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Protein

Oviduct-specific glycoprotein

Gene

Ovgp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fertilization

Enzyme and pathway databases

ReactomeiR-MMU-1300644. Interaction With The Zona Pellucida.

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Oviduct-specific glycoprotein
Alternative name(s):
Estrogen-dependent oviduct protein
Oviductal glycoprotein
Oviductin
Gene namesi
Name:Ovgp1
Synonyms:Chit5, Ogp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106661. Ovgp1.

Subcellular locationi

GO - Cellular componenti

  • egg coat Source: MGI
  • perivitelline space Source: MGI
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 721700Oviduct-specific glycoproteinPRO_0000011975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62010.
PaxDbiQ62010.
PRIDEiQ62010.

PTM databases

iPTMnetiQ62010.
PhosphoSiteiQ62010.

Expressioni

Tissue specificityi

Epithelial cells of the oviduct.

Gene expression databases

BgeeiQ62010.
CleanExiMM_OVGP1.
ExpressionAtlasiQ62010. baseline and differential.
GenevisibleiQ62010. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000573.

Structurei

3D structure databases

ProteinModelPortaliQ62010.
SMRiQ62010. Positions 22-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati486 – 49271
Repeati493 – 49972
Repeati500 – 50673
Repeati507 – 51374
Repeati514 – 52075
Repeati521 – 52776
Repeati528 – 53477
Repeati535 – 54178
Repeati542 – 54879
Repeati549 – 555710
Repeati556 – 562711
Repeati563 – 569712
Repeati570 – 576713
Repeati577 – 583714
Repeati584 – 590715
Repeati591 – 597716
Repeati598 – 604717
Repeati605 – 611718
Repeati612 – 618719
Repeati619 – 625720
Repeati626 – 632721

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni486 – 63214721 X 7 AA tandem repeats of S-K-[TAI]-[TI]-[TAP]-[GED]-[IVM]Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111109.
HOVERGENiHBG011684.
InParanoidiQ62010.
KOiK17526.
OMAiNDESTEW.
OrthoDBiEOG7ZGX3G.
PhylomeDBiQ62010.
TreeFamiTF315610.

Family and domain databases

Gene3Di3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLLLLAGL VLLMKHSDGT AYKLVCYFTN WAHSRPGPAS IMPHDLDPFL
60 70 80 90 100
CTHLIFAFAS MSNNQIVAKN LQDENVLYPE FNKLKERNRE LKTLLSIGGW
110 120 130 140 150
NFGTSRFTAM LSTLANREKF IDSVISFLRI HGFDGLDLFF LYPGLRGSPP
160 170 180 190 200
HDRWNFLFLI EELQFAFERE ALLTQHPRLL LSAAVSGIPS IIHTSYDALL
210 220 230 240 250
LGRRLDFINV LSYDLHGSWE KFTGHNSPLF SLPEDSKSSA YAMNYWRKLG
260 270 280 290 300
TPADKLIMGF PTYGRNFYLL KESKNGLQTA SMGPASPGKY TKQAGFLAYY
310 320 330 340 350
EVCSFVQRAK KHWIDYQYVP YAFKGKEWLG YDDTISFSYK AMYVKREHFG
360 370 380 390 400
GAMVWTLDMD DVRGTFCGNG PFPLVHILNE LLVQTESNST PLPQFWFTSS
410 420 430 440 450
VNASGPGSEN TALTEVLTTD TIKILPPGGE AMTTEVHRRY ENMTTVPSDG
460 470 480 490 500
SVTPGGTASP RKHAVTPENN TMAAEAKTMS TLDFFSKTTT GVSKTTTGIS
510 520 530 540 550
KTTTGVSKTT TGVSKATAGI SKTIPEISKA TAGVSKTTTG VSKTTTGISK
560 570 580 590 600
TITGVSKTTT GISKTTTGIS KTTTGVSKIT TGVSKTTTGI SKTTTGISQT
610 620 630 640 650
TTGISKTTTD ISKTTTGISK TTPGISKTTP GMTVIVQTQA NEAETTATMD
660 670 680 690 700
HQSVTPTEMD TTLFYLKTMT PSEKETSRKK TMVLEKATVS PREMSATPNG
710 720
QSKTLKWASL ITEVETYSQD G
Length:721
Mass (Da):78,808
Last modified:November 1, 1997 - v1
Checksum:i37246C8F01665652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32137 mRNA. Translation: BAA06863.1.
CCDSiCCDS17716.1.
RefSeqiNP_031722.1. NM_007696.2.
UniGeneiMm.431947.

Genome annotation databases

EnsembliENSMUST00000000573; ENSMUSP00000000573; ENSMUSG00000074340.
GeneIDi12659.
KEGGimmu:12659.
UCSCiuc008qvq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32137 mRNA. Translation: BAA06863.1.
CCDSiCCDS17716.1.
RefSeqiNP_031722.1. NM_007696.2.
UniGeneiMm.431947.

3D structure databases

ProteinModelPortaliQ62010.
SMRiQ62010. Positions 22-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000573.

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

PTM databases

iPTMnetiQ62010.
PhosphoSiteiQ62010.

Proteomic databases

MaxQBiQ62010.
PaxDbiQ62010.
PRIDEiQ62010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000573; ENSMUSP00000000573; ENSMUSG00000074340.
GeneIDi12659.
KEGGimmu:12659.
UCSCiuc008qvq.1. mouse.

Organism-specific databases

CTDi5016.
MGIiMGI:106661. Ovgp1.

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111109.
HOVERGENiHBG011684.
InParanoidiQ62010.
KOiK17526.
OMAiNDESTEW.
OrthoDBiEOG7ZGX3G.
PhylomeDBiQ62010.
TreeFamiTF315610.

Enzyme and pathway databases

ReactomeiR-MMU-1300644. Interaction With The Zona Pellucida.

Miscellaneous databases

PROiQ62010.
SOURCEiSearch...

Gene expression databases

BgeeiQ62010.
CleanExiMM_OVGP1.
ExpressionAtlasiQ62010. baseline and differential.
GenevisibleiQ62010. MM.

Family and domain databases

Gene3Di3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of a mouse oviduct-specific glycoprotein."
    Sendai Y., Komiya H., Suzuki K., Onuma T., Kikuchi M., Hoshi H., Araki Y.
    Biol. Reprod. 53:285-294(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Oviduct.

Entry informationi

Entry nameiOVGP1_MOUSE
AccessioniPrimary (citable) accession number: Q62010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.