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Protein

ATP-dependent RNA helicase DDX3Y

Gene

Ddx3y

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 206ATPPROSITE-ProRule annotation8
Nucleotide bindingi223 – 230ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX3Y (EC:3.6.4.13)
Alternative name(s):
D1Pas1-related sequence 1
DEAD box protein 3, Y-chromosomal
DEAD-box RNA helicase DEAD2
Short name:
mDEAD2
Gene namesi
Name:Ddx3y
Synonyms:D1Pas1-rs1, Dead2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome Y

Organism-specific databases

MGIiMGI:1349406. Ddx3y.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000550122 – 658ATP-dependent RNA helicase DDX3YAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei101Omega-N-methylarginineBy similarity1
Modified residuei104PhosphotyrosineBy similarity1
Modified residuei110Omega-N-methylarginineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei455PhosphoserineCombined sources1
Modified residuei590Omega-N-methylarginineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei603PhosphoserineBy similarity1
Modified residuei615Omega-N-methylarginineBy similarity1
Modified residuei628Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ62095.
MaxQBiQ62095.
PaxDbiQ62095.
PRIDEiQ62095.

PTM databases

iPTMnetiQ62095.
PhosphoSitePlusiQ62095.

Expressioni

Tissue specificityi

Found in heart, brain, liver, skeletal muscle, kidney and testis. Low expression detected in lung. In testis, expressed in all types of spermatogenic cells including spermatogonia, spermatocytes, spermatids and somatic Sertoli cells within the seminiferous tubules. Also expressed in Leydig cells and other interstitial cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000069045.
ExpressionAtlasiQ62095. baseline and differential.
GenevisibleiQ62095. MM.

Interactioni

Subunit structurei

May interact with TDRD3.By similarity

Protein-protein interaction databases

BioGridi205050. 2 interactors.
MINTiMINT-1865273.
STRINGi10090.ENSMUSP00000088729.

Structurei

3D structure databases

ProteinModelPortaliQ62095.
SMRiQ62095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 402Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST193
Domaini413 – 574Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 207Q motifAdd BLAST29
Motifi346 – 349DEAD box4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0335. Eukaryota.
ENOG410XNTI. LUCA.
GeneTreeiENSGT00770000120531.
HOGENOMiHOG000268804.
HOVERGENiHBG015893.
InParanoidiQ62095.
KOiK17642.
OMAiRYACTSI.
OrthoDBiEOG091G04U3.
PhylomeDBiQ62095.
TreeFamiTF300364.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVAAESTA GLDQQFVGLD LKSSDNQNGG GNTESKGRYI PPHLRNRETS
60 70 80 90 100
KGVCDKDSSG WSCSKDKDAY SSFGSRDSRG KPNYFSDRGS GSRGRFDDHG
110 120 130 140 150
RNDYDGIGGR DRTGFGKFER SGHSRWSDRS DEDDWSKPLP PSERLEQELF
160 170 180 190 200
SGGNTGINFE KYDDIPVEAT GNNCPPHIEN FSDIEMGEII MGNIELTRYT
210 220 230 240 250
RPTPVQKHAI PIIKEKRDLM ACAQTGSGKT AAFLLPILSQ IYTDGPGEAL
260 270 280 290 300
KAMKENGRYG RRKQYPISLV LAPTRELAVQ IYEEARKFSY RSRVRPCVVY
310 320 330 340 350
GGADTVQQIR DLERGCHLLV ATPGRLVDMM ERGKIGLDFC KYLVLDEADR
360 370 380 390 400
MLDMGFEPQI RRIVEQDTMP PKGVRHTMMF SATFPKEIQM LARDFLDEYI
410 420 430 440 450
FLAVGRVGST SENITQKVVW VEELDKRSFL LDLLNATGKD SLTLVFVETK
460 470 480 490 500
KGADSLENFL FQERYACTSI HGDRSQKDRE EALHQFRSGR KPILVATAVA
510 520 530 540 550
ARGLDISNVK HVINFDLPSD IEEYVHRIGR TGRVGNLGLA TSFFNERNLN
560 570 580 590 600
ITKDLLDLLV EAKQEVPSWL ESMAYEHHYK GSSRGRSKSR FSGGFGARDY
610 620 630 640 650
RQSSGSANAG FNSNRANSSR SSGSSHNRGF GGGGYGGFYN NDGYGGNYNS

QAVDWWGN
Length:658
Mass (Da):73,428
Last modified:August 16, 2005 - v2
Checksum:iC64668326B2C3BB9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti527R → S in AAA53631 (PubMed:8144024).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007376 mRNA. Translation: CAA07483.1.
BC021453 mRNA. Translation: AAH21453.1.
L25337 mRNA. Translation: AAA53631.1.
CCDSiCCDS30543.1.
RefSeqiNP_036138.1. NM_012008.2.
UniGeneiMm.302938.

Genome annotation databases

EnsembliENSMUST00000091190; ENSMUSP00000088729; ENSMUSG00000069045.
GeneIDi26900.
KEGGimmu:26900.
UCSCiuc009uzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007376 mRNA. Translation: CAA07483.1.
BC021453 mRNA. Translation: AAH21453.1.
L25337 mRNA. Translation: AAA53631.1.
CCDSiCCDS30543.1.
RefSeqiNP_036138.1. NM_012008.2.
UniGeneiMm.302938.

3D structure databases

ProteinModelPortaliQ62095.
SMRiQ62095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205050. 2 interactors.
MINTiMINT-1865273.
STRINGi10090.ENSMUSP00000088729.

PTM databases

iPTMnetiQ62095.
PhosphoSitePlusiQ62095.

Proteomic databases

EPDiQ62095.
MaxQBiQ62095.
PaxDbiQ62095.
PRIDEiQ62095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091190; ENSMUSP00000088729; ENSMUSG00000069045.
GeneIDi26900.
KEGGimmu:26900.
UCSCiuc009uzm.2. mouse.

Organism-specific databases

CTDi8653.
MGIiMGI:1349406. Ddx3y.

Phylogenomic databases

eggNOGiKOG0335. Eukaryota.
ENOG410XNTI. LUCA.
GeneTreeiENSGT00770000120531.
HOGENOMiHOG000268804.
HOVERGENiHBG015893.
InParanoidiQ62095.
KOiK17642.
OMAiRYACTSI.
OrthoDBiEOG091G04U3.
PhylomeDBiQ62095.
TreeFamiTF300364.

Miscellaneous databases

PROiQ62095.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069045.
ExpressionAtlasiQ62095. baseline and differential.
GenevisibleiQ62095. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX3Y_MOUSE
AccessioniPrimary (citable) accession number: Q62095
Secondary accession number(s): Q9QWS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.