Ddx3y

Functionⁱ

Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	199 – 206	ATPPROSITE-ProRule annotation		8
Nucleotide bindingⁱ	223 – 230	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ATP-dependent RNA helicase activity Source: GO_Central
RNA binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

chromosome segregation Source: GO_Central
regulation of gene expression Source: GO_Central
RNA secondary structure unwinding Source: GO_Central
translational initiation Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-dependent RNA helicase DDX3Y (EC:3.6.4.13) Alternative name(s): D1Pas1-related sequence 1 DEAD box protein 3, Y-chromosomal DEAD-box RNA helicase DEAD2 Short name: mDEAD2
Gene namesⁱ	Name:Ddx3y Synonyms:D1Pas1-rs1, Dead2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome Y

Organism-specific databases

MGIⁱ	MGI:1349406. Ddx3y.

Subcellular locationⁱ

Note:

Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.

GO - Cellular componentⁱ

cytoplasmic ribonucleoprotein granule Source: GO_Central
cytosol Source: MGI
membrane Source: MGI
nucleolus Source: GO_Central
nucleus Source: MGI

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000055012	2 – 658	ATP-dependent RNA helicase DDX3YAdd BLAST		657

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	56	N6-acetyllysineBy similarity	1
Modified residueⁱ	86	PhosphoserineBy similarity	1
Modified residueⁱ	90	PhosphoserineBy similarity	1
Modified residueⁱ	101	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	104	PhosphotyrosineBy similarity	1
Modified residueⁱ	110	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	117	N6-acetyllysineBy similarity	1
Modified residueⁱ	130	PhosphoserineBy similarity	1
Modified residueⁱ	182	PhosphoserineBy similarity	1
Cross-linkⁱ	214	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	455	PhosphoserineCombined sources	1
Modified residueⁱ	590	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	592	PhosphoserineBy similarity	1
Modified residueⁱ	603	PhosphoserineBy similarity	1
Modified residueⁱ	615	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	628	Omega-N-methylarginineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q62095.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62095.
PaxDbⁱ	Q62095.
PRIDEⁱ	Q62095.

PTM databases

iPTMnetⁱ	Q62095.
PhosphoSitePlusⁱ	Q62095.

Expressionⁱ

Tissue specificityⁱ

Found in heart, brain, liver, skeletal muscle, kidney and testis. Low expression detected in lung. In testis, expressed in all types of spermatogenic cells including spermatogonia, spermatocytes, spermatids and somatic Sertoli cells within the seminiferous tubules. Also expressed in Leydig cells and other interstitial cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000069045.
ExpressionAtlasⁱ	Q62095. baseline and differential.
Genevisibleⁱ	Q62095. MM.

Interactionⁱ

Subunit structureⁱ

May interact with TDRD3.By similarity

Protein-protein interaction databases

BioGridⁱ	205050. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1865273.
STRINGⁱ	10090.ENSMUSP00000088729.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62095.
SMRⁱ	Q62095.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	210 – 402	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		193
Domainⁱ	413 – 574	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		162

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	179 – 207	Q motifAdd BLAST		29
Motifⁱ	346 – 349	DEAD box		4

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0335. Eukaryota. ENOG410XNTI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137887.
HOGENOMⁱ	HOG000268804.
HOVERGENⁱ	HBG015893.
InParanoidⁱ	Q62095.
KEGG Orthology (KO) More...KOⁱ	K17642.
OMAⁱ	NHGNSRL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04U3.
PhylomeDBⁱ	Q62095.
TreeFamⁱ	TF300364.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011545. DEAD/DEAH_box_helicase_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. IPR000629. RNA-helicase_DEAD-box_CS. IPR014014. RNA_helicase_DEAD_Q_motif.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit.
SMARTⁱ	View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00039. DEAD_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51195. Q_MOTIF. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q62095-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQVAAESTA GLDQQFVGLD LKSSDNQNGG GNTESKGRYI PPHLRNRETS 
        60         70         80         90        100
KGVCDKDSSG WSCSKDKDAY SSFGSRDSRG KPNYFSDRGS GSRGRFDDHG 
       110        120        130        140        150
RNDYDGIGGR DRTGFGKFER SGHSRWSDRS DEDDWSKPLP PSERLEQELF 
       160        170        180        190        200
SGGNTGINFE KYDDIPVEAT GNNCPPHIEN FSDIEMGEII MGNIELTRYT 
       210        220        230        240        250
RPTPVQKHAI PIIKEKRDLM ACAQTGSGKT AAFLLPILSQ IYTDGPGEAL 
       260        270        280        290        300
KAMKENGRYG RRKQYPISLV LAPTRELAVQ IYEEARKFSY RSRVRPCVVY 
       310        320        330        340        350
GGADTVQQIR DLERGCHLLV ATPGRLVDMM ERGKIGLDFC KYLVLDEADR 
       360        370        380        390        400
MLDMGFEPQI RRIVEQDTMP PKGVRHTMMF SATFPKEIQM LARDFLDEYI 
       410        420        430        440        450
FLAVGRVGST SENITQKVVW VEELDKRSFL LDLLNATGKD SLTLVFVETK 
       460        470        480        490        500
KGADSLENFL FQERYACTSI HGDRSQKDRE EALHQFRSGR KPILVATAVA 
       510        520        530        540        550
ARGLDISNVK HVINFDLPSD IEEYVHRIGR TGRVGNLGLA TSFFNERNLN 
       560        570        580        590        600
ITKDLLDLLV EAKQEVPSWL ESMAYEHHYK GSSRGRSKSR FSGGFGARDY 
       610        620        630        640        650
RQSSGSANAG FNSNRANSSR SSGSSHNRGF GGGGYGGFYN NDGYGGNYNS 

QAVDWWGN

Length:658

Mass (Da):73,428

Last modified:August 16, 2005 - v2

Checksum:ⁱC64668326B2C3BB9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	527	R → S in AAA53631 (PubMed:8144024).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ007376 mRNA. Translation: CAA07483.1. BC021453 mRNA. Translation: AAH21453.1. L25337 mRNA. Translation: AAA53631.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30543.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036138.1. NM_012008.2.
UniGeneⁱ	Mm.302938.

Genome annotation databases

Ensemblⁱ	ENSMUST00000091190; ENSMUSP00000088729; ENSMUSG00000069045.
GeneIDⁱ	26900.
KEGGⁱ	mmu:26900.
UCSC genome browser More...UCSCⁱ	uc009uzm.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ007376 mRNA. Translation: CAA07483.1. BC021453 mRNA. Translation: AAH21453.1. L25337 mRNA. Translation: AAA53631.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30543.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036138.1. NM_012008.2.
UniGeneⁱ	Mm.302938.

3D structure databases

ProteinModelPortalⁱ	Q62095.
SMRⁱ	Q62095.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205050. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1865273.
STRINGⁱ	10090.ENSMUSP00000088729.

PTM databases

iPTMnetⁱ	Q62095.
PhosphoSitePlusⁱ	Q62095.

Proteomic databases

EPDⁱ	Q62095.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62095.
PaxDbⁱ	Q62095.
PRIDEⁱ	Q62095.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000091190; ENSMUSP00000088729; ENSMUSG00000069045.
GeneIDⁱ	26900.
KEGGⁱ	mmu:26900.
UCSC genome browser More...UCSCⁱ	uc009uzm.2. mouse.

Organism-specific databases

CTDⁱ	8653.
MGIⁱ	MGI:1349406. Ddx3y.

Phylogenomic databases

eggNOGⁱ	KOG0335. Eukaryota. ENOG410XNTI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137887.
HOGENOMⁱ	HOG000268804.
HOVERGENⁱ	HBG015893.
InParanoidⁱ	Q62095.
KEGG Orthology (KO) More...KOⁱ	K17642.
OMAⁱ	NHGNSRL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04U3.
PhylomeDBⁱ	Q62095.
TreeFamⁱ	TF300364.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62095.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000069045.
ExpressionAtlasⁱ	Q62095. baseline and differential.
Genevisibleⁱ	Q62095. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011545. DEAD/DEAH_box_helicase_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. IPR000629. RNA-helicase_DEAD-box_CS. IPR014014. RNA_helicase_DEAD_Q_motif.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit.
SMARTⁱ	View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00039. DEAD_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51195. Q_MOTIF. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DDX3Y_MOUSE
Accessionⁱ	Q62095Primary (citable) accession number: Q62095 Secondary accession number(s): Q9QWS9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	August 16, 2005
	Last modified:	July 5, 2017
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62095 (DDX3Y_MOUSE)

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ATP-dependent RNA helicase DDX3Y

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ