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Q61983

- NPT1_MOUSE

UniProt

Q61983 - NPT1_MOUSE

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Protein

Sodium-dependent phosphate transport protein 1

Gene

Slc17a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

GO - Molecular functioni

  1. phosphate ion transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
  2. urate metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_251149. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name:
Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene namesi
Name:Slc17a1
Synonyms:Npt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:103209. Slc17a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei337 – 35620HelicalSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Sodium-dependent phosphate transport protein 1PRO_0000220937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ61983.

PTM databases

PhosphoSiteiQ61983.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiQ61983.
ExpressionAtlasiQ61983. baseline and differential.
GenevestigatoriQ61983.

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

Protein-protein interaction databases

IntActiQ61983. 4 interactions.
MINTiMINT-152357.
STRINGi10090.ENSMUSP00000006785.

Structurei

3D structure databases

ProteinModelPortaliQ61983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230813.
HOVERGENiHBG008834.
InParanoidiQ61983.
KOiK12300.
OMAiFCSFRYG.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004745. Pi_cotranspt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61983-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG
60 70 80 90 100
SPHLSNESVV EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS
110 120 130 140 150
GIYPMKRIIG SSLFLSSLMS LLLPPAAQVG AALVIVCRVL QGIAQGTVST
160 170 180 190 200
GQHEIWVKWA PPLERGRLTS MTLSGFVMGP FIVLLVSGFI CDLLGWPMVF
210 220 230 240 250
YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL MQQASSGRQS
260 270 280 290 300
LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL
310 320 330 340 350
LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI
360 370 380 390 400
MCLLYLSYNF YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT
410 420 430 440 450
ALIGMFGGLI SSTLAGLILN QDPEYAWHKI FFLMAGINVT CLVFYFLFAK
460
GEIQDWAKEI KTTRL
Length:465
Mass (Da):51,649
Last modified:July 27, 2011 - v2
Checksum:iF60BF9F9C04F3A2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231L → I in CAA54459. (PubMed:7611445)Curated
Sequence conflicti123 – 1231L → I in AAK97542. (PubMed:11704559)Curated
Sequence conflicti431 – 4311F → S in CAA54459. (PubMed:7611445)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77241 mRNA. Translation: CAA54459.1.
AL606464, AL590388 Genomic DNA. Translation: CAI35969.2.
AF361768, AF361764, AF361766 Genomic DNA. Translation: AAK97542.1.
CCDSiCCDS26372.1.
PIRiS69915.
RefSeqiNP_001164109.1. NM_001170638.1.
NP_033224.3. NM_009198.3.
UniGeneiMm.2656.

Genome annotation databases

EnsembliENSMUST00000006785; ENSMUSP00000006785; ENSMUSG00000021335.
ENSMUST00000110413; ENSMUSP00000106043; ENSMUSG00000021335.
GeneIDi20504.
KEGGimmu:20504.
UCSCiuc007pvf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77241 mRNA. Translation: CAA54459.1 .
AL606464 , AL590388 Genomic DNA. Translation: CAI35969.2 .
AF361768 , AF361764 , AF361766 Genomic DNA. Translation: AAK97542.1 .
CCDSi CCDS26372.1.
PIRi S69915.
RefSeqi NP_001164109.1. NM_001170638.1.
NP_033224.3. NM_009198.3.
UniGenei Mm.2656.

3D structure databases

ProteinModelPortali Q61983.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61983. 4 interactions.
MINTi MINT-152357.
STRINGi 10090.ENSMUSP00000006785.

Protein family/group databases

TCDBi 2.A.1.14.6. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q61983.

Proteomic databases

PRIDEi Q61983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006785 ; ENSMUSP00000006785 ; ENSMUSG00000021335 .
ENSMUST00000110413 ; ENSMUSP00000106043 ; ENSMUSG00000021335 .
GeneIDi 20504.
KEGGi mmu:20504.
UCSCi uc007pvf.2. mouse.

Organism-specific databases

CTDi 6568.
MGIi MGI:103209. Slc17a1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000119079.
HOGENOMi HOG000230813.
HOVERGENi HBG008834.
InParanoidi Q61983.
KOi K12300.
OMAi FCSFRYG.
TreeFami TF313535.

Enzyme and pathway databases

Reactomei REACT_251149. Organic anion transporters.

Miscellaneous databases

ChiTaRSi Slc17a1. mouse.
NextBioi 298683.
PROi Q61983.
SOURCEi Search...

Gene expression databases

Bgeei Q61983.
ExpressionAtlasi Q61983. baseline and differential.
Genevestigatori Q61983.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004745. Pi_cotranspt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00894. 2A0114euk. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter."
    Chong S.S., Kozak C.A., Liu L., Kristjansson K., Dunn S.T., Bourdeau J.E., Hughes M.R.
    Am. J. Physiol. 268:F1038-F1045(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity."
    Soumounou Y., Gauthier C., Tenenhouse H.S.
    Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
    Strain: 129/SvJ.
  4. "Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins."
    Gisler S.M., Stagljar I., Traebert M., Bacic D., Biber J., Murer H.
    J. Biol. Chem. 276:9206-9213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDZK1.

Entry informationi

Entry nameiNPT1_MOUSE
AccessioniPrimary (citable) accession number: Q61983
Secondary accession number(s): A9Z1Z4, Q91YA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3