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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of growth and differentiation of liver cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1069SubstrateSequence analysis1
Active sitei1110Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1154SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase PTP-RL10
Gene namesi
Name:Ptpn21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1344406 Ptpn21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194401 – 1176Tyrosine-protein phosphatase non-receptor type 21Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei577PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei710PhosphoserineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei799PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62136
PaxDbiQ62136
PRIDEiQ62136

PTM databases

iPTMnetiQ62136
PhosphoSitePlusiQ62136

Expressioni

Tissue specificityi

Liver.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082197

Structurei

3D structure databases

ProteinModelPortaliQ62136
SMRiQ62136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 308FERMPROSITE-ProRule annotationAdd BLAST286
Domaini898 – 1169Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1110 – 1116Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi340 – 343Poly-Pro4
Compositional biasi565 – 572Poly-Pro8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0792 Eukaryota
COG5599 LUCA
HOGENOMiHOG000115775
HOVERGENiHBG053757
InParanoidiQ62136
PhylomeDBiQ62136

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR014392 Tyr_Pase_non-rcpt_typ-14/21
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000934 Tyr-Ptase_nr14, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q62136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG
110 120 130 140 150
VLFYVPSVSQ LQQEITRYQY YLQLKKDILE GNLPCTLEHA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALL PVAWLQDEKV LEEAAQKVAL LHQKYRGLTA
210 220 230 240 250
PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR
310 320 330 340 350
HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH
360 370 380 390 400
YTEPFASSQD NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST
410 420 430 440 450
NSLNTLQPYL QPSPMSSNPS ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD
460 470 480 490 500
YETVMKQLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP
510 520 530 540 550
HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP ELTNVQLQAQ
560 570 580 590 600
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL
660 670 680 690 700
RLKERTVSAS AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS
710 720 730 740 750
LSDATMLIDS SEEDEDLEED SSREQAISAV SEPRLTAAFS QELNYPCASA
760 770 780 790 800
TPITGPLHIF EPKPHVTEPE KRAKDISPVH LVVETHRPRR DGLLTPSMSE
810 820 830 840 850
SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG MKKTRADAKK
860 870 880 890 900
IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT
910 920 930 940 950
EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT
960 970 980 990 1000
GYINASHIKV SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA
1010 1020 1030 1040 1050
EEEGGREKSF RYWPRLGSRH NTVTYGRFKI TTRFRTDSGC YATTGLKMKH
1060 1070 1080 1090 1100
LLTGQERTVW HLQYTDWPEH GCPEDLKGFL SYLEEIQSVR RHTNSTSEPK
1110 1120 1130 1140 1150
SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR VLDMLRQQRM
1160 1170
MLVQTLGQYT FVYRVLIQFL KSSRLI
Length:1,176
Mass (Da):133,491
Last modified:November 1, 1996 - v1
Checksum:i529FBE22F1335B75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37801 mRNA Translation: BAA07053.1
CCDSiCCDS26098.1
PIRiI58345
UniGeneiMm.4420
Mm.483252

Similar proteinsi

Entry informationi

Entry nameiPTN21_MOUSE
AccessioniPrimary (citable) accession number: Q62136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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