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Q61JF9

- CISY_CAEBR

UniProt

Q61JF9 - CISY_CAEBR

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Protein

Probable citrate synthase, mitochondrial

Gene

cts-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cts-1
ORF Names:CBG09810
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG09810; CBP02471; WBGene00031330; Cbr-cts-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 468Probable citrate synthase, mitochondrialPRO_0000291600
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6238.CBG09810.

Structurei

3D structure databases

ProteinModelPortaliQ61JF9.
SMRiQ61JF9. Positions 32-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000130831.
InParanoidiQ61JF9.
KOiK01647.
OMAiELIYEDC.
OrthoDBiEOG73BVCB.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61JF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPITGTVLRR FITKGVIPMC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV
60 70 80 90 100
KSFRAEHGNT VVQSVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA KGGEEPLPEA IWWLLCTGDV PSEAQTAAIT KEWNARADLP
160 170 180 190 200
THVVRMLDNF PDNLHPMAQF IAAIAALNNE SKFAGAYARG VAKASYWEYA
210 220 230 240 250
YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA NFSSMLGYDD
260 270 280 290 300
PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLA FSAAMAGLAG
310 320 330 340 350
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYE CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW
410 420 430 440 450
PNVDSHSGVL LQYFGMTEMS FYTVLFGVSR ALGCLSQLIW ARGMGLPLER
460
PKSHSTEGLI KLAMAAKK
Length:468
Mass (Da):51,615
Last modified:November 23, 2004 - v1
Checksum:i9BF4AEAFBB4D1DDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29361.1.
RefSeqiXP_002641515.1. XM_002641469.1.

Genome annotation databases

EnsemblMetazoaiCBG09810; CBG09810; CBG09810.
GeneIDi8583506.
KEGGicbr:CBG09810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29361.1 .
RefSeqi XP_002641515.1. XM_002641469.1.

3D structure databases

ProteinModelPortali Q61JF9.
SMRi Q61JF9. Positions 32-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG09810.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG09810 ; CBG09810 ; CBG09810 .
GeneIDi 8583506.
KEGGi cbr:CBG09810.

Organism-specific databases

CTDi 8583506.
WormBasei CBG09810 ; CBP02471 ; WBGene00031330 ; Cbr-cts-1.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000130831.
InParanoidi Q61JF9.
KOi K01647.
OMAi ELIYEDC.
OrthoDBi EOG73BVCB.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCISY_CAEBR
AccessioniPrimary (citable) accession number: Q61JF9
Secondary accession number(s): A8X9P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3