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Protein

Sodium-dependent phosphate transport protein 1

Gene

Slc17a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-428643. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name:
Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene namesi
Name:Slc17a1
Synonyms:Npt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103209. Slc17a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei337 – 356HelicalSequence analysisAdd BLAST20
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209371 – 465Sodium-dependent phosphate transport protein 1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ61983.
PRIDEiQ61983.

PTM databases

iPTMnetiQ61983.
PhosphoSitePlusiQ61983.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiENSMUSG00000021335.
ExpressionAtlasiQ61983. baseline and differential.
GenevisibleiQ61983. MM.

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

Protein-protein interaction databases

IntActiQ61983. 4 interactors.
MINTiMINT-152357.
STRINGi10090.ENSMUSP00000006785.

Structurei

3D structure databases

ProteinModelPortaliQ61983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230813.
HOVERGENiHBG008834.
InParanoidiQ61983.
KOiK12300.
OMAiCLNLTMV.
OrthoDBiEOG091G08YP.
TreeFamiTF313535.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG
60 70 80 90 100
SPHLSNESVV EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS
110 120 130 140 150
GIYPMKRIIG SSLFLSSLMS LLLPPAAQVG AALVIVCRVL QGIAQGTVST
160 170 180 190 200
GQHEIWVKWA PPLERGRLTS MTLSGFVMGP FIVLLVSGFI CDLLGWPMVF
210 220 230 240 250
YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL MQQASSGRQS
260 270 280 290 300
LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL
310 320 330 340 350
LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI
360 370 380 390 400
MCLLYLSYNF YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT
410 420 430 440 450
ALIGMFGGLI SSTLAGLILN QDPEYAWHKI FFLMAGINVT CLVFYFLFAK
460
GEIQDWAKEI KTTRL
Length:465
Mass (Da):51,649
Last modified:July 27, 2011 - v2
Checksum:iF60BF9F9C04F3A2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123L → I in CAA54459 (PubMed:7611445).Curated1
Sequence conflicti123L → I in AAK97542 (PubMed:11704559).Curated1
Sequence conflicti431F → S in CAA54459 (PubMed:7611445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77241 mRNA. Translation: CAA54459.1.
AL606464, AL590388 Genomic DNA. Translation: CAI35969.2.
AF361768, AF361764, AF361766 Genomic DNA. Translation: AAK97542.1.
CCDSiCCDS26372.1.
PIRiS69915.
RefSeqiNP_001164109.1. NM_001170638.1.
NP_033224.3. NM_009198.3.
UniGeneiMm.2656.

Genome annotation databases

EnsembliENSMUST00000006785; ENSMUSP00000006785; ENSMUSG00000021335.
ENSMUST00000110413; ENSMUSP00000106043; ENSMUSG00000021335.
GeneIDi20504.
KEGGimmu:20504.
UCSCiuc007pvf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77241 mRNA. Translation: CAA54459.1.
AL606464, AL590388 Genomic DNA. Translation: CAI35969.2.
AF361768, AF361764, AF361766 Genomic DNA. Translation: AAK97542.1.
CCDSiCCDS26372.1.
PIRiS69915.
RefSeqiNP_001164109.1. NM_001170638.1.
NP_033224.3. NM_009198.3.
UniGeneiMm.2656.

3D structure databases

ProteinModelPortaliQ61983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61983. 4 interactors.
MINTiMINT-152357.
STRINGi10090.ENSMUSP00000006785.

Protein family/group databases

TCDBi2.A.1.14.6. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ61983.
PhosphoSitePlusiQ61983.

Proteomic databases

PaxDbiQ61983.
PRIDEiQ61983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006785; ENSMUSP00000006785; ENSMUSG00000021335.
ENSMUST00000110413; ENSMUSP00000106043; ENSMUSG00000021335.
GeneIDi20504.
KEGGimmu:20504.
UCSCiuc007pvf.2. mouse.

Organism-specific databases

CTDi6568.
MGIiMGI:103209. Slc17a1.

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230813.
HOVERGENiHBG008834.
InParanoidiQ61983.
KOiK12300.
OMAiCLNLTMV.
OrthoDBiEOG091G08YP.
TreeFamiTF313535.

Enzyme and pathway databases

ReactomeiR-MMU-428643. Organic anion transporters.

Miscellaneous databases

ChiTaRSiSlc17a1. mouse.
PROiQ61983.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021335.
ExpressionAtlasiQ61983. baseline and differential.
GenevisibleiQ61983. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPT1_MOUSE
AccessioniPrimary (citable) accession number: Q61983
Secondary accession number(s): A9Z1Z4, Q91YA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.