Q61S97 (GMPPB_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase beta
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta

Gene names

Name:	tag-335
ORF Names:	CBG06266

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Mannose-1-phosphate guanyltransferase beta		PRO_0000307169

Sequences

	Sequence		Length	Mass (Da)
	Q61S97 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: E0A3A4DE5C38321A	FASTA	364	39,800
	10 20 30 40 50 60 MKALILVGGY GTRLRPLTLT QPKPLVEFAN KPMMLHQMEA LAAVGVDTVV LAVSYRAEQL 70 80 90 100 110 120 EAEMTVHADR LGVKLIFSLE EEPLGTAGPL ALARKHLEDD DPFFVLNSDV ICDFPFKQMV 130 140 150 160 170 180 EFHKQHGKEG TIAVTKVEEP SKYGVVVFKE DGKIDDFVEK PQEYVGNKIN AGLYIFNSAI 190 200 210 220 230 240 LDRIPLKPTS IEKEIFPQMA TSGNLYAYVL PGFWMDVGQP KDFLKGMSLF LNHVQTTRTG 250 260 270 280 290 300 ALATGSNIHG TATIRGSVLV DPSATVGENC VIGPDVVIGP RVQIEGGVRI QHSTILSDST 310 320 330 340 350 360 VGNYSWVSGS IIGRECHIGS WVRMENVCVL GDDVVVKDEV YLNEASVLPH KVIAVNVPSK DIIM

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000470 Genomic DNA. Translation: CAP26139.2.
3D structure databases
HSSP	HSSP built from PDB template 1WVC based on UniProtKB P26396.
ProteinModelPortal	Q61S97.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61S97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
WormBase	CBG06266; CBP34494; WBGene00028569.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00132. Hexapep. 2 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPB_CAEBR

Accession

Primary (citable) accession number: Q61S97
Secondary accession number(s): A8X0H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	September 21, 2011
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project