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Q62130

- PTN14_MOUSE

UniProt

Q62130 - PTN14_MOUSE

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Protein
Tyrosine-protein phosphatase non-receptor type 14
Gene
Ptpn14
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1123 – 11231Phosphocysteine intermediate By similarity
Binding sitei1167 – 11671Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB
  2. transcription cofactor activity Source: UniProtKB

GO - Biological processi

  1. lymphangiogenesis Source: UniProtKB
  2. negative regulation of cell proliferation Source: Ensembl
  3. regulation of protein export from nucleus Source: UniProtKB
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 14 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase PTP36
Gene namesi
Name:Ptpn14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:102467. Ptpn14.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Nucleus By similarity
Note: Translocation into the nucleus is associated with induction of cell proliferation By similarity. Partially colocalized with actin filaments at the plasma membrane By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

PTPN14 deficient mice have swelling of the limbs or periorbital edema. These mice also show hyperplasia of lymphatic capillaries of the ears. There is no evidence of choanal atresia or any overtly dysmorphic features.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11891189Tyrosine-protein phosphatase non-receptor type 14
PRO_0000219438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei486 – 4861Phosphoserine By similarity
Modified residuei591 – 5911Phosphoserine By similarity
Modified residuei594 – 5941Phosphoserine By similarity
Modified residuei646 – 6461Phosphoserine By similarity

Post-translational modificationi

Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62130.
PRIDEiQ62130.

PTM databases

PhosphoSiteiQ62130.

Expressioni

Tissue specificityi

Thymus; in cells of both hematopoietic and non-hematopoietic origins.

Gene expression databases

ArrayExpressiQ62130.
GenevestigatoriQ62130.

Interactioni

Subunit structurei

Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC By similarity. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity By similarity.

Protein-protein interaction databases

IntActiQ62130. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ62130.
SMRiQ62130. Positions 24-303, 897-1186.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 306286FERM
Add
BLAST
Domaini911 – 1182272Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1123 – 11297Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi566 – 5738Poly-Pro
Compositional biasi635 – 6395Poly-Gly
Compositional biasi712 – 7187Poly-Glu

Sequence similaritiesi

Contains 1 FERM domain.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117681.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62130.
KOiK18025.
OMAiVTTKFRT.
OrthoDBiEOG7PK8XS.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62130-1 [UniParc]FASTAAdd to Basket

« Hide

MPFGLKLRRT RRYNVLSKNC FVTRIRLLDS NVIECTLSVE STGQECLEAV     50
AQRLELRETH YFGLWFLSKS QQARWVELEK PLKKHLDKFA NEPLLFFGVM 100
FYVPNVSRLQ QEATRYQYYL QVKKDVLEGR LRCSLEQVIR LAGLAVQADF 150
GDYNQFDSQE FLREYVLFPM DLAMEEAALE ELTQKVAQEH KAHSGILPAE 200
AELMYINEVE RLDGFGQEIF PVKDSHGNSV HLGIFFMGIF VRNRVGRQAV 250
IYRWNDIGSV THSKAAILLE LIDKEETALF HTDDIENAKY ISRLFTTRHK 300
FYKQNKICTE QSNSPPPIRR QPTWSRSSLP RQQPYILPPM HVQCSEHYSE 350
THTSQDSIFP GNEEALYCRS HNSLDLNYLN GTVTNGSVCS VHSVNSLSCS 400
QSFIQASPVS SNLSIPGSDI MRADYIPSHR HSTIIVPSYR PTPDYETVMR 450
QMKRGLMHAD SQSRSLRNLN IINTHAYNQP EELVYSQPEM RERHPYTVPY 500
AHQGCYGHKL VSPSDQMNPQ NCAMPIKPGA SSISHTVSTP ELANMQLQGA 550
QHYSTAHMLK NYLFRPPPPY PRPRPATSTP DLASHRHKYV SGSSPDLVTR 600
KVQLSVKTFQ EDSSPVVHQS LQEVSEPLTA TKHHGGGGGT VNKRHSLEVM 650
NSMVRGMEAM TLKSLNIPMA RRNTLREQGP SEETGGHEVH GLPQYHHKKT 700
FSDATMLIHS SESEEEEETL EAAPQVPVLR EKVEYSAQLQ AALARIPNRP 750
PPEYPGPRKS VSNGALRQDQ GTPLPAMARC RVLRHGPSKA LSVSRAEQLA 800
VNGASLGPSI SEPDLTSVKE RVKKEPVKER PVSEMFSLED SIIEREMMIR 850
NLEKQKMTGP QAQKRPLMLA ALNGLSVARV SGREDGHHDA TRVPIDERLR 900
ALKKKLEDGM VFTEYEQIPN KKANGVFSTA TLPENAERSR IREVVPYEEN 950
RVELIPTKEN NTGYINASHI KVVVGGSEWH YIATQGPLPH TCHDFWQMVW 1000
EQGVNVIAMV TAEEEGGRTK SHRYWPKLGS KHSSATYGKF KVTTKFRTDS 1050
GCYATTGLKV KHLLSGQERT VWHLQYTDWP HHGCPEDVQG FLSYLEEIQS 1100
VRRHTNSVLE GIRTRHPPIV VHCSAGVGRT GVVILSELMI YCLEHNEKVE 1150
VPTMLRFLRE QRMFMIQTIA QYKFVYQVLV QFLQNSRLI 1189
Length:1,189
Mass (Da):135,042
Last modified:March 6, 2013 - v2
Checksum:i7FAFED60C5145477
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231T → A in BAA06628. 1 Publication
Sequence conflicti887 – 8871H → R in BAA06628. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31842 mRNA. Translation: BAA06628.1.
AC140250 Genomic DNA. No translation available.
AC140461 Genomic DNA. No translation available.
CH466555 Genomic DNA. Translation: EDL13025.1.
CH466555 Genomic DNA. Translation: EDL13028.1.
CCDSiCCDS15609.1.
PIRiJC2366.
RefSeqiNP_033002.2. NM_008976.2.
XP_006497192.1. XM_006497129.1.
XP_006497193.1. XM_006497130.1.
XP_006497194.1. XM_006497131.1.
XP_006497195.1. XM_006497132.1.
XP_006497196.1. XM_006497133.1.
UniGeneiMm.4498.

Genome annotation databases

EnsembliENSMUST00000027898; ENSMUSP00000027898; ENSMUSG00000026604.
ENSMUST00000097442; ENSMUSP00000095051; ENSMUSG00000026604.
GeneIDi19250.
KEGGimmu:19250.
UCSCiuc007eau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31842 mRNA. Translation: BAA06628.1 .
AC140250 Genomic DNA. No translation available.
AC140461 Genomic DNA. No translation available.
CH466555 Genomic DNA. Translation: EDL13025.1 .
CH466555 Genomic DNA. Translation: EDL13028.1 .
CCDSi CCDS15609.1.
PIRi JC2366.
RefSeqi NP_033002.2. NM_008976.2.
XP_006497192.1. XM_006497129.1.
XP_006497193.1. XM_006497130.1.
XP_006497194.1. XM_006497131.1.
XP_006497195.1. XM_006497132.1.
XP_006497196.1. XM_006497133.1.
UniGenei Mm.4498.

3D structure databases

ProteinModelPortali Q62130.
SMRi Q62130. Positions 24-303, 897-1186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62130. 1 interaction.

PTM databases

PhosphoSitei Q62130.

Proteomic databases

PaxDbi Q62130.
PRIDEi Q62130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027898 ; ENSMUSP00000027898 ; ENSMUSG00000026604 .
ENSMUST00000097442 ; ENSMUSP00000095051 ; ENSMUSG00000026604 .
GeneIDi 19250.
KEGGi mmu:19250.
UCSCi uc007eau.1. mouse.

Organism-specific databases

CTDi 5784.
MGIi MGI:102467. Ptpn14.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117681.
HOGENOMi HOG000115775.
HOVERGENi HBG053757.
InParanoidi Q62130.
KOi K18025.
OMAi VTTKFRT.
OrthoDBi EOG7PK8XS.
TreeFami TF315900.

Miscellaneous databases

NextBioi 296086.
PROi Q62130.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62130.
Genevestigatori Q62130.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells."
    Sawada M., Ogata M., Fujino Y., Hamaoka T.
    Biochem. Biophys. Res. Commun. 203:479-484(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CB-17/SCID.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans."
    Au A.C., Hernandez P.A., Lieber E., Nadroo A.M., Shen Y.M., Kelley K.A., Gelb B.D., Diaz G.A.
    Am. J. Hum. Genet. 87:436-444(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPTN14_MOUSE
AccessioniPrimary (citable) accession number: Q62130
Secondary accession number(s): G5E8M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2013
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi