Q62087 (PON3_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Serum paraoxonase/lactonase 3 EC=3.1.1.2 EC=3.1.1.81 EC=3.1.8.1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 354 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents By similarity. |
| Catalytic activity | A phenyl acetate + H2O = a phenol + acetate. Ref.5 An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. Ref.5 An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine. Ref.5 |
| Cofactor | Binds 2 calcium ions per subunit By similarity. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Secreted › extracellular space By similarity. |
| Post-translational modification | Glycosylated By similarity. The signal sequence is not cleaved By similarity. |
| Sequence similarities | Belongs to the paraoxonase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | Calcium Metal-binding |
| Molecular function | Hydrolase |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aryldialkylphosphatase activity Inferred from electronic annotation. Source: EC arylesterase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 354 | 354 | Serum paraoxonase/lactonase 3 | PRO_0000223291 | |||||||
| Signal peptide | 1 – ? | Not cleaved Potential | |||||||||
Sites | |||||||||||
| Active site | 114 | 1 | Proton acceptor By similarity | ||||||||
| Metal binding | 53 | 1 | Calcium 1; catalytic By similarity | ||||||||
| Metal binding | 54 | 1 | Calcium 2 By similarity | ||||||||
| Metal binding | 116 | 1 | Calcium 2; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 167 | 1 | Calcium 1; catalytic By similarity | ||||||||
| Metal binding | 168 | 1 | Calcium 2 By similarity | ||||||||
| Metal binding | 223 | 1 | Calcium 1; catalytic By similarity | ||||||||
| Metal binding | 268 | 1 | Calcium 1; catalytic By similarity | ||||||||
| Metal binding | 269 | 1 | Calcium 1; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 165 | 1 | Phosphoserine By similarity | ||||||||
| Glycosylation | 50 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 269 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 323 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 42 ↔ 352 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 3 | 1 | K → H in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 8 | 1 | T → P in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 248 | 1 | K → E in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 273 | 1 | D → A in AAC42090. Ref.1 | ||||||||
| Sequence conflict | 297 | 1 | D → G in AAC42090. Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family." Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N. Genomics 33:498-507(1996) [PubMed: 8661009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NOD. Tissue: Thymus. |
| [3] | Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thyroid. |
| [5] | "Quorum quenching enzyme activity is widely conserved in the sera of mammalian species." Yang F., Wang L.H., Wang J., Dong Y.H., Hu J.Y., Zhang L.H. FEBS Lett. 579:3713-3717(2005) [PubMed: 15963993] [Abstract] Cited for: CATALYTIC ACTIVITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L76193 mRNA. Translation: AAC42090.1. AK088572 mRNA. Translation: BAC40430.1. CH466533 Genomic DNA. Translation: EDL13970.1. BC099416 mRNA. Translation: AAH99416.1. |
| IPI | IPI00121114. |
| RefSeq | NP_766594.1. NM_173006.1. |
| UniGene | Mm.9122. |
3D structure databases | |
| ProteinModelPortal | Q62087. |
| SMR | Q62087. Positions 19-354. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q62087. |
PTM databases | |
| PhosphoSite | Q62087. |
Proteomic databases | |
| PRIDE | Q62087. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000031773; ENSMUSP00000031773; ENSMUSG00000029759. |
| GeneID | 269823. |
| KEGG | mmu:269823. |
| UCSC | uc009awe.1. mouse. |
Organism-specific databases | |
| CTD | 5446. |
| MGI | MGI:106686. Pon3. |
Phylogenomic databases | |
| HOGENOM | HBG613410. |
| HOVERGEN | HBG003604. |
| InParanoid | Q62087. |
| OMA | YFTNFFL. |
| OrthoDB | EOG4XD3RN. |
| PhylomeDB | Q62087. |
Gene expression databases | |
| ArrayExpress | Q62087. |
| Bgee | Q62087. |
| CleanEx | MM_PON3. |
| Genevestigator | Q62087. |
| GermOnline | ENSMUSG00000029759. Mus musculus. |
Family and domain databases | |
| InterPro | IPR011042. 6-blade_b-propeller_TolB-like. IPR002640. Arylesterase. IPR008364. Paraoxonase2. [Graphical view] |
| Gene3D | G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit. |
| KO | K01045. |
| Pfam | PF01731. Arylesterase. 1 hit. [Graphical view] |
| PRINTS | PR01785. PARAOXONASE. PR01787. PARAOXONASE2. |
| ProtoNet | Search... |
Other | |
| NextBio | 393049. |
| SOURCE | Search... |
Entry information
| Entry name | PON3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q62087 Secondary accession number(s): Q4FZK0, Q8C2I7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with