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Protein

Neuronatin

Gene

Nnat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.

GO - Biological processi

  • brain development Source: GO_Central
  • positive regulation of insulin secretion Source: MGI
  • regulation of protein localization Source: MGI
  • response to glucose Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:Nnat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104716. Nnat.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181NeuronatinPRO_0000096883Add
BLAST

Proteomic databases

PaxDbiQ61979.

PTM databases

iPTMnetiQ61979.
PhosphoSiteiQ61979.

Expressioni

Tissue specificityi

Highest in brain and ovary.

Developmental stagei

Expressed in rhombomeres 3 and 5 during early hindbrain development and in the floor of the foregut pocket. Also expressed in the early Rathke pouch, derived adenohypophysis, and developing inner ear. During later embryogenesis, strongly expressed in the major part of the central and peripheral nervous system.

Gene expression databases

BgeeiENSMUSG00000067786.
CleanExiMM_NNAT.
ExpressionAtlasiQ61979. baseline and differential.
GenevisibleiQ61979. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105152.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
HOGENOMiHOG000113807.
HOVERGENiHBG001605.
InParanoidiQ61979.
PhylomeDBiQ61979.
TreeFamiTF338710.

Family and domain databases

InterProiIPR024885. Neuronatin.
[Graphical view]
PANTHERiPTHR15285. PTHR15285. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61979-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AHTVSRTGRQ VLGERRQRAP N
Length:81
Mass (Da):9,211
Last modified:February 1, 1997 - v2
Checksum:i067086DB0A4E3D20
GO
Isoform 2 (identifier: Q61979-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,127
Checksum:i184E7C8A2E706C87
GO

Sequence cautioni

The sequence CAA58551 differs from that shown.Incorrect N-terminal sequence due to reversal of the first 22 base pairs of the cDNA.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 5127Missing in isoform 2. 1 PublicationVSP_004333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83568 mRNA. Translation: CAA58551.1. Sequence problems.
X83569 mRNA. Translation: CAA58552.1.
X83570 mRNA. Translation: CAA58553.1.
AF303656 Genomic DNA. Translation: AAL01185.1.
AK160626 mRNA. Translation: BAE35925.1.
AL672259 Genomic DNA. Translation: CAM16145.1.
BC036984 mRNA. Translation: AAH36984.1.
CCDSiCCDS38306.1. [Q61979-1]
CCDS38307.1. [Q61979-3]
PIRiS51082.
S51083.
S51084.
RefSeqiNP_001278057.1. NM_001291128.1.
NP_001278058.1. NM_001291129.1.
NP_001278059.1. NM_001291130.1.
NP_035053.1. NM_010923.3. [Q61979-1]
NP_851291.1. NM_180960.3. [Q61979-3]
UniGeneiMm.34330.
Mm.486979.

Genome annotation databases

EnsembliENSMUST00000109526; ENSMUSP00000105152; ENSMUSG00000067786. [Q61979-1]
ENSMUST00000153739; ENSMUSP00000129821; ENSMUSG00000067786. [Q61979-3]
GeneIDi18111.
KEGGimmu:18111.
UCSCiuc008npe.2. mouse. [Q61979-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83568 mRNA. Translation: CAA58551.1. Sequence problems.
X83569 mRNA. Translation: CAA58552.1.
X83570 mRNA. Translation: CAA58553.1.
AF303656 Genomic DNA. Translation: AAL01185.1.
AK160626 mRNA. Translation: BAE35925.1.
AL672259 Genomic DNA. Translation: CAM16145.1.
BC036984 mRNA. Translation: AAH36984.1.
CCDSiCCDS38306.1. [Q61979-1]
CCDS38307.1. [Q61979-3]
PIRiS51082.
S51083.
S51084.
RefSeqiNP_001278057.1. NM_001291128.1.
NP_001278058.1. NM_001291129.1.
NP_001278059.1. NM_001291130.1.
NP_035053.1. NM_010923.3. [Q61979-1]
NP_851291.1. NM_180960.3. [Q61979-3]
UniGeneiMm.34330.
Mm.486979.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105152.

PTM databases

iPTMnetiQ61979.
PhosphoSiteiQ61979.

Proteomic databases

PaxDbiQ61979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109526; ENSMUSP00000105152; ENSMUSG00000067786. [Q61979-1]
ENSMUST00000153739; ENSMUSP00000129821; ENSMUSG00000067786. [Q61979-3]
GeneIDi18111.
KEGGimmu:18111.
UCSCiuc008npe.2. mouse. [Q61979-1]

Organism-specific databases

CTDi4826.
MGIiMGI:104716. Nnat.

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
HOGENOMiHOG000113807.
HOVERGENiHBG001605.
InParanoidiQ61979.
PhylomeDBiQ61979.
TreeFamiTF338710.

Miscellaneous databases

PROiQ61979.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067786.
CleanExiMM_NNAT.
ExpressionAtlasiQ61979. baseline and differential.
GenevisibleiQ61979. MM.

Family and domain databases

InterProiIPR024885. Neuronatin.
[Graphical view]
PANTHERiPTHR15285. PTHR15285. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNNAT_MOUSE
AccessioniPrimary (citable) accession number: Q61979
Secondary accession number(s): Q548Q0, Q61980, Q61981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.