Reviewed,
UniProtKB/Swiss-Prot Q62073 (M3K7_MOUSE)
Last modified
October 13, 2009.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mitogen-activated protein kinase kinase kinase 7 EC=2.7.11.25 Alternative name(s): Transforming growth factor-beta-activated kinase 1 Short name=TGF-beta-activated kinase 1 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 579 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway. Ref.1 |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium. |
| Subunit structure | Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2 By similarity. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity By similarity. |
| Post-translational modification | Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| MAP3K7IP2 | Q9NYJ8 | 1 | EBI-1775345,EBI-358708 | From a different organism. |
| Map3k7ip2 | Q99K90 | 4 | EBI-1775345,EBI-1775124 | |
| MAP3K7IP3 | Q8N5C8 | 1 | EBI-1775345,EBI-359964 | From a different organism. |
| Mapk8ip1 | Q9WVI9-2 | 1 | EBI-1775345,EBI-288464 | |
| VRK2 | Q86Y07-1 | 2 | EBI-1775345,EBI-1207633 | From a different organism. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 579 | 579 | Mitogen-activated protein kinase kinase kinase 7 | PRO_0000086253 | |||||
Regions | |||||||||
| Domain | 36 – 291 | 256 | Protein kinase | ||||||
| Nucleotide binding | 42 – 50 | 9 | ATP By similarity | ||||||
| Compositional bias | 8 – 16 | 9 | Poly-Ser | ||||||
Sites | |||||||||
| Active site | 156 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 63 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 184 | 1 | Phosphothreonine; by autocatalysis By similarity | ||||||
| Modified residue | 187 | 1 | Phosphothreonine; by autocatalysis By similarity | ||||||
| Modified residue | 192 | 1 | Phosphoserine; by autocatalysis By similarity | ||||||
| Modified residue | 389 | 1 | Phosphoserine Ref.5 | ||||||
| Modified residue | 412 | 1 | Phosphoserine Ref.5 Ref.3 Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction." Yamaguchi K., Shirakabe K., Shibuya H., Irie K., Ohishi I., Ueno N., Taniguchi T., Nishida E., Matsumoto K. Science 270:2008-2011(1995) [PubMed: 8533096] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. |
| [2] | "Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)." Li M.G., Katsura K., Nomiyama H., Komaki K., Ninomiya-Tsuji J., Matsumoto K., Kobayashi T., Tamura S. J. Biol. Chem. 278:12013-12021(2003) [PubMed: 12556533] [Abstract] Cited for: INTERACTION WITH PPM1L. |
| [3] | "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412, MASS SPECTROMETRY. Tissue: Brain cortex. |
| [4] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412, MASS SPECTROMETRY. Tissue: Liver. |
| [5] | "The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-412, MASS SPECTROMETRY. Tissue: Macrophage. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D76446 mRNA. Translation: BAA11184.1. | |
| IPI | IPI00121080. |
| RefSeq | NP_766276.1. |
| UniGene | Mm.258589 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q62073. 5 interactions. |
| STRING | Q62073. |
PTM databases | |
| PhosphoSite | Q62073. |
Proteomic databases | |
| PRIDE | Q62073. |
Genome annotation databases | |
| Ensembl | ENSMUST00000037607; ENSMUSP00000040307; ENSMUSG00000028284; Mus musculus. [Genome view] ENSMUST00000080933; ENSMUSP00000079734; ENSMUSG00000028284; Mus musculus. [Genome view] |
| GeneID | 26409. |
| KEGG | mmu:26409. |
| UCSC | uc008sep.1. mouse. |
Organism-specific databases | |
| CTD | 26409. |
| MGI | MGI:1346877. Map3k7. |
Phylogenomic databases | |
| HOVERGEN | Q62073. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.25. 244. |
Gene expression databases | |
| ArrayExpress | Q62073. |
| Bgee | Q62073. |
| CleanEx | MM_MAP3K7. |
| Genevestigator | Q62073. |
| GermOnline | ENSMUSG00000028284. Mus musculus. |
Family and domain databases | |
| InterPro | IPR015786. MAPKKK-related. IPR017421. MAPKKK7. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR001245. Tyr_pkinase. [Graphical view] |
| PANTHER | PTHR23257:SF92. MAPKKK-related. 1 hit. |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| PIRSF | PIRSF038168. MAPKKK7. 1 hit. |
| PRINTS | PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 304393. |
| SOURCE | Search... |
Entry information
| Entry name | M3K7_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q62073 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


