Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62137

- JAK3_MOUSE

UniProt

Q62137 - JAK3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tyrosine-protein kinase JAK3

Gene

Jak3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei851 – 8511ATPPROSITE-ProRule annotation
Active sitei945 – 9451Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi824 – 8329ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: MGI

GO - Biological processi

  1. B cell differentiation Source: BHF-UCL
  2. cytokine-mediated signaling pathway Source: MGI
  3. enzyme linked receptor protein signaling pathway Source: MGI
  4. innate immune response Source: UniProtKB-KW
  5. interleukin-4-mediated signaling pathway Source: Ensembl
  6. intracellular signal transduction Source: MGI
  7. lymph node development Source: MGI
  8. negative regulation of dendritic cell cytokine production Source: BHF-UCL
  9. negative regulation of FasL biosynthetic process Source: BHF-UCL
  10. negative regulation of interleukin-10 production Source: BHF-UCL
  11. negative regulation of interleukin-12 production Source: BHF-UCL
  12. negative regulation of T cell activation Source: BHF-UCL
  13. negative regulation of T-helper 1 cell differentiation Source: BHF-UCL
  14. negative regulation of thymocyte apoptotic process Source: BHF-UCL
  15. peptidyl-tyrosine phosphorylation Source: MGI
  16. positive regulation of activated T cell proliferation Source: BHF-UCL
  17. positive regulation of calcium ion transport Source: BHF-UCL
  18. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  19. positive regulation of dendritic cell apoptotic process Source: BHF-UCL
  20. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  21. positive regulation of immune response Source: BHF-UCL
  22. positive regulation of T cell proliferation Source: BHF-UCL
  23. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  24. protein autophosphorylation Source: BHF-UCL
  25. regulation of T cell apoptotic process Source: BHF-UCL
  26. response to interleukin-15 Source: BHF-UCL
  27. response to interleukin-2 Source: BHF-UCL
  28. response to interleukin-4 Source: BHF-UCL
  29. response to interleukin-9 Source: BHF-UCL
  30. T cell homeostasis Source: BHF-UCL
  31. tyrosine phosphorylation of Stat5 protein Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiREACT_198701. Interleukin-7 signaling.
REACT_210793. Interleukin receptor SHC signaling.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.
REACT_261365. Interleukin-2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase JAK3 (EC:2.7.10.2)
Alternative name(s):
Janus kinase 3
Short name:
JAK-3
Gene namesi
Name:Jak3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99928. Jak3.

Subcellular locationi

Endomembrane system By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoskeleton Source: InterPro
  3. cytosol Source: Reactome
  4. intracellular Source: BHF-UCL
  5. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show a severe block in B-cell development at the pre-B stage in the bone marrow. Additionally, they possesses small thymuses revealing a defect in T-cell development. The distribution of developmental subsets is relatively normal, suggesting a block in the expansion of early T-cell progenitors. Peripheral T-cells are present at normal or increased numbers but are functionally incompetent.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi853 – 8531L → R: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11001100Tyrosine-protein kinase JAK3PRO_0000088116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei781 – 7811Phosphotyrosine; by autocatalysisBy similarity
Modified residuei900 – 9001PhosphotyrosineBy similarity
Modified residuei935 – 9351PhosphotyrosineBy similarity
Modified residuei976 – 9761Phosphotyrosine; by autocatalysisBy similarity
Modified residuei977 – 9771Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated, leading to regulate its activity. IL2 promotes phosphorylation on tyrosine residues, including autophosphorylation on Tyr-781 (By similarity). Dephosphorylation of Tyr-976 and Tyr-977 by PTPN2 negatively regulates cytokine-mediated signaling (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62137.

PTM databases

PhosphoSiteiQ62137.

Expressioni

Tissue specificityi

In contrast with the ubiquitous expression of the other JAKs, JAK3 is predominantly expressed in hematopoietic tissues.1 Publication

Gene expression databases

BgeeiQ62137.
CleanExiMM_JAK3.
GenevestigatoriQ62137.

Interactioni

Subunit structurei

Interacts with STAM2 and MYO18A. Interacts with SHB (By similarity).By similarity

Protein-protein interaction databases

BioGridi200858. 5 interactions.
IntActiQ62137. 2 interactions.
MINTiMINT-1523453.

Structurei

3D structure databases

ProteinModelPortaliQ62137.
SMRiQ62137. Positions 24-1094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 353330FERMPROSITE-ProRule annotationAdd
BLAST
Domaini372 – 472101SH2; atypicalAdd
BLAST
Domaini517 – 777261Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini818 – 1100283Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 223223Interaction with cytokine/interferon/growth hormone receptorsBy similarityAdd
BLAST

Domaini

Possesses two phosphotransferase domains. The second one contains the catalytic domain, while the presence of a pseudokinase domain is required for suppression of basal activity of JAK3.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118799.
HOVERGENiHBG006195.
InParanoidiQ62137.
KOiK11218.
OrthoDBiEOG7BW0HM.
PhylomeDBiQ62137.
TreeFamiTF327041.

Family and domain databases

InterProiIPR019749. Band_41_domain.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775. Tyr_kinase_non-rcpt_Jak3.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR01826. JANUSKINASE3.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q62137-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPSEETPL IPQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDYLA
60 70 80 90 100
EDLCVRAAKA CGILPVYHSL FALATEDFSC WFPPSHIFCI EDVDTQVLVY
110 120 130 140 150
RLRFYFPDWF GLETCHRFGL RKDLTSAILD LHVLEHLFAQ HRSDLVSGRL
160 170 180 190 200
PVGLSMKEQG EFLSLAVLDL AQMAREQAQR PGELLKTVSY KACLPPSLRD
210 220 230 240 250
VIQGQNFVTR RRIRRTVVLA LRRVVACQAD RYALMAKYIL DLERLHPAAT
260 270 280 290 300
TETFRVGLPG AQEEPGLLRV AGDNGISWSS GDQELFQTFC DFPEIVDVSI
310 320 330 340 350
KQAPRVGPAG EHRLVTVTRM DGHILEAEFP GLPEALSFVA LVDGYFRLIC
360 370 380 390 400
DSRHYFCKEV APPRLLEEEA ELCHGPITLD FAIHKLKAAG SLPGTYILRR
410 420 430 440 450
SPQDYDSFLL TACVQTPLGP DYKGCLIRQD PSGAFSLVGL SQPHRSLREL
460 470 480 490 500
LAACWNSGLR VDGAALNLTS CCAPRPKEKS NLIVVRRGCT PAPAPGCSPS
510 520 530 540 550
CCALTQLSFH TIPTDSLEWH ENLGHGSFTK IFRGRRREVV DGETHDSEVL
560 570 580 590 600
LKVMDSRHRN CMESFLEAAS LMSQVSYPHL VLLHGVCMAG DSIMVQEFVY
610 620 630 640 650
LGAIDMYLRK RGHLVSASWK LQVTKQLAYA LNYLEDKGLP HGNVSARKVL
660 670 680 690 700
LAREGGDGNP PFIKLSDPGV SPTVLSLEML TDRIPWVAPE CLQEAQTLCL
710 720 730 740 750
EADKWGFGAT TWEVFSGGPA HITSLEPAKK LKFYEDQGQL PALKWTELAG
760 770 780 790 800
LITQCMAYDP GRRPSFRAIL RDLNGLITSD YELLSDPTPG IPSPRDELCG
810 820 830 840 850
GAQLYACQDP AIFEERHLKY ISLLGKGNFG SVELCRYDPL GDNTGPLVAV
860 870 880 890 900
KQLQHSGPDQ QRDFQREIQI LKALHSDFIV KYRGVSYGPG RQSLRLVMEY
910 920 930 940 950
LPSGCLRDFL QRHRARLHTD RLLLFAWQIC KGMEYLGARR CVHRDLAARN
960 970 980 990 1000
ILVESEAHVK IADFGLAKLL PLGKDYYVVR EPGQSPIFWY APESLSDNIF
1010 1020 1030 1040 1050
SRQSDVWSFG VVLYELFTYC DKSCSPSAEF LRMMGPEREG PPLCRLLELL
1060 1070 1080 1090 1100
AEGRRLPPPP TCPTEVQELM QLCWAPSPHD RPAFGTLSPQ LDALWRGRPG
Length:1,100
Mass (Da):122,641
Last modified:August 21, 2007 - v2
Checksum:i979A120861ED37C1
GO
Isoform 2 (identifier: Q62137-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-284: E → EVLGLGLRSG...RRYCLSFLPQ
     379-379: L → LGASWGQQWGWGWAARTVLGWTWLLSWPRL

Note: No experimental confirmation available.

Show »
Length:1,319
Mass (Da):146,899
Checksum:iCC2DDD3C6F824439
GO

Sequence cautioni

The sequence AAA21415.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAA21565.1 differs from that shown. Reason: Frameshift at positions 222 and 232. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621G → A in AAA21415. (PubMed:7518579)Curated
Sequence conflicti62 – 621G → A in AAA21565. (PubMed:8605329)Curated
Sequence conflicti277 – 2771S → P in AAA21565. (PubMed:8605329)Curated
Sequence conflicti281 – 2833GDQ → ND in AAA21565. (PubMed:8605329)Curated
Sequence conflicti301 – 3011K → N in AAA21565. (PubMed:8605329)Curated
Sequence conflicti362 – 3621P → A in AAA21415. (PubMed:7518579)Curated
Sequence conflicti371 – 3722EL → DV in AAA21565. (PubMed:8605329)Curated
Sequence conflicti390 – 3901G → A in AAA21415. (PubMed:7518579)Curated
Sequence conflicti454 – 4541Missing in BAC40305. (PubMed:16141072)Curated
Sequence conflicti467 – 4671N → Y in AAA21565. (PubMed:8605329)Curated
Sequence conflicti490 – 4901T → N in AAA21565. (PubMed:8605329)Curated
Sequence conflicti518 – 5192EW → G in AAA21415. (PubMed:7518579)Curated
Sequence conflicti535 – 5351R → S in AAA21565. (PubMed:8605329)Curated
Sequence conflicti699 – 6991C → G in BAC40305. (PubMed:16141072)Curated
Sequence conflicti699 – 6991C → G in BAC29956. (PubMed:16141072)Curated
Sequence conflicti699 – 6991C → G in BAE24964. (PubMed:16141072)Curated
Sequence conflicti699 – 6991C → G in BAE33790. (PubMed:16141072)Curated
Sequence conflicti699 – 6991C → G in BAE37819. (PubMed:16141072)Curated
Sequence conflicti716 – 7172SG → QR in AAA21565. (PubMed:8605329)Curated
Sequence conflicti800 – 8001G → VA in AAA21565. (PubMed:8605329)Curated
Sequence conflicti826 – 8261K → N in AAI31647. (PubMed:15489334)Curated
Sequence conflicti841 – 8411Missing in AAA21415. (PubMed:7518579)Curated
Sequence conflicti857 – 8571G → V in AAA21565. (PubMed:8605329)Curated
Sequence conflicti909 – 9091F → L in AAA21565. (PubMed:8605329)Curated
Sequence conflicti915 – 9162AR → G in AAA21565. (PubMed:8605329)Curated
Sequence conflicti916 – 9161R → A in AAA21415. (PubMed:7518579)Curated
Sequence conflicti1032 – 10321R → S in BAC40305. (PubMed:16141072)Curated
Sequence conflicti1032 – 10321R → S in BAC29956. (PubMed:16141072)Curated
Sequence conflicti1032 – 10321R → S in BAE24964. (PubMed:16141072)Curated
Sequence conflicti1032 – 10321R → S in BAE33790. (PubMed:16141072)Curated
Sequence conflicti1032 – 10321R → S in BAE37819. (PubMed:16141072)Curated
Sequence conflicti1074 – 10741W → V in AAA21415. (PubMed:7518579)Curated
Sequence conflicti1077 – 10771S → E in AAA21565. (PubMed:8605329)Curated
Sequence conflicti1085 – 10851G → A in AAA21565. (PubMed:8605329)Curated
Sequence conflicti1093 – 10931A → G in AAA21415. (PubMed:7518579)Curated
Sequence conflicti1093 – 10931A → P in AAA21565. (PubMed:8605329)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 2841E → EVLGLGLRSGVRGEAWRLVK KPVRTIRKVASPGRADCTTG QGGGVNLKVGPGMELPQGLT WGVTRRVRLDRGRGRTEGDS MDWISGHDPTRPVFSPLTSS PPPHKWRWEGGRRGGCAGSR SVIPWLLSLFLFFFFNGFAR QGFSYSSGCPGTHFVRPGWP RTQKSACLCLSSAVIKGRVP LRRYCLSFLPQ in isoform 2. 1 PublicationVSP_027575
Alternative sequencei379 – 3791L → LGASWGQQWGWGWAARTVLG WTWLLSWPRL in isoform 2. 1 PublicationVSP_027576

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33768 mRNA. Translation: AAA21415.1. Frameshift.
L40172 mRNA. Translation: AAC42085.1.
L32955 mRNA. Translation: AAA21565.1. Frameshift.
AK038268 mRNA. Translation: BAC29956.1.
AK142178 mRNA. Translation: BAE24964.1.
AK156646 mRNA. Translation: BAE33790.1.
AK164520 mRNA. Translation: BAE37819.1.
AK088365 mRNA. Translation: BAC40305.1.
BC105577 mRNA. Translation: AAI05578.1.
BC131646 mRNA. Translation: AAI31647.1.
BC131647 mRNA. Translation: AAI31648.1.
CCDSiCCDS22403.1. [Q62137-1]
PIRiI58401.
S48053.
RefSeqiNP_001177759.1. NM_001190830.1.
NP_034719.2. NM_010589.6.
UniGeneiMm.249645.
Mm.476857.

Genome annotation databases

EnsembliENSMUST00000051995; ENSMUSP00000060073; ENSMUSG00000031805.
ENSMUST00000110012; ENSMUSP00000105639; ENSMUSG00000031805.
ENSMUST00000110013; ENSMUSP00000105640; ENSMUSG00000031805.
GeneIDi16453.
KEGGimmu:16453.
UCSCiuc009mel.2. mouse. [Q62137-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33768 mRNA. Translation: AAA21415.1 . Frameshift.
L40172 mRNA. Translation: AAC42085.1 .
L32955 mRNA. Translation: AAA21565.1 . Frameshift.
AK038268 mRNA. Translation: BAC29956.1 .
AK142178 mRNA. Translation: BAE24964.1 .
AK156646 mRNA. Translation: BAE33790.1 .
AK164520 mRNA. Translation: BAE37819.1 .
AK088365 mRNA. Translation: BAC40305.1 .
BC105577 mRNA. Translation: AAI05578.1 .
BC131646 mRNA. Translation: AAI31647.1 .
BC131647 mRNA. Translation: AAI31648.1 .
CCDSi CCDS22403.1. [Q62137-1 ]
PIRi I58401.
S48053.
RefSeqi NP_001177759.1. NM_001190830.1.
NP_034719.2. NM_010589.6.
UniGenei Mm.249645.
Mm.476857.

3D structure databases

ProteinModelPortali Q62137.
SMRi Q62137. Positions 24-1094.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200858. 5 interactions.
IntActi Q62137. 2 interactions.
MINTi MINT-1523453.

Chemistry

BindingDBi Q62137.
ChEMBLi CHEMBL5250.

PTM databases

PhosphoSitei Q62137.

Proteomic databases

PRIDEi Q62137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051995 ; ENSMUSP00000060073 ; ENSMUSG00000031805 .
ENSMUST00000110012 ; ENSMUSP00000105639 ; ENSMUSG00000031805 .
ENSMUST00000110013 ; ENSMUSP00000105640 ; ENSMUSG00000031805 .
GeneIDi 16453.
KEGGi mmu:16453.
UCSCi uc009mel.2. mouse. [Q62137-1 ]

Organism-specific databases

CTDi 3718.
MGIi MGI:99928. Jak3.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118799.
HOVERGENi HBG006195.
InParanoidi Q62137.
KOi K11218.
OrthoDBi EOG7BW0HM.
PhylomeDBi Q62137.
TreeFami TF327041.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.
Reactomei REACT_198701. Interleukin-7 signaling.
REACT_210793. Interleukin receptor SHC signaling.
REACT_220092. GPVI-mediated activation cascade.
REACT_223974. G beta:gamma signalling through PI3Kgamma.
REACT_261365. Interleukin-2 signaling.

Miscellaneous databases

NextBioi 289723.
PROi Q62137.
SOURCEi Search...

Gene expression databases

Bgeei Q62137.
CleanExi MM_JAK3.
Genevestigatori Q62137.

Family and domain databases

InterProi IPR019749. Band_41_domain.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775. Tyr_kinase_non-rcpt_Jak3.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 2 hits.
[Graphical view ]
PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
PRINTSi PR01823. JANUSKINASE.
PR01826. JANUSKINASE3.
PR00109. TYRKINASE.
SMARTi SM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells."
    Rane S.G., Reddy E.P.
    Oncogene 9:2415-2423(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells."
    Gurniak C.B., Berg L.J.
    Blood 87:3151-3160(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, MUTAGENESIS OF LEU-853.
    Strain: BALB/C X 129.
    Tissue: Thymus.
  3. "Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells."
    Witthuhn B.A., Silvennoinen O., Miura O., Lai K.S., Cwik C., Liu E.T., Ihle J.N.
    Nature 370:153-157(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Heart, Spleen and Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. "Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3."
    Thomis D.C., Gurniak C.B., Tivol E., Sharpe A.H., Berg L.J.
    Science 270:794-797(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. Cited for: DISRUPTION PHENOTYPE.
  8. "Peripheral expression of Jak3 is required to maintain T lymphocyte function."
    Thomis D.C., Berg L.J.
    J. Exp. Med. 185:197-206(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "T cell development and activation in Jak3-deficient mice."
    Baird A.M., Thomis D.C., Berg L.J.
    J. Leukoc. Biol. 63:669-677(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  10. "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival."
    Ji H., Zhai Q., Zhu J., Yan M., Sun L., Liu X., Zheng Z.
    Biochem. Biophys. Res. Commun. 270:267-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYO18A.

Entry informationi

Entry nameiJAK3_MOUSE
AccessioniPrimary (citable) accession number: Q62137
Secondary accession number(s): A2RRI3
, Q0D2M8, Q61746, Q61747, Q8BTY6, Q8BYU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3