Q619N4 (ACP1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative acid phosphatase 1
EC=3.1.3.2

Gene names

ORF Names:

CBG14199

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 426	408	Putative acid phosphatase 1		PRO_0000248566
Regions
	Topological domain	19 – 388	370	Extracellular Potential
	Transmembrane	389 – 409	21	Helical; Potential
	Topological domain	410 – 426	17	Cytoplasmic Potential
Sites
	Active site	29	1	Nucleophile By similarity
	Active site	276	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	37	1	N-linked (GlcNAc...) Potential
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Glycosylation	380	1	N-linked (GlcNAc...) Potential
	Disulfide bond	133 ↔ 369		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q619N4 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5CA7D6B37BF30CE5	FASTA	426	48,455
	10 20 30 40 50 60 MRVLFYVFPF VIFALSQAQL ISVHVIFRHG ARAPVLNVTS EEAKSYFYRG LGQLTDVCIE 70 80 90 100 110 120 QAKLIGKVLK DRYVNTFVDA RMLPTQLLFR SSPVERCLMT IQTVGNTMFV NSTPPVQTVA 130 140 150 160 170 180 KPDDFLLVPK LDCAFQIDEW TNFFNLTEND KKQAKKNPWF ISEKALRRAT AASQTLQQRS 190 200 210 220 230 240 DENLPALILE KDAGLAVPSW FNEEAYKESL TVFYKALAVM SSVGEYKSSK GIRVKTGLLL 250 260 270 280 290 300 DKILNDIQEK VRCHEKNQKG HISCDRHKLQ VFSTHDLLIL PFLDALGIRE AALGEDLPPK 310 320 330 340 350 360 FLSAIIIETM LLDDIPFVKV FYRGDPRDIT LRDMTGLVRN CPPNQALCPV NLFTSCCGEF 370 380 390 400 410 420 ITADPRRECY EEKADQQLHN WTMTTVSWIL IGISAFLLII LIIMSYLAVR YKNRSVVTIK KVCLEN

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE600983 Genomic DNA. Translation: CAP32804.1.
RefSeq	XP_002644366.1. XM_002644320.1.
3D structure databases
ProteinModelPortal	Q619N4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG14199; CBG14199; CBG14199.
GeneID	8586361.
KEGG	cbr:CBG14199.
Organism-specific databases
CTD	8586361.
WormBase	CBG14199; CBP03468; WBGene00034774.
Phylogenomic databases
eggNOG	NOG306642.
HOGENOM	HOG000115658.
OMA	VERCLMT.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP1_CAEBR

Accession

Primary (citable) accession number: Q619N4
Secondary accession number(s): A8XJH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	November 23, 2004
Last modified:	May 29, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project