Reviewed,
UniProtKB/Swiss-Prot Q619W7 (HEXA_CAEBR)
Last modified
February 9, 2010.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Beta-hexosaminidase A EC=3.2.1.52 Alternative name(s): N-acetyl-beta-glucosaminidase Beta-N-acetylhexosaminidase | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis briggsae [Complete proteome] | ||||
| Taxonomic identifier | 6238 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 552 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose By similarity. UniProtKB Q22492 |
| Catalytic activity | Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. UniProtKB P06865 |
| Subcellular location | Lysosome By similarity UniProtKB P06865. |
| Sequence similarities | Belongs to the glycosyl hydrolase 20 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | beta-N-acetylhexosaminidase activity Inferred from sequence or structural similarity. Source: UniProtKB cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 15 | 15 | Potential | ||||||
| Chain | 16 – 552 | 537 | Beta-hexosaminidase A | PRO_0000312664 | |||||
Sites | |||||||||
| Active site | 322 | 1 | Proton donor By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 44 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 348 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 409 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 457 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. Waterston R.H.PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CAAC02000521 Genomic DNA. Translation: CAP32722.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NOW based on UniProtKB P07686. |
| ModBase | Search... |
Organism-specific databases | |
| WormBase | WBGene00034691. Cbr-hex-1. |
Phylogenomic databases | |
| HOGENOM | HBG591688. |
| PhylomeDB | Q619W7. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.52. 261794. |
Family and domain databases | |
| InterPro | IPR001540. Glyco_hydro_20. IPR015883. Glyco_hydro_20_cat-core. IPR017853. Glyco_hydro_catalytic_core. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view] |
| Gene3D | G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit. |
| PANTHER | PTHR22600. Glyco_hydro_20. 1 hit. |
| Pfam | PF00728. Glyco_hydro_20. 1 hit. [Graphical view] |
| PRINTS | PR00738. GLHYDRLASE20. |
| ProtoNet | Search... |
Entry information
| Entry name | HEXA_CAEBR | ||||||||
| Accession | Primary (citable) accession number: Q619W7 Secondary accession number(s): A8XJ97 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


