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Protein

Zinc finger protein 90

Gene

Zfp90

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri208 – 23023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: UniProtKB

GO - Biological processi

  • negative regulation of DNA binding Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 90
Short name:
Zfp-90
Alternative name(s):
Zinc finger protein NK10
Gene namesi
Name:Zfp90
Synonyms:Nk10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:104786. Zfp90.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Zinc finger protein 90PRO_0000047311Add
BLAST

Proteomic databases

EPDiQ61967.
MaxQBiQ61967.
PaxDbiQ61967.
PRIDEiQ61967.

PTM databases

iPTMnetiQ61967.
PhosphoSiteiQ61967.

Expressioni

Tissue specificityi

Brain, heart, spleen, thymus, and testis.1 Publication

Developmental stagei

There is a marked increase after postnatal stages 18-20 (simultaneously to the appearance of haploid cell stages). Maximal expression is observed around 2 weeks postnatally, with the exception of brain and testis, where the expression is highest in earlier developmental stages.1 Publication

Gene expression databases

BgeeiQ61967.
CleanExiMM_ZFP90.
GenevisibleiQ61967. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034382.

Structurei

3D structure databases

ProteinModelPortaliQ61967.
SMRiQ61967. Positions 14-55, 178-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri208 – 23023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ61967.
KOiK09228.
OMAiHENAHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ61967.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPPTAKP QESVTFKDVA VNFTQEEWHH VGPAQRSLYR DVMLENYNHL
60 70 80 90 100
VSLGYQVSKP EVIFKLEQGE EPWISEKEIQ RPFCPDWKTR PESSRSPQQG
110 120 130 140 150
VSEVFLRTNV LSHTTIGDIW NVAIQGHQES GRRHLGPEAS SQKKITTLEK
160 170 180 190 200
KIEQNKVGED SSLSTDLVPQ LDISSSIRPS DCKTFGNNLE HNSELVTQSN
210 220 230 240 250
ILAKKKPYKC DKCRKSFIHR SSLNKHEKIH KGDPYSNGTD QGAQSGRKHH
260 270 280 290 300
ECADCGKTFL WRTQLTEHQR IHTGEKPFEC NVCGKAFRHS SSLGQHENAH
310 320 330 340 350
TGEKPYQCSL CGKAFQRSSS LVQHQRIHTG EKPYRCNLCG RSFRHSTSLT
360 370 380 390 400
QHEVTHSGEK PFQCKECGKA FSRCSSLVQH ERTHTGEKPF ECSICGRAFG
410 420 430 440 450
QSPSLYKHMR IHKRSKPYQS NNFSLAFVPN TPLPQGEGLL TEVKSYHCND
460 470 480 490 500
CGKDFGHITD FSEHQRLHAG ENSYGSEQTL LGQQSLSHPR EKPYQCNVCG
510 520 530 540 550
KAFKRSTSFI EHHRIHTGEK PYECNECGEA FSRLSSLTQH ERTHTGEKPY
560 570 580 590 600
ECIDCGKAFS QSSSLIQHER THTGEKPYEC NECGRAFRKK TNLHDHQRTH
610 620 630
TGEKPYACKE CGRNFSRSSA LTKHHRVHAR NKLQES
Length:636
Mass (Da):72,423
Last modified:November 1, 1996 - v1
Checksum:i1269BEC7729E369F
GO

Sequence cautioni

The sequence BAE32436.1 differs from that shown.After frameshift's correction, the CDS was not identified.Curated
The sequence BAE32436.1 differs from that shown. Reason: Frameshift at positions 124 and 261. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531L → A in BAE32436 (PubMed:16141072).Curated
Sequence conflicti545 – 5451T → A in BAE32436 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79828 mRNA. Translation: CAA56225.1.
AK032286 mRNA. Translation: BAC27794.1.
AK050519 mRNA. Translation: BAC34302.1.
AK154205 mRNA. Translation: BAE32436.1. Sequence problems.
BC046298 mRNA. Translation: AAH46298.1.
CCDSiCCDS22635.1.
PIRiI48689.
RefSeqiNP_035894.1. NM_011764.3.
UniGeneiMm.295582.

Genome annotation databases

EnsembliENSMUST00000034382; ENSMUSP00000034382; ENSMUSG00000031907.
GeneIDi22751.
KEGGimmu:22751.
UCSCiuc009ngd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79828 mRNA. Translation: CAA56225.1.
AK032286 mRNA. Translation: BAC27794.1.
AK050519 mRNA. Translation: BAC34302.1.
AK154205 mRNA. Translation: BAE32436.1. Sequence problems.
BC046298 mRNA. Translation: AAH46298.1.
CCDSiCCDS22635.1.
PIRiI48689.
RefSeqiNP_035894.1. NM_011764.3.
UniGeneiMm.295582.

3D structure databases

ProteinModelPortaliQ61967.
SMRiQ61967. Positions 14-55, 178-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034382.

PTM databases

iPTMnetiQ61967.
PhosphoSiteiQ61967.

Proteomic databases

EPDiQ61967.
MaxQBiQ61967.
PaxDbiQ61967.
PRIDEiQ61967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034382; ENSMUSP00000034382; ENSMUSG00000031907.
GeneIDi22751.
KEGGimmu:22751.
UCSCiuc009ngd.1. mouse.

Organism-specific databases

CTDi146198.
MGIiMGI:104786. Zfp90.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ61967.
KOiK09228.
OMAiHENAHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ61967.
TreeFamiTF350822.

Miscellaneous databases

ChiTaRSiZfp90. mouse.
NextBioi303249.
PROiQ61967.
SOURCEiSearch...

Gene expression databases

BgeeiQ61967.
CleanExiMM_ZFP90.
GenevisibleiQ61967. MM.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains."
    Lange R., Christoph A., Thiesen H.-J., Vopper G., Johnson K.R., Lemaire L., Plomann M., Cremer H., Barthels D., Heinlein U.A.O.
    DNA Cell Biol. 14:971-981(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell, Olfactory bulb and Pancreatic islet.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiZFP90_MOUSE
AccessioniPrimary (citable) accession number: Q61967
Secondary accession number(s): Q3U4J5, Q543I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.