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Q62136

- PTN21_MOUSE

UniProt

Q62136 - PTN21_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in the regulation of growth and differentiation of liver cells.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1069 – 10691SubstrateSequence Analysis
    Active sitei1110 – 11101Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1154 – 11541SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase PTP-RL10
    Gene namesi
    Name:Ptpn21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1344406. Ptpn21.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11761176Tyrosine-protein phosphatase non-receptor type 21PRO_0000219440Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei577 – 5771Phosphoserine1 Publication
    Modified residuei637 – 6371Phosphoserine1 Publication
    Modified residuei806 – 8061Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ62136.

    PTM databases

    PhosphoSiteiQ62136.

    Expressioni

    Tissue specificityi

    Liver.

    Gene expression databases

    GenevestigatoriQ62136.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62136.
    SMRiQ62136. Positions 26-329, 884-1173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 308286FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini898 – 1169272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1110 – 11167Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi340 – 3434Poly-Pro
    Compositional biasi565 – 5728Poly-Pro

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000115775.
    HOVERGENiHBG053757.
    InParanoidiQ62136.
    PhylomeDBiQ62136.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62136-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE     50
    AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG 100
    VLFYVPSVSQ LQQEITRYQY YLQLKKDILE GNLPCTLEHA IQLAGLAVQA 150
    DFGDFDQYES QDFLQKFALL PVAWLQDEKV LEEAAQKVAL LHQKYRGLTA 200
    PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP 250
    PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 300
    HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH 350
    YTEPFASSQD NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST 400
    NSLNTLQPYL QPSPMSSNPS ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD 450
    YETVMKQLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP 500
    HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP ELTNVQLQAQ 550
    DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 600
    HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL 650
    RLKERTVSAS AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS 700
    LSDATMLIDS SEEDEDLEED SSREQAISAV SEPRLTAAFS QELNYPCASA 750
    TPITGPLHIF EPKPHVTEPE KRAKDISPVH LVVETHRPRR DGLLTPSMSE 800
    SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG MKKTRADAKK 850
    IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT 900
    EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT 950
    GYINASHIKV SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA 1000
    EEEGGREKSF RYWPRLGSRH NTVTYGRFKI TTRFRTDSGC YATTGLKMKH 1050
    LLTGQERTVW HLQYTDWPEH GCPEDLKGFL SYLEEIQSVR RHTNSTSEPK 1100
    SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR VLDMLRQQRM 1150
    MLVQTLGQYT FVYRVLIQFL KSSRLI 1176
    Length:1,176
    Mass (Da):133,491
    Last modified:November 1, 1996 - v1
    Checksum:i529FBE22F1335B75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D37801 mRNA. Translation: BAA07053.1.
    CCDSiCCDS26098.1.
    PIRiI58345.
    UniGeneiMm.4420.
    Mm.483252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D37801 mRNA. Translation: BAA07053.1 .
    CCDSi CCDS26098.1.
    PIRi I58345.
    UniGenei Mm.4420.
    Mm.483252.

    3D structure databases

    ProteinModelPortali Q62136.
    SMRi Q62136. Positions 26-329, 884-1173.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62136.

    Proteomic databases

    PRIDEi Q62136.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1344406. Ptpn21.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000115775.
    HOVERGENi HBG053757.
    InParanoidi Q62136.
    PhylomeDBi Q62136.

    Miscellaneous databases

    ChiTaRSi PTPN21. mouse.
    PROi Q62136.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q62136.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1."
      Higashitsuji H., Arii S., Furutani M., Imamura M., Kaneko Y., Takenawa J., Nakayama H., Fujita J.
      Oncogene 10:407-414(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Liver.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-637 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiPTN21_MOUSE
    AccessioniPrimary (citable) accession number: Q62136
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3