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Q61C05

- CNEP1_CAEBR

UniProt

Q61C05 - CNEP1_CAEBR

Protein

CTD nuclear envelope phosphatase 1 homolog

Gene

cnep-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. nuclear envelope organization Source: UniProtKB
    2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
    3. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTD nuclear envelope phosphatase 1 homolog (EC:3.1.3.16)
    Short name:
    CTDNEP1
    Alternative name(s):
    Serine/threonine-protein phosphatase dullard homolog
    Small C-terminal domain phosphatase-like phosphatase 2
    Gene namesi
    Name:cnep-1
    Synonyms:scpl-2
    ORF Names:CBG13136
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG13136; CBP03219; WBGene00033948; Cbr-cnep-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. Nem1-Spo7 phosphatase complex Source: UniProtKB
    5. nuclear envelope Source: UniProtKB
    6. nuclear membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246CTD nuclear envelope phosphatase 1 homologPRO_0000297974Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG13136.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61C05.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 220168FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dullard family.Curated
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5190.
    KOiK17617.
    OMAiLLGIRTF.
    OrthoDBiEOG7MKW6W.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61C05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSFAQTVFY VLAGLFNVFL LYFRKTNRAY CKYQVVKYHS NIPMSPLTTH    50
    RLLTVKRKIL VLDLDETLIH SHHDGVLRQT VKPGTPSDFT IRVVIDRHPV 100
    KFSVHERPHV DYFLTVVSQW YELVVFTASM EVYGSSVADK LDRGRGILKR 150
    RYFRQHCTME VGGYTKDLSA IHPDLSSICI LDNSPGAYRK FPHNAIPIPS 200
    WFSDPNDTCL LNLLPFLDAL RFTSDVRSVL SRNMQVLPET QTVQYY 246
    Length:246
    Mass (Da):28,419
    Last modified:November 23, 2004 - v1
    Checksum:i793ED6CE6513D471
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601401 Genomic DNA. Translation: CAP31978.3.
    RefSeqiXP_002646742.1. XM_002646696.1.

    Genome annotation databases

    EnsemblMetazoaiCBG13136; CBG13136; CBG13136.
    GeneIDi8588741.
    KEGGicbr:CBG13136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601401 Genomic DNA. Translation: CAP31978.3 .
    RefSeqi XP_002646742.1. XM_002646696.1.

    3D structure databases

    ProteinModelPortali Q61C05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG13136.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG13136 ; CBG13136 ; CBG13136 .
    GeneIDi 8588741.
    KEGGi cbr:CBG13136.

    Organism-specific databases

    CTDi 8588741.
    WormBasei CBG13136 ; CBP03219 ; WBGene00033948 ; Cbr-cnep-1.

    Phylogenomic databases

    eggNOGi COG5190.
    KOi K17617.
    OMAi LLGIRTF.
    OrthoDBi EOG7MKW6W.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiCNEP1_CAEBR
    AccessioniPrimary (citable) accession number: Q61C05
    Secondary accession number(s): A8XH54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3