Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62066

- PHX2A_MOUSE

UniProt

Q62066 - PHX2A_MOUSE

Protein

Paired mesoderm homeobox protein 2A

Gene

Phox2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi90 – 14960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. locus ceruleus development Source: MGI
    2. midbrain development Source: MGI
    3. noradrenergic neuron differentiation Source: MGI
    4. oculomotor nerve formation Source: BHF-UCL
    5. parasympathetic nervous system development Source: MGI
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. regulation of respiratory gaseous exchange Source: MGI
    8. somatic motor neuron differentiation Source: MGI
    9. sympathetic nervous system development Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW
    11. trochlear nerve formation Source: BHF-UCL

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired mesoderm homeobox protein 2A
    Alternative name(s):
    Aristaless homeobox protein homolog
    PHOX2A homeodomain protein
    Paired-like homeobox 2A
    Gene namesi
    Name:Phox2a
    Synonyms:Arix, Phox2, Pmx2, Pmx2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:106633. Phox2a.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Paired mesoderm homeobox protein 2APRO_0000049260Add
    BLAST

    Proteomic databases

    PRIDEiQ62066.

    PTM databases

    PhosphoSiteiQ62066.

    Expressioni

    Gene expression databases

    BgeeiQ62066.
    CleanExiMM_PHOX2A.
    GenevestigatoriQ62066.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000008090.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62066.
    SMRiQ62066. Positions 92-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi193 – 1986Poly-Pro
    Compositional biasi233 – 24210Poly-Gly

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG301263.
    GeneTreeiENSGT00750000117318.
    HOGENOMiHOG000013060.
    HOVERGENiHBG053590.
    InParanoidiQ62066.
    KOiK09330.
    OMAiKGPLWAG.
    OrthoDBiEOG7C2R1F.
    PhylomeDBiQ62066.
    TreeFamiTF351612.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62066-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP    50
    ALGSSNCALG ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA 100
    QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN RRAKFRKQER 150
    AASAKGAAGA TGAKKGEARC SSEDDDSKES TCSPTPDSTA SLPPPPAPSL 200
    ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG TGAAELLKAW 250
    QPAEPGPGPF SGVLSSFHRK PGPALKTNLF 280
    Length:280
    Mass (Da):29,417
    Last modified:November 1, 1996 - v1
    Checksum:iF7CBFBCE66B57A5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75014 mRNA. Translation: CAA52923.1.
    CCDSiCCDS21514.1.
    PIRiI48713.
    RefSeqiNP_032913.1. NM_008887.2.
    UniGeneiMm.5028.

    Genome annotation databases

    EnsembliENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
    GeneIDi11859.
    KEGGimmu:11859.
    UCSCiuc009ipe.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75014 mRNA. Translation: CAA52923.1 .
    CCDSi CCDS21514.1.
    PIRi I48713.
    RefSeqi NP_032913.1. NM_008887.2.
    UniGenei Mm.5028.

    3D structure databases

    ProteinModelPortali Q62066.
    SMRi Q62066. Positions 92-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000008090.

    PTM databases

    PhosphoSitei Q62066.

    Proteomic databases

    PRIDEi Q62066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008090 ; ENSMUSP00000008090 ; ENSMUSG00000007946 .
    GeneIDi 11859.
    KEGGi mmu:11859.
    UCSCi uc009ipe.2. mouse.

    Organism-specific databases

    CTDi 401.
    MGIi MGI:106633. Phox2a.

    Phylogenomic databases

    eggNOGi NOG301263.
    GeneTreei ENSGT00750000117318.
    HOGENOMi HOG000013060.
    HOVERGENi HBG053590.
    InParanoidi Q62066.
    KOi K09330.
    OMAi KGPLWAG.
    OrthoDBi EOG7C2R1F.
    PhylomeDBi Q62066.
    TreeFami TF351612.

    Miscellaneous databases

    NextBioi 279855.
    PROi Q62066.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62066.
    CleanExi MM_PHOX2A.
    Genevestigatori Q62066.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype."
      Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., Brunet J.-F.
      Development 119:881-896(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: A/J.

    Entry informationi

    Entry nameiPHX2A_MOUSE
    AccessioniPrimary (citable) accession number: Q62066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3