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Q61JR3 (GLC7A_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1-alpha

EC=3.1.3.16
Alternative name(s):
Glc seven-like phosphatase 1
Gene names
Name:gsp-1
ORF Names:CBG09676
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Serine/threonine-protein phosphatase PP1-alpha
PRO_0000268636

Sites

Active site1251Proton donor By similarity
Metal binding641Manganese 1 By similarity
Metal binding661Manganese 1 By similarity
Metal binding921Manganese 1 By similarity
Metal binding921Manganese 2 By similarity
Metal binding1241Manganese 2 By similarity
Metal binding1731Manganese 2 By similarity
Metal binding2481Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61JR3 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 500145324CA16D1B

FASTA32937,205
        10         20         30         40         50         60 
MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP ILLELEAPLK 

        70         80         90        100        110        120 
ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS LETICLLLAY KVKYPENFFL 

       130        140        150        160        170        180 
LRGNHECASI NRIYGFYDEC KRRFSIKLWK TFTDCFNCLP IAALIDEKIF CCHGGLSPDL 

       190        200        210        220        230        240 
QNMEQIRRVM RPTDVPDTGL LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD 

       250        260        270        280        290        300 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE 

       310        320 
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600998 Genomic DNA. Translation: CAP28943.1.
RefSeqXP_002637166.1. XM_002637120.1.

3D structure databases

ProteinModelPortalQ61JR3.
SMRQ61JR3. Positions 4-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG09676.

Proteomic databases

PRIDEQ61JR3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG09676; CBG09676; CBG09676.
GeneID8579162.
KEGGcbr:CBG09676.

Organism-specific databases

CTD8579162.
WormBaseCBG09676; CBP02415; WBGene00031226; Cbr-gsp-1.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172697.
KOK06269.
OMAPDLQGME.
OrthoDBEOG7TJ3K3.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLC7A_CAEBR
AccessionPrimary (citable) accession number: Q61JR3
Secondary accession number(s): A8X8I2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families