Serine/threonine-protein phosphatase PP1-alpha

Preferred order of sections

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP1-alpha
EC=3.1.3.16

Alternative name(s):
Glc seven-like phosphatase 1

Gene names

Name:	gsp-1
ORF Names:	CBG09676

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation By similarity.
Catalytic activity	A phosphoprotein + H₂O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-1 subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Meiosis Mitosis
Ligand	Iron Manganese Metal-binding
Molecular function	Chromatin regulator Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW meiosis Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 329

329

Serine/threonine-protein phosphatase PP1-alpha

PRO_0000268636

Sites

Active site

125

1

Proton donor By similarity

Metal binding

64

1

Iron By similarity

Metal binding

66

1

Iron By similarity

Metal binding

92

1

Iron By similarity

Metal binding

92

1

Manganese By similarity

Metal binding

124

1

Manganese By similarity

Metal binding

173

1

Manganese By similarity

Metal binding

248

1

Manganese By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q61JR3 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 500145324CA16D1B
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FASTA

329

37,205

        10         20         30         40         50         60 
MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP ILLELEAPLK 

        70         80         90        100        110        120 
ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS LETICLLLAY KVKYPENFFL 

       130        140        150        160        170        180 
LRGNHECASI NRIYGFYDEC KRRFSIKLWK TFTDCFNCLP IAALIDEKIF CCHGGLSPDL 

       190        200        210        220        230        240 
QNMEQIRRVM RPTDVPDTGL LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD 

       250        260        270        280        290        300 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE 

       310        320 
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK

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References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics."
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W.

Waterston R.H.
PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE600998 Genomic DNA. Translation: CAP28943.1.
RefSeq	XP_002637166.1. XM_002637120.1.
3D structure databases
HSSP	HSSP built from PDB template 1S70 based on UniProtKB P62140.
ProteinModelPortal	Q61JR3.
SMR	Q61JR3. Positions 4-309.
ModBase	Search...
Proteomic databases
PRIDE	Q61JR3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG09676; CBG09676; CBG09676.
GeneID	8579162.
KEGG	cbr:CBG09676.
Organism-specific databases
CTD	8579162.
WormBase	CBG09676; CBP02415; WBGene00031226; Cbr-gsp-1.
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000172697.
KO	K06269.
OMA	PDLQGME.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLC7A_CAEBR

Accession

Primary (citable) accession number: Q61JR3
Secondary accession number(s): A8X8I2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 23, 2004
Last modified:	November 28, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents