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Q62000 (MIME_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene names
Name:Ogn
Synonyms:Og
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Contains 7 LRR (leucine-rich) repeats.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 298279Mimecan
PRO_0000032761

Regions

Repeat112 – 13120LRR 1
Repeat132 – 15524LRR 2
Repeat156 – 17924LRR 3
Repeat180 – 19920LRR 4
Repeat200 – 22526LRR 5
Repeat226 – 24621LRR 6
Repeat247 – 27731LRR 7
Compositional bias94 – 10613Cys-rich

Amino acid modifications

Glycosylation2581N-linked (GlcNAc...) Potential
Disulfide bond255 ↔ 288 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62000 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0C5DB4A5AB6B05FE

FASTA29834,012
        10         20         30         40         50         60 
METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK YLDGKSIKEK 

        70         80         90        100        110        120 
ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE 

       130        140        150        160        170        180 
SAYLYARFNK IKKLTAKDFA DMPNLRRLDF TGNLIEDIED GTFSKLSLLE ELTLAENQLL 

       190        200        210        220        230        240 
RLPVLPPKLT LLNAKHNKIK SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH 

       250        260        270        280        290 
LQFNSISSLT DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the mouse osteoglycin-encoding gene."
Ujita M., Shinomura T., Kimata K.
Gene 158:237-240(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Limb bud.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSCCDS26505.1.
PIRJC4130.
RefSeqNP_032786.1. NM_008760.4.
UniGeneMm.4258.
Mm.470076.

3D structure databases

ProteinModelPortalQ62000.
SMRQ62000. Positions 97-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ62000. 1 interaction.
MINTMINT-4101955.

PTM databases

PhosphoSiteQ62000.

Proteomic databases

MaxQBQ62000.
PaxDbQ62000.
PRIDEQ62000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneID18295.
KEGGmmu:18295.
UCSCuc007qjr.1. mouse.

Organism-specific databases

CTD4969.
MGIMGI:109278. Ogn.

Phylogenomic databases

eggNOGNOG318805.
GeneTreeENSGT00730000110781.
HOGENOMHOG000273909.
HOVERGENHBG006850.
InParanoidQ62000.
KOK08126.
OMADTRYIRD.
OrthoDBEOG75TMD0.
PhylomeDBQ62000.
TreeFamTF351924.

Gene expression databases

ArrayExpressQ62000.
BgeeQ62000.
CleanExMM_OGN.
GenevestigatorQ62000.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027211. Mimecan.
[Graphical view]
PANTHERPTHR24371:SF5. PTHR24371:SF5. 1 hit.
PfamPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio293748.
PROQ62000.
SOURCESearch...

Entry information

Entry nameMIME_MOUSE
AccessionPrimary (citable) accession number: Q62000
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot