Q62087 (PON3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serum paraoxonase/lactonase 3
EC=3.1.1.2
EC=3.1.1.81
EC=3.1.8.1

Gene names

Name:

Pon3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents By similarity.
Catalytic activity	A phenyl acetate + H2O = a phenol + acetate. Ref.5 An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. Ref.5 An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine. Ref.5
Cofactor	Binds 2 calcium ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted › extracellular space By similarity.
Post-translational modification	Glycosylated By similarity. The signal sequence is not cleaved By similarity.
Sequence similarities	Belongs to the paraoxonase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aryldialkylphosphatase activity Inferred from electronic annotation. Source: EC arylesterase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Serum paraoxonase/lactonase 3		PRO_0000223291
	Signal peptide	1 – ?		Not cleaved Potential
Sites
	Active site	114	1	Proton acceptor By similarity
	Metal binding	53	1	Calcium 1; catalytic By similarity
	Metal binding	54	1	Calcium 2 By similarity
	Metal binding	116	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	167	1	Calcium 1; catalytic By similarity
	Metal binding	168	1	Calcium 2 By similarity
	Metal binding	223	1	Calcium 1; catalytic By similarity
	Metal binding	268	1	Calcium 1; catalytic By similarity
	Metal binding	269	1	Calcium 1; catalytic By similarity
Amino acid modifications
	Modified residue	165	1	Phosphoserine By similarity
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential
	Glycosylation	323	1	N-linked (GlcNAc...) Potential
	Disulfide bond	42 ↔ 352		By similarity
Experimental info
	Sequence conflict	3	1	K → H in AAC42090. Ref.1
	Sequence conflict	8	1	T → P in AAC42090. Ref.1
	Sequence conflict	248	1	K → E in AAC42090. Ref.1
	Sequence conflict	273	1	D → A in AAC42090. Ref.1
	Sequence conflict	297	1	D → G in AAC42090. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q62087 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: D66534EAA4EB10F2	FASTA	354	39,351
	10 20 30 40 50 60 MGKLVALTLL GACLALIGER LLNFRERVST TREIKATEPQ NCHLIEGLEN GSEDIDILPS 70 80 90 100 110 120 GLAFISTGLK YPGMPAFAPD KPGRIFLMDL NEQNPEAQAL EISGGLDQES LNPHGISTFI 130 140 150 160 170 180 DKDNTAYLYV VNHPNMDSTV EIFKFEEQQR SLIHLKTLKH ELLKSVNDIV VLGPEQFYAT 190 200 210 220 230 240 RDHYFTSYFL VLLEMILDPH WTSVVFYSPK EVKVVAQGFS SANGITVSLD QKFVYVADVT 250 260 270 280 290 300 AKNIHIMKKH DNWDLTPVKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LIYNPEDPPG 310 320 330 340 350 SEVLRIQDSL SDKPRVSTLY ANNGSVLQGS TVASVYHKRM LIGTIFHKAL YCDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family." Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N. Genomics 33:498-507(1996) [PubMed: 8661009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NOD. Tissue: Thymus.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thyroid.
[5]	"Quorum quenching enzyme activity is widely conserved in the sera of mammalian species." Yang F., Wang L.H., Wang J., Dong Y.H., Hu J.Y., Zhang L.H. FEBS Lett. 579:3713-3717(2005) [PubMed: 15963993] [Abstract] Cited for: CATALYTIC ACTIVITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L76193 mRNA. Translation: AAC42090.1. AK088572 mRNA. Translation: BAC40430.1. CH466533 Genomic DNA. Translation: EDL13970.1. BC099416 mRNA. Translation: AAH99416.1.
IPI	IPI00121114.
RefSeq	NP_766594.1. NM_173006.1.
UniGene	Mm.9122.
3D structure databases
ProteinModelPortal	Q62087.
SMR	Q62087. Positions 19-354.
ModBase	Search...
Protein-protein interaction databases
STRING	Q62087.
PTM databases
PhosphoSite	Q62087.
Proteomic databases
PRIDE	Q62087.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031773; ENSMUSP00000031773; ENSMUSG00000029759.
GeneID	269823.
KEGG	mmu:269823.
UCSC	uc009awe.1. mouse.
Organism-specific databases
CTD	5446.
MGI	MGI:106686. Pon3.
Phylogenomic databases
HOGENOM	HBG613410.
HOVERGEN	HBG003604.
InParanoid	Q62087.
OMA	YFTNFFL.
OrthoDB	EOG4XD3RN.
PhylomeDB	Q62087.
Gene expression databases
ArrayExpress	Q62087.
Bgee	Q62087.
CleanEx	MM_PON3.
Genevestigator	Q62087.
GermOnline	ENSMUSG00000029759. Mus musculus.
Family and domain databases
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR002640. Arylesterase. IPR008364. Paraoxonase2. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
KO	K01045.
Pfam	PF01731. Arylesterase. 1 hit. [Graphical view]
PRINTS	PR01785. PARAOXONASE. PR01787. PARAOXONASE2.
ProtoNet	Search...
Other
NextBio	393049.
SOURCE	Search...

Entry information

Entry name

PON3_MOUSE

Accession

Primary (citable) accession number: Q62087
Secondary accession number(s): Q4FZK0, Q8C2I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 19, 2004
Last modified:	November 16, 2011
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program