Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61XX9

- RNC_CAEBR

UniProt

Q61XX9 - RNC_CAEBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonuclease 3

Gene

drsh-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.Sequence Analysis

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi851 – 8511Magnesium or manganeseBy similarity
Sitei917 – 9171Important for activityBy similarity
Metal bindingi921 – 9211Magnesium or manganeseBy similarity
Metal bindingi924 – 9241Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. gonadal mesoderm development Source: UniProtKB-KW
  3. primary miRNA processing Source: UniProtKB
  4. RNA phosphodiester bond hydrolysis Source: GOC
  5. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  6. rRNA catabolic process Source: InterPro
  7. rRNA processing Source: UniProtKB-KW
  8. sexual reproduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Differentiation, Gonadal differentiation, Ribosome biogenesis, rRNA processing

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Protein drosha
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:drsh-1By similarity
ORF Names:CBG03798
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG03798; CBP21344; WBGene00026581; Cbr-drsh-1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10611061Ribonuclease 3PRO_0000309457Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG03798.

Structurei

3D structure databases

ProteinModelPortaliQ61XX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini586 – 759174RNase III 1Sequence AnalysisAdd
BLAST
Domaini811 – 935125RNase III 2Sequence AnalysisAdd
BLAST
Domaini962 – 103776DRBMSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.Sequence Analysis
Contains 2 RNase III domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0571.
HOGENOMiHOG000154167.
InParanoidiQ61XX9.
KOiK03685.
OMAiEPILHNE.
OrthoDBiEOG773XF7.

Family and domain databases

Gene3Di1.10.1520.10. 3 hits.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 3 hits.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 2 hits.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61XX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFTEIHKRS RRKKFQQIHQ DRKDEMIQQL GRRFHNQPST SATYPSAVED
60 70 80 90 100
IPLPSEVPNV FGAPPPLTNA DFHRNFLVDP DVVVSHSASL IRSNRHIVKA
110 120 130 140 150
EDAEQYMMVS RERVGTTAER VLEDFNSRVI KPLKAKRRLQ IDVPYIDHPL
160 170 180 190 200
HSMRSKTPER KENEEDSDSE IRSSDSSSDA EYGSDVEEEP DSCRRKKRTH
210 220 230 240 250
KIQKADSSQT KVEEKERQNT LLRMGIERKR NHPNAIDPHI SYNEKGLGND
260 270 280 290 300
SPECRCPFPI RNRGLKHGYY AGENQVLKCS KNDRANLHYY TLHVTPAPNE
310 320 330 340 350
SQIQKTQMLI NGMEYHFEGF TMVTHAPLPD CMTRRPVFKY SIDYEFQLIE
360 370 380 390 400
EFMPTECFDP EDCNSIFEYI FHDIFELLDF DLYPKHLPPG TASCPTIHIV
410 420 430 440 450
PRFVAMENNT TFIWSSKTVL AFFLLHGKNN MFSPEDVEKN CAMSDDAFGR
460 470 480 490 500
TIAKLKQSIV LNPMKKPSAL RADWFSRDLE NKEMFLIQNT IRSQNFASPF
510 520 530 540 550
LPQIAALEKK MSRLKQEKKD SGNKNPHYEN LKAELIVLKD KHREARQLKL
560 570 580 590 600
KLPVKDYIDT GLKPDVVAHV AMAIIASHHI RYNFSLSVFE KVIEYKFNDR
610 620 630 640 650
RIVELALIHS SFRSYYGTTP DHVKNMISNC GYRKKYGAEE RREKKKGIIS
660 670 680 690 700
LFNIMGGETS GGEPILHNER LEYLGDAVVE LIASHHLFFI LNHHFEGGLA
710 720 730 740 750
TYRTALVQNR NLAKLAMNCR IDEMLQFAHG ADLINEAEWK HALANAFEAL
760 770 780 790 800
MAGVFLDSGI APCDAIFSKA MYGKDPEMKK VWDHLNEHEL KIEDPLGDRD
810 820 830 840 850
LSRITPALTD FHRLEQIIGI EFNNIRLLAK AFTRRNVPFN DLTKGHNQRL
860 870 880 890 900
EWLGDSVLQL IISDYLYRNF PLHHEGHMSL LRTSLVSNQT QSVVCDDLGF
910 920 930 940 950
QEFVIKAPHR KNDLKMKDKA DLVEAFIGAL YVDKGLEYCR SFIRTVFCPR
960 970 980 990 1000
LKHFINSEKW NDAKSHLQQW CLAIRDSRNP NPAMPEYRLL GIQGPTNNRI
1010 1020 1030 1040 1050
FRVAVYFRGE RLSSAAASNM HTAELKAAEN ALAALEKASF SRMREKYMSG
1060
RQHRLHRIFF S
Length:1,061
Mass (Da):122,481
Last modified:November 23, 2004 - v1
Checksum:i796401EAD0B5138E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600906 Genomic DNA. Translation: CAP24627.1.
RefSeqiXP_002639240.1. XM_002639194.1.

Genome annotation databases

EnsemblMetazoaiCBG03798; CBG03798; CBG03798.
GeneIDi8581234.
KEGGicbr:CBG03798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600906 Genomic DNA. Translation: CAP24627.1 .
RefSeqi XP_002639240.1. XM_002639194.1.

3D structure databases

ProteinModelPortali Q61XX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG03798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG03798 ; CBG03798 ; CBG03798 .
GeneIDi 8581234.
KEGGi cbr:CBG03798.

Organism-specific databases

CTDi 8581234.
WormBasei CBG03798 ; CBP21344 ; WBGene00026581 ; Cbr-drsh-1.

Phylogenomic databases

eggNOGi COG0571.
HOGENOMi HOG000154167.
InParanoidi Q61XX9.
KOi K03685.
OMAi EPILHNE.
OrthoDBi EOG773XF7.

Family and domain databases

Gene3Di 1.10.1520.10. 3 hits.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 3 hits.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 2 hits.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiRNC_CAEBR
AccessioniPrimary (citable) accession number: Q61XX9
Secondary accession number(s): A8WWR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3