Q62066 (PHX2A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Paired mesoderm homeobox protein 2A

Alternative name(s):
Aristaless homeobox protein homolog
PHOX2A homeodomain protein
Paired-like homeobox 2A

Gene names

Name:	Phox2a
Synonyms:	Arix, Phox2, Pmx2, Pmx2a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	locus ceruleus development Inferred from mutant phenotype. Source: MGI midbrain development Inferred from mutant phenotype. Source: MGI noradrenergic neuron differentiation Inferred from mutant phenotype. Source: MGI parasympathetic nervous system development Inferred from mutant phenotype. Source: MGI regulation of respiratory gaseous exchange Inferred from mutant phenotype. Source: MGI somatic motor neuron differentiation Inferred from mutant phenotype. Source: MGI sympathetic nervous system development Inferred from mutant phenotype. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Paired mesoderm homeobox protein 2A		PRO_0000049260
Regions
	DNA binding	90 – 149	60	Homeobox
	Compositional bias	193 – 198	6	Poly-Pro
	Compositional bias	233 – 242	10	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q62066 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F7CBFBCE66B57A5D	FASTA	280	29,417
	10 20 30 40 50 60 MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG 70 80 90 100 110 120 ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR 130 140 150 160 170 180 EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA TGAKKGEARC SSEDDDSKES 190 200 210 220 230 240 TCSPTPDSTA SLPPPPAPSL ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG 250 260 270 280 TGAAELLKAW QPAEPGPGPF SGVLSSFHRK PGPALKTNLF

References

[1]	"The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype." Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C., Brunet J.-F. Development 119:881-896(1993) [PubMed: 7910552] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: A/J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X75014 mRNA. Translation: CAA52923.1.
IPI	IPI00121059.
PIR	I48713.
RefSeq	NP_032913.1. NM_008887.2.
UniGene	Mm.5028.
3D structure databases
ProteinModelPortal	Q62066.
SMR	Q62066. Positions 92-149.
ModBase	Search...
Protein-protein interaction databases
STRING	Q62066.
PTM databases
PhosphoSite	Q62066.
Proteomic databases
PRIDE	Q62066.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
GeneID	11859.
KEGG	mmu:11859.
UCSC	uc009ipe.2. mouse.
Organism-specific databases
CTD	401.
MGI	MGI:106633. Phox2a.
Phylogenomic databases
eggNOG	roNOG16149.
GeneTree	ENSGT00600000084177.
HOGENOM	HBG444376.
HOVERGEN	HBG053590.
InParanoid	Q62066.
OMA	WAGVTGG.
OrthoDB	EOG4N30PS.
Gene expression databases
ArrayExpress	Q62066.
Bgee	Q62066.
CleanEx	MM_PHOX2A.
Genevestigator	Q62066.
GermOnline	ENSMUSG00000007946. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09330.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279855.
SOURCE	Search...

Entry information

Entry name

PHX2A_MOUSE

Accession

Primary (citable) accession number: Q62066

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program