Reviewed, UniProtKB/Swiss-Prot Q61C05 (DULRD_CAEBR)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase dullard homolog
    EC=3.1.3.16
Alternative name(s):
    Small C-terminal domain phosphatase-like phosphatase 2

Gene names

Name:	scpl-2
ORF Names:	CBG13136

Organism

Caenorhabditis briggsae [Complete proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine phosphatase which may be required for proper nuclear membrane morphology By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the dullard family. Contains 1 FCP1 homology domain.
Sequence caution	The sequence CAP31978.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nuclear envelope organization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear envelope Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Serine/threonine-protein phosphatase dullard homolog		PRO_0000297974
Regions
	Transmembrane	3 – 23	21	Potential
	Domain	53 – 220	168	FCP1 homology

Sequences

	Sequence		Length	Mass (Da)
	Q61C05-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 793ED6CE6513D471	FASTA	246	28,419
	10 20 30 40 50 60 MTSFAQTVFY VLAGLFNVFL LYFRKTNRAY CKYQVVKYHS NIPMSPLTTH RLLTVKRKIL 70 80 90 100 110 120 VLDLDETLIH SHHDGVLRQT VKPGTPSDFT IRVVIDRHPV KFSVHERPHV DYFLTVVSQW 130 140 150 160 170 180 YELVVFTASM EVYGSSVADK LDRGRGILKR RYFRQHCTME VGGYTKDLSA IHPDLSSICI 190 200 210 220 230 240 LDNSPGAYRK FPHNAIPIPS WFSDPNDTCL LNLLPFLDAL RFTSDVRSVL SRNMQVLPET QTVQYY

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000514 Genomic DNA. Translation: CAP31978.2. Sequence problems.
RefSeq	XP_002646742.1.
3D structure databases
HSSP	HSSP built from PDB template 1TA0 based on UniProtKB Q9GZU7.
SMR	Q61C05. Positions 54-232.
ModBase	Search...
Genome annotation databases
GeneID	8588741.
Organism-specific databases
WormBase	WBGene00033948. Cbr-scpl-2.
Phylogenomic databases
OMA	VSQWYDL.
PhylomeDB	Q61C05.
Enzyme and pathway databases
BRENDA	3.1.3.16. 261794.
Family and domain databases
InterPro	IPR011948. Dullard. IPR004274. NIF. [Graphical view]
Pfam	PF03031. NIF. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02251. HIF-SF_euk. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DULRD_CAEBR

Accession

Primary (citable) accession number: Q61C05
Secondary accession number(s): A8XH54

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project