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Protein

Mimecan

Gene

Ogn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.By similarity

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.
REACT_268667. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_269577. Defective CHST6 causes MCDC1.

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene namesi
Name:Ogn
Synonyms:Og
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:109278. Ogn.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  4. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 298279MimecanPRO_0000032761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62000.
PaxDbiQ62000.
PRIDEiQ62000.

PTM databases

PhosphoSiteiQ62000.

Expressioni

Gene expression databases

BgeeiQ62000.
CleanExiMM_OGN.
ExpressionAtlasiQ62000. baseline and differential.
GenevestigatoriQ62000.

Interactioni

Protein-protein interaction databases

IntActiQ62000. 1 interaction.
MINTiMINT-4101955.

Structurei

3D structure databases

ProteinModelPortaliQ62000.
SMRiQ62000. Positions 92-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati112 – 13120LRR 1Add
BLAST
Repeati132 – 15524LRR 2Add
BLAST
Repeati156 – 17924LRR 3Add
BLAST
Repeati180 – 19920LRR 4Add
BLAST
Repeati200 – 22526LRR 5Add
BLAST
Repeati226 – 24621LRR 6Add
BLAST
Repeati247 – 27731LRR 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 10613Cys-richAdd
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG318805.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ62000.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
PhylomeDBiQ62000.
TreeFamiTF351924.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK
60 70 80 90 100
YLDGKSIKEK ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DMPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELTLAENQLL RLPVLPPKLT LLNAKHNKIK
210 220 230 240 250
SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH LQFNSISSLT
260 270 280 290
DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):34,012
Last modified:November 1, 1996 - v1
Checksum:i0C5DB4A5AB6B05FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSiCCDS26505.1.
PIRiJC4130.
RefSeqiNP_032786.1. NM_008760.4.
UniGeneiMm.4258.
Mm.470076.

Genome annotation databases

EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneIDi18295.
KEGGimmu:18295.
UCSCiuc007qjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSiCCDS26505.1.
PIRiJC4130.
RefSeqiNP_032786.1. NM_008760.4.
UniGeneiMm.4258.
Mm.470076.

3D structure databases

ProteinModelPortaliQ62000.
SMRiQ62000. Positions 92-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62000. 1 interaction.
MINTiMINT-4101955.

PTM databases

PhosphoSiteiQ62000.

Proteomic databases

MaxQBiQ62000.
PaxDbiQ62000.
PRIDEiQ62000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneIDi18295.
KEGGimmu:18295.
UCSCiuc007qjr.1. mouse.

Organism-specific databases

CTDi4969.
MGIiMGI:109278. Ogn.

Phylogenomic databases

eggNOGiNOG318805.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ62000.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
PhylomeDBiQ62000.
TreeFamiTF351924.

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.
REACT_268667. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).
REACT_269577. Defective CHST6 causes MCDC1.

Miscellaneous databases

NextBioi293748.
PROiQ62000.
SOURCEiSearch...

Gene expression databases

BgeeiQ62000.
CleanExiMM_OGN.
ExpressionAtlasiQ62000. baseline and differential.
GenevestigatoriQ62000.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse osteoglycin-encoding gene."
    Ujita M., Shinomura T., Kimata K.
    Gene 158:237-240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Limb bud.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMIME_MOUSE
AccessioniPrimary (citable) accession number: Q62000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.