAIHKLKAAG SLPGTYILRR 400
    SPQDYDSFLL TACVQTPLGP DYKGCLIRQD PSGAFSLVGL SQPHRSLREL 450
    LAACWNSGLR VDGAALNLTS CCAPRPKEKS NLIVVRRGCT PAPAPGCSPS 500
    CCALTQLSFH TIPTDSLEWH ENLGHGSFTK IFRGRRREVV DGETHDSEVL 550
    LKVMDSRHRN CMESFLEAAS LMSQVSYPHL VLLHGVCMAG DSIMVQEFVY 600
    LGAIDMYLRK RGHLVSASWK LQVTKQLAYA LNYLEDKGLP HGNVSARKVL 650
    LAREGGDGNP PFIKLSDPGV SPTVLSLEML TDRIPWVAPE CLQEAQTLCL 700
    EADKWGFGAT TWEVFSGGPA HITSLEPAKK LKFYEDQGQL PALKWTELAG 750
    LITQCMAYDP GRRPSFRAIL RDLNGLITSD YELLSDPTPG IPSPRDELCG 800
    GAQLYACQDP AIFEERHLKY ISLLGKGNFG SVELCRYDPL GDNTGPLVAV 850
    KQLQHSGPDQ QRDFQREIQI LKALHSDFIV KYRGVSYGPG RQSLRLVMEY 900
    LPSGCLRDFL QRHRARLHTD RLLLFAWQIC KGMEYLGARR CVHRDLAARN 950
    ILVESEAHVK IADFGLAKLL PLGKDYYVVR EPGQSPIFWY APESLSDNIF 1000
    SRQSDVWSFG VVLYELFTYC DKSCSPSAEF LRMMGPEREG PPLCRLLELL 1050
    AEGRRLPPPP TCPTEVQELM QLCWAPSPHD RPAFGTLSPQ LDALWRGRPG 1100
    Length:1,100
    Mass (Da):122,641
    Last modified:August 21, 2007 - v2
    Checksum:i979A120861ED37C1
    GO
    Isoform 2 (identifier: Q62137-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         284-284: E → EVLGLGLRSG...RRYCLSFLPQ
         379-379: L → LGASWGQQWGWGWAARTVLGWTWLLSWPRL

    Note: No experimental confirmation available.

    Show »
    Length:1,319
    Mass (Da):146,899
    Checksum:iCC2DDD3C6F824439
    GO

    Sequence cautioni

    The sequence AAA21415.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence AAA21565.1 differs from that shown. Reason: Frameshift at positions 222 and 232.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621G → A in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti62 – 621G → A in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti277 – 2771S → P in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti281 – 2833GDQ → ND in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti301 – 3011K → N in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti362 – 3621P → A in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti371 – 3722EL → DV in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti390 – 3901G → A in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti454 – 4541Missing in BAC40305. (PubMed:16141072)Curated
    Sequence conflicti467 – 4671N → Y in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti490 – 4901T → N in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti518 – 5192EW → G in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti535 – 5351R → S in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti699 – 6991C → G in BAC40305. (PubMed:16141072)Curated
    Sequence conflicti699 – 6991C → G in BAC29956. (PubMed:16141072)Curated
    Sequence conflicti699 – 6991C → G in BAE24964. (PubMed:16141072)Curated
    Sequence conflicti699 – 6991C → G in BAE33790. (PubMed:16141072)Curated
    Sequence conflicti699 – 6991C → G in BAE37819. (PubMed:16141072)Curated
    Sequence conflicti716 – 7172SG → QR in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti800 – 8001G → VA in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti826 – 8261K → N in AAI31647. (PubMed:15489334)Curated
    Sequence conflicti841 – 8411Missing in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti857 – 8571G → V in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti909 – 9091F → L in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti915 – 9162AR → G in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti916 – 9161R → A in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti1032 – 10321R → S in BAC40305. (PubMed:16141072)Curated
    Sequence conflicti1032 – 10321R → S in BAC29956. (PubMed:16141072)Curated
    Sequence conflicti1032 – 10321R → S in BAE24964. (PubMed:16141072)Curated
    Sequence conflicti1032 – 10321R → S in BAE33790. (PubMed:16141072)Curated
    Sequence conflicti1032 – 10321R → S in BAE37819. (PubMed:16141072)Curated
    Sequence conflicti1074 – 10741W → V in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti1077 – 10771S → E in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti1085 – 10851G → A in AAA21565. (PubMed:8605329)Curated
    Sequence conflicti1093 – 10931A → G in AAA21415. (PubMed:7518579)Curated
    Sequence conflicti1093 – 10931A → P in AAA21565. (PubMed:8605329)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei284 – 2841E → EVLGLGLRSGVRGEAWRLVK KPVRTIRKVASPGRADCTTG QGGGVNLKVGPGMELPQGLT WGVTRRVRLDRGRGRTEGDS MDWISGHDPTRPVFSPLTSS PPPHKWRWEGGRRGGCAGSR SVIPWLLSLFLFFFFNGFAR QGFSYSSGCPGTHFVRPGWP RTQKSACLCLSSAVIKGRVP LRRYCLSFLPQ in isoform 2. 1 PublicationVSP_027575
    Alternative sequencei379 – 3791L → LGASWGQQWGWGWAARTVLG WTWLLSWPRL in isoform 2. 1 PublicationVSP_027576

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33768 mRNA. Translation: AAA21415.1. Frameshift.
    L40172 mRNA. Translation: AAC42085.1.
    L32955 mRNA. Translation: AAA21565.1. Frameshift.
    AK038268 mRNA. Translation: BAC29956.1.
    AK142178 mRNA. Translation: BAE24964.1.
    AK156646 mRNA. Translation: BAE33790.1.
    AK164520 mRNA. Translation: BAE37819.1.
    AK088365 mRNA. Translation: BAC40305.1.
    BC105577 mRNA. Translation: AAI05578.1.
    BC131646 mRNA. Translation: AAI31647.1.
    BC131647 mRNA. Translation: AAI31648.1.
    CCDSiCCDS22403.1. [Q62137-1]
    PIRiI58401.
    S48053.
    RefSeqiNP_001177759.1. NM_001190830.1.
    NP_034719.2. NM_010589.6.
    UniGeneiMm.249645.
    Mm.476857.

    Genome annotation databases

    EnsembliENSMUST00000051995; ENSMUSP00000060073; ENSMUSG00000031805.
    ENSMUST00000110012; ENSMUSP00000105639; ENSMUSG00000031805.
    ENSMUST00000110013; ENSMUSP00000105640; ENSMUSG00000031805.
    GeneIDi16453.
    KEGGimmu:16453.
    UCSCiuc009mel.2. mouse. [Q62137-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33768 mRNA. Translation: AAA21415.1 . Frameshift.
    L40172 mRNA. Translation: AAC42085.1 .
    L32955 mRNA. Translation: AAA21565.1 . Frameshift.
    AK038268 mRNA. Translation: BAC29956.1 .
    AK142178 mRNA. Translation: BAE24964.1 .
    AK156646 mRNA. Translation: BAE33790.1 .
    AK164520 mRNA. Translation: BAE37819.1 .
    AK088365 mRNA. Translation: BAC40305.1 .
    BC105577 mRNA. Translation: AAI05578.1 .
    BC131646 mRNA. Translation: AAI31647.1 .
    BC131647 mRNA. Translation: AAI31648.1 .
    CCDSi CCDS22403.1. [Q62137-1 ]
    PIRi I58401.
    S48053.
    RefSeqi NP_001177759.1. NM_001190830.1.
    NP_034719.2. NM_010589.6.
    UniGenei Mm.249645.
    Mm.476857.

    3D structure databases

    ProteinModelPortali Q62137.
    SMRi Q62137. Positions 24-1094.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200858. 5 interactions.
    IntActi Q62137. 2 interactions.
    MINTi MINT-1523453.

    Chemistry

    BindingDBi Q62137.
    ChEMBLi CHEMBL5250.

    PTM databases

    PhosphoSitei Q62137.

    Proteomic databases

    PRIDEi Q62137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051995 ; ENSMUSP00000060073 ; ENSMUSG00000031805 .
    ENSMUST00000110012 ; ENSMUSP00000105639 ; ENSMUSG00000031805 .
    ENSMUST00000110013 ; ENSMUSP00000105640 ; ENSMUSG00000031805 .
    GeneIDi 16453.
    KEGGi mmu:16453.
    UCSCi uc009mel.2. mouse. [Q62137-1 ]

    Organism-specific databases

    CTDi 3718.
    MGIi MGI:99928. Jak3.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00710000106680.
    HOVERGENi HBG006195.
    KOi K11218.
    OrthoDBi EOG7BW0HM.
    PhylomeDBi Q62137.
    TreeFami TF327041.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.
    Reactomei REACT_198701. Interleukin-7 signaling.
    REACT_210793. Interleukin receptor SHC signaling.

    Miscellaneous databases

    NextBioi 289723.
    PROi Q62137.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62137.
    CleanExi MM_JAK3.
    Genevestigatori Q62137.

    Family and domain databases

    InterProi IPR019749. Band_41_domain.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR020775. Tyr_kinase_non-rcpt_Jak3.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSi PR01823. JANUSKINASE.
    PR01826. JANUSKINASE3.
    PR00109. TYRKINASE.
    SMARTi SM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells."
      Rane S.G., Reddy E.P.
      Oncogene 9:2415-2423(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells."
      Gurniak C.B., Berg L.J.
      Blood 87:3151-3160(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, MUTAGENESIS OF LEU-853.
      Strain: BALB/C X 129.
      Tissue: Thymus.
    3. "Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells."
      Witthuhn B.A., Silvennoinen O., Miura O., Lai K.S., Cwik C., Liu E.T., Ihle J.N.
      Nature 370:153-157(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Heart, Spleen and Thymus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    6. "Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3."
      Thomis D.C., Gurniak C.B., Tivol E., Sharpe A.H., Berg L.J.
      Science 270:794-797(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    7. Cited for: DISRUPTION PHENOTYPE.
    8. "Peripheral expression of Jak3 is required to maintain T lymphocyte function."
      Thomis D.C., Berg L.J.
      J. Exp. Med. 185:197-206(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "T cell development and activation in Jak3-deficient mice."
      Baird A.M., Thomis D.C., Berg L.J.
      J. Leukoc. Biol. 63:669-677(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    10. "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival."
      Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z.
      Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYO18A.

    Entry informationi

    Entry nameiJAK3_MOUSE
    AccessioniPrimary (citable) accession number: Q62137
    Secondary accession number(s): A2RRI3
    , Q0D2M8, Q61746, Q61747, Q8BTY6, Q8BYU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3