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Protein

Serum paraoxonase/lactonase 3

Gene

Pon3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity).By similarity

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2. 3474.
3.1.8.1. 3474.
ReactomeiR-MMU-2142688. Synthesis of 5-eicosatetraenoic acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/lactonase 3 (EC:3.1.1.2, EC:3.1.1.81, EC:3.1.8.1)
Gene namesi
Name:Pon3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106686. Pon3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002232912 – 354Serum paraoxonase/lactonase 3Add BLAST353
Signal peptidei2 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Modified residuei165PhosphoserineBy similarity1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity
The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ62087.
MaxQBiQ62087.
PaxDbiQ62087.
PeptideAtlasiQ62087.
PRIDEiQ62087.

PTM databases

iPTMnetiQ62087.
PhosphoSitePlusiQ62087.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029759.
CleanExiMM_PON3.
ExpressionAtlasiQ62087. baseline and differential.
GenevisibleiQ62087. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62087. 2 interactors.
MINTiMINT-4108218.
STRINGi10090.ENSMUSP00000031773.

Structurei

3D structure databases

ProteinModelPortaliQ62087.
SMRiQ62087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ62087.
KOiK01045.
OMAiQKYVYVA.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ62087.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLVALTLL GACLALIGER LLNFRERVST TREIKATEPQ NCHLIEGLEN
60 70 80 90 100
GSEDIDILPS GLAFISTGLK YPGMPAFAPD KPGRIFLMDL NEQNPEAQAL
110 120 130 140 150
EISGGLDQES LNPHGISTFI DKDNTAYLYV VNHPNMDSTV EIFKFEEQQR
160 170 180 190 200
SLIHLKTLKH ELLKSVNDIV VLGPEQFYAT RDHYFTSYFL VLLEMILDPH
210 220 230 240 250
WTSVVFYSPK EVKVVAQGFS SANGITVSLD QKFVYVADVT AKNIHIMKKH
260 270 280 290 300
DNWDLTPVKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LIYNPEDPPG
310 320 330 340 350
SEVLRIQDSL SDKPRVSTLY ANNGSVLQGS TVASVYHKRM LIGTIFHKAL

YCDL
Length:354
Mass (Da):39,351
Last modified:July 19, 2004 - v2
Checksum:iD66534EAA4EB10F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3K → H in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti8T → P in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti248K → E in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti273D → A in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti297D → G in AAC42090 (PubMed:8661009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76193 mRNA. Translation: AAC42090.1.
AK088572 mRNA. Translation: BAC40430.1.
CH466533 Genomic DNA. Translation: EDL13970.1.
BC099416 mRNA. Translation: AAH99416.1.
CCDSiCCDS19899.1.
RefSeqiNP_766594.1. NM_173006.1.
UniGeneiMm.9122.

Genome annotation databases

EnsembliENSMUST00000031773; ENSMUSP00000031773; ENSMUSG00000029759.
GeneIDi269823.
KEGGimmu:269823.
UCSCiuc009awe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76193 mRNA. Translation: AAC42090.1.
AK088572 mRNA. Translation: BAC40430.1.
CH466533 Genomic DNA. Translation: EDL13970.1.
BC099416 mRNA. Translation: AAH99416.1.
CCDSiCCDS19899.1.
RefSeqiNP_766594.1. NM_173006.1.
UniGeneiMm.9122.

3D structure databases

ProteinModelPortaliQ62087.
SMRiQ62087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62087. 2 interactors.
MINTiMINT-4108218.
STRINGi10090.ENSMUSP00000031773.

PTM databases

iPTMnetiQ62087.
PhosphoSitePlusiQ62087.

Proteomic databases

EPDiQ62087.
MaxQBiQ62087.
PaxDbiQ62087.
PeptideAtlasiQ62087.
PRIDEiQ62087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031773; ENSMUSP00000031773; ENSMUSG00000029759.
GeneIDi269823.
KEGGimmu:269823.
UCSCiuc009awe.1. mouse.

Organism-specific databases

CTDi5446.
MGIiMGI:106686. Pon3.

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ62087.
KOiK01045.
OMAiQKYVYVA.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ62087.
TreeFamiTF322436.

Enzyme and pathway databases

BRENDAi3.1.1.2. 3474.
3.1.8.1. 3474.
ReactomeiR-MMU-2142688. Synthesis of 5-eicosatetraenoic acids.

Miscellaneous databases

PROiQ62087.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029759.
CleanExiMM_PON3.
ExpressionAtlasiQ62087. baseline and differential.
GenevisibleiQ62087. MM.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNetiSearch...

Entry informationi

Entry nameiPON3_MOUSE
AccessioniPrimary (citable) accession number: Q62087
Secondary accession number(s): Q4FZK0, Q8C2I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.