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Q62132

- PTPRR_MOUSE

UniProt

Q62132 - PTPRR_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase R
Gene
Ptprr, Ptp13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei553 – 5531Substrate By similarity
Active sitei587 – 5871Phosphocysteine intermediate By similarity
Binding sitei631 – 6311Substrate By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein kinase binding Source: UniProtKB
  3. protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. in utero embryonic development Source: UniProtKB
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
Short name:
R-PTP-R
Alternative name(s):
Phosphotyrosine phosphatase 13
Protein-tyrosine-phosphatase SL
Gene namesi
Name:Ptprr
Synonyms:Ptp13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:109559. Ptprr.

Subcellular locationi

Isoform Alpha : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform Beta : Cytoplasm
Note: Locates to the areas within the cytoplasm.1 Publication
Isoform Gamma : Cytoplasm
Note: Locates to the areas within the cytoplasm.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 226203Extracellular Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Topological domaini248 – 656409Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi338 – 3381S → A: Loss of phosphorylation by PKA, constitutive MAPK binding. 1 Publication
Mutagenesisi338 – 3381S → E: Mimics phosphorylation by PKA, prevents MAPK binding. 1 Publication
Mutagenesisi587 – 5871C → S: Loss of phosphatase activity. 1 Publication
Mutagenesisi593 – 5931R → M: Loss of phosphatase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 656633Receptor-type tyrosine-protein phosphatase R
PRO_0000025460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Modified residuei338 – 3381Phosphoserine; by PKA1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ62132.

PTM databases

PhosphoSiteiQ62132.

Expressioni

Tissue specificityi

Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon.4 Publications

Developmental stagei

Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification.1 Publication

Gene expression databases

BgeeiQ62132.
CleanExiMM_PTPRR.
GenevestigatoriQ62132.

Interactioni

Subunit structurei

Interacts with MAPKs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk1P630855EBI-6954051,EBI-397697
MAPK3P273613EBI-6954051,EBI-73995From a different organism.

Protein-protein interaction databases

IntActiQ62132. 5 interactions.
MINTiMINT-99987.
STRINGi10090.ENSMUSP00000064392.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi363 – 37210
Helixi379 – 3879
Turni388 – 3903
Helixi391 – 3988
Turni406 – 4083
Helixi414 – 4174
Helixi427 – 4293
Helixi442 – 4443
Beta strandi447 – 4515
Helixi454 – 4563
Beta strandi460 – 4645
Helixi469 – 4713
Helixi472 – 48110
Beta strandi486 – 4894
Beta strandi493 – 4986
Beta strandi506 – 5116
Beta strandi514 – 52310
Beta strandi525 – 53612
Beta strandi539 – 54810
Helixi561 – 57515
Beta strandi583 – 5919
Helixi592 – 61019
Beta strandi611 – 6133
Helixi615 – 62511
Helixi633 – 64816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JLNX-ray1.81A361-655[»]
ProteinModelPortaliQ62132.
SMRiQ62132. Positions 360-655.

Miscellaneous databases

EvolutionaryTraceiQ62132.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 646255Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni587 – 5937Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117606.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ62132.
KOiK04458.
OMAiPIGLQER.
OrthoDBiEOG7288QX.
PhylomeDBiQ62132.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF001997. PTPRR. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q62132-1) [UniParc]FASTAAdd to Basket

Also known as: PTPBR7

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP VFIYDHSQDI    50
KKSLDIAQEA YKHNYHSPSE VQISKHHQII NSAFPRPAYD PSLNLLAESD 100
QDLEIENLPI PAANVIVVTL QMDITKLNIT LLRIFRQGVA AALGLLPQQV 150
HINRLIEKKN QVELFVSPGN RKPGETQALQ AEEVLRSLNV DGLHQSLPQF 200
GITDVAPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII VTCLMIIYRL 250
KERLQLSLRQ DKEKNQEIHL SPIARQQAQS EAKTTHSMVQ PDQAPKVLNV 300
VVDPQGQCTP EIRNSTSTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG 350
SVEPFVAVST PREKVAMEYL QSASRVLTRS QLRDVVASSH LLQSEFMEIP 400
MNFVDPKEID IPRHGTKNRY KTILPNPLSR VCLRPKNITD SLSTYINANY 450
IRGYSGKEKA FIATQGPMIN TVNDFWQMVW QEDSPVIVMI TKLKEKNEKC 500
VLYWPEKRGI YGKVEVLVTG VTECDNYTIR NLVLKQGSHT QHVKHYWYTS 550
WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 600
SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL 650
SPETVE 656
Length:656
Mass (Da):74,036
Last modified:November 1, 1996 - v1
Checksum:i31FA82F582992720
GO
Isoform Beta (identifier: Q62132-2) [UniParc]FASTAAdd to Basket

Also known as: PTP-SL

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     108-121: LPIPAANVIVVTLQ → MHRNTRSVSTPTLQ

Show »
Length:549
Mass (Da):61,921
Checksum:iC82AB43DF4C4FD7A
GO
Isoform Gamma (identifier: Q62132-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Show »
Length:412
Mass (Da):46,585
Checksum:iC51B5F816CB8C874
GO

Sequence cautioni

The sequence CAA82958.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 244244Missing in isoform Gamma.
VSP_005161Add
BLAST
Alternative sequencei1 – 107107Missing in isoform Beta.
VSP_005159Add
BLAST
Alternative sequencei108 – 12114LPIPA…VVTLQ → MHRNTRSVSTPTLQ in isoform Beta.
VSP_005160Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31898 mRNA. Translation: BAA06696.1.
Z30313 mRNA. Translation: CAA82957.1.
Z30313 mRNA. Translation: CAA82958.1. Different initiation.
AF129509 mRNA. Translation: AAD29673.1.
AF041866 mRNA. Translation: AAD09171.1.
CCDSiCCDS24182.1. [Q62132-1]
CCDS48693.1. [Q62132-3]
CCDS56750.1. [Q62132-2]
PIRiA55574.
RefSeqiNP_001155309.1. NM_001161837.1. [Q62132-2]
NP_001155310.1. NM_001161838.1. [Q62132-3]
NP_001155311.1. NM_001161839.1. [Q62132-3]
NP_001155312.1. NM_001161840.1. [Q62132-3]
NP_035347.1. NM_011217.2. [Q62132-1]
UniGeneiMm.336316.

Genome annotation databases

EnsembliENSMUST00000063470; ENSMUSP00000064392; ENSMUSG00000020151. [Q62132-1]
ENSMUST00000105271; ENSMUSP00000100907; ENSMUSG00000020151. [Q62132-2]
ENSMUST00000128399; ENSMUSP00000114455; ENSMUSG00000020151. [Q62132-3]
ENSMUST00000148731; ENSMUSP00000120965; ENSMUSG00000020151. [Q62132-3]
ENSMUST00000155606; ENSMUSP00000122259; ENSMUSG00000020151. [Q62132-3]
GeneIDi19279.
KEGGimmu:19279.
UCSCiuc007hbp.2. mouse. [Q62132-1]
uc007hbr.2. mouse. [Q62132-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31898 mRNA. Translation: BAA06696.1 .
Z30313 mRNA. Translation: CAA82957.1 .
Z30313 mRNA. Translation: CAA82958.1 . Different initiation.
AF129509 mRNA. Translation: AAD29673.1 .
AF041866 mRNA. Translation: AAD09171.1 .
CCDSi CCDS24182.1. [Q62132-1 ]
CCDS48693.1. [Q62132-3 ]
CCDS56750.1. [Q62132-2 ]
PIRi A55574.
RefSeqi NP_001155309.1. NM_001161837.1. [Q62132-2 ]
NP_001155310.1. NM_001161838.1. [Q62132-3 ]
NP_001155311.1. NM_001161839.1. [Q62132-3 ]
NP_001155312.1. NM_001161840.1. [Q62132-3 ]
NP_035347.1. NM_011217.2. [Q62132-1 ]
UniGenei Mm.336316.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JLN X-ray 1.81 A 361-655 [» ]
ProteinModelPortali Q62132.
SMRi Q62132. Positions 360-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62132. 5 interactions.
MINTi MINT-99987.
STRINGi 10090.ENSMUSP00000064392.

PTM databases

PhosphoSitei Q62132.

Proteomic databases

PRIDEi Q62132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063470 ; ENSMUSP00000064392 ; ENSMUSG00000020151 . [Q62132-1 ]
ENSMUST00000105271 ; ENSMUSP00000100907 ; ENSMUSG00000020151 . [Q62132-2 ]
ENSMUST00000128399 ; ENSMUSP00000114455 ; ENSMUSG00000020151 . [Q62132-3 ]
ENSMUST00000148731 ; ENSMUSP00000120965 ; ENSMUSG00000020151 . [Q62132-3 ]
ENSMUST00000155606 ; ENSMUSP00000122259 ; ENSMUSG00000020151 . [Q62132-3 ]
GeneIDi 19279.
KEGGi mmu:19279.
UCSCi uc007hbp.2. mouse. [Q62132-1 ]
uc007hbr.2. mouse. [Q62132-2 ]

Organism-specific databases

CTDi 5801.
MGIi MGI:109559. Ptprr.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117606.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi Q62132.
KOi K04458.
OMAi PIGLQER.
OrthoDBi EOG7288QX.
PhylomeDBi Q62132.
TreeFami TF331016.

Miscellaneous databases

EvolutionaryTracei Q62132.
NextBioi 296188.
PROi Q62132.
SOURCEi Search...

Gene expression databases

Bgeei Q62132.
CleanExi MM_PTPRR.
Genevestigatori Q62132.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001997. PTPRR. 1 hit.
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain."
    Ogata M., Sawada M., Fujino Y., Hamaoka T.
    J. Biol. Chem. 270:2337-2343(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Brain.
  2. "A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain."
    Hendriks W., Schepens J., Brugman C., Zeeuwen P., Wieringa B.
    Biochem. J. 305:499-504(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  3. "Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse."
    Augustine K.A., Silbiger S.M., Bucay N., Ulias L., Boynton A., Trebasky L.D., Medlock E.S.
    Anat. Rec. 258:221-234(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Colon.
  4. "Evidence that the protein tyrosine phosphatase (PC12,Br7,Sl) gamma (-) isoform modulates chondrogenic patterning and growth."
    Augustine K.A., Rossi R.M., Silbiger S.M., Bucay N., Duryea D., Marshall W.S., Medlock E.S.
    Int. J. Dev. Biol. 44:361-371(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GAMMA), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase."
    Blanco-Aparicio C., Torres J., Pulido R.
    J. Cell Biol. 147:1129-1136(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MAPK1; MAPK3 AND MAPK14, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-338, MUTAGENESIS OF SER-338; CYS-587 AND ARG-593.
    Tissue: Brain.

Entry informationi

Entry nameiPTPRR_MOUSE
AccessioniPrimary (citable) accession number: Q62132
Secondary accession number(s): Q64491, Q64492, Q9QUH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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