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Q62000

- MIME_MOUSE

UniProt

Q62000 - MIME_MOUSE

Protein

Mimecan

Gene

Ogn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.By similarity

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_198578. Keratan sulfate biosynthesis.
    REACT_198960. Keratan sulfate degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mimecan
    Alternative name(s):
    Osteoglycin
    Gene namesi
    Name:Ogn
    Synonyms:Og
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:109278. Ogn.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 298279MimecanPRO_0000032761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi255 ↔ 288By similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ62000.
    PaxDbiQ62000.
    PRIDEiQ62000.

    PTM databases

    PhosphoSiteiQ62000.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62000.
    BgeeiQ62000.
    CleanExiMM_OGN.
    GenevestigatoriQ62000.

    Interactioni

    Protein-protein interaction databases

    IntActiQ62000. 1 interaction.
    MINTiMINT-4101955.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62000.
    SMRiQ62000. Positions 97-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati112 – 13120LRR 1Add
    BLAST
    Repeati132 – 15524LRR 2Add
    BLAST
    Repeati156 – 17924LRR 3Add
    BLAST
    Repeati180 – 19920LRR 4Add
    BLAST
    Repeati200 – 22526LRR 5Add
    BLAST
    Repeati226 – 24621LRR 6Add
    BLAST
    Repeati247 – 27731LRR 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi94 – 10613Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 7 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG318805.
    GeneTreeiENSGT00730000110781.
    HOGENOMiHOG000273909.
    HOVERGENiHBG006850.
    InParanoidiQ62000.
    KOiK08126.
    OMAiDTRYIRD.
    OrthoDBiEOG75TMD0.
    PhylomeDBiQ62000.
    TreeFamiTF351924.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR027211. Mimecan.
    [Graphical view]
    PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
    PfamiPF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62000-1 [UniParc]FASTAAdd to Basket

    « Hide

    METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK    50
    YLDGKSIKEK ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL 100
    SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DMPNLRRLDF 150
    TGNLIEDIED GTFSKLSLLE ELTLAENQLL RLPVLPPKLT LLNAKHNKIK 200
    SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH LQFNSISSLT 250
    DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF 298
    Length:298
    Mass (Da):34,012
    Last modified:November 1, 1996 - v1
    Checksum:i0C5DB4A5AB6B05FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31951 mRNA. Translation: BAA06721.1.
    BC021939 mRNA. Translation: AAH21939.1.
    CCDSiCCDS26505.1.
    PIRiJC4130.
    RefSeqiNP_032786.1. NM_008760.4.
    UniGeneiMm.4258.
    Mm.470076.

    Genome annotation databases

    EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
    GeneIDi18295.
    KEGGimmu:18295.
    UCSCiuc007qjr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31951 mRNA. Translation: BAA06721.1 .
    BC021939 mRNA. Translation: AAH21939.1 .
    CCDSi CCDS26505.1.
    PIRi JC4130.
    RefSeqi NP_032786.1. NM_008760.4.
    UniGenei Mm.4258.
    Mm.470076.

    3D structure databases

    ProteinModelPortali Q62000.
    SMRi Q62000. Positions 97-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62000. 1 interaction.
    MINTi MINT-4101955.

    PTM databases

    PhosphoSitei Q62000.

    Proteomic databases

    MaxQBi Q62000.
    PaxDbi Q62000.
    PRIDEi Q62000.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021822 ; ENSMUSP00000021822 ; ENSMUSG00000021390 .
    GeneIDi 18295.
    KEGGi mmu:18295.
    UCSCi uc007qjr.1. mouse.

    Organism-specific databases

    CTDi 4969.
    MGIi MGI:109278. Ogn.

    Phylogenomic databases

    eggNOGi NOG318805.
    GeneTreei ENSGT00730000110781.
    HOGENOMi HOG000273909.
    HOVERGENi HBG006850.
    InParanoidi Q62000.
    KOi K08126.
    OMAi DTRYIRD.
    OrthoDBi EOG75TMD0.
    PhylomeDBi Q62000.
    TreeFami TF351924.

    Enzyme and pathway databases

    Reactomei REACT_198578. Keratan sulfate biosynthesis.
    REACT_198960. Keratan sulfate degradation.

    Miscellaneous databases

    NextBioi 293748.
    PROi Q62000.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62000.
    Bgeei Q62000.
    CleanExi MM_OGN.
    Genevestigatori Q62000.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR027211. Mimecan.
    [Graphical view ]
    PANTHERi PTHR24371:SF5. PTHR24371:SF5. 1 hit.
    Pfami PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the mouse osteoglycin-encoding gene."
      Ujita M., Shinomura T., Kimata K.
      Gene 158:237-240(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Limb bud.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMIME_MOUSE
    AccessioniPrimary (citable) accession number: Q62000
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3