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Protein
Submitted name:

Protein tyrosine kinase

Gene

Tyro3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine kinaseImported
Gene namesi
Name:Tyro3Imported
Synonyms:brtImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104294. Tyro3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei414 – 436HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ62121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 114Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST86
Domaini125 – 205Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST81
Domaini213 – 306Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini307 – 401Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini503 – 780Protein kinaseInterPro annotationAdd BLAST278

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOGENOMiHOG000231685.
HOVERGENiHBG006346.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKLENTLG RWAGENGLSI GEYLAIKGLK LMGAPVKMTV SQGQPVKLNC
60 70 80 90 100
SVEGMEDPDI HWMKGWHRGP ECKPGVHLHQ RAQLDWLTQP KVSGASDAGL
110 120 130 140 150
YWCQVKDGEE TKISQSVWLT VEGVPFFTVE PKDLAVQPNA PFQLSCEAVG
160 170 180 190 200
PPEPVTIYWW RGLTKVGGPA PFPFVLNVTG VTQRTEFSCE ARNIKGLATS
210 220 230 240 250
RPAIVRLQAP PAAPFNTTVT TISSYNASVA WVPGADGLAL LHSCTVQVAH
260 270 280 290 300
APGEWEALAV VVPVPPFTCL LRNLAPATNY SLRVRCANAL GPSPTRLGAL
310 320 330 340 350
SDKGPSAAEL LRISMPFVPD SGLILEWEEV IPEDPGEGPL GPYKLSWVQE
360 370 380 390 400
NGTQDELMVE GTRANLTDWD PQKDLILRVC ASNAIGDGPW SQPLVVSSHD
410 420 430 440 450
HAGRQGPPHS RTSWVPVVLG VLTALITAAA LALILLRKRR KETRFGQAFD
460 470 480 490 500
SVMARGEPAV HFRAARSFNR ERPERIEATL DSLGISDELK EKLEDVLIPE
510 520 530 540 550
QQFTLGRMLG KGEFGSVREA QLKQEDGSFV KVAVKMLKAD IIASSDIEEF
560 570 580 590 600
LREAACMKEF DHPHVAKLVG VSLRSRAKGR LPIPMVILPF MKHGDLHAFL
610 620 630 640 650
LASRIGENPF NLPLQTLVRF MVDIRCGMEY LSSRNFIHRD LAARNCMLAE
660 670 680 690 700
DMTVCVADFG LSRKIYSGDY YRQGCASKLP VKWLALESLA DNLYTVHSDV
710 720 730 740 750
WAFGVTMWEI MTRGQTPYAG IENAEIYNYL IGGNRLKQPP ECMEEVYDLM
760 770 780 790 800
YQCWSADPKQ RPSFTCLRME LENILGHLSV LSTSQDPFYI NIERAEQPTE
810 820 830 840 850
SGSPELDCGE RSSSEAGDGS GVGAVGGIPS DSRYIFSPGA IRVTRAAGAA

ARKPPQ
Length:856
Mass (Da):93,931
Last modified:November 1, 1996 - v1
Checksum:i389A022D662103BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17393 mRNA. Translation: BAA04216.1.
PIRiI58411.
UniGeneiMm.2901.
Mm.424496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17393 mRNA. Translation: BAA04216.1.
PIRiI58411.
UniGeneiMm.2901.
Mm.424496.

3D structure databases

ProteinModelPortaliQ62121.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104294. Tyro3.

Phylogenomic databases

HOGENOMiHOG000231685.
HOVERGENiHBG006346.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ62121_MOUSE
AccessioniPrimary (citable) accession number: Q62121
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.