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Q61JF9 (CISY_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable citrate synthase, mitochondrial

EC=2.3.3.16
Gene names
Name:cts-1
ORF Names:CBG09810
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 468Probable citrate synthase, mitochondrialPRO_0000291600

Sites

Active site3031 By similarity
Active site3491 By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61JF9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 9BF4AEAFBB4D1DDE

FASTA46851,615
        10         20         30         40         50         60 
MPITGTVLRR FITKGVIPMC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV KSFRAEHGNT 

        70         80         90        100        110        120 
VVQSVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI PECQKLLPKA KGGEEPLPEA 

       130        140        150        160        170        180 
IWWLLCTGDV PSEAQTAAIT KEWNARADLP THVVRMLDNF PDNLHPMAQF IAAIAALNNE 

       190        200        210        220        230        240 
SKFAGAYARG VAKASYWEYA YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA 

       250        260        270        280        290        300 
NFSSMLGYDD PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLA FSAAMAGLAG 

       310        320        330        340        350        360 
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA VLRKTDPRYE 

       370        380        390        400        410        420 
CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW PNVDSHSGVL LQYFGMTEMS 

       430        440        450        460 
FYTVLFGVSR ALGCLSQLIW ARGMGLPLER PKSHSTEGLI KLAMAAKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601459 Genomic DNA. Translation: CAP29361.1.
RefSeqXP_002641515.1. XM_002641469.1.

3D structure databases

ProteinModelPortalQ61JF9.
SMRQ61JF9. Positions 32-462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG09810.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG09810; CBG09810; CBG09810.
GeneID8583506.
KEGGcbr:CBG09810.

Organism-specific databases

CTD8583506.
WormBaseCBG09810; CBP02471; WBGene00031330; Cbr-cts-1.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000130831.
KOK01647.
OMAELIYEDC.
OrthoDBEOG73BVCB.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_CAEBR
AccessionPrimary (citable) accession number: Q61JF9
Secondary accession number(s): A8X9P6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways