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Q61XX9 (RNC_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Protein drosha
Ribonuclease III
Short name=RNase III
Gene names
Name:drsh-1
ORF Names:CBG03798
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1061 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA By similarity. UniProtKB O01326 UniProtKB Q9NRR4

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Nucleus By similarity UniProtKB Q9NRR4.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 2 RNase III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10611061Ribonuclease 3
PRO_0000309457

Regions

Domain586 – 759174RNase III 1
Domain811 – 935125RNase III 2
Domain962 – 103776DRBM

Sites

Metal binding8511Magnesium or manganese By similarity
Metal binding9211Magnesium or manganese By similarity
Metal binding9241Magnesium or manganese By similarity
Site9171Important for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61XX9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 796401EAD0B5138E

FASTA1,061122,481
        10         20         30         40         50         60 
MDFTEIHKRS RRKKFQQIHQ DRKDEMIQQL GRRFHNQPST SATYPSAVED IPLPSEVPNV 

        70         80         90        100        110        120 
FGAPPPLTNA DFHRNFLVDP DVVVSHSASL IRSNRHIVKA EDAEQYMMVS RERVGTTAER 

       130        140        150        160        170        180 
VLEDFNSRVI KPLKAKRRLQ IDVPYIDHPL HSMRSKTPER KENEEDSDSE IRSSDSSSDA 

       190        200        210        220        230        240 
EYGSDVEEEP DSCRRKKRTH KIQKADSSQT KVEEKERQNT LLRMGIERKR NHPNAIDPHI 

       250        260        270        280        290        300 
SYNEKGLGND SPECRCPFPI RNRGLKHGYY AGENQVLKCS KNDRANLHYY TLHVTPAPNE 

       310        320        330        340        350        360 
SQIQKTQMLI NGMEYHFEGF TMVTHAPLPD CMTRRPVFKY SIDYEFQLIE EFMPTECFDP 

       370        380        390        400        410        420 
EDCNSIFEYI FHDIFELLDF DLYPKHLPPG TASCPTIHIV PRFVAMENNT TFIWSSKTVL 

       430        440        450        460        470        480 
AFFLLHGKNN MFSPEDVEKN CAMSDDAFGR TIAKLKQSIV LNPMKKPSAL RADWFSRDLE 

       490        500        510        520        530        540 
NKEMFLIQNT IRSQNFASPF LPQIAALEKK MSRLKQEKKD SGNKNPHYEN LKAELIVLKD 

       550        560        570        580        590        600 
KHREARQLKL KLPVKDYIDT GLKPDVVAHV AMAIIASHHI RYNFSLSVFE KVIEYKFNDR 

       610        620        630        640        650        660 
RIVELALIHS SFRSYYGTTP DHVKNMISNC GYRKKYGAEE RREKKKGIIS LFNIMGGETS 

       670        680        690        700        710        720 
GGEPILHNER LEYLGDAVVE LIASHHLFFI LNHHFEGGLA TYRTALVQNR NLAKLAMNCR 

       730        740        750        760        770        780 
IDEMLQFAHG ADLINEAEWK HALANAFEAL MAGVFLDSGI APCDAIFSKA MYGKDPEMKK 

       790        800        810        820        830        840 
VWDHLNEHEL KIEDPLGDRD LSRITPALTD FHRLEQIIGI EFNNIRLLAK AFTRRNVPFN 

       850        860        870        880        890        900 
DLTKGHNQRL EWLGDSVLQL IISDYLYRNF PLHHEGHMSL LRTSLVSNQT QSVVCDDLGF 

       910        920        930        940        950        960 
QEFVIKAPHR KNDLKMKDKA DLVEAFIGAL YVDKGLEYCR SFIRTVFCPR LKHFINSEKW 

       970        980        990       1000       1010       1020 
NDAKSHLQQW CLAIRDSRNP NPAMPEYRLL GIQGPTNNRI FRVAVYFRGE RLSSAAASNM 

      1030       1040       1050       1060 
HTAELKAAEN ALAALEKASF SRMREKYMSG RQHRLHRIFF S 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600906 Genomic DNA. Translation: CAP24627.1.
RefSeqXP_002639240.1. XM_002639194.1.

3D structure databases

ProteinModelPortalQ61XX9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG03798.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG03798; CBG03798; CBG03798.
GeneID8581234.
KEGGcbr:CBG03798.

Organism-specific databases

CTD8581234.
WormBaseCBG03798; CBP21344; WBGene00026581; Cbr-drsh-1.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000154167.
KOK03685.
OMAEPILHNE.
OrthoDBEOG773XF7.

Family and domain databases

Gene3D1.10.1520.10. 3 hits.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMSSF69065. SSF69065. 3 hits.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 2 hits.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_CAEBR
AccessionPrimary (citable) accession number: Q61XX9
Secondary accession number(s): A8WWR6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families