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Q62000

- MIME_MOUSE

UniProt

Q62000 - MIME_MOUSE

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Protein

Mimecan

Gene

Ogn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.By similarity

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene namesi
Name:Ogn
Synonyms:Og
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:109278. Ogn.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 298279MimecanPRO_0000032761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62000.
PaxDbiQ62000.
PRIDEiQ62000.

PTM databases

PhosphoSiteiQ62000.

Expressioni

Gene expression databases

BgeeiQ62000.
CleanExiMM_OGN.
ExpressionAtlasiQ62000. baseline and differential.
GenevestigatoriQ62000.

Interactioni

Protein-protein interaction databases

IntActiQ62000. 1 interaction.
MINTiMINT-4101955.

Structurei

3D structure databases

ProteinModelPortaliQ62000.
SMRiQ62000. Positions 97-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati112 – 13120LRR 1Add
BLAST
Repeati132 – 15524LRR 2Add
BLAST
Repeati156 – 17924LRR 3Add
BLAST
Repeati180 – 19920LRR 4Add
BLAST
Repeati200 – 22526LRR 5Add
BLAST
Repeati226 – 24621LRR 6Add
BLAST
Repeati247 – 27731LRR 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 10613Cys-richAdd
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG318805.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ62000.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
PhylomeDBiQ62000.
TreeFamiTF351924.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24371:SF5. PTHR24371:SF5. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62000-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK
60 70 80 90 100
YLDGKSIKEK ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DMPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELTLAENQLL RLPVLPPKLT LLNAKHNKIK
210 220 230 240 250
SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH LQFNSISSLT
260 270 280 290
DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):34,012
Last modified:November 1, 1996 - v1
Checksum:i0C5DB4A5AB6B05FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSiCCDS26505.1.
PIRiJC4130.
RefSeqiNP_032786.1. NM_008760.4.
UniGeneiMm.4258.
Mm.470076.

Genome annotation databases

EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneIDi18295.
KEGGimmu:18295.
UCSCiuc007qjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31951 mRNA. Translation: BAA06721.1 .
BC021939 mRNA. Translation: AAH21939.1 .
CCDSi CCDS26505.1.
PIRi JC4130.
RefSeqi NP_032786.1. NM_008760.4.
UniGenei Mm.4258.
Mm.470076.

3D structure databases

ProteinModelPortali Q62000.
SMRi Q62000. Positions 97-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62000. 1 interaction.
MINTi MINT-4101955.

PTM databases

PhosphoSitei Q62000.

Proteomic databases

MaxQBi Q62000.
PaxDbi Q62000.
PRIDEi Q62000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021822 ; ENSMUSP00000021822 ; ENSMUSG00000021390 .
GeneIDi 18295.
KEGGi mmu:18295.
UCSCi uc007qjr.1. mouse.

Organism-specific databases

CTDi 4969.
MGIi MGI:109278. Ogn.

Phylogenomic databases

eggNOGi NOG318805.
GeneTreei ENSGT00730000110781.
HOGENOMi HOG000273909.
HOVERGENi HBG006850.
InParanoidi Q62000.
KOi K08126.
OMAi DTRYIRD.
OrthoDBi EOG75TMD0.
PhylomeDBi Q62000.
TreeFami TF351924.

Enzyme and pathway databases

Reactomei REACT_198578. Keratan sulfate biosynthesis.
REACT_198960. Keratan sulfate degradation.

Miscellaneous databases

NextBioi 293748.
PROi Q62000.
SOURCEi Search...

Gene expression databases

Bgeei Q62000.
CleanExi MM_OGN.
ExpressionAtlasi Q62000. baseline and differential.
Genevestigatori Q62000.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view ]
PANTHERi PTHR24371:SF5. PTHR24371:SF5. 1 hit.
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse osteoglycin-encoding gene."
    Ujita M., Shinomura T., Kimata K.
    Gene 158:237-240(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Limb bud.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMIME_MOUSE
AccessioniPrimary (citable) accession number: Q62000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3