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Q62136

- PTN21_MOUSE

UniProt

Q62136 - PTN21_MOUSE

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Protein
Tyrosine-protein phosphatase non-receptor type 21
Gene
Ptpn21
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the regulation of growth and differentiation of liver cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1069 – 10691Substrate Reviewed prediction
Active sitei1110 – 11101Phosphocysteine intermediate By similarity
Binding sitei1154 – 11541Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase PTP-RL10
Gene namesi
Name:Ptpn21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1344406. Ptpn21.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11761176Tyrosine-protein phosphatase non-receptor type 21
PRO_0000219440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine1 Publication
Modified residuei637 – 6371Phosphoserine1 Publication
Modified residuei806 – 8061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62136.

PTM databases

PhosphoSiteiQ62136.

Expressioni

Tissue specificityi

Liver.

Gene expression databases

GenevestigatoriQ62136.

Structurei

3D structure databases

ProteinModelPortaliQ62136.
SMRiQ62136. Positions 26-329, 884-1173.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 308286FERM
Add
BLAST
Domaini898 – 1169272Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1110 – 11167Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi340 – 3434Poly-Pro
Compositional biasi565 – 5728Poly-Pro

Sequence similaritiesi

Contains 1 FERM domain.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62136.
PhylomeDBiQ62136.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62136-1 [UniParc]FASTAAdd to Basket

« Hide

MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE     50
AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG 100
VLFYVPSVSQ LQQEITRYQY YLQLKKDILE GNLPCTLEHA IQLAGLAVQA 150
DFGDFDQYES QDFLQKFALL PVAWLQDEKV LEEAAQKVAL LHQKYRGLTA 200
PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP 250
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 300
HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH 350
YTEPFASSQD NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST 400
NSLNTLQPYL QPSPMSSNPS ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD 450
YETVMKQLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP 500
HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP ELTNVQLQAQ 550
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 600
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL 650
RLKERTVSAS AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS 700
LSDATMLIDS SEEDEDLEED SSREQAISAV SEPRLTAAFS QELNYPCASA 750
TPITGPLHIF EPKPHVTEPE KRAKDISPVH LVVETHRPRR DGLLTPSMSE 800
SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG MKKTRADAKK 850
IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT 900
EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT 950
GYINASHIKV SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA 1000
EEEGGREKSF RYWPRLGSRH NTVTYGRFKI TTRFRTDSGC YATTGLKMKH 1050
LLTGQERTVW HLQYTDWPEH GCPEDLKGFL SYLEEIQSVR RHTNSTSEPK 1100
SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR VLDMLRQQRM 1150
MLVQTLGQYT FVYRVLIQFL KSSRLI 1176
Length:1,176
Mass (Da):133,491
Last modified:November 1, 1996 - v1
Checksum:i529FBE22F1335B75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37801 mRNA. Translation: BAA07053.1.
CCDSiCCDS26098.1.
PIRiI58345.
UniGeneiMm.4420.
Mm.483252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37801 mRNA. Translation: BAA07053.1 .
CCDSi CCDS26098.1.
PIRi I58345.
UniGenei Mm.4420.
Mm.483252.

3D structure databases

ProteinModelPortali Q62136.
SMRi Q62136. Positions 26-329, 884-1173.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62136.

Proteomic databases

PRIDEi Q62136.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1344406. Ptpn21.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000115775.
HOVERGENi HBG053757.
InParanoidi Q62136.
PhylomeDBi Q62136.

Miscellaneous databases

ChiTaRSi PTPN21. mouse.
PROi Q62136.
SOURCEi Search...

Gene expression databases

Genevestigatori Q62136.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1."
    Higashitsuji H., Arii S., Furutani M., Imamura M., Kaneko Y., Takenawa J., Nakayama H., Fujita J.
    Oncogene 10:407-414(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Liver.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-637 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTN21_MOUSE
AccessioniPrimary (citable) accession number: Q62136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi