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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

Ptger2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. cellular response to prostaglandin E stimulus Source: BHF-UCL
  3. regulation of cell proliferation Source: MGI
  4. response to lipopolysaccharide Source: MGI
  5. response to progesterone Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_301895. Prostanoid ligand receptors.
REACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:Ptger2
Synonyms:Ptgerep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:97794. Ptger2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 6618CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 9226Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 11220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17725Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 19922ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22425Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 26238CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini324 – 36239CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Prostaglandin E2 receptor EP2 subtypePRO_0000070055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ62053.

PTM databases

PhosphoSiteiQ62053.

Expressioni

Gene expression databases

BgeeiQ62053.
CleanExiMM_PTGER2.
ExpressionAtlasiQ62053. baseline and differential.
GenevestigatoriQ62053.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038483.

Structurei

3D structure databases

ProteinModelPortaliQ62053.
SMRiQ62053. Positions 13-53, 123-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62053.
KOiK04259.
OMAiDPWVFAI.
OrthoDBiEOG72VH6G.
PhylomeDBiQ62053.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR
60 70 80 90 100
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL
110 120 130 140 150
VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS
160 170 180 190 200
RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL
210 220 230 240 250
YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR
260 270 280 290 300
GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA
310 320 330 340 350
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS
360
SASKQTDLCG QL
Length:362
Mass (Da):40,479
Last modified:November 1, 1996 - v1
Checksum:iA79FCEE8B6771F44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50589 mRNA. Translation: BAA09137.1.
BC005440 mRNA. Translation: AAH05440.1.
CCDSiCCDS26972.1.
PIRiS66674.
RefSeqiNP_032990.1. NM_008964.4.
UniGeneiMm.4630.

Genome annotation databases

EnsembliENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
GeneIDi19217.
KEGGimmu:19217.
UCSCiuc007tgd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50589 mRNA. Translation: BAA09137.1.
BC005440 mRNA. Translation: AAH05440.1.
CCDSiCCDS26972.1.
PIRiS66674.
RefSeqiNP_032990.1. NM_008964.4.
UniGeneiMm.4630.

3D structure databases

ProteinModelPortaliQ62053.
SMRiQ62053. Positions 13-53, 123-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038483.

Chemistry

BindingDBiQ62053.
ChEMBLiCHEMBL2488.
GuidetoPHARMACOLOGYi341.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ62053.

Proteomic databases

PRIDEiQ62053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
GeneIDi19217.
KEGGimmu:19217.
UCSCiuc007tgd.2. mouse.

Organism-specific databases

CTDi5732.
MGIiMGI:97794. Ptger2.

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62053.
KOiK04259.
OMAiDPWVFAI.
OrthoDBiEOG72VH6G.
PhylomeDBiQ62053.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_301895. Prostanoid ligand receptors.
REACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi295980.
PROiQ62053.
SOURCEiSearch...

Gene expression databases

BgeeiQ62053.
CleanExiMM_PTGER2.
ExpressionAtlasiQ62053. baseline and differential.
GenevestigatoriQ62053.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis."
    Katsuyama M., Nishigaki N., Sugimoto Y., Morimoto K., Negishi M., Narumiya S., Ichikawa A.
    FEBS Lett. 372:151-156(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPE2R2_MOUSE
AccessioniPrimary (citable) accession number: Q62053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.