Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61983

- NPT1_MOUSE

UniProt

Q61983 - NPT1_MOUSE

Protein

Sodium-dependent phosphate transport protein 1

Gene

Slc17a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane.

    GO - Molecular functioni

    1. phosphate ion transmembrane transporter activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW
    2. urate metabolic process Source: Ensembl

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.1.14.6. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transport protein 1
    Alternative name(s):
    Na(+)/PI cotransporter 1
    Renal Na(+)-dependent phosphate cotransporter 1
    Renal sodium-dependent phosphate transport protein 1
    Short name:
    Renal sodium-phosphate transport protein 1
    Sodium/phosphate cotransporter 1
    Solute carrier family 17 member 1
    Gene namesi
    Name:Slc17a1
    Synonyms:Npt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:103209. Slc17a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Sodium-dependent phosphate transport protein 1PRO_0000220937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ61983.

    PTM databases

    PhosphoSiteiQ61983.

    Expressioni

    Tissue specificityi

    Kidney.

    Gene expression databases

    BgeeiQ61983.
    GenevestigatoriQ61983.

    Interactioni

    Subunit structurei

    Interacts with PDZK1.1 Publication

    Protein-protein interaction databases

    IntActiQ61983. 4 interactions.
    MINTiMINT-152357.
    STRINGi10090.ENSMUSP00000006785.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61983.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00640000091442.
    HOGENOMiHOG000230813.
    HOVERGENiHBG008834.
    InParanoidiA9Z1Z4.
    KOiK12300.
    OMAiFCSFRYG.
    TreeFamiTF313535.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004745. Pi_cotranspt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00894. 2A0114euk. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61983-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG    50
    SPHLSNESVV EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS 100
    GIYPMKRIIG SSLFLSSLMS LLLPPAAQVG AALVIVCRVL QGIAQGTVST 150
    GQHEIWVKWA PPLERGRLTS MTLSGFVMGP FIVLLVSGFI CDLLGWPMVF 200
    YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL MQQASSGRQS 250
    LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL 300
    LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI 350
    MCLLYLSYNF YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT 400
    ALIGMFGGLI SSTLAGLILN QDPEYAWHKI FFLMAGINVT CLVFYFLFAK 450
    GEIQDWAKEI KTTRL 465
    Length:465
    Mass (Da):51,649
    Last modified:July 27, 2011 - v2
    Checksum:iF60BF9F9C04F3A2D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231L → I in CAA54459. (PubMed:7611445)Curated
    Sequence conflicti123 – 1231L → I in AAK97542. (PubMed:11704559)Curated
    Sequence conflicti431 – 4311F → S in CAA54459. (PubMed:7611445)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77241 mRNA. Translation: CAA54459.1.
    AL606464, AL590388 Genomic DNA. Translation: CAI35969.2.
    AF361768, AF361764, AF361766 Genomic DNA. Translation: AAK97542.1.
    CCDSiCCDS26372.1.
    PIRiS69915.
    RefSeqiNP_001164109.1. NM_001170638.1.
    NP_033224.3. NM_009198.3.
    UniGeneiMm.2656.

    Genome annotation databases

    EnsembliENSMUST00000006785; ENSMUSP00000006785; ENSMUSG00000021335.
    ENSMUST00000110413; ENSMUSP00000106043; ENSMUSG00000021335.
    GeneIDi20504.
    KEGGimmu:20504.
    UCSCiuc007pvf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77241 mRNA. Translation: CAA54459.1 .
    AL606464 , AL590388 Genomic DNA. Translation: CAI35969.2 .
    AF361768 , AF361764 , AF361766 Genomic DNA. Translation: AAK97542.1 .
    CCDSi CCDS26372.1.
    PIRi S69915.
    RefSeqi NP_001164109.1. NM_001170638.1.
    NP_033224.3. NM_009198.3.
    UniGenei Mm.2656.

    3D structure databases

    ProteinModelPortali Q61983.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61983. 4 interactions.
    MINTi MINT-152357.
    STRINGi 10090.ENSMUSP00000006785.

    Protein family/group databases

    TCDBi 2.A.1.14.6. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q61983.

    Proteomic databases

    PRIDEi Q61983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006785 ; ENSMUSP00000006785 ; ENSMUSG00000021335 .
    ENSMUST00000110413 ; ENSMUSP00000106043 ; ENSMUSG00000021335 .
    GeneIDi 20504.
    KEGGi mmu:20504.
    UCSCi uc007pvf.2. mouse.

    Organism-specific databases

    CTDi 6568.
    MGIi MGI:103209. Slc17a1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00640000091442.
    HOGENOMi HOG000230813.
    HOVERGENi HBG008834.
    InParanoidi A9Z1Z4.
    KOi K12300.
    OMAi FCSFRYG.
    TreeFami TF313535.

    Miscellaneous databases

    NextBioi 298683.
    PROi Q61983.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61983.
    Genevestigatori Q61983.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004745. Pi_cotranspt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00894. 2A0114euk. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter."
      Chong S.S., Kozak C.A., Liu L., Kristjansson K., Dunn S.T., Bourdeau J.E., Hughes M.R.
      Am. J. Physiol. 268:F1038-F1045(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity."
      Soumounou Y., Gauthier C., Tenenhouse H.S.
      Am. J. Physiol. 281:F1082-F1091(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
      Strain: 129/SvJ.
    4. "Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins."
      Gisler S.M., Stagljar I., Traebert M., Bacic D., Biber J., Murer H.
      J. Biol. Chem. 276:9206-9213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDZK1.

    Entry informationi

    Entry nameiNPT1_MOUSE
    AccessioniPrimary (citable) accession number: Q61983
    Secondary accession number(s): A9Z1Z4, Q91YA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3