Reviewed,
UniProtKB/Swiss-Prot Q62087 (PON3_MOUSE)
Last modified
June 16, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serum paraoxonase/lactonase 3 EC=3.1.1.- | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 354 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents By similarity. |
| Catalytic activity | A phenyl acetate + H2O = a phenol + acetate. An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. |
| Subcellular location | Secreted › extracellular space By similarity. |
| Post-translational modification | Glycosylated By similarity. The signal sequence is not cleaved By similarity. |
| Sequence similarities | Belongs to the paraoxonase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | arylesterase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 354 | 354 | Serum paraoxonase/lactonase 3 | PRO_0000223291 | |||||||
| Signal peptide | 1 – ? | Not cleaved Potential | |||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 50 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 269 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 323 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 42 ↔ 352 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 3 | 1 | K → H in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 8 | 1 | T → P in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 248 | 1 | K → E in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 273 | 1 | D → A in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 297 | 1 | D → G in AAC42090. Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family." Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N. Genomics 33:498-507(1996) [PubMed: 8661009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NOD. Tissue: Thymus. |
Cross-references
Sequence databases | |
|---|---|
| L76193 mRNA. Translation: AAC42090.1. AK088572 mRNA. Translation: BAC40430.1. | |
| IPI | IPI00121114. |
| RefSeq | NP_766594.1. |
| UniGene | Mm.9122 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q62087. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000029759. Mus musculus. [Contig view] |
| GeneID | 269823. |
| KEGG | mmu:269823. |
Organism-specific databases | |
| MGI | MGI:106686. Pon3. |
Phylogenomic databases | |
| HOGENOM | Q62087. |
| HOVERGEN | Q62087. |
| OMA | Q62087. YFTNFFL. |
Gene expression databases | |
| ArrayExpress | Q62087. |
| Bgee | Q62087. |
| CleanEx | MM_PON3. |
| GermOnline | ENSMUSG00000029759. Mus musculus. |
Family and domain databases | |
| InterPro | IPR011042. 6-blade_b-propeller_TolB-like. IPR002640. Arylesterase. IPR008364. Paraoxonase2. [Graphical view] |
| Gene3D | G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit. |
| Pfam | PF01731. Arylesterase. 1 hit. [Graphical view] |
| PRINTS | PR01785. PARAOXONASE. PR01787. PARAOXONASE2. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 393049. |
| SOURCE | Search... |
Entry information
| Entry name | PON3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q62087 Secondary accession number(s): Q8C2I7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


