Q62136 (PTN21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 21
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine phosphatase PTP-RL10

Gene names

Name:

Ptpn21

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1176 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the regulation of growth and differentiation of liver cells.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Liver.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1176	1176	Tyrosine-protein phosphatase non-receptor type 21		PRO_0000219440
Regions
	Domain	23 – 308	286	FERM
	Domain	898 – 1169	272	Tyrosine-protein phosphatase
	Region	1110 – 1116	7	Substrate binding By similarity
	Compositional bias	340 – 343	4	Poly-Pro
	Compositional bias	565 – 572	8	Poly-Pro
Sites
	Active site	1110	1	Phosphocysteine intermediate By similarity
	Binding site	1069	1	Substrate Potential
	Binding site	1154	1	Substrate By similarity
Amino acid modifications
	Modified residue	637	1	Phosphoserine By similarity
	Modified residue	797	1	Phosphoserine Ref.2
	Modified residue	822	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q62136 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 529FBE22F1335B75	FASTA	1,176	133,491
	10 20 30 40 50 60 MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE 70 80 90 100 110 120 VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG VLFYVPSVSQ LQQEITRYQY 130 140 150 160 170 180 YLQLKKDILE GNLPCTLEHA IQLAGLAVQA DFGDFDQYES QDFLQKFALL PVAWLQDEKV 190 200 210 220 230 240 LEEAAQKVAL LHQKYRGLTA PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG 250 260 270 280 290 300 IFVKHKNGRP PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 310 320 330 340 350 360 HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH YTEPFASSQD 370 380 390 400 410 420 NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST NSLNTLQPYL QPSPMSSNPS 430 440 450 460 470 480 ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD YETVMKQLNR GMVHADRHSH SLRNLNIGSS 490 500 510 520 530 540 YAYSRPDALV YSQPEIREHP HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP 550 560 570 580 590 600 ELTNVQLQAQ DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 610 620 630 640 650 660 HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL RLKERTVSAS 670 680 690 700 710 720 AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS LSDATMLIDS SEEDEDLEED 730 740 750 760 770 780 SSREQAISAV SEPRLTAAFS QELNYPCASA TPITGPLHIF EPKPHVTEPE KRAKDISPVH 790 800 810 820 830 840 LVVETHRPRR DGLLTPSMSE SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG 850 860 870 880 890 900 MKKTRADAKK IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT 910 920 930 940 950 960 EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT GYINASHIKV 970 980 990 1000 1010 1020 SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA EEEGGREKSF RYWPRLGSRH 1030 1040 1050 1060 1070 1080 NTVTYGRFKI TTRFRTDSGC YATTGLKMKH LLTGQERTVW HLQYTDWPEH GCPEDLKGFL 1090 1100 1110 1120 1130 1140 SYLEEIQSVR RHTNSTSEPK SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR 1150 1160 1170 VLDMLRQQRM MLVQTLGQYT FVYRVLIQFL KSSRLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1." Higashitsuji H., Arii S., Furutani M., Imamura M., Kaneko Y., Takenawa J., Nakayama H., Fujita J. Oncogene 10:407-414(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Liver.
[2]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797, MASS SPECTROMETRY. Tissue: Liver.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-822, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D37801 mRNA. Translation: BAA07053.1.
IPI	IPI00224153.
PIR	I58345.
UniGene	Mm.4420. Mm.483252.
3D structure databases
ProteinModelPortal	Q62136.
SMR	Q62136. Positions 26-329, 884-1173.
ModBase	Search...
PTM databases
PhosphoSite	Q62136.
Proteomic databases
PRIDE	Q62136.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1344406. Ptpn21.
Phylogenomic databases
eggNOG	COG5599.
HOGENOM	HOG000115775.
HOVERGEN	HBG053757.
InParanoid	Q62136.
OrthoDB	EOG46MBHR.
Gene expression databases
Genevestigator	Q62136.
GermOnline	ENSMUSG00000021009. Mus musculus.
Family and domain databases
Gene3D	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019750. Band_41_fam. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_like_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR014392. Tyr_Pase_non-rcpt_typ-14/21. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTS	PR00935. BAND41. PR00700. PRTYPHPHTASE.
SMART	SM00295. B41. 1 hit. SM00194. PTPc. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit.
PROSITE	PS00660. FERM_1. 1 hit. PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTPN21. mouse.
SOURCE	Search...

Entry information

Entry name

PTN21_MOUSE

Accession

Primary (citable) accession number: Q62136

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program