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Q61KR9

- CALR_CAEBR

UniProt

Q61KR9 - CALR_CAEBR

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Protein

Calreticulin

Gene

crt-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051CarbohydrateBy similarity
Binding sitei107 – 1071CarbohydrateBy similarity
Binding sitei124 – 1241CarbohydrateBy similarity
Binding sitei131 – 1311CarbohydrateBy similarity
Binding sitei312 – 3121CarbohydrateBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
Gene namesi
Name:crt-1
ORF Names:CBG09253
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG09253; CBP02265; WBGene00030869; Cbr-crt-1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 396381CalreticulinPRO_0000246154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi101 ↔ 133By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG09253.

Structurei

3D structure databases

ProteinModelPortaliQ61KR9.
SMRiQ61KR9. Positions 200-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati186 – 197121-1Add
BLAST
Repeati205 – 216121-2Add
BLAST
Repeati222 – 233121-3Add
BLAST
Repeati239 – 250121-4Add
BLAST
Repeati254 – 264112-1Add
BLAST
Repeati268 – 278112-2Add
BLAST
Repeati282 – 292112-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni? – 192N-domain
Regioni186 – 250654 X approximate repeatsAdd
BLAST
Regioni193 – 301109P-domainAdd
BLAST
Regioni254 – 292393 X approximate repeatsAdd
BLAST
Regioni302 – 39695C-domainAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi393 – 3964Prevents secretion from ERPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi332 – 39160Asp/Glu/Lys-richAdd
BLAST

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).By similarity
The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
The zinc binding sites are localized to the N-domain.By similarity

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG305105.
HOGENOMiHOG000192435.
InParanoidiQ61KR9.
KOiK08057.
OMAiVKLFPDG.
OrthoDBiEOG77126Z.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61KR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLCLLAIV AVVSAEVYFK EEFNDASWEK RWVQSKHKDD FGAFKLSAGK
60 70 80 90 100
FFDVESRDQG IQTSQDAKFY SRAAKFDKEF SNKGKTLVIQ YTVKHEQGID
110 120 130 140 150
CGGGYVKVMR GDADLADFHG ETPYNVMFGP DICGPTRRVH VILNYKGENK
160 170 180 190 200
LIKKEITCKS DELTHLYTLI LNADNTYEVK IDGESAQTGS LEEDWDLLPA
210 220 230 240 250
KKIKDPDAKK PEDWDEREYI DDAEDVKPED WEKPEHIPDP DAKKPEDWDD
260 270 280 290 300
EMDGEWEPPM IDNPEYKGEW KPKQIKNPAY KGKWIHPEIE NPEYTPDDEL
310 320 330 340 350
YLYENWGAIG FDLWQVKSGT IFDNVLITDS VEEAEAHAAE TFDKLKTVEK
360 370 380 390
EKKEKADEEA RKVEEEARKK AEEEKEAKKD DDEEEEKEEE EGHDEL
Length:396
Mass (Da):45,809
Last modified:November 23, 2004 - v1
Checksum:iCE7E53118485EFF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600954 Genomic DNA. Translation: CAP29301.1.
RefSeqiXP_002636809.1. XM_002636763.1.

Genome annotation databases

EnsemblMetazoaiCBG09253; CBG09253; CBG09253.
GeneIDi8578804.
KEGGicbr:CBG09253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600954 Genomic DNA. Translation: CAP29301.1 .
RefSeqi XP_002636809.1. XM_002636763.1.

3D structure databases

ProteinModelPortali Q61KR9.
SMRi Q61KR9. Positions 200-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG09253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG09253 ; CBG09253 ; CBG09253 .
GeneIDi 8578804.
KEGGi cbr:CBG09253.

Organism-specific databases

CTDi 8578804.
WormBasei CBG09253 ; CBP02265 ; WBGene00030869 ; Cbr-crt-1.

Phylogenomic databases

eggNOGi NOG305105.
HOGENOMi HOG000192435.
InParanoidi Q61KR9.
KOi K08057.
OMAi VKLFPDG.
OrthoDBi EOG77126Z.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002356. Calreticulin. 1 hit.
PRINTSi PR00626. CALRETICULIN.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCALR_CAEBR
AccessioniPrimary (citable) accession number: Q61KR9
Secondary accession number(s): A8X9I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3