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Q62053

- PE2R2_MOUSE

UniProt

Q62053 - PE2R2_MOUSE

Protein

Prostaglandin E2 receptor EP2 subtype

Gene

Ptger2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

    GO - Molecular functioni

    1. prostaglandin E receptor activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    2. cellular response to prostaglandin E stimulus Source: BHF-UCL
    3. regulation of cell proliferation Source: MGI
    4. response to lipopolysaccharide Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Short name:
    PGE receptor EP2 subtype
    Short name:
    PGE2 receptor EP2 subtype
    Alternative name(s):
    Prostanoid EP2 receptor
    Gene namesi
    Name:Ptger2
    Synonyms:Ptgerep2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:97794. Ptger2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Prostaglandin E2 receptor EP2 subtypePRO_0000070055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ62053.

    PTM databases

    PhosphoSiteiQ62053.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62053.
    BgeeiQ62053.
    CleanExiMM_PTGER2.
    GenevestigatoriQ62053.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000038483.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62053.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini93 – 11220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 19922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 26238CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 36239CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei67 – 9226Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17725Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22425Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275624.
    GeneTreeiENSGT00690000101953.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiQ62053.
    KOiK04259.
    OMAiRVCTYFA.
    OrthoDBiEOG72VH6G.
    PhylomeDBiQ62053.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR    50
    WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL 100
    VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS 150
    RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL 200
    YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR 250
    GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA 300
    LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS 350
    SASKQTDLCG QL 362
    Length:362
    Mass (Da):40,479
    Last modified:November 1, 1996 - v1
    Checksum:iA79FCEE8B6771F44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50589 mRNA. Translation: BAA09137.1.
    BC005440 mRNA. Translation: AAH05440.1.
    CCDSiCCDS26972.1.
    PIRiS66674.
    RefSeqiNP_032990.1. NM_008964.4.
    UniGeneiMm.4630.

    Genome annotation databases

    EnsembliENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
    GeneIDi19217.
    KEGGimmu:19217.
    UCSCiuc007tgd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50589 mRNA. Translation: BAA09137.1 .
    BC005440 mRNA. Translation: AAH05440.1 .
    CCDSi CCDS26972.1.
    PIRi S66674.
    RefSeqi NP_032990.1. NM_008964.4.
    UniGenei Mm.4630.

    3D structure databases

    ProteinModelPortali Q62053.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000038483.

    Chemistry

    BindingDBi Q62053.
    ChEMBLi CHEMBL2488.
    GuidetoPHARMACOLOGYi 341.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q62053.

    Proteomic databases

    PRIDEi Q62053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046891 ; ENSMUSP00000038483 ; ENSMUSG00000037759 .
    GeneIDi 19217.
    KEGGi mmu:19217.
    UCSCi uc007tgd.2. mouse.

    Organism-specific databases

    CTDi 5732.
    MGIi MGI:97794. Ptger2.

    Phylogenomic databases

    eggNOGi NOG275624.
    GeneTreei ENSGT00690000101953.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi Q62053.
    KOi K04259.
    OMAi RVCTYFA.
    OrthoDBi EOG72VH6G.
    PhylomeDBi Q62053.
    TreeFami TF324982.

    Miscellaneous databases

    NextBioi 295980.
    PROi Q62053.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62053.
    Bgeei Q62053.
    CleanExi MM_PTGER2.
    Genevestigatori Q62053.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis."
      Katsuyama M., Nishigaki N., Sugimoto Y., Morimoto K., Negishi M., Narumiya S., Ichikawa A.
      FEBS Lett. 372:151-156(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiPE2R2_MOUSE
    AccessioniPrimary (citable) accession number: Q62053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3