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Q62053 (PE2R2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin E2 receptor EP2 subtype

Short name=PGE receptor EP2 subtype
Short name=PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene names
Name:Ptger2
Synonyms:Ptgerep2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Prostaglandin E2 receptor EP2 subtype
PRO_0000070055

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 6618Cytoplasmic Potential
Transmembrane67 – 9226Helical; Name=2; Potential
Topological domain93 – 11220Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 15219Cytoplasmic Potential
Transmembrane153 – 17725Helical; Name=4; Potential
Topological domain178 – 19922Extracellular Potential
Transmembrane200 – 22425Helical; Name=5; Potential
Topological domain225 – 26238Cytoplasmic Potential
Transmembrane263 – 28624Helical; Name=6; Potential
Topological domain287 – 29913Extracellular Potential
Transmembrane300 – 32324Helical; Name=7; Potential
Topological domain324 – 36239Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62053 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A79FCEE8B6771F44

FASTA36240,479
        10         20         30         40         50         60 
MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR WRGDTGCSAG 

        70         80         90        100        110        120 
SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL VALAPESHAC TYFAFTMTFF 

       130        140        150        160        170        180 
SLATMLMLFA MALERYLSIG YPYFYRRHLS RRGGLAVLPV IYGASLLFCS LPLLNYGEYV 

       190        200        210        220        230        240 
QYCPGTWCFI RHGRTAYLQL YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS 

       250        260        270        280        290        300 
SLRGPGSRRR GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA 

       310        320        330        340        350        360 
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS SASKQTDLCG 


QL 

« Hide

References

« Hide 'large scale' references
[1]"The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis."
Katsuyama M., Nishigaki N., Sugimoto Y., Morimoto K., Negishi M., Narumiya S., Ichikawa A.
FEBS Lett. 372:151-156(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50589 mRNA. Translation: BAA09137.1.
BC005440 mRNA. Translation: AAH05440.1.
CCDSCCDS26972.1.
PIRS66674.
RefSeqNP_032990.1. NM_008964.4.
UniGeneMm.4630.

3D structure databases

ProteinModelPortalQ62053.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000038483.

Chemistry

BindingDBQ62053.
ChEMBLCHEMBL2488.
GuidetoPHARMACOLOGY341.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ62053.

Proteomic databases

PRIDEQ62053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
GeneID19217.
KEGGmmu:19217.
UCSCuc007tgd.2. mouse.

Organism-specific databases

CTD5732.
MGIMGI:97794. Ptger2.

Phylogenomic databases

eggNOGNOG275624.
GeneTreeENSGT00690000101953.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidQ62053.
KOK04259.
OMARVCTYFA.
OrthoDBEOG72VH6G.
PhylomeDBQ62053.
TreeFamTF324982.

Gene expression databases

ArrayExpressQ62053.
BgeeQ62053.
CleanExMM_PTGER2.
GenevestigatorQ62053.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295980.
PROQ62053.
SOURCESearch...

Entry information

Entry namePE2R2_MOUSE
AccessionPrimary (citable) accession number: Q62053
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries