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Q619W7

- HEXA_CAEBR

UniProt

Q619W7 - HEXA_CAEBR

Protein

Beta-hexosaminidase A

Gene

hex-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei322 – 3221Proton donorBy similarity

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase A (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase
    N-acetyl-beta-glucosaminidase
    Gene namesi
    Name:hex-1By similarity
    ORF Names:CBG14058
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG14058; CBP29009; WBGene00034691; Cbr-hex-1.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 552537Beta-hexosaminidase APRO_0000312664Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3525.
    HOGENOMiHOG000157972.
    OrthoDBiEOG7KDFB6.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSiPR00738. GLHYDRLASE20.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q619W7-1 [UniParc]FASTAAdd to Basket

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    MRLIVLSLLF TSTLAWFYGR DEPDRWSVGG VWPLPQKIIY GSKNRTLTYD    50
    KIGIDLGDKK DCDVLLAMAD NYMNKWLFPY PVEMKTGGTE DFIITVTVKE 100
    ECPGGPPVHG ASEEYLLRVS VSEAVINAQT VWGALRAMET LSHLVFYDQK 150
    SQEYQIRTAE IFDKPRFPVR GIMIDSSRHF LSLNVIKRQL EIMSMNKLNV 200
    LHWHLVDSES FPYTSQKFPE LHGVGAYSPR HVYSREDISE VIAFARLRGI 250
    RVIPEFDLPG HTSSWKGRKG FLTECFDEKG EETFLPNLVD PMNDANFDFL 300
    AEFLEEVTET FPDQFLHLGG DEVSDYIVEC WVRNKKIRKF MDEKGFGNNT 350
    VLLENYFFEK LFSIVEKLKL KRKPIFWQEV FDNNIPDPNS IIHIWKGNTH 400
    EEIYEQVKNI TSKNFPVIVS ACWYLNYIKY GADWRDEIRG TAPSNSRYYY 450
    CDPTSFNGTD TQKNLVLGGI AAIWGELVDN TNIEARLWPR ASAAAERLWS 500
    PAEKTQKAEN AWPRMHELRC RLVSRGYRIQ PNNNPDYCPF EFDEPPATKS 550
    EL 552
    Length:552
    Mass (Da):63,880
    Last modified:September 22, 2009 - v2
    Checksum:iF51F5E37E49720A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600983 Genomic DNA. Translation: CAP32722.2.

    Genome annotation databases

    EnsemblMetazoaiCBG14058; CBG14058; CBG14058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600983 Genomic DNA. Translation: CAP32722.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG14058 ; CBG14058 ; CBG14058 .

    Organism-specific databases

    WormBasei CBG14058 ; CBP29009 ; WBGene00034691 ; Cbr-hex-1.

    Phylogenomic databases

    eggNOGi COG3525.
    HOGENOMi HOG000157972.
    OrthoDBi EOG7KDFB6.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSi PR00738. GLHYDRLASE20.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiHEXA_CAEBR
    AccessioniPrimary (citable) accession number: Q619W7
    Secondary accession number(s): A8XJ97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3