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Protein

Paired mesoderm homeobox protein 2A

Gene

Phox2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi90 – 14960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. locus ceruleus development Source: MGI
  2. midbrain development Source: MGI
  3. noradrenergic neuron differentiation Source: MGI
  4. oculomotor nerve formation Source: BHF-UCL
  5. parasympathetic nervous system development Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  7. regulation of respiratory gaseous exchange Source: MGI
  8. somatic motor neuron differentiation Source: MGI
  9. sympathetic nervous system development Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. trochlear nerve formation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2A
Alternative name(s):
Aristaless homeobox protein homolog
PHOX2A homeodomain protein
Paired-like homeobox 2A
Gene namesi
Name:Phox2a
Synonyms:Arix, Phox2, Pmx2, Pmx2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:106633. Phox2a.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nuclear chromatin Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Paired mesoderm homeobox protein 2APRO_0000049260Add
BLAST

Proteomic databases

MaxQBiQ62066.
PRIDEiQ62066.

PTM databases

PhosphoSiteiQ62066.

Expressioni

Gene expression databases

BgeeiQ62066.
CleanExiMM_PHOX2A.
GenevestigatoriQ62066.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008090.

Structurei

3D structure databases

ProteinModelPortaliQ62066.
SMRiQ62066. Positions 92-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 1986Poly-Pro
Compositional biasi233 – 24210Poly-Gly

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG301263.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000013060.
HOVERGENiHBG053590.
InParanoidiQ62066.
KOiK09330.
OMAiKGPLWAG.
OrthoDBiEOG7C2R1F.
PhylomeDBiQ62066.
TreeFamiTF351612.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP
60 70 80 90 100
ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA
110 120 130 140 150
QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER
160 170 180 190 200
AASAKGAAGA TGAKKGEARC SSEDDDSKES TCSPTPDSTA SLPPPPAPSL
210 220 230 240 250
ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG TGAAELLKAW
260 270 280
QPAEPGPGPF SGVLSSFHRK PGPALKTNLF
Length:280
Mass (Da):29,417
Last modified:November 1, 1996 - v1
Checksum:iF7CBFBCE66B57A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75014 mRNA. Translation: CAA52923.1.
CCDSiCCDS21514.1.
PIRiI48713.
RefSeqiNP_032913.1. NM_008887.2.
UniGeneiMm.5028.

Genome annotation databases

EnsembliENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
GeneIDi11859.
KEGGimmu:11859.
UCSCiuc009ipe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75014 mRNA. Translation: CAA52923.1.
CCDSiCCDS21514.1.
PIRiI48713.
RefSeqiNP_032913.1. NM_008887.2.
UniGeneiMm.5028.

3D structure databases

ProteinModelPortaliQ62066.
SMRiQ62066. Positions 92-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008090.

PTM databases

PhosphoSiteiQ62066.

Proteomic databases

MaxQBiQ62066.
PRIDEiQ62066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
GeneIDi11859.
KEGGimmu:11859.
UCSCiuc009ipe.2. mouse.

Organism-specific databases

CTDi401.
MGIiMGI:106633. Phox2a.

Phylogenomic databases

eggNOGiNOG301263.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000013060.
HOVERGENiHBG053590.
InParanoidiQ62066.
KOiK09330.
OMAiKGPLWAG.
OrthoDBiEOG7C2R1F.
PhylomeDBiQ62066.
TreeFamiTF351612.

Miscellaneous databases

NextBioi279855.
PROiQ62066.
SOURCEiSearch...

Gene expression databases

BgeeiQ62066.
CleanExiMM_PHOX2A.
GenevestigatoriQ62066.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype."
    Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., Brunet J.-F.
    Development 119:881-896(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J.

Entry informationi

Entry nameiPHX2A_MOUSE
AccessioniPrimary (citable) accession number: Q62066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.