Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q62136 (PTN21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 21

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase PTP-RL10
Gene names
Name:Ptpn21
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1176 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the regulation of growth and differentiation of liver cells.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

Liver.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11761176Tyrosine-protein phosphatase non-receptor type 21
PRO_0000219440

Regions

Domain23 – 308286FERM
Domain898 – 1169272Tyrosine-protein phosphatase
Region1110 – 11167Substrate binding By similarity
Compositional bias340 – 3434Poly-Pro
Compositional bias565 – 5728Poly-Pro

Sites

Active site11101Phosphocysteine intermediate By similarity
Binding site10691Substrate Potential
Binding site11541Substrate By similarity

Amino acid modifications

Modified residue5771Phosphoserine Ref.2
Modified residue6371Phosphoserine Ref.2
Modified residue8061Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q62136 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 529FBE22F1335B75

FASTA1,176133,491
        10         20         30         40         50         60 
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE 

        70         80         90        100        110        120 
VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG VLFYVPSVSQ LQQEITRYQY 

       130        140        150        160        170        180 
YLQLKKDILE GNLPCTLEHA IQLAGLAVQA DFGDFDQYES QDFLQKFALL PVAWLQDEKV 

       190        200        210        220        230        240 
LEEAAQKVAL LHQKYRGLTA PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG 

       250        260        270        280        290        300 
IFVKHKNGRP PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 

       310        320        330        340        350        360 
HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH YTEPFASSQD 

       370        380        390        400        410        420 
NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST NSLNTLQPYL QPSPMSSNPS 

       430        440        450        460        470        480 
ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD YETVMKQLNR GMVHADRHSH SLRNLNIGSS 

       490        500        510        520        530        540 
YAYSRPDALV YSQPEIREHP HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP 

       550        560        570        580        590        600 
ELTNVQLQAQ DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 

       610        620        630        640        650        660 
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL RLKERTVSAS 

       670        680        690        700        710        720 
AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS LSDATMLIDS SEEDEDLEED 

       730        740        750        760        770        780 
SSREQAISAV SEPRLTAAFS QELNYPCASA TPITGPLHIF EPKPHVTEPE KRAKDISPVH 

       790        800        810        820        830        840 
LVVETHRPRR DGLLTPSMSE SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG 

       850        860        870        880        890        900 
MKKTRADAKK IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT 

       910        920        930        940        950        960 
EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT GYINASHIKV 

       970        980        990       1000       1010       1020 
SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA EEEGGREKSF RYWPRLGSRH 

      1030       1040       1050       1060       1070       1080 
NTVTYGRFKI TTRFRTDSGC YATTGLKMKH LLTGQERTVW HLQYTDWPEH GCPEDLKGFL 

      1090       1100       1110       1120       1130       1140 
SYLEEIQSVR RHTNSTSEPK SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR 

      1150       1160       1170 
VLDMLRQQRM MLVQTLGQYT FVYRVLIQFL KSSRLI 

« Hide

References

« Hide 'large scale' references
[1]"Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1."
Higashitsuji H., Arii S., Furutani M., Imamura M., Kaneko Y., Takenawa J., Nakayama H., Fujita J.
Oncogene 10:407-414(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Liver.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-637 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D37801 mRNA. Translation: BAA07053.1.
PIRI58345.
UniGeneMm.4420.
Mm.483252.

3D structure databases

ProteinModelPortalQ62136.
SMRQ62136. Positions 26-329, 884-1173.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ62136.

Proteomic databases

PRIDEQ62136.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1344406. Ptpn21.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000115775.
HOVERGENHBG053757.
InParanoidQ62136.
PhylomeDBQ62136.

Gene expression databases

GenevestigatorQ62136.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTPN21. mouse.
PROQ62136.
SOURCESearch...

Entry information

Entry namePTN21_MOUSE
AccessionPrimary (citable) accession number: Q62136
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot