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Q62066

- PHX2A_MOUSE

UniProt

Q62066 - PHX2A_MOUSE

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Protein

Paired mesoderm homeobox protein 2A

Gene

Phox2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi90 – 14960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. locus ceruleus development Source: MGI
  2. midbrain development Source: MGI
  3. noradrenergic neuron differentiation Source: MGI
  4. oculomotor nerve formation Source: BHF-UCL
  5. parasympathetic nervous system development Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of respiratory gaseous exchange Source: MGI
  8. somatic motor neuron differentiation Source: MGI
  9. sympathetic nervous system development Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. trochlear nerve formation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2A
Alternative name(s):
Aristaless homeobox protein homolog
PHOX2A homeodomain protein
Paired-like homeobox 2A
Gene namesi
Name:Phox2a
Synonyms:Arix, Phox2, Pmx2, Pmx2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:106633. Phox2a.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Paired mesoderm homeobox protein 2APRO_0000049260Add
BLAST

Proteomic databases

MaxQBiQ62066.
PRIDEiQ62066.

PTM databases

PhosphoSiteiQ62066.

Expressioni

Gene expression databases

BgeeiQ62066.
CleanExiMM_PHOX2A.
GenevestigatoriQ62066.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008090.

Structurei

3D structure databases

ProteinModelPortaliQ62066.
SMRiQ62066. Positions 92-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 1986Poly-Pro
Compositional biasi233 – 24210Poly-Gly

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG301263.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000013060.
HOVERGENiHBG053590.
InParanoidiQ62066.
KOiK09330.
OMAiKGPLWAG.
OrthoDBiEOG7C2R1F.
PhylomeDBiQ62066.
TreeFamiTF351612.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP
60 70 80 90 100
ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA
110 120 130 140 150
QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER
160 170 180 190 200
AASAKGAAGA TGAKKGEARC SSEDDDSKES TCSPTPDSTA SLPPPPAPSL
210 220 230 240 250
ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG TGAAELLKAW
260 270 280
QPAEPGPGPF SGVLSSFHRK PGPALKTNLF
Length:280
Mass (Da):29,417
Last modified:November 1, 1996 - v1
Checksum:iF7CBFBCE66B57A5D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75014 mRNA. Translation: CAA52923.1.
CCDSiCCDS21514.1.
PIRiI48713.
RefSeqiNP_032913.1. NM_008887.2.
UniGeneiMm.5028.

Genome annotation databases

EnsembliENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
GeneIDi11859.
KEGGimmu:11859.
UCSCiuc009ipe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75014 mRNA. Translation: CAA52923.1 .
CCDSi CCDS21514.1.
PIRi I48713.
RefSeqi NP_032913.1. NM_008887.2.
UniGenei Mm.5028.

3D structure databases

ProteinModelPortali Q62066.
SMRi Q62066. Positions 92-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000008090.

PTM databases

PhosphoSitei Q62066.

Proteomic databases

MaxQBi Q62066.
PRIDEi Q62066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008090 ; ENSMUSP00000008090 ; ENSMUSG00000007946 .
GeneIDi 11859.
KEGGi mmu:11859.
UCSCi uc009ipe.2. mouse.

Organism-specific databases

CTDi 401.
MGIi MGI:106633. Phox2a.

Phylogenomic databases

eggNOGi NOG301263.
GeneTreei ENSGT00760000118958.
HOGENOMi HOG000013060.
HOVERGENi HBG053590.
InParanoidi Q62066.
KOi K09330.
OMAi KGPLWAG.
OrthoDBi EOG7C2R1F.
PhylomeDBi Q62066.
TreeFami TF351612.

Miscellaneous databases

NextBioi 279855.
PROi Q62066.
SOURCEi Search...

Gene expression databases

Bgeei Q62066.
CleanExi MM_PHOX2A.
Genevestigatori Q62066.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype."
    Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., Brunet J.-F.
    Development 119:881-896(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J.

Entry informationi

Entry nameiPHX2A_MOUSE
AccessioniPrimary (citable) accession number: Q62066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3