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Q61JR3

- GLC7A_CAEBR

UniProt

Q61JR3 - GLC7A_CAEBR

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Protein

Serine/threonine-protein phosphatase PP1-alpha

Gene

gsp-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi66 – 661Manganese 1By similarity
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Active sitei125 – 1251Proton donorBy similarity
Metal bindingi173 – 1731Manganese 2By similarity
Metal bindingi248 – 2481Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. meiotic nuclear division Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Meiosis, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-alpha (EC:3.1.3.16)
Alternative name(s):
Glc seven-like phosphatase 1
Gene namesi
Name:gsp-1
ORF Names:CBG09676
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG09676; CBP02415; WBGene00031226; Cbr-gsp-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Serine/threonine-protein phosphatase PP1-alphaPRO_0000268636Add
BLAST

Proteomic databases

PRIDEiQ61JR3.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG09676.

Structurei

3D structure databases

ProteinModelPortaliQ61JR3.
SMRiQ61JR3. Positions 4-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
InParanoidiQ61JR3.
KOiK06269.
OMAiPDLQGME.
OrthoDBiEOG7TJ3K3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61JR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KVKYPENFFL LRGNHECASI NRIYGFYDEC KRRFSIKLWK
160 170 180 190 200
TFTDCFNCLP IAALIDEKIF CCHGGLSPDL QNMEQIRRVM RPTDVPDTGL
210 220 230 240 250
LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE
310 320
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK
Length:329
Mass (Da):37,205
Last modified:November 23, 2004 - v1
Checksum:i500145324CA16D1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600998 Genomic DNA. Translation: CAP28943.1.
RefSeqiXP_002637166.1. XM_002637120.1.

Genome annotation databases

EnsemblMetazoaiCBG09676; CBG09676; CBG09676.
GeneIDi8579162.
KEGGicbr:CBG09676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600998 Genomic DNA. Translation: CAP28943.1 .
RefSeqi XP_002637166.1. XM_002637120.1.

3D structure databases

ProteinModelPortali Q61JR3.
SMRi Q61JR3. Positions 4-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG09676.

Proteomic databases

PRIDEi Q61JR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG09676 ; CBG09676 ; CBG09676 .
GeneIDi 8579162.
KEGGi cbr:CBG09676.

Organism-specific databases

CTDi 8579162.
WormBasei CBG09676 ; CBP02415 ; WBGene00031226 ; Cbr-gsp-1.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172697.
InParanoidi Q61JR3.
KOi K06269.
OMAi PDLQGME.
OrthoDBi EOG7TJ3K3.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiGLC7A_CAEBR
AccessioniPrimary (citable) accession number: Q61JR3
Secondary accession number(s): A8X8I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3