ID   O10J5_MOUSE             Reviewed;         309 AA.
AC   Q62007;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Olfactory receptor 10J5 {ECO:0000305};
DE   AltName: Full=Olfactory receptor 16;
GN   Name=Or10j5 {ECO:0000312|MGI:MGI:106648};
GN   Synonyms=Mor23 {ECO:0000303|PubMed:8619840}, Olfr16
GN   {ECO:0000312|MGI:MGI:106648};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|EMBL:CAA63545.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=8619840; DOI=10.1006/bbrc.1996.0580;
RA   Asai H., Kasai H., Matsuda Y., Yamazaki N., Nagawa F., Sakano H.,
RA   Tsuboi A.;
RT   "Genomic structure and transcription of a murine odorant receptor gene:
RT   differential initiation of transcription in the olfactory and testicular
RT   cells.";
RL   Biochem. Biophys. Res. Commun. 221:240-247(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA   Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA   Walker M., Williams E.M., Trask B.J.;
RT   "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT   of over 400 genes, extensive alternate splicing and unequal expression
RT   levels.";
RL   Genome Biol. 4:R71.1-R71.13(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=10097159; DOI=10.1073/pnas.96.7.4040;
RA   Touhara K., Sengoku S., Inaki K., Tsuboi A., Hirono J., Sato T., Sakano H.,
RA   Haga T.;
RT   "Functional identification and reconstitution of an odorant receptor in
RT   single olfactory neurons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:4040-4045(1999).
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15522887; DOI=10.1242/jcs.01507;
RA   Fukuda N., Yomogida K., Okabe M., Touhara K.;
RT   "Functional characterization of a mouse testicular olfactory receptor and
RT   its role in chemosensing and in regulation of sperm motility.";
RL   J. Cell Sci. 117:5835-5845(2004).
RN   [7]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=19922870; DOI=10.1016/j.devcel.2009.09.004;
RA   Griffin C.A., Kafadar K.A., Pavlath G.K.;
RT   "MOR23 promotes muscle regeneration and regulates cell adhesion and
RT   migration.";
RL   Dev. Cell 17:649-661(2009).
RN   [8]
RP   FUNCTION.
RX   PubMed=25791473; DOI=10.1016/j.bbrc.2015.03.046;
RA   Kim S.H., Yoon Y.C., Lee A.S., Kang N., Koo J., Rhyu M.R., Park J.H.;
RT   "Expression of human olfactory receptor 10J5 in heart aorta, coronary
RT   artery, and endothelial cells and its functional role in angiogenesis.";
RL   Biochem. Biophys. Res. Commun. 460:404-408(2015).
RN   [9]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28842679; DOI=10.1038/s41598-017-10379-x;
RA   Tong T., Ryu S.E., Min Y., de March C.A., Bushdid C., Golebiowski J.,
RA   Moon C., Park T.;
RT   "Olfactory receptor 10J5 responding to alpha-cedrene regulates hepatic
RT   steatosis via the cAMP-PKA pathway.";
RL   Sci. Rep. 7:9471-9471(2017).
CC   -!- FUNCTION: Olfactory receptor. Activated by the synthetic floral
CC       odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of
CC       cedarwood oil (PubMed:25791473, PubMed:28842679, PubMed:10097159). Its
CC       activation increases intracellular Ca(2+) (PubMed:25791473,
CC       PubMed:28842679, PubMed:10097159, PubMed:15522887). Acts as a key
CC       regulator of myogenesis through its actions on cell migration and
CC       adhesion by activating the Ca(2+)-dependent AKT signal transduction
CC       pathway (PubMed:19922870). Acts also as a regulator of angiogenesis
CC       (PubMed:25791473). Moreover, plays a role in the regulation of lipid
CC       accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679).
CC       Involved in sperm chemotaxis and motility (PubMed:15522887).
CC       {ECO:0000269|PubMed:10097159, ECO:0000269|PubMed:15522887,
CC       ECO:0000269|PubMed:19922870, ECO:0000269|PubMed:25791473,
CC       ECO:0000269|PubMed:28842679}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28842679};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in the olfactory epithelium as well as in
CC       the testis (PubMed:8619840). Expressed in round spermatids during
CC       stages VI-VIII of spermatogenesis (PubMed:15522887).
CC       {ECO:0000269|PubMed:15522887, ECO:0000269|PubMed:8619840}.
CC   -!- DEVELOPMENTAL STAGE: Up-regulated during myogenesis in vitro and muscle
CC       regeneration in vivo. {ECO:0000269|PubMed:19922870}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; X92969; CAA63545.1; -; Genomic_DNA.
DR   EMBL; AY318634; AAP71794.1; -; Genomic_DNA.
DR   EMBL; BC119298; AAI19299.1; -; mRNA.
DR   EMBL; BC119300; AAI19301.1; -; mRNA.
DR   CCDS; CCDS15521.1; -.
DR   RefSeq; NP_032789.1; NM_008763.2.
DR   AlphaFoldDB; Q62007; -.
DR   SMR; Q62007; -.
DR   STRING; 10090.ENSMUSP00000149249; -.
DR   PaxDb; 10090-ENSMUSP00000041524; -.
DR   Antibodypedia; 20471; 150 antibodies from 24 providers.
DR   Ensembl; ENSMUST00000038432.7; ENSMUSP00000041524.5; ENSMUSG00000037924.7.
DR   Ensembl; ENSMUST00000215254.2; ENSMUSP00000149249.2; ENSMUSG00000037924.7.
DR   GeneID; 18313; -.
DR   KEGG; mmu:18313; -.
DR   UCSC; uc007dqz.2; mouse.
DR   AGR; MGI:106648; -.
DR   CTD; 127385; -.
DR   MGI; MGI:106648; Or10j5.
DR   VEuPathDB; HostDB:ENSMUSG00000037924; -.
DR   eggNOG; ENOG502RU27; Eukaryota.
DR   GeneTree; ENSGT00940000159272; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q62007; -.
DR   OMA; SIFGKHQ; -.
DR   OrthoDB; 4018856at2759; -.
DR   PhylomeDB; Q62007; -.
DR   TreeFam; TF337624; -.
DR   Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 18313; 1 hit in 70 CRISPR screens.
DR   PRO; PR:Q62007; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q62007; Protein.
DR   Bgee; ENSMUSG00000037924; Expressed in spermatid and 21 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR   GO; GO:0016020; C:membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IDA:UniProtKB.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IDA:UniProtKB.
DR   GO; GO:0055088; P:lipid homeostasis; IMP:UniProtKB.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0045765; P:regulation of angiogenesis; IMP:UniProtKB.
DR   GO; GO:0051147; P:regulation of muscle cell differentiation; IMP:UniProtKB.
DR   GO; GO:0007608; P:sensory perception of smell; IDA:UniProtKB.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF700; OLFACTORY RECEPTOR 10J5; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Cell membrane; Chemotaxis; Disulfide bond;
KW   G-protein coupled receptor; Membrane; Myogenesis; Olfaction; Receptor;
KW   Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 10J5"
FT                   /id="PRO_0000454829"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..84
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..203
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        204..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DISULFID        97..178
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   309 AA;  34256 MW;  BEE5CF666D0F7D68 CRC64;
     MQRNNFTEVI EFVFLGFSSF GKHQITLFVV FLTIYILTLA GNIIIVTITH IDHHLHTPMY
     FFLSMLASSE TVYTLVIVPR MLSSLIFYNL PISLAGCATQ MFFFVTLATN NCFLLTAMGY
     DRYVAICNPL RYTIIMSKGM CALLVCGSLG TGLVMAVLHV PAMFHLPFCG TVVEHFFCDI
     YPVMKLSCVD TTVNEIINYG VSSFVILVPI GLIFISYVLI VSSILKIVST EGQKKAFATC
     ASHLTVVIVH YGCASIAYLK PKSESSVEKD LLLSVTYTII TPLLNPVVYS LRNKEVKDAL
     CRAVGRNTS
//