Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61KR9

- CALR_CAEBR

UniProt

Q61KR9 - CALR_CAEBR

Protein

Calreticulin

Gene

crt-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei105 – 1051CarbohydrateBy similarity
    Binding sitei107 – 1071CarbohydrateBy similarity
    Binding sitei124 – 1241CarbohydrateBy similarity
    Binding sitei131 – 1311CarbohydrateBy similarity
    Binding sitei312 – 3121CarbohydrateBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calreticulin
    Gene namesi
    Name:crt-1
    ORF Names:CBG09253
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG09253; CBP02265; WBGene00030869; Cbr-crt-1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 396381CalreticulinPRO_0000246154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi101 ↔ 133By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG09253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61KR9.
    SMRiQ61KR9. Positions 200-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati186 – 197121-1Add
    BLAST
    Repeati205 – 216121-2Add
    BLAST
    Repeati222 – 233121-3Add
    BLAST
    Repeati239 – 250121-4Add
    BLAST
    Repeati254 – 264112-1Add
    BLAST
    Repeati268 – 278112-2Add
    BLAST
    Repeati282 – 292112-3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni? – 192N-domain
    Regioni186 – 250654 X approximate repeatsAdd
    BLAST
    Regioni193 – 301109P-domainAdd
    BLAST
    Regioni254 – 292393 X approximate repeatsAdd
    BLAST
    Regioni302 – 39695C-domainAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi393 – 3964Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi332 – 39160Asp/Glu/Lys-richAdd
    BLAST

    Domaini

    Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.By similarity
    The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
    The zinc binding sites are localized to the N-domain.By similarity

    Sequence similaritiesi

    Belongs to the calreticulin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG305105.
    HOGENOMiHOG000192435.
    KOiK08057.
    OMAiVKLFPDG.
    OrthoDBiEOG77126Z.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009169. Calreticulin.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view]
    PANTHERiPTHR11073. PTHR11073. 1 hit.
    PfamiPF00262. Calreticulin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002356. Calreticulin. 1 hit.
    PRINTSiPR00626. CALRETICULIN.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF63887. SSF63887. 1 hit.
    PROSITEiPS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 3 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61KR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLCLLAIV AVVSAEVYFK EEFNDASWEK RWVQSKHKDD FGAFKLSAGK    50
    FFDVESRDQG IQTSQDAKFY SRAAKFDKEF SNKGKTLVIQ YTVKHEQGID 100
    CGGGYVKVMR GDADLADFHG ETPYNVMFGP DICGPTRRVH VILNYKGENK 150
    LIKKEITCKS DELTHLYTLI LNADNTYEVK IDGESAQTGS LEEDWDLLPA 200
    KKIKDPDAKK PEDWDEREYI DDAEDVKPED WEKPEHIPDP DAKKPEDWDD 250
    EMDGEWEPPM IDNPEYKGEW KPKQIKNPAY KGKWIHPEIE NPEYTPDDEL 300
    YLYENWGAIG FDLWQVKSGT IFDNVLITDS VEEAEAHAAE TFDKLKTVEK 350
    EKKEKADEEA RKVEEEARKK AEEEKEAKKD DDEEEEKEEE EGHDEL 396
    Length:396
    Mass (Da):45,809
    Last modified:November 23, 2004 - v1
    Checksum:iCE7E53118485EFF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600954 Genomic DNA. Translation: CAP29301.1.
    RefSeqiXP_002636809.1. XM_002636763.1.

    Genome annotation databases

    EnsemblMetazoaiCBG09253; CBG09253; CBG09253.
    GeneIDi8578804.
    KEGGicbr:CBG09253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600954 Genomic DNA. Translation: CAP29301.1 .
    RefSeqi XP_002636809.1. XM_002636763.1.

    3D structure databases

    ProteinModelPortali Q61KR9.
    SMRi Q61KR9. Positions 200-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG09253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG09253 ; CBG09253 ; CBG09253 .
    GeneIDi 8578804.
    KEGGi cbr:CBG09253.

    Organism-specific databases

    CTDi 8578804.
    WormBasei CBG09253 ; CBP02265 ; WBGene00030869 ; Cbr-crt-1.

    Phylogenomic databases

    eggNOGi NOG305105.
    HOGENOMi HOG000192435.
    KOi K08057.
    OMAi VKLFPDG.
    OrthoDBi EOG77126Z.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009169. Calreticulin.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view ]
    PANTHERi PTHR11073. PTHR11073. 1 hit.
    Pfami PF00262. Calreticulin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002356. Calreticulin. 1 hit.
    PRINTSi PR00626. CALRETICULIN.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF63887. SSF63887. 1 hit.
    PROSITEi PS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 3 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiCALR_CAEBR
    AccessioniPrimary (citable) accession number: Q61KR9
    Secondary accession number(s): A8X9I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3