Reviewed, UniProtKB/Swiss-Prot Q62066 (PHX2A_MOUSE)

Names and origin

Protein names

Recommended name:
    Paired mesoderm homeobox protein 2A
Alternative name(s):
    Paired-like homeobox 2A
    PHOX2A homeodomain protein
    Aristaless homeobox protein homolog

Gene names

Name:	Phox2a
Synonyms:	Arix, Phox2, Pmx2, Pmx2a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Gene Ontology (GO)
Biological process	locus ceruleus development Inferred from mutant phenotype. Source: MGI parasympathetic nervous system development Inferred from mutant phenotype. Source: MGI regulation of respiratory gaseous exchange Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW somatic motor neuron differentiation Inferred from mutant phenotype. Source: MGI sympathetic nervous system development Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Paired mesoderm homeobox protein 2A		PRO_0000049260
Regions
	DNA binding	90 – 149	60	Homeobox
	Compositional bias	193 – 198	6	Poly-Pro
	Compositional bias	233 – 242	10	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q62066-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F7CBFBCE66B57A5D	FASTA	280	29,417
	10 20 30 40 50 60 MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG 70 80 90 100 110 120 ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR 130 140 150 160 170 180 EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA TGAKKGEARC SSEDDDSKES 190 200 210 220 230 240 TCSPTPDSTA SLPPPPAPSL ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG 250 260 270 280 TGAAELLKAW QPAEPGPGPF SGVLSSFHRK PGPALKTNLF

References

[1]	"The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype." Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., Brunet J.-F. Development 119:881-896(1993) [PubMed: 7910552] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: A/J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X75014 mRNA. Translation: CAA52923.1.
IPI	IPI00121059.
PIR	I48713.
RefSeq	NP_032913.1.
UniGene	Mm.5028
3D structure databases
HSSP	HSSP built from PDB template 1FJL based on UniProtKB P06601.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000007946. Mus musculus. [Contig view]
GeneID	11859.
KEGG	mmu:11859.
Organism-specific databases
MGI	MGI:106633. Phox2a.
Phylogenomic databases
HOGENOM	Q62066.
HOVERGEN	Q62066.
OMA	Q62066. PAPYSAX.
Gene expression databases
ArrayExpress	Q62066.
Bgee	Q62066.
CleanEx	MM_PHOX2A.
GermOnline	ENSMUSG00000007946. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279855.
SOURCE	Search...

Entry information

Entry name

PHX2A_MOUSE

Accession

Primary (citable) accession number: Q62066

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)