Reviewed, UniProtKB/Swiss-Prot Q61983 (NPT1_MOUSE)

Names and origin

Protein names

Recommended name:
    Sodium-dependent phosphate transport protein 1
Alternative name(s):
    Sodium/phosphate cotransporter 1
    Na(+)/PI cotransporter 1
    Solute carrier family 17 member 1
    Renal sodium-dependent phosphate transport protein 1
      Short name=Renal sodium-phosphate transport protein 1
    Renal Na(+)-dependent phosphate cotransporter 1

Gene names

Name:	Slc17a1
Synonyms:	Npt1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.
Subunit structure	Interacts with PDZK1. Ref.3
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Kidney.
Sequence similarities	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	Sodium
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	phosphate transport Inferred from electronic annotation. Source: InterPro sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphate transmembrane transporter activity Inferred from electronic annotation. Source: InterPro sodium ion binding Inferred from electronic annotation. Source: UniProtKB-KW symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Sodium-dependent phosphate transport protein 1		PRO_0000220937
Regions
	Transmembrane	79 – 99	21	Potential
	Transmembrane	117 – 137	21	Potential
	Transmembrane	176 – 196	21	Potential
	Transmembrane	199 – 219	21	Potential
	Transmembrane	260 – 280	21	Potential
	Transmembrane	304 – 324	21	Potential
	Transmembrane	337 – 356	20	Potential
	Transmembrane	363 – 383	21	Potential
	Transmembrane	399 – 419	21	Potential
	Transmembrane	429 – 449	21	Potential
Amino acid modifications
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Glycosylation	47	1	N-linked (GlcNAc...) Potential
	Glycosylation	56	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q61983-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C67EE25A2C291EEF	FASTA	465	51,589
	10 20 30 40 50 60 MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG SPHLSNESVV 70 80 90 100 110 120 EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS GIYPMKRIIG SSLFLSSLMS 130 140 150 160 170 180 LLIPPAAQVG AALVIVCRVL QGIAQGTVST GQHEIWVKWA PPLERGRLTS MTLSGFVMGP 190 200 210 220 230 240 FIVLLVSGFI CDLLGWPMVF YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL 250 260 270 280 290 300 MQQASSGRQS LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL 310 320 330 340 350 360 LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI MCLLYLSYNF 370 380 390 400 410 420 YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT ALIGMFGGLI SSTLAGLILN 430 440 450 460 QDPEYAWHKI SFLMAGINVT CLVFYFLFAK GEIQDWAKEI KTTRL

References

[1]	"Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter." Chong S.S., Kozak C.A., Liu L., Kristjansson K., Dunn S.T., Bourdeau J.E., Hughes M.R. Am. J. Physiol. 268:F1038-F1045(1995) [PubMed: 7611445] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity." Soumounou Y., Gauthier C., Tenenhouse H.S. Am. J. Physiol. 281:F1082-F1091(2001) [PubMed: 11704559] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148. Strain: 129/SvJ.
[3]	"Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins." Gisler S.M., Stagljar I., Traebert M., Bacic D., Biber J., Murer H. J. Biol. Chem. 276:9206-9213(2001) [PubMed: 11099500] [Abstract] Cited for: INTERACTION WITH PDZK1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X77241 mRNA. Translation: CAA54459.1. AF361768, AF361764, AF361766 Genomic DNA. Translation: AAK97542.1.
IPI	IPI00127655.
PIR	S69915.
UniGene	Mm.2656
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	2.A.1.14.6. major facilitator superfamily (MFS).
Genome annotation databases
Ensembl	ENSMUSG00000021335. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:103209. Slc17a1.
Phylogenomic databases
HOGENOM	Q61983.
HOVERGEN	Q61983.
Gene expression databases
ArrayExpress	Q61983.
Bgee	Q61983.
GermOnline	ENSMUSG00000021335. Mus musculus.
Family and domain databases
InterPro	IPR011701. MFS_1. IPR004745. Pi_cotranspt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00894. 2A0114euk. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

NPT1_MOUSE

Accession

Primary (citable) accession number: Q61983
Secondary accession number(s): Q91YA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)