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Q61JF9

- CISY_CAEBR

UniProt

Q61JF9 - CISY_CAEBR

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Protein
Probable citrate synthase, mitochondrial
Gene
cts-1, CBG09810
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031 By similarity
Active sitei349 – 3491 By similarity
Active sitei404 – 4041 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cts-1
ORF Names:CBG09810
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG09810; CBP02471; WBGene00031330; Cbr-cts-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 468Probable citrate synthase, mitochondrialPRO_0000291600
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi6238.CBG09810.

Structurei

3D structure databases

ProteinModelPortaliQ61JF9.
SMRiQ61JF9. Positions 32-462.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000130831.
KOiK01647.
OMAiELIYEDC.
OrthoDBiEOG73BVCB.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61JF9-1 [UniParc]FASTAAdd to Basket

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MPITGTVLRR FITKGVIPMC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV    50
KSFRAEHGNT VVQSVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI 100
PECQKLLPKA KGGEEPLPEA IWWLLCTGDV PSEAQTAAIT KEWNARADLP 150
THVVRMLDNF PDNLHPMAQF IAAIAALNNE SKFAGAYARG VAKASYWEYA 200
YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA NFSSMLGYDD 250
PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLA FSAAMAGLAG 300
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA 350
VLRKTDPRYE CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW 400
PNVDSHSGVL LQYFGMTEMS FYTVLFGVSR ALGCLSQLIW ARGMGLPLER 450
PKSHSTEGLI KLAMAAKK 468
Length:468
Mass (Da):51,615
Last modified:November 23, 2004 - v1
Checksum:i9BF4AEAFBB4D1DDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601459 Genomic DNA. Translation: CAP29361.1.
RefSeqiXP_002641515.1. XM_002641469.1.

Genome annotation databases

EnsemblMetazoaiCBG09810; CBG09810; CBG09810.
GeneIDi8583506.
KEGGicbr:CBG09810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601459 Genomic DNA. Translation: CAP29361.1 .
RefSeqi XP_002641515.1. XM_002641469.1.

3D structure databases

ProteinModelPortali Q61JF9.
SMRi Q61JF9. Positions 32-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG09810.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG09810 ; CBG09810 ; CBG09810 .
GeneIDi 8583506.
KEGGi cbr:CBG09810.

Organism-specific databases

CTDi 8583506.
WormBasei CBG09810 ; CBP02471 ; WBGene00031330 ; Cbr-cts-1.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000130831.
KOi K01647.
OMAi ELIYEDC.
OrthoDBi EOG73BVCB.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCISY_CAEBR
AccessioniPrimary (citable) accession number: Q61JF9
Secondary accession number(s): A8X9P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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