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Protein

CTD nuclear envelope phosphatase 1 homolog

Gene

cnep-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. nuclear envelope organization Source: UniProtKB
  2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  3. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1 homolog (EC:3.1.3.16)
Short name:
CTDNEP1
Alternative name(s):
Serine/threonine-protein phosphatase dullard homolog
Small C-terminal domain phosphatase-like phosphatase 2
Gene namesi
Name:cnep-1
Synonyms:scpl-2
ORF Names:CBG13136
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componentsi: Chromosome II, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG13136; CBP03219; WBGene00033948; Cbr-cnep-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. Nem1-Spo7 phosphatase complex Source: UniProtKB
  5. nuclear envelope Source: UniProtKB
  6. nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246CTD nuclear envelope phosphatase 1 homologPRO_0000297974Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG13136.

Structurei

3D structure databases

ProteinModelPortaliQ61C05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 220168FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dullard family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
InParanoidiQ61C05.
KOiK17617.
OMAiRYFRQHC.
OrthoDBiEOG7MKW6W.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61C05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFAQTVFY VLAGLFNVFL LYFRKTNRAY CKYQVVKYHS NIPMSPLTTH
60 70 80 90 100
RLLTVKRKIL VLDLDETLIH SHHDGVLRQT VKPGTPSDFT IRVVIDRHPV
110 120 130 140 150
KFSVHERPHV DYFLTVVSQW YELVVFTASM EVYGSSVADK LDRGRGILKR
160 170 180 190 200
RYFRQHCTME VGGYTKDLSA IHPDLSSICI LDNSPGAYRK FPHNAIPIPS
210 220 230 240
WFSDPNDTCL LNLLPFLDAL RFTSDVRSVL SRNMQVLPET QTVQYY
Length:246
Mass (Da):28,419
Last modified:November 23, 2004 - v1
Checksum:i793ED6CE6513D471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601401 Genomic DNA. Translation: CAP31978.3.
RefSeqiXP_002646742.1. XM_002646696.1.

Genome annotation databases

EnsemblMetazoaiCBG13136; CBG13136; CBG13136.
GeneIDi8588741.
KEGGicbr:CBG13136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601401 Genomic DNA. Translation: CAP31978.3.
RefSeqiXP_002646742.1. XM_002646696.1.

3D structure databases

ProteinModelPortaliQ61C05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG13136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG13136; CBG13136; CBG13136.
GeneIDi8588741.
KEGGicbr:CBG13136.

Organism-specific databases

CTDi8588741.
WormBaseiCBG13136; CBP03219; WBGene00033948; Cbr-cnep-1.

Phylogenomic databases

eggNOGiCOG5190.
InParanoidiQ61C05.
KOiK17617.
OMAiRYFRQHC.
OrthoDBiEOG7MKW6W.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCNEP1_CAEBR
AccessioniPrimary (citable) accession number: Q61C05
Secondary accession number(s): A8XH54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.