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Q61XX9

- RNC_CAEBR

UniProt

Q61XX9 - RNC_CAEBR

Protein

Ribonuclease 3

Gene

drsh-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.Sequence Analysis

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi851 – 8511Magnesium or manganeseBy similarity
    Sitei917 – 9171Important for activityBy similarity
    Metal bindingi921 – 9211Magnesium or manganeseBy similarity
    Metal bindingi924 – 9241Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. gonadal mesoderm development Source: UniProtKB-KW
    3. primary miRNA processing Source: UniProtKB
    4. RNA phosphodiester bond hydrolysis Source: GOC
    5. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    6. rRNA catabolic process Source: InterPro
    7. rRNA processing Source: UniProtKB-KW
    8. sexual reproduction Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Differentiation, Gonadal differentiation, Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3 (EC:3.1.26.3)
    Alternative name(s):
    Protein drosha
    Ribonuclease III
    Short name:
    RNase III
    Gene namesi
    Name:drsh-1By similarity
    ORF Names:CBG03798
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG03798; CBP21344; WBGene00026581; Cbr-drsh-1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10611061Ribonuclease 3PRO_0000309457Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG03798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61XX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini586 – 759174RNase III 1Sequence AnalysisAdd
    BLAST
    Domaini811 – 935125RNase III 2Sequence AnalysisAdd
    BLAST
    Domaini962 – 103776DRBMSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.Sequence Analysis
    Contains 2 RNase III domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0571.
    HOGENOMiHOG000154167.
    KOiK03685.
    OMAiEPILHNE.
    OrthoDBiEOG773XF7.

    Family and domain databases

    Gene3Di1.10.1520.10. 3 hits.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    PF00636. Ribonuclease_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 2 hits.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 3 hits.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 2 hits.
    PS50142. RNASE_3_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61XX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFTEIHKRS RRKKFQQIHQ DRKDEMIQQL GRRFHNQPST SATYPSAVED     50
    IPLPSEVPNV FGAPPPLTNA DFHRNFLVDP DVVVSHSASL IRSNRHIVKA 100
    EDAEQYMMVS RERVGTTAER VLEDFNSRVI KPLKAKRRLQ IDVPYIDHPL 150
    HSMRSKTPER KENEEDSDSE IRSSDSSSDA EYGSDVEEEP DSCRRKKRTH 200
    KIQKADSSQT KVEEKERQNT LLRMGIERKR NHPNAIDPHI SYNEKGLGND 250
    SPECRCPFPI RNRGLKHGYY AGENQVLKCS KNDRANLHYY TLHVTPAPNE 300
    SQIQKTQMLI NGMEYHFEGF TMVTHAPLPD CMTRRPVFKY SIDYEFQLIE 350
    EFMPTECFDP EDCNSIFEYI FHDIFELLDF DLYPKHLPPG TASCPTIHIV 400
    PRFVAMENNT TFIWSSKTVL AFFLLHGKNN MFSPEDVEKN CAMSDDAFGR 450
    TIAKLKQSIV LNPMKKPSAL RADWFSRDLE NKEMFLIQNT IRSQNFASPF 500
    LPQIAALEKK MSRLKQEKKD SGNKNPHYEN LKAELIVLKD KHREARQLKL 550
    KLPVKDYIDT GLKPDVVAHV AMAIIASHHI RYNFSLSVFE KVIEYKFNDR 600
    RIVELALIHS SFRSYYGTTP DHVKNMISNC GYRKKYGAEE RREKKKGIIS 650
    LFNIMGGETS GGEPILHNER LEYLGDAVVE LIASHHLFFI LNHHFEGGLA 700
    TYRTALVQNR NLAKLAMNCR IDEMLQFAHG ADLINEAEWK HALANAFEAL 750
    MAGVFLDSGI APCDAIFSKA MYGKDPEMKK VWDHLNEHEL KIEDPLGDRD 800
    LSRITPALTD FHRLEQIIGI EFNNIRLLAK AFTRRNVPFN DLTKGHNQRL 850
    EWLGDSVLQL IISDYLYRNF PLHHEGHMSL LRTSLVSNQT QSVVCDDLGF 900
    QEFVIKAPHR KNDLKMKDKA DLVEAFIGAL YVDKGLEYCR SFIRTVFCPR 950
    LKHFINSEKW NDAKSHLQQW CLAIRDSRNP NPAMPEYRLL GIQGPTNNRI 1000
    FRVAVYFRGE RLSSAAASNM HTAELKAAEN ALAALEKASF SRMREKYMSG 1050
    RQHRLHRIFF S 1061
    Length:1,061
    Mass (Da):122,481
    Last modified:November 23, 2004 - v1
    Checksum:i796401EAD0B5138E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600906 Genomic DNA. Translation: CAP24627.1.
    RefSeqiXP_002639240.1. XM_002639194.1.

    Genome annotation databases

    EnsemblMetazoaiCBG03798; CBG03798; CBG03798.
    GeneIDi8581234.
    KEGGicbr:CBG03798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600906 Genomic DNA. Translation: CAP24627.1 .
    RefSeqi XP_002639240.1. XM_002639194.1.

    3D structure databases

    ProteinModelPortali Q61XX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG03798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG03798 ; CBG03798 ; CBG03798 .
    GeneIDi 8581234.
    KEGGi cbr:CBG03798.

    Organism-specific databases

    CTDi 8581234.
    WormBasei CBG03798 ; CBP21344 ; WBGene00026581 ; Cbr-drsh-1.

    Phylogenomic databases

    eggNOGi COG0571.
    HOGENOMi HOG000154167.
    KOi K03685.
    OMAi EPILHNE.
    OrthoDBi EOG773XF7.

    Family and domain databases

    Gene3Di 1.10.1520.10. 3 hits.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    PF00636. Ribonuclease_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 3 hits.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 2 hits.
    PS50142. RNASE_3_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiRNC_CAEBR
    AccessioniPrimary (citable) accession number: Q61XX9
    Secondary accession number(s): A8WWR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3