Reviewed, UniProtKB/Swiss-Prot Q61XD3 (AIR2_CAEBR)

Names and origin

Protein names

Recommended name:
    Aurora/Ipl1-related protein kinase 2
    EC=2.7.11.1
Alternative name(s):
    Aurora-B

Gene names

Name:	air-2
ORF Names:	CBG04030

Organism

Caenorhabditis briggsae [Complete proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates tlk-1 and zen-4 By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with zen-4 and icp-1. Part of a complex containing at least air-2; icp-1; csc-1 and bir-1. Interacts with tlk-1 and bmk-1 By similarity.
Subcellular location	Note= Meiotic and mitotic chromosomes. During each division, relocates to the midbody microtubules By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition Meiosis Mitosis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chromatin regulator Developmental protein Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW meiosis Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Aurora/Ipl1-related protein kinase 2		PRO_0000268639
Regions
	Domain	27 – 277	251	Protein kinase
	Nucleotide binding	33 – 41	9	ATP By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	56	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q61XD3-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 46AFF54C88C21685	FASTA	302	34,465
	10 20 30 40 50 60 MENKPQILQT KSKNTPNKGG KLSINDFEIG RPLGKGKFGS VYLARTKTGH FHCAIKVLFK 70 80 90 100 110 120 SQLISGGVEH QLEREIEIQS HLQHPNIIRL YNYFWDAKKI YLILEYAPGG EMYKQLTTQK 130 140 150 160 170 180 RFTEAMAGKY MYEIADALSY CHRKNVIHRD IKPENLLIGA QGELKIGDFG WSVHAPSNKR 190 200 210 220 230 240 QTMCGTMDYL PPEMVNGNSH SDAVDLWAIG VLCYEFLVGK PPFEHENQAD TYSAIKAGRF 250 260 270 280 290 300 TYPDFVKKGA RDLIGKLLVV DPRRRCSLQE VKDHYWVTSM LDSCRRAAEK QKAERAASLR DH

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CAAC02000457 Genomic DNA. Translation: CAP24824.1.
3D structure databases
ModBase	Search...
Organism-specific databases
WormBase	WBGene00026778. CBG04030.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AIR2_CAEBR

Accession

Primary (citable) accession number: Q61XD3
Secondary accession number(s): A8WW15

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 23, 2004
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project