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Q62066 (PHX2A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired mesoderm homeobox protein 2A
Alternative name(s):
Aristaless homeobox protein homolog
PHOX2A homeodomain protein
Paired-like homeobox 2A
Gene names
Name:Phox2a
Synonyms:Arix, Phox2, Pmx2, Pmx2a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlocus ceruleus development

Inferred from mutant phenotype PubMed 21068058PubMed 9115735. Source: MGI

midbrain development

Inferred from mutant phenotype PubMed 21752929. Source: MGI

noradrenergic neuron differentiation

Inferred from mutant phenotype PubMed 21068058. Source: MGI

oculomotor nerve formation

Inferred from mutant phenotype PubMed 9374403. Source: BHF-UCL

parasympathetic nervous system development

Inferred from mutant phenotype PubMed 9115735. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of respiratory gaseous exchange

Inferred from mutant phenotype PubMed 17218061. Source: MGI

somatic motor neuron differentiation

Inferred from mutant phenotype PubMed 16319924. Source: MGI

sympathetic nervous system development

Inferred from mutant phenotype PubMed 9115735. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

trochlear nerve formation

Inferred from mutant phenotype PubMed 9374403. Source: BHF-UCL

   Cellular_componentnuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 12023301PubMed 18076286. Source: MGI

   Molecular_functionRNA polymerase II regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Paired mesoderm homeobox protein 2A
PRO_0000049260

Regions

DNA binding90 – 14960Homeobox
Compositional bias193 – 1986Poly-Pro
Compositional bias233 – 24210Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
Q62066 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F7CBFBCE66B57A5D

FASTA28029,417
        10         20         30         40         50         60 
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG 

        70         80         90        100        110        120 
ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR 

       130        140        150        160        170        180 
EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA TGAKKGEARC SSEDDDSKES 

       190        200        210        220        230        240 
TCSPTPDSTA SLPPPPAPSL ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG 

       250        260        270        280 
TGAAELLKAW QPAEPGPGPF SGVLSSFHRK PGPALKTNLF 

« Hide

References

[1]"The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype."
Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., Brunet J.-F.
Development 119:881-896(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: A/J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75014 mRNA. Translation: CAA52923.1.
CCDSCCDS21514.1.
PIRI48713.
RefSeqNP_032913.1. NM_008887.2.
UniGeneMm.5028.

3D structure databases

ProteinModelPortalQ62066.
SMRQ62066. Positions 92-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000008090.

PTM databases

PhosphoSiteQ62066.

Proteomic databases

PRIDEQ62066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
GeneID11859.
KEGGmmu:11859.
UCSCuc009ipe.2. mouse.

Organism-specific databases

CTD401.
MGIMGI:106633. Phox2a.

Phylogenomic databases

eggNOGNOG301263.
GeneTreeENSGT00750000117318.
HOGENOMHOG000013060.
HOVERGENHBG053590.
InParanoidQ62066.
KOK09330.
OMAKGPLWAG.
OrthoDBEOG7C2R1F.
PhylomeDBQ62066.
TreeFamTF351612.

Gene expression databases

BgeeQ62066.
CleanExMM_PHOX2A.
GenevestigatorQ62066.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279855.
PROQ62066.
SOURCESearch...

Entry information

Entry namePHX2A_MOUSE
AccessionPrimary (citable) accession number: Q62066
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot