Q61CA3 (PGAM5_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial
EC=3.1.3.16

Alternative name(s):
Phosphoglycerate mutase family member 5 homolog

Gene names

Name:	pgam-5
ORF Names:	CBG13006

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Mitochondrion By similarity. Mitochondrion outer membrane By similarity. Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Serine/threonine-protein phosphatase Pgam5, mitochondrial		PRO_0000288788
Regions
	Transmembrane	7 – 23	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q61CA3 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 13294946775B4DB6	FASTA	283	32,352
	10 20 30 40 50 60 MVSKILMYGL PSAAVAVGTA LLNEDNRNTI FRKAFAFTQN HTPKSFDEHF PRGEWDKNWD 70 80 90 100 110 120 FRDPTSLVDK SKWEKADEVG KKKLLEECKA TASRNIFLIR HGQYHLDREQ KHLTELGREQ 130 140 150 160 170 180 AELLGKRLAN SDIKFTNMTM STMTRATETA NIILKHLPGD LPKSSSSLIE EGPPYPPVPD 190 200 210 220 230 240 HKTWRPLDPE FYTEAARIES AFRKLIHRAP PSQKEDSYEL IVCHANVIRY FICRALQFPP 250 260 270 280 EGWLRMSLGN CSITWLVIRP KGHVSIRSVG DIGHLTPNKI SFT

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE600938 Genomic DNA. Translation: CAP31880.1.
3D structure databases
ProteinModelPortal	Q61CA3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG13006; CBG13006; CBG13006.
Organism-specific databases
WormBase	CBG13006; CBP36220; WBGene00033850; Cbr-pgam-5.
Phylogenomic databases
eggNOG	NOG71348.
HOGENOM	HOG000261217.
Family and domain databases
InterPro	IPR013078. His_Pase_superF_clade-1. [Graphical view]
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGAM5_CAEBR

Accession

Primary (citable) accession number: Q61CA3
Secondary accession number(s): A8XGV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	September 22, 2009
Last modified:	October 3, 2012
This is version 32 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project