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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of growth and differentiation of liver cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1069SubstrateSequence analysis1
Active sitei1110Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1154SubstrateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase PTP-RL10
Gene namesi
Name:Ptpn21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1344406. Ptpn21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194401 – 1176Tyrosine-protein phosphatase non-receptor type 21Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei577PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei710PhosphoserineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei799PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62136.
PaxDbiQ62136.
PRIDEiQ62136.

PTM databases

iPTMnetiQ62136.
PhosphoSitePlusiQ62136.

Expressioni

Tissue specificityi

Liver.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082197.

Structurei

3D structure databases

ProteinModelPortaliQ62136.
SMRiQ62136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 308FERMPROSITE-ProRule annotationAdd BLAST286
Domaini898 – 1169Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1110 – 1116Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi340 – 343Poly-Pro4
Compositional biasi565 – 572Poly-Pro8

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0792. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62136.
PhylomeDBiQ62136.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG
110 120 130 140 150
VLFYVPSVSQ LQQEITRYQY YLQLKKDILE GNLPCTLEHA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALL PVAWLQDEKV LEEAAQKVAL LHQKYRGLTA
210 220 230 240 250
PEAELLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR
310 320 330 340 350
HKFYRLNQCS LQTQAATLNS VRRDSSSRMS LPKPQPYAMP PPPQLHYNGH
360 370 380 390 400
YTEPFASSQD NIFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST
410 420 430 440 450
NSLNTLQPYL QPSPMSSNPS ITGSDVMRPD SLPSHRHSAL IPPSYRPTPD
460 470 480 490 500
YETVMKQLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP
510 520 530 540 550
HLTSPQSAHY PFNLNYSFHS QSPYPYPAER RPVVGAVSVP ELTNVQLQAQ
560 570 580 590 600
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL
660 670 680 690 700
RLKERTVSAS AADVAPRTFS AGSQSSVFSD KMKQEGTEEQ EGGRYSHKKS
710 720 730 740 750
LSDATMLIDS SEEDEDLEED SSREQAISAV SEPRLTAAFS QELNYPCASA
760 770 780 790 800
TPITGPLHIF EPKPHVTEPE KRAKDISPVH LVVETHRPRR DGLLTPSMSE
810 820 830 840 850
SDLTTSGRYR ARRDSVKKRP VSDLLSGKKS AVEGLPPLGG MKKTRADAKK
860 870 880 890 900
IGPLKLAALN GLSLSRLPLP DEGKEVSTRA TNDERCKVLE QRLEQGMVFT
910 920 930 940 950
EYERILKKRL VDGECSTARL PENAERNRFQ DVLPYDDARV ELVPTKENNT
960 970 980 990 1000
GYINASHIKV SVSGIEWDYI ATQGPLQNTC QDFWQMVWEQ GVAIIAMVTA
1010 1020 1030 1040 1050
EEEGGREKSF RYWPRLGSRH NTVTYGRFKI TTRFRTDSGC YATTGLKMKH
1060 1070 1080 1090 1100
LLTGQERTVW HLQYTDWPEH GCPEDLKGFL SYLEEIQSVR RHTNSTSEPK
1110 1120 1130 1140 1150
SHNPPLLVHC SAGVGRTGVV ILSEIMVACL EHNEVLDIPR VLDMLRQQRM
1160 1170
MLVQTLGQYT FVYRVLIQFL KSSRLI
Length:1,176
Mass (Da):133,491
Last modified:November 1, 1996 - v1
Checksum:i529FBE22F1335B75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37801 mRNA. Translation: BAA07053.1.
CCDSiCCDS26098.1.
PIRiI58345.
UniGeneiMm.4420.
Mm.483252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37801 mRNA. Translation: BAA07053.1.
CCDSiCCDS26098.1.
PIRiI58345.
UniGeneiMm.4420.
Mm.483252.

3D structure databases

ProteinModelPortaliQ62136.
SMRiQ62136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082197.

PTM databases

iPTMnetiQ62136.
PhosphoSitePlusiQ62136.

Proteomic databases

MaxQBiQ62136.
PaxDbiQ62136.
PRIDEiQ62136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1344406. Ptpn21.

Phylogenomic databases

eggNOGiKOG0792. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62136.
PhylomeDBiQ62136.

Miscellaneous databases

PROiQ62136.
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN21_MOUSE
AccessioniPrimary (citable) accession number: Q62136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.