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Q62053

- PE2R2_MOUSE

UniProt

Q62053 - PE2R2_MOUSE

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Protein
Prostaglandin E2 receptor EP2 subtype
Gene
Ptger2, Ptgerep2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. cellular response to prostaglandin E stimulus Source: BHF-UCL
  3. regulation of cell proliferation Source: MGI
  4. response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:Ptger2
Synonyms:Ptgerep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:97794. Ptger2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed prediction
Add
BLAST
Transmembranei25 – 4824Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 6618Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei67 – 9226Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini93 – 11220Extracellular Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini134 – 15219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei153 – 17725Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini178 – 19922Extracellular Reviewed prediction
Add
BLAST
Transmembranei200 – 22425Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini225 – 26238Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei263 – 28624Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini287 – 29913Extracellular Reviewed prediction
Add
BLAST
Transmembranei300 – 32324Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini324 – 36239Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Prostaglandin E2 receptor EP2 subtype
PRO_0000070055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ62053.

PTM databases

PhosphoSiteiQ62053.

Expressioni

Gene expression databases

ArrayExpressiQ62053.
BgeeiQ62053.
CleanExiMM_PTGER2.
GenevestigatoriQ62053.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038483.

Structurei

3D structure databases

ProteinModelPortaliQ62053.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00690000101953.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62053.
KOiK04259.
OMAiRVCTYFA.
OrthoDBiEOG72VH6G.
PhylomeDBiQ62053.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62053-1 [UniParc]FASTAAdd to Basket

« Hide

MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR    50
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL 100
VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS 150
RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL 200
YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR 250
GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA 300
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS 350
SASKQTDLCG QL 362
Length:362
Mass (Da):40,479
Last modified:November 1, 1996 - v1
Checksum:iA79FCEE8B6771F44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50589 mRNA. Translation: BAA09137.1.
BC005440 mRNA. Translation: AAH05440.1.
CCDSiCCDS26972.1.
PIRiS66674.
RefSeqiNP_032990.1. NM_008964.4.
UniGeneiMm.4630.

Genome annotation databases

EnsembliENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
GeneIDi19217.
KEGGimmu:19217.
UCSCiuc007tgd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50589 mRNA. Translation: BAA09137.1 .
BC005440 mRNA. Translation: AAH05440.1 .
CCDSi CCDS26972.1.
PIRi S66674.
RefSeqi NP_032990.1. NM_008964.4.
UniGenei Mm.4630.

3D structure databases

ProteinModelPortali Q62053.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000038483.

Chemistry

BindingDBi Q62053.
ChEMBLi CHEMBL2488.
GuidetoPHARMACOLOGYi 341.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q62053.

Proteomic databases

PRIDEi Q62053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046891 ; ENSMUSP00000038483 ; ENSMUSG00000037759 .
GeneIDi 19217.
KEGGi mmu:19217.
UCSCi uc007tgd.2. mouse.

Organism-specific databases

CTDi 5732.
MGIi MGI:97794. Ptger2.

Phylogenomic databases

eggNOGi NOG275624.
GeneTreei ENSGT00690000101953.
HOGENOMi HOG000115475.
HOVERGENi HBG003074.
InParanoidi Q62053.
KOi K04259.
OMAi RVCTYFA.
OrthoDBi EOG72VH6G.
PhylomeDBi Q62053.
TreeFami TF324982.

Miscellaneous databases

NextBioi 295980.
PROi Q62053.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62053.
Bgeei Q62053.
CleanExi MM_PTGER2.
Genevestigatori Q62053.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis."
    Katsuyama M., Nishigaki N., Sugimoto Y., Morimoto K., Negishi M., Narumiya S., Ichikawa A.
    FEBS Lett. 372:151-156(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPE2R2_MOUSE
AccessioniPrimary (citable) accession number: Q62053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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