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Q62130

- PTN14_MOUSE

UniProt

Q62130 - PTN14_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 14

Gene

Ptpn14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (06 Mar 2013)
      Previous versions | rss
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    Functioni

    Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1123 – 11231Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1167 – 11671SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB
    2. transcription cofactor activity Source: UniProtKB

    GO - Biological processi

    1. lymphangiogenesis Source: UniProtKB
    2. negative regulation of cell proliferation Source: Ensembl
    3. regulation of protein export from nucleus Source: UniProtKB
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 14 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase PTP36
    Gene namesi
    Name:Ptpn14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:102467. Ptpn14.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Nucleus By similarity
    Note: Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    PTPN14 deficient mice have swelling of the limbs or periorbital edema. These mice also show hyperplasia of lymphatic capillaries of the ears. There is no evidence of choanal atresia or any overtly dysmorphic features.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11891189Tyrosine-protein phosphatase non-receptor type 14PRO_0000219438Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei486 – 4861PhosphoserineBy similarity
    Modified residuei591 – 5911PhosphoserineBy similarity
    Modified residuei594 – 5941PhosphoserineBy similarity
    Modified residuei646 – 6461PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ62130.
    PRIDEiQ62130.

    PTM databases

    PhosphoSiteiQ62130.

    Expressioni

    Tissue specificityi

    Thymus; in cells of both hematopoietic and non-hematopoietic origins.

    Gene expression databases

    ArrayExpressiQ62130.
    GenevestigatoriQ62130.

    Interactioni

    Subunit structurei

    Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity.By similarity

    Protein-protein interaction databases

    IntActiQ62130. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62130.
    SMRiQ62130. Positions 24-303, 897-1186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 306286FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini911 – 1182272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1123 – 11297Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi566 – 5738Poly-Pro
    Compositional biasi635 – 6395Poly-Gly
    Compositional biasi712 – 7187Poly-Glu

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117681.
    HOGENOMiHOG000115775.
    HOVERGENiHBG053757.
    InParanoidiQ62130.
    KOiK18025.
    OMAiVTTKFRT.
    OrthoDBiEOG7PK8XS.
    TreeFamiTF315900.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFGLKLRRT RRYNVLSKNC FVTRIRLLDS NVIECTLSVE STGQECLEAV     50
    AQRLELRETH YFGLWFLSKS QQARWVELEK PLKKHLDKFA NEPLLFFGVM 100
    FYVPNVSRLQ QEATRYQYYL QVKKDVLEGR LRCSLEQVIR LAGLAVQADF 150
    GDYNQFDSQE FLREYVLFPM DLAMEEAALE ELTQKVAQEH KAHSGILPAE 200
    AELMYINEVE RLDGFGQEIF PVKDSHGNSV HLGIFFMGIF VRNRVGRQAV 250
    IYRWNDIGSV THSKAAILLE LIDKEETALF HTDDIENAKY ISRLFTTRHK 300
    FYKQNKICTE QSNSPPPIRR QPTWSRSSLP RQQPYILPPM HVQCSEHYSE 350
    THTSQDSIFP GNEEALYCRS HNSLDLNYLN GTVTNGSVCS VHSVNSLSCS 400
    QSFIQASPVS SNLSIPGSDI MRADYIPSHR HSTIIVPSYR PTPDYETVMR 450
    QMKRGLMHAD SQSRSLRNLN IINTHAYNQP EELVYSQPEM RERHPYTVPY 500
    AHQGCYGHKL VSPSDQMNPQ NCAMPIKPGA SSISHTVSTP ELANMQLQGA 550
    QHYSTAHMLK NYLFRPPPPY PRPRPATSTP DLASHRHKYV SGSSPDLVTR 600
    KVQLSVKTFQ EDSSPVVHQS LQEVSEPLTA TKHHGGGGGT VNKRHSLEVM 650
    NSMVRGMEAM TLKSLNIPMA RRNTLREQGP SEETGGHEVH GLPQYHHKKT 700
    FSDATMLIHS SESEEEEETL EAAPQVPVLR EKVEYSAQLQ AALARIPNRP 750
    PPEYPGPRKS VSNGALRQDQ GTPLPAMARC RVLRHGPSKA LSVSRAEQLA 800
    VNGASLGPSI SEPDLTSVKE RVKKEPVKER PVSEMFSLED SIIEREMMIR 850
    NLEKQKMTGP QAQKRPLMLA ALNGLSVARV SGREDGHHDA TRVPIDERLR 900
    ALKKKLEDGM VFTEYEQIPN KKANGVFSTA TLPENAERSR IREVVPYEEN 950
    RVELIPTKEN NTGYINASHI KVVVGGSEWH YIATQGPLPH TCHDFWQMVW 1000
    EQGVNVIAMV TAEEEGGRTK SHRYWPKLGS KHSSATYGKF KVTTKFRTDS 1050
    GCYATTGLKV KHLLSGQERT VWHLQYTDWP HHGCPEDVQG FLSYLEEIQS 1100
    VRRHTNSVLE GIRTRHPPIV VHCSAGVGRT GVVILSELMI YCLEHNEKVE 1150
    VPTMLRFLRE QRMFMIQTIA QYKFVYQVLV QFLQNSRLI 1189
    Length:1,189
    Mass (Da):135,042
    Last modified:March 6, 2013 - v2
    Checksum:i7FAFED60C5145477
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231T → A in BAA06628. (PubMed:8074693)Curated
    Sequence conflicti887 – 8871H → R in BAA06628. (PubMed:8074693)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31842 mRNA. Translation: BAA06628.1.
    AC140250 Genomic DNA. No translation available.
    AC140461 Genomic DNA. No translation available.
    CH466555 Genomic DNA. Translation: EDL13025.1.
    CH466555 Genomic DNA. Translation: EDL13028.1.
    CCDSiCCDS15609.1.
    PIRiJC2366.
    RefSeqiNP_033002.2. NM_008976.2.
    XP_006497192.1. XM_006497129.1.
    XP_006497193.1. XM_006497130.1.
    XP_006497194.1. XM_006497131.1.
    XP_006497195.1. XM_006497132.1.
    XP_006497196.1. XM_006497133.1.
    UniGeneiMm.4498.

    Genome annotation databases

    EnsembliENSMUST00000027898; ENSMUSP00000027898; ENSMUSG00000026604.
    ENSMUST00000097442; ENSMUSP00000095051; ENSMUSG00000026604.
    GeneIDi19250.
    KEGGimmu:19250.
    UCSCiuc007eau.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31842 mRNA. Translation: BAA06628.1 .
    AC140250 Genomic DNA. No translation available.
    AC140461 Genomic DNA. No translation available.
    CH466555 Genomic DNA. Translation: EDL13025.1 .
    CH466555 Genomic DNA. Translation: EDL13028.1 .
    CCDSi CCDS15609.1.
    PIRi JC2366.
    RefSeqi NP_033002.2. NM_008976.2.
    XP_006497192.1. XM_006497129.1.
    XP_006497193.1. XM_006497130.1.
    XP_006497194.1. XM_006497131.1.
    XP_006497195.1. XM_006497132.1.
    XP_006497196.1. XM_006497133.1.
    UniGenei Mm.4498.

    3D structure databases

    ProteinModelPortali Q62130.
    SMRi Q62130. Positions 24-303, 897-1186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62130. 1 interaction.

    PTM databases

    PhosphoSitei Q62130.

    Proteomic databases

    PaxDbi Q62130.
    PRIDEi Q62130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027898 ; ENSMUSP00000027898 ; ENSMUSG00000026604 .
    ENSMUST00000097442 ; ENSMUSP00000095051 ; ENSMUSG00000026604 .
    GeneIDi 19250.
    KEGGi mmu:19250.
    UCSCi uc007eau.1. mouse.

    Organism-specific databases

    CTDi 5784.
    MGIi MGI:102467. Ptpn14.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117681.
    HOGENOMi HOG000115775.
    HOVERGENi HBG053757.
    InParanoidi Q62130.
    KOi K18025.
    OMAi VTTKFRT.
    OrthoDBi EOG7PK8XS.
    TreeFami TF315900.

    Miscellaneous databases

    NextBioi 296086.
    PROi Q62130.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62130.
    Genevestigatori Q62130.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells."
      Sawada M., Ogata M., Fujino Y., Hamaoka T.
      Biochem. Biophys. Res. Commun. 203:479-484(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CB-17/SCID.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans."
      Au A.C., Hernandez P.A., Lieber E., Nadroo A.M., Shen Y.M., Kelley K.A., Gelb B.D., Diaz G.A.
      Am. J. Hum. Genet. 87:436-444(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPTN14_MOUSE
    AccessioniPrimary (citable) accession number: Q62130
    Secondary accession number(s): G5E8M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 6, 2013
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3