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Protein

Mimecan

Gene

Ogn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene namesi
Name:Ogn
Synonyms:Og
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:109278. Ogn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003276120 – 298MimecanAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62000.
PaxDbiQ62000.
PeptideAtlasiQ62000.
PRIDEiQ62000.

PTM databases

iPTMnetiQ62000.
PhosphoSitePlusiQ62000.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021390.
CleanExiMM_OGN.
ExpressionAtlasiQ62000. baseline and differential.
GenevisibleiQ62000. MM.

Interactioni

Protein-protein interaction databases

IntActiQ62000. 1 interactor.
MINTiMINT-4101955.
STRINGi10090.ENSMUSP00000021822.

Structurei

3D structure databases

ProteinModelPortaliQ62000.
SMRiQ62000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati112 – 131LRR 1Add BLAST20
Repeati132 – 155LRR 2Add BLAST24
Repeati156 – 179LRR 3Add BLAST24
Repeati180 – 199LRR 4Add BLAST20
Repeati200 – 225LRR 5Add BLAST26
Repeati226 – 246LRR 6Add BLAST21
Repeati247 – 277LRR 7Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 106Cys-richAdd BLAST13

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ62000.
KOiK08126.
OMAiRMDEIRM.
OrthoDBiEOG091G0E49.
PhylomeDBiQ62000.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK
60 70 80 90 100
YLDGKSIKEK ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DMPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELTLAENQLL RLPVLPPKLT LLNAKHNKIK
210 220 230 240 250
SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH LQFNSISSLT
260 270 280 290
DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):34,012
Last modified:November 1, 1996 - v1
Checksum:i0C5DB4A5AB6B05FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSiCCDS26505.1.
PIRiJC4130.
RefSeqiNP_032786.1. NM_008760.4.
UniGeneiMm.4258.
Mm.470076.

Genome annotation databases

EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneIDi18295.
KEGGimmu:18295.
UCSCiuc007qjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31951 mRNA. Translation: BAA06721.1.
BC021939 mRNA. Translation: AAH21939.1.
CCDSiCCDS26505.1.
PIRiJC4130.
RefSeqiNP_032786.1. NM_008760.4.
UniGeneiMm.4258.
Mm.470076.

3D structure databases

ProteinModelPortaliQ62000.
SMRiQ62000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62000. 1 interactor.
MINTiMINT-4101955.
STRINGi10090.ENSMUSP00000021822.

PTM databases

iPTMnetiQ62000.
PhosphoSitePlusiQ62000.

Proteomic databases

MaxQBiQ62000.
PaxDbiQ62000.
PeptideAtlasiQ62000.
PRIDEiQ62000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
GeneIDi18295.
KEGGimmu:18295.
UCSCiuc007qjr.1. mouse.

Organism-specific databases

CTDi4969.
MGIiMGI:109278. Ogn.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ62000.
KOiK08126.
OMAiRMDEIRM.
OrthoDBiEOG091G0E49.
PhylomeDBiQ62000.
TreeFamiTF351924.

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.

Miscellaneous databases

PROiQ62000.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021390.
CleanExiMM_OGN.
ExpressionAtlasiQ62000. baseline and differential.
GenevisibleiQ62000. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIME_MOUSE
AccessioniPrimary (citable) accession number: Q62000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.