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Q62136

- PTN21_MOUSE

UniProt

Q62136 - PTN21_MOUSE

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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the regulation of growth and differentiation of liver cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1069 – 10691SubstrateSequence Analysis
Active sitei1110 – 11101Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1154 – 11541SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase PTP-RL10
Gene namesi
Name:Ptpn21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1344406. Ptpn21.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11761176Tyrosine-protein phosphatase non-receptor type 21PRO_0000219440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine1 Publication
Modified residuei637 – 6371Phosphoserine1 Publication
Modified residuei806 – 8061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62136.
PRIDEiQ62136.

PTM databases

PhosphoSiteiQ62136.

Expressioni

Tissue specificityi

Liver.

Gene expression databases

GenevestigatoriQ62136.

Structurei

3D structure databases

ProteinModelPortaliQ62136.
SMRiQ62136. Positions 26-329, 884-1173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 308286FERMPROSITE-ProRule annotationAdd
BLAST
Domaini898 – 1169272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1110 – 11167Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi340 – 3434Poly-Pro
Compositional biasi565 – 5728Poly-Pro

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62136.
PhylomeDBiQ62136.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62136-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG
110 120 130 140 150
VLFYVPSVSQ LQQEITRYQY YLQLKKDILE GNLPCTLEHA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALL PVAWLQDEKV LEEAAQKVAL LHQKYRGLTA
210 220 230 240 250
PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR
310 320 330 340 350
HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH
360 370 380 390 400
YTEPFASSQD NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST
410 420 430 440 450
NSLNTLQPYL QPSPMSSNPS ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD
460 470 480 490 500
YETVMKQLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP
510 520 530 540 550
HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP ELTNVQLQAQ
560 570 580 590 600
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL
660 670 680 690 700
RLKERTVSAS AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS
710 720 730 740 750
LSDATMLIDS SEEDEDLEED SSREQAISAV SEPRLTAAFS QELNYPCASA
760 770 780 790 800
TPITGPLHIF EPKPHVTEPE KRAKDISPVH LVVETHRPRR DGLLTPSMSE
810 820 830 840 850
SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG MKKTRADAKK
860 870 880 890 900
IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT
910 920 930 940 950
EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT
960 970 980 990 1000
GYINASHIKV SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA
1010 1020 1030 1040 1050
EEEGGREKSF RYWPRLGSRH NTVTYGRFKI TTRFRTDSGC YATTGLKMKH
1060 1070 1080 1090 1100
LLTGQERTVW HLQYTDWPEH GCPEDLKGFL SYLEEIQSVR RHTNSTSEPK
1110 1120 1130 1140 1150
SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR VLDMLRQQRM
1160 1170
MLVQTLGQYT FVYRVLIQFL KSSRLI
Length:1,176
Mass (Da):133,491
Last modified:November 1, 1996 - v1
Checksum:i529FBE22F1335B75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37801 mRNA. Translation: BAA07053.1.
CCDSiCCDS26098.1.
PIRiI58345.
UniGeneiMm.4420.
Mm.483252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37801 mRNA. Translation: BAA07053.1 .
CCDSi CCDS26098.1.
PIRi I58345.
UniGenei Mm.4420.
Mm.483252.

3D structure databases

ProteinModelPortali Q62136.
SMRi Q62136. Positions 26-329, 884-1173.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62136.

Proteomic databases

MaxQBi Q62136.
PRIDEi Q62136.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1344406. Ptpn21.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000115775.
HOVERGENi HBG053757.
InParanoidi Q62136.
PhylomeDBi Q62136.

Miscellaneous databases

PROi Q62136.
SOURCEi Search...

Gene expression databases

Genevestigatori Q62136.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1."
    Higashitsuji H., Arii S., Furutani M., Imamura M., Kaneko Y., Takenawa J., Nakayama H., Fujita J.
    Oncogene 10:407-414(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Liver.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-637 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTN21_MOUSE
AccessioniPrimary (citable) accession number: Q62136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3