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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

Ptger2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • cellular response to prostaglandin E stimulus Source: BHF-UCL
  • inflammatory response Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • regulation of cell proliferation Source: MGI
  • response to lipopolysaccharide Source: MGI
  • response to progesterone Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908. Prostanoid ligand receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:Ptger2
Synonyms:Ptgerep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:97794. Ptger2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 66CytoplasmicSequence analysisAdd BLAST18
Transmembranei67 – 92Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini93 – 112ExtracellularSequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 152CytoplasmicSequence analysisAdd BLAST19
Transmembranei153 – 177Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini178 – 199ExtracellularSequence analysisAdd BLAST22
Transmembranei200 – 224Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini225 – 262CytoplasmicSequence analysisAdd BLAST38
Transmembranei263 – 286Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 323Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini324 – 362CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2488.
GuidetoPHARMACOLOGYi341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700551 – 362Prostaglandin E2 receptor EP2 subtypeAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62053.
PRIDEiQ62053.

PTM databases

PhosphoSitePlusiQ62053.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037759.
CleanExiMM_PTGER2.
ExpressionAtlasiQ62053. baseline and differential.
GenevisibleiQ62053. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038483.

Chemistry databases

BindingDBiQ62053.

Structurei

3D structure databases

ProteinModelPortaliQ62053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62053.
KOiK04259.
OMAiNDSWPED.
OrthoDBiEOG091G0F07.
PhylomeDBiQ62053.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR
60 70 80 90 100
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL
110 120 130 140 150
VALAPESHAC TYFAFTMTFF SLATMLMLFA MALERYLSIG YPYFYRRHLS
160 170 180 190 200
RRGGLAVLPV IYGASLLFCS LPLLNYGEYV QYCPGTWCFI RHGRTAYLQL
210 220 230 240 250
YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS SLRGPGSRRR
260 270 280 290 300
GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA
310 320 330 340 350
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS
360
SASKQTDLCG QL
Length:362
Mass (Da):40,479
Last modified:November 1, 1996 - v1
Checksum:iA79FCEE8B6771F44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50589 mRNA. Translation: BAA09137.1.
BC005440 mRNA. Translation: AAH05440.1.
CCDSiCCDS26972.1.
PIRiS66674.
RefSeqiNP_032990.1. NM_008964.4.
UniGeneiMm.4630.

Genome annotation databases

EnsembliENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
GeneIDi19217.
KEGGimmu:19217.
UCSCiuc007tgd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50589 mRNA. Translation: BAA09137.1.
BC005440 mRNA. Translation: AAH05440.1.
CCDSiCCDS26972.1.
PIRiS66674.
RefSeqiNP_032990.1. NM_008964.4.
UniGeneiMm.4630.

3D structure databases

ProteinModelPortaliQ62053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038483.

Chemistry databases

BindingDBiQ62053.
ChEMBLiCHEMBL2488.
GuidetoPHARMACOLOGYi341.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ62053.

Proteomic databases

PaxDbiQ62053.
PRIDEiQ62053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
GeneIDi19217.
KEGGimmu:19217.
UCSCiuc007tgd.2. mouse.

Organism-specific databases

CTDi5732.
MGIiMGI:97794. Ptger2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ62053.
KOiK04259.
OMAiNDSWPED.
OrthoDBiEOG091G0F07.
PhylomeDBiQ62053.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiR-MMU-391908. Prostanoid ligand receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ62053.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037759.
CleanExiMM_PTGER2.
ExpressionAtlasiQ62053. baseline and differential.
GenevisibleiQ62053. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R2_MOUSE
AccessioniPrimary (citable) accession number: Q62053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.