SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62000

- MIME_MOUSE

UniProt

Q62000 - MIME_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mimecan
Gene
Ogn, Og
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 By similarity.

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene namesi
Name:Ogn
Synonyms:Og
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:109278. Ogn.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 298279Mimecan
PRO_0000032761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi255 ↔ 288 By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62000.
PaxDbiQ62000.
PRIDEiQ62000.

PTM databases

PhosphoSiteiQ62000.

Expressioni

Gene expression databases

ArrayExpressiQ62000.
BgeeiQ62000.
CleanExiMM_OGN.
GenevestigatoriQ62000.

Interactioni

Protein-protein interaction databases

IntActiQ62000. 1 interaction.
MINTiMINT-4101955.

Structurei

3D structure databases

ProteinModelPortaliQ62000.
SMRiQ62000. Positions 97-263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati112 – 13120LRR 1
Add
BLAST
Repeati132 – 15524LRR 2
Add
BLAST
Repeati156 – 17924LRR 3
Add
BLAST
Repeati180 – 19920LRR 4
Add
BLAST
Repeati200 – 22526LRR 5
Add
BLAST
Repeati226 – 24621LRR 6
Add
BLAST
Repeati247 – 27731LRR 7
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 10613Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG318805.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ62000.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
PhylomeDBiQ62000.
TreeFamiTF351924.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62000-1 [UniParc]FASTAAdd to Basket

« Hide

METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK    50
YLDGKSIKEK ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL 100
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DMPNLRRLDF 150
TGNLIEDIED GTFSKLSLLE ELTLAENQLL RLPVLPPKLT LLNAKHNKIK 200
SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH LQFNSISSLT 250
DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF 298
Length:298
Mass (Da):34,012
Last modified:November 1, 1996 - v1
Checksum:i0C5DB4A5AB6B05FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSiCCDS26505.1.
PIRiJC4130.
RefSeqiNP_032786.1. NM_008760.4.
UniGeneiMm.4258.
Mm.470076.

Genome annotation databases

EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneIDi18295.
KEGGimmu:18295.
UCSCiuc007qjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31951 mRNA. Translation: BAA06721.1 .
BC021939 mRNA. Translation: AAH21939.1 .
CCDSi CCDS26505.1.
PIRi JC4130.
RefSeqi NP_032786.1. NM_008760.4.
UniGenei Mm.4258.
Mm.470076.

3D structure databases

ProteinModelPortali Q62000.
SMRi Q62000. Positions 97-263.
ModBasei Search...

Protein-protein interaction databases

IntActi Q62000. 1 interaction.
MINTi MINT-4101955.

PTM databases

PhosphoSitei Q62000.

Proteomic databases

MaxQBi Q62000.
PaxDbi Q62000.
PRIDEi Q62000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021822 ; ENSMUSP00000021822 ; ENSMUSG00000021390 .
GeneIDi 18295.
KEGGi mmu:18295.
UCSCi uc007qjr.1. mouse.

Organism-specific databases

CTDi 4969.
MGIi MGI:109278. Ogn.

Phylogenomic databases

eggNOGi NOG318805.
GeneTreei ENSGT00730000110781.
HOGENOMi HOG000273909.
HOVERGENi HBG006850.
InParanoidi Q62000.
KOi K08126.
OMAi DTRYIRD.
OrthoDBi EOG75TMD0.
PhylomeDBi Q62000.
TreeFami TF351924.

Enzyme and pathway databases

Reactomei REACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.

Miscellaneous databases

NextBioi 293748.
PROi Q62000.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62000.
Bgeei Q62000.
CleanExi MM_OGN.
Genevestigatori Q62000.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view ]
PANTHERi PTHR24371:SF5. PTHR24371:SF5. 1 hit.
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse osteoglycin-encoding gene."
    Ujita M., Shinomura T., Kimata K.
    Gene 158:237-240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Limb bud.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMIME_MOUSE
AccessioniPrimary (citable) accession number: Q62000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi