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Q61KR9 (CALR_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calreticulin
Gene names
Name:crt-1
ORF Names:CBG09253
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Domain

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.

The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.

The zinc binding sites are localized to the N-domain By similarity.

Sequence similarities

Belongs to the calreticulin family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Lectin
Metal-binding
Zinc
   Molecular functionChaperone
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 396381Calreticulin
PRO_0000246154

Regions

Repeat186 – 197121-1
Repeat205 – 216121-2
Repeat222 – 233121-3
Repeat239 – 250121-4
Repeat254 – 264112-1
Repeat268 – 278112-2
Repeat282 – 292112-3
Region186 – 250654 X approximate repeats
Region? – 192N-domain
Region193 – 301109P-domain
Region254 – 292393 X approximate repeats
Region302 – 39695C-domain
Motif393 – 3964Prevents secretion from ER By similarity
Compositional bias332 – 39160Asp/Glu/Lys-rich

Sites

Binding site1051Carbohydrate By similarity
Binding site1071Carbohydrate By similarity
Binding site1241Carbohydrate By similarity
Binding site1311Carbohydrate By similarity
Binding site3121Carbohydrate By similarity

Amino acid modifications

Disulfide bond101 ↔ 133 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61KR9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: CE7E53118485EFF7

FASTA39645,809
        10         20         30         40         50         60 
MKSLCLLAIV AVVSAEVYFK EEFNDASWEK RWVQSKHKDD FGAFKLSAGK FFDVESRDQG 

        70         80         90        100        110        120 
IQTSQDAKFY SRAAKFDKEF SNKGKTLVIQ YTVKHEQGID CGGGYVKVMR GDADLADFHG 

       130        140        150        160        170        180 
ETPYNVMFGP DICGPTRRVH VILNYKGENK LIKKEITCKS DELTHLYTLI LNADNTYEVK 

       190        200        210        220        230        240 
IDGESAQTGS LEEDWDLLPA KKIKDPDAKK PEDWDEREYI DDAEDVKPED WEKPEHIPDP 

       250        260        270        280        290        300 
DAKKPEDWDD EMDGEWEPPM IDNPEYKGEW KPKQIKNPAY KGKWIHPEIE NPEYTPDDEL 

       310        320        330        340        350        360 
YLYENWGAIG FDLWQVKSGT IFDNVLITDS VEEAEAHAAE TFDKLKTVEK EKKEKADEEA 

       370        380        390 
RKVEEEARKK AEEEKEAKKD DDEEEEKEEE EGHDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600954 Genomic DNA. Translation: CAP29301.1.
RefSeqXP_002636809.1. XM_002636763.1.

3D structure databases

ProteinModelPortalQ61KR9.
SMRQ61KR9. Positions 200-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG09253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG09253; CBG09253; CBG09253.
GeneID8578804.
KEGGcbr:CBG09253.

Organism-specific databases

CTD8578804.
WormBaseCBG09253; CBP02265; WBGene00030869; Cbr-crt-1.

Phylogenomic databases

eggNOGNOG305105.
HOGENOMHOG000192435.
KOK08057.
OMAVKLFPDG.
OrthoDBEOG77126Z.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERPTHR11073. PTHR11073. 1 hit.
PfamPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFPIRSF002356. Calreticulin. 1 hit.
PRINTSPR00626. CALRETICULIN.
SUPFAMSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCALR_CAEBR
AccessionPrimary (citable) accession number: Q61KR9
Secondary accession number(s): A8X9I9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 23, 2004
Last modified: November 13, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families