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Q61983 (NPT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name=Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene names
Name:Slc17a1
Synonyms:Npt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

Subunit structure

Interacts with PDZK1. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Kidney.

Sequence similarities

Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Sodium-dependent phosphate transport protein 1
PRO_0000220937

Regions

Transmembrane79 – 9921Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane260 – 28021Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane337 – 35620Helical; Potential
Transmembrane363 – 38321Helical; Potential
Transmembrane399 – 41921Helical; Potential
Transmembrane429 – 44921Helical; Potential

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation561N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1231L → I in CAA54459. Ref.1
Sequence conflict1231L → I in AAK97542. Ref.3
Sequence conflict4311F → S in CAA54459. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61983 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F60BF9F9C04F3A2D

FASTA46551,649
        10         20         30         40         50         60 
MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG SPHLSNESVV 

        70         80         90        100        110        120 
EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS GIYPMKRIIG SSLFLSSLMS 

       130        140        150        160        170        180 
LLLPPAAQVG AALVIVCRVL QGIAQGTVST GQHEIWVKWA PPLERGRLTS MTLSGFVMGP 

       190        200        210        220        230        240 
FIVLLVSGFI CDLLGWPMVF YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL 

       250        260        270        280        290        300 
MQQASSGRQS LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL 

       310        320        330        340        350        360 
LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI MCLLYLSYNF 

       370        380        390        400        410        420 
YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT ALIGMFGGLI SSTLAGLILN 

       430        440        450        460 
QDPEYAWHKI FFLMAGINVT CLVFYFLFAK GEIQDWAKEI KTTRL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter."
Chong S.S., Kozak C.A., Liu L., Kristjansson K., Dunn S.T., Bourdeau J.E., Hughes M.R.
Am. J. Physiol. 268:F1038-F1045(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity."
Soumounou Y., Gauthier C., Tenenhouse H.S.
Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
Strain: 129/SvJ.
[4]"Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins."
Gisler S.M., Stagljar I., Traebert M., Bacic D., Biber J., Murer H.
J. Biol. Chem. 276:9206-9213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDZK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77241 mRNA. Translation: CAA54459.1.
AL606464, AL590388 Genomic DNA. Translation: CAI35969.2.
AF361768, AF361764, AF361766 Genomic DNA. Translation: AAK97542.1.
CCDSCCDS26372.1.
PIRS69915.
RefSeqNP_001164109.1. NM_001170638.1.
NP_033224.3. NM_009198.3.
UniGeneMm.2656.

3D structure databases

ProteinModelPortalQ61983.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61983. 4 interactions.
MINTMINT-152357.
STRING10090.ENSMUSP00000006785.

Protein family/group databases

TCDB2.A.1.14.6. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ61983.

Proteomic databases

PRIDEQ61983.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006785; ENSMUSP00000006785; ENSMUSG00000021335.
ENSMUST00000110413; ENSMUSP00000106043; ENSMUSG00000021335.
GeneID20504.
KEGGmmu:20504.
UCSCuc007pvf.2. mouse.

Organism-specific databases

CTD6568.
MGIMGI:103209. Slc17a1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00640000091442.
HOGENOMHOG000230813.
HOVERGENHBG008834.
InParanoidA9Z1Z4.
KOK12300.
OMAFCSFRYG.
TreeFamTF313535.

Gene expression databases

BgeeQ61983.
GenevestigatorQ61983.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00894. 2A0114euk. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298683.
PROQ61983.
SOURCESearch...

Entry information

Entry nameNPT1_MOUSE
AccessionPrimary (citable) accession number: Q61983
Secondary accession number(s): A9Z1Z4, Q91YA1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot