ID PHX2A_MOUSE Reviewed; 280 AA. AC Q62066; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 24-JAN-2024, entry version 170. DE RecName: Full=Paired mesoderm homeobox protein 2A; DE AltName: Full=Aristaless homeobox protein homolog; DE AltName: Full=PHOX2A homeodomain protein; DE AltName: Full=Paired-like homeobox 2A; GN Name=Phox2a; Synonyms=Arix, Phox2, Pmx2, Pmx2a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=A/J; RX PubMed=7910552; DOI=10.1242/dev.119.3.881; RA Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., RA Brunet J.-F.; RT "The mouse homeodomain protein Phox2 regulates Ncam promoter activity in RT concert with Cux/CDP and is a putative determinant of neurotransmitter RT phenotype."; RL Development 119:881-896(1993). CC -!- FUNCTION: May be involved in regulating the specificity of expression CC of the catecholamine biosynthetic genes. Acts as a transcription CC activator/factor. Could maintain the noradrenergic phenotype (By CC similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X75014; CAA52923.1; -; mRNA. DR CCDS; CCDS21514.1; -. DR PIR; I48713; I48713. DR RefSeq; NP_032913.1; NM_008887.2. DR AlphaFoldDB; Q62066; -. DR SMR; Q62066; -. DR STRING; 10090.ENSMUSP00000008090; -. DR iPTMnet; Q62066; -. DR PhosphoSitePlus; Q62066; -. DR MaxQB; Q62066; -. DR PaxDb; 10090-ENSMUSP00000008090; -. DR ProteomicsDB; 288203; -. DR Antibodypedia; 16943; 223 antibodies from 35 providers. DR DNASU; 11859; -. DR Ensembl; ENSMUST00000008090.11; ENSMUSP00000008090.9; ENSMUSG00000007946.12. DR GeneID; 11859; -. DR KEGG; mmu:11859; -. DR UCSC; uc009ipe.2; mouse. DR AGR; MGI:106633; -. DR CTD; 401; -. DR MGI; MGI:106633; Phox2a. DR VEuPathDB; HostDB:ENSMUSG00000007946; -. DR eggNOG; KOG0484; Eukaryota. DR GeneTree; ENSGT00940000161147; -. DR HOGENOM; CLU_081152_0_0_1; -. DR InParanoid; Q62066; -. DR OMA; YGDFSPC; -. DR OrthoDB; 2901226at2759; -. DR PhylomeDB; Q62066; -. DR TreeFam; TF351612; -. DR BioGRID-ORCS; 11859; 3 hits in 77 CRISPR screens. DR PRO; PR:Q62066; -. DR Proteomes; UP000000589; Chromosome 7. DR RNAct; Q62066; Protein. DR Bgee; ENSMUSG00000007946; Expressed in superior cervical ganglion and 86 other cell types or tissues. DR GO; GO:0000785; C:chromatin; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:MGI. DR GO; GO:0021703; P:locus ceruleus development; IMP:MGI. DR GO; GO:0030901; P:midbrain development; IMP:MGI. DR GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:MGI. DR GO; GO:0021623; P:oculomotor nerve formation; IMP:BHF-UCL. DR GO; GO:0048486; P:parasympathetic nervous system development; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0043576; P:regulation of respiratory gaseous exchange; IMP:MGI. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0021523; P:somatic motor neuron differentiation; IMP:MGI. DR GO; GO:0048485; P:sympathetic nervous system development; IMP:MGI. DR GO; GO:0021642; P:trochlear nerve formation; IMP:BHF-UCL. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1. DR PANTHER; PTHR24329:SF303; PAIRED MESODERM HOMEOBOX PROTEIN 2A; 1. DR Pfam; PF00046; Homeodomain; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR Genevisible; Q62066; MM. PE 2: Evidence at transcript level; KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..280 FT /note="Paired mesoderm homeobox protein 2A" FT /id="PRO_0000049260" FT DNA_BIND 90..149 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 145..244 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 260..280 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 167..181 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 188..205 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 280 AA; 29417 MW; F7CBFBCE66B57A5D CRC64; MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA TGAKKGEARC SSEDDDSKES TCSPTPDSTA SLPPPPAPSL ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG TGAAELLKAW QPAEPGPGPF SGVLSSFHRK PGPALKTNLF //