Myl10

Functionⁱ

Miscellaneous

This chain binds calcium.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	73 – 84	1PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

Complete GO annotation...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-445355. Smooth Muscle Contraction.

Reactomeⁱ

R-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myosin regulatory light chain 10 Alternative name(s): Myosin light chain 2, lymphocyte-specific Precursor lymphocyte-specific regulatory light chain
Gene namesⁱ	Name:Myl10 Synonyms:Mylc2pl, Plrlc
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1891705. Myl10.

Subcellular locationⁱ

GO - Cellular componentⁱ

mitochondrion
Source: MGI
Inferred from direct assayⁱ
- 18614015

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000322131	1 – 202	Myosin regulatory light chain 10Add BLAST		202

Proteomic databases

PaxDbⁱ	Q62082.
PeptideAtlas More...PeptideAtlasⁱ	Q62082.
PRIDEⁱ	Q62082.

PTM databases

iPTMnetⁱ	Q62082.
PhosphoSitePlusⁱ	Q62082.

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in precursor B- and T-lymphocytes.1 Publication

Inductionⁱ

Up-regulated by interleukin-7.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000005474.
ExpressionAtlasⁱ	Q62082. baseline and differential.

Interactionⁱ

Subunit structureⁱ

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

IntActⁱ	Q62082. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4109927.
STRINGⁱ	10090.ENSMUSP00000005611.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62082.
SMRⁱ	Q62082.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	60 – 95	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	130 – 165	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	166 – 201	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0031. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119196.
HOGENOMⁱ	HOG000233018.
InParanoidⁱ	Q62082.
KEGG Orthology (KO) More...KOⁱ	K12756.
PhylomeDBⁱ	Q62082.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13405. EF-hand_6. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q62082-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQSSLDHGV QGPVAGTGDF GPLKEATATG FISCAQAPRR ARKRVEGTAS 
        60         70         80         90        100
SNVFSMFDQS QIQEFKEAFT IMDQNRDGFI DKEDLRDTFA ALGRINVKNE 
       110        120        130        140        150
ELEAMVKEAP GPINFTVFLT MFGEKLKGTD PEETILHAFK VFDTEGKGFV 
       160        170        180        190        200
KADFIKEKLM TQADRFSEEE VKQMFAAFPP DVCGNLDYRN LCYVITHGEE 

KD

Length:202

Mass (Da):22,511

Last modified:November 1, 1996 - v1

Checksum:ⁱ97C976AD9E1A90BD

GO

Isoform 2 (identifier: Q62082-2) [UniParc]FASTA Add to basket

Also known as: PLRLC-C

The sequence of this isoform differs from the canonical sequence as follows:
129-202: TDPEETILHA...YVITHGEEKD → SHCAELFYES...SRLTSLRKSL

« Hide

        10         20         30         40         50
MGQSSLDHGV QGPVAGTGDF GPLKEATATG FISCAQAPRR ARKRVEGTAS 
        60         70         80         90        100
SNVFSMFDQS QIQEFKEAFT IMDQNRDGFI DKEDLRDTFA ALGRINVKNE 
       110        120        130        140        150
ELEAMVKEAP GPINFTVFLT MFGEKLKGSH CAELFYESSR PQSRGPLWGQ 
       160        170        180 
GREWLAEART QKRLYCTPSK CLTLKEKALS RLTSLRKSL

Show »

Length:189

Mass (Da):21,031

Checksum:ⁱ93D3C1C0053963C5

GO

Isoform 3 (identifier: Q62082-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.

« Hide

        10         20         30         40         50
MDQNRDGFID KEDLRDTFAA LGRINVKNEE LEAMVKEAPG PINFTVFLTM 
        60         70         80         90        100
FGEKLKGTDP EETILHAFKV FDTEGKGFVK ADFIKEKLMT QADRFSEEEV 
       110        120        130 
KQMFAAFPPD VCGNLDYRNL CYVITHGEEK D

Show »

Length:131

Mass (Da):14,978

Checksum:ⁱ2F01E3293C70C07A

GO

Sequence cautionⁱ

The sequence CAA46794 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA46796 differs from that shown. Reason: Erroneous translation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031873	1 – 71	Missing in isoform 3. 1 PublicationAdd BLAST		71
Alternative sequenceⁱVSP_031874	129 – 202	TDPEE…GEEKD → SHCAELFYESSRPQSRGPLW GQGREWLAEARTQKRLYCTP SKCLTLKEKALSRLTSLRKS L in isoform 2. 1 PublicationAdd BLAST		74

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X65979 mRNA. Translation: CAA46794.1. Different initiation. X65981 mRNA. Translation: CAA46796.1. Sequence problems. BC125528 mRNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS80434.1. [Q62082-3]
PIRⁱ	S20990. S20992.
NCBI Reference Sequences More...RefSeqⁱ	NP_001078856.1. NM_001085387.2. [Q62082-3] NP_001289950.1. NM_001303021.1. [Q62082-3]
UniGeneⁱ	Mm.5178.

Genome annotation databases

Ensemblⁱ	ENSMUST00000196436; ENSMUSP00000142495; ENSMUSG00000005474. [Q62082-3] ENSMUST00000197186; ENSMUSP00000143165; ENSMUSG00000005474. [Q62082-3]
GeneIDⁱ	59310.
KEGGⁱ	mmu:59310.
UCSC genome browser More...UCSCⁱ	uc009aau.1. mouse. [Q62082-1] uc012eet.1. mouse. [Q62082-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X65979 mRNA. Translation: CAA46794.1. Different initiation. X65981 mRNA. Translation: CAA46796.1. Sequence problems. BC125528 mRNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS80434.1. [Q62082-3]
PIRⁱ	S20990. S20992.
NCBI Reference Sequences More...RefSeqⁱ	NP_001078856.1. NM_001085387.2. [Q62082-3] NP_001289950.1. NM_001303021.1. [Q62082-3]
UniGeneⁱ	Mm.5178.

3D structure databases

ProteinModelPortalⁱ	Q62082.
SMRⁱ	Q62082.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q62082. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4109927.
STRINGⁱ	10090.ENSMUSP00000005611.

PTM databases

iPTMnetⁱ	Q62082.
PhosphoSitePlusⁱ	Q62082.

Proteomic databases

PaxDbⁱ	Q62082.
PeptideAtlas More...PeptideAtlasⁱ	Q62082.
PRIDEⁱ	Q62082.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000196436; ENSMUSP00000142495; ENSMUSG00000005474. [Q62082-3] ENSMUST00000197186; ENSMUSP00000143165; ENSMUSG00000005474. [Q62082-3]
GeneIDⁱ	59310.
KEGGⁱ	mmu:59310.
UCSC genome browser More...UCSCⁱ	uc009aau.1. mouse. [Q62082-1] uc012eet.1. mouse. [Q62082-2]

Organism-specific databases

CTDⁱ	93408.
MGIⁱ	MGI:1891705. Myl10.

Phylogenomic databases

eggNOGⁱ	KOG0031. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119196.
HOGENOMⁱ	HOG000233018.
InParanoidⁱ	Q62082.
KEGG Orthology (KO) More...KOⁱ	K12756.
PhylomeDBⁱ	Q62082.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-445355. Smooth Muscle Contraction.

Reactomeⁱ

R-MMU-445355. Smooth Muscle Contraction.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62082.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005474.
ExpressionAtlasⁱ	Q62082. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13405. EF-hand_6. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYL10_MOUSE
Accessionⁱ	Q62082Primary (citable) accession number: Q62082 Secondary accession number(s): Q62080
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	November 1, 1996
	Last modified:	May 10, 2017
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62082 (MYL10_MOUSE)

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Myosin regulatory light chain 10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (3)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ