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Protein

Protein phosphatase 1 regulatory subunit 14B

Gene

Ppp1r14b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14B
Alternative name(s):
Phosphatase holoenzyme inhibitor 1
Short name:
PHI-1
Phospholipase C-beta-3 neighbouring gene protein
Gene namesi
Name:Ppp1r14b
Synonyms:Png
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:107682. Ppp1r14b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi57T → A: Abolishes phosphorylation and strongly reduces inhibitory activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714912 – 147Protein phosphatase 1 regulatory subunit 14BAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei29PhosphotyrosineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei57Phosphothreonine2 Publications1

Post-translational modificationi

Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro).2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62084.
MaxQBiQ62084.
PaxDbiQ62084.
PeptideAtlasiQ62084.
PRIDEiQ62084.

PTM databases

iPTMnetiQ62084.
PhosphoSitePlusiQ62084.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in testis. Detected at low levels in the other tissues tested. Highly expressed in cardiac muscle, bladder and aorta (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000056612.
GenevisibleiQ62084. MM.

Interactioni

Protein-protein interaction databases

IntActiQ62084. 1 interactor.
MINTiMINT-4108281.
STRINGi10090.ENSMUSP00000064129.

Structurei

3D structure databases

ProteinModelPortaliQ62084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 103Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYZK. Eukaryota.
ENOG4111NI3. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ62084.
KOiK17555.
OMAiCEEEAIP.
OrthoDBiEOG091G122D.
PhylomeDBiQ62084.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSGPAGGA ALAAPAPGPG SGSTGPRVYF QSPPGAAGEG PGGADDDGPV
60 70 80 90 100
RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL
110 120 130 140
LDMESDDTRA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK
Length:147
Mass (Da):15,957
Last modified:November 9, 2004 - v2
Checksum:iD1E0383A3A9DF822
GO

Sequence cautioni

The sequence CAA66121 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97490 mRNA. Translation: CAA66121.1. Different initiation.
BC082545 mRNA. Translation: AAH82545.2.
BC125650 mRNA. Translation: AAI25651.1.
BC125654 mRNA. Translation: AAI25655.1.
CCDSiCCDS29514.1.
PIRiJC4871.
RefSeqiNP_032915.2. NM_008889.2.
UniGeneiMm.140.

Genome annotation databases

EnsembliENSMUST00000070850; ENSMUSP00000064129; ENSMUSG00000056612.
GeneIDi18938.
KEGGimmu:18938.
UCSCiuc008gjs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97490 mRNA. Translation: CAA66121.1. Different initiation.
BC082545 mRNA. Translation: AAH82545.2.
BC125650 mRNA. Translation: AAI25651.1.
BC125654 mRNA. Translation: AAI25655.1.
CCDSiCCDS29514.1.
PIRiJC4871.
RefSeqiNP_032915.2. NM_008889.2.
UniGeneiMm.140.

3D structure databases

ProteinModelPortaliQ62084.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62084. 1 interactor.
MINTiMINT-4108281.
STRINGi10090.ENSMUSP00000064129.

PTM databases

iPTMnetiQ62084.
PhosphoSitePlusiQ62084.

Proteomic databases

EPDiQ62084.
MaxQBiQ62084.
PaxDbiQ62084.
PeptideAtlasiQ62084.
PRIDEiQ62084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070850; ENSMUSP00000064129; ENSMUSG00000056612.
GeneIDi18938.
KEGGimmu:18938.
UCSCiuc008gjs.1. mouse.

Organism-specific databases

CTDi26472.
MGIiMGI:107682. Ppp1r14b.

Phylogenomic databases

eggNOGiENOG410IYZK. Eukaryota.
ENOG4111NI3. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ62084.
KOiK17555.
OMAiCEEEAIP.
OrthoDBiEOG091G122D.
PhylomeDBiQ62084.
TreeFamiTF105546.

Miscellaneous databases

ChiTaRSiPpp1r14b. mouse.
PROiQ62084.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056612.
GenevisibleiQ62084. MM.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPP14B_MOUSE
AccessioniPrimary (citable) accession number: Q62084
Secondary accession number(s): Q640Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.