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Q619W7 (HEXA_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase A

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:hex-1
ORF Names:CBG14058
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose By similarity. UniProtKB Q22492

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. UniProtKB P06865

Subcellular location

Lysosome By similarity UniProtKB P06865.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 552537Beta-hexosaminidase A
PRO_0000312664

Sites

Active site3221Proton donor By similarity

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation4091N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q619W7 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: F51F5E37E49720A0

FASTA55263,880
        10         20         30         40         50         60 
MRLIVLSLLF TSTLAWFYGR DEPDRWSVGG VWPLPQKIIY GSKNRTLTYD KIGIDLGDKK 

        70         80         90        100        110        120 
DCDVLLAMAD NYMNKWLFPY PVEMKTGGTE DFIITVTVKE ECPGGPPVHG ASEEYLLRVS 

       130        140        150        160        170        180 
VSEAVINAQT VWGALRAMET LSHLVFYDQK SQEYQIRTAE IFDKPRFPVR GIMIDSSRHF 

       190        200        210        220        230        240 
LSLNVIKRQL EIMSMNKLNV LHWHLVDSES FPYTSQKFPE LHGVGAYSPR HVYSREDISE 

       250        260        270        280        290        300 
VIAFARLRGI RVIPEFDLPG HTSSWKGRKG FLTECFDEKG EETFLPNLVD PMNDANFDFL 

       310        320        330        340        350        360 
AEFLEEVTET FPDQFLHLGG DEVSDYIVEC WVRNKKIRKF MDEKGFGNNT VLLENYFFEK 

       370        380        390        400        410        420 
LFSIVEKLKL KRKPIFWQEV FDNNIPDPNS IIHIWKGNTH EEIYEQVKNI TSKNFPVIVS 

       430        440        450        460        470        480 
ACWYLNYIKY GADWRDEIRG TAPSNSRYYY CDPTSFNGTD TQKNLVLGGI AAIWGELVDN 

       490        500        510        520        530        540 
TNIEARLWPR ASAAAERLWS PAEKTQKAEN AWPRMHELRC RLVSRGYRIQ PNNNPDYCPF 

       550 
EFDEPPATKS EL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600983 Genomic DNA. Translation: CAP32722.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG14058; CBG14058; CBG14058.

Organism-specific databases

WormBaseCBG14058; CBP29009; WBGene00034691; Cbr-hex-1.

Phylogenomic databases

eggNOGCOG3525.
HOGENOMHOG000157972.
OrthoDBEOG7KDFB6.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PIRSFPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSPR00738. GLHYDRLASE20.
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEXA_CAEBR
AccessionPrimary (citable) accession number: Q619W7
Secondary accession number(s): A8XJ97
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 22, 2009
Last modified: November 13, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries