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Q61955

- KLK8_MOUSE

UniProt

Q61955 - KLK8_MOUSE

Protein

Kallikrein-8

Gene

Klk8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.8 Publications

    Catalytic activityi

    Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys.

    Enzyme regulationi

    Strongly inhibited by diisopropyl fluorophosphate, leupeptin and (4-amidinophenyl)methanesulfonyl 1-fluoride.1 Publication

    Kineticsi

    1. KM=300 µM for Boc-Val-Pro-Arg-MCA1 Publication
    2. KM=540 µM for Boc-Phe-Ser-Arg-MCA1 Publication
    3. KM=280 µM for D-Val-Leu-Arg-MCA1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei212 – 2121Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. cell death Source: UniProtKB
    2. keratinocyte proliferation Source: UniProtKB
    3. memory Source: UniProtKB
    4. negative regulation of axon regeneration Source: UniProtKB
    5. negative regulation of myelination Source: UniProtKB
    6. neuron projection morphogenesis Source: UniProtKB
    7. regulation of synapse organization Source: UniProtKB
    8. response to wounding Source: UniProtKB
    9. synapse organization Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.118. 3474.

    Protein family/group databases

    MEROPSiS01.244.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-8 (EC:3.4.21.118)
    Short name:
    mK8
    Alternative name(s):
    Neuropsin
    Short name:
    NP
    Serine protease 19
    Gene namesi
    Name:Klk8
    Synonyms:Nrpn, Prss19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1343327. Klk8.

    Subcellular locationi

    Secreted. Cytoplasm
    Note: Shows a cytoplasmic distribution in the keratinocytes.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice display marked abnormalities of synapses and neurons in the CA1 subfield of the hippocampus with enlarged and elongated pyramidal cell soma and reduced asymmetrical synapse numbers. Mutants also display impaired spatial memory acquisition, increased hippocampal susceptibility to hyperexcitability in response to repetitive afferent stimulation and prolonged recovery of UV-irradiated skin. Following spinal cord injury, mutants display reduced demyelination, oligodendrocyte death and axonal degeneration, and inproved hind limb recovery, suggesting that attenuation of neuropsin activity may be beneficial in the treatment of spinal cord injury. Blocking of Klk8 activity by intraventricular injection with monoclonal antibodies reduces or eliminates epileptic seizures in kindled mice.7 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Propeptidei29 – 3241 PublicationPRO_0000027948
    Chaini33 – 260228Kallikrein-8PRO_0000027949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi39 ↔ 173
    Disulfide bondi58 ↔ 74
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 246
    Disulfide bondi152 ↔ 218
    Disulfide bondi184 ↔ 198
    Disulfide bondi208 ↔ 233

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ61955.
    PRIDEiQ61955.

    PTM databases

    PhosphoSiteiQ61955.

    Expressioni

    Tissue specificityi

    Expressed in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Also detected in spinal cord gray matter and in keratinized stratified epithelia of epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus and forestomach. In skin and mucus membranes, expressed in stratum spinosum and stratum granulosum. Expressed during estrus in vaginal epithelial cells but not stromal cells. Within the vaginal epithelium, expressed in prickle cells, granular cells and parakeratotic cells but not in basal cells. Not expressed in uterus. Expressed in the keratinocytes.7 Publications

    Developmental stagei

    Expression is detected in the brain from embryonic day 12 and continues into adulthood.1 Publication

    Inductioni

    By chemical/incision-induced brain injury which leads to increased expression in axon fiber bundles of the peri-lesioned region, by electrically-induced seizure (kindling) in brain, by UV irradiation in skin and by incisional and chemically-induced skin wounding which causes epidermal proliferation and hyperkeratosis. Induced by chemically-induced oxidative stress which leads to increased expression in the hippocampal pyramidal neurons 2 hours after treatment. Levels then decrease, drop to 60% of pretreated control levels at day 7 when avoidance learning is impaired and return to control levels at day 30. Also induced by spinal crush injury which leads to increased expression in spinal cord white matter adjacent to the lesion. Expression increases between days 1-14 post-injury with a peak at day 4.8 Publications

    Gene expression databases

    BgeeiQ61955.
    CleanExiMM_KLK8.
    GenevestigatoriQ61955.

    Interactioni

    Subunit structurei

    Interacts with SPINK9.By similarity

    Protein-protein interaction databases

    BioGridi234416. 1 interaction.
    STRINGi10090.ENSMUSP00000082588.

    Structurei

    Secondary structure

    1
    260
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi47 – 526
    Beta strandi55 – 6410
    Beta strandi67 – 704
    Helixi72 – 743
    Beta strandi80 – 845
    Beta strandi96 – 983
    Beta strandi100 – 1056
    Beta strandi122 – 1287
    Beta strandi133 – 1364
    Beta strandi151 – 1588
    Beta strandi160 – 1645
    Beta strandi172 – 1787
    Helixi181 – 1877
    Turni189 – 1913
    Beta strandi196 – 2005
    Beta strandi215 – 2184
    Beta strandi221 – 2288
    Beta strandi231 – 2333
    Beta strandi240 – 2445
    Helixi245 – 25612

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NPMX-ray2.10A/B33-257[»]
    ProteinModelPortaliQ61955.
    SMRiQ61955. Positions 33-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ61955.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 257225Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117409.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ61955.
    KOiK08650.
    OMAiTKLYAEN.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ61955.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRPPPCAIQ PWILLLLFMG AWAGLTRAQG SKILEGRECI PHSQPWQAAL    50
    FQGERLICGG VLVGDRWVLT AAHCKKQKYS VRLGDHSLQS RDQPEQEIQV 100
    AQSIQHPCYN NSNPEDHSHD IMLIRLQNSA NLGDKVKPVQ LANLCPKVGQ 150
    KCIISGWGTV TSPQENFPNT LNCAEVKIYS QNKCERAYPG KITEGMVCAG 200
    SSNGADTCQG DSGGPLVCDG MLQGITSWGS DPCGKPEKPG VYTKICRYTT 250
    WIKKTMDNRD 260
    Length:260
    Mass (Da):28,524
    Last modified:November 1, 1996 - v1
    Checksum:iBE5F6F6BE37CD60E
    GO

    Mass spectrometryi

    Molecular mass is 26613 Da from positions 29 - 260. Determined by MALDI. 1 Publication
    Molecular mass is 26229 Da from positions 33 - 260. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30785 mRNA. Translation: BAA06451.1.
    AB032202 Genomic DNA. Translation: BAA92435.1.
    BC055895 mRNA. Translation: AAH55895.1.
    AB074296 mRNA. Translation: BAB92021.1.
    CCDSiCCDS21182.1.
    PIRiI56559.
    RefSeqiNP_032966.1. NM_008940.2.
    XP_006540971.1. XM_006540908.1.
    UniGeneiMm.458023.

    Genome annotation databases

    EnsembliENSMUST00000085461; ENSMUSP00000082588; ENSMUSG00000064023.
    GeneIDi259277.
    KEGGimmu:259277.
    UCSCiuc009gns.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30785 mRNA. Translation: BAA06451.1 .
    AB032202 Genomic DNA. Translation: BAA92435.1 .
    BC055895 mRNA. Translation: AAH55895.1 .
    AB074296 mRNA. Translation: BAB92021.1 .
    CCDSi CCDS21182.1.
    PIRi I56559.
    RefSeqi NP_032966.1. NM_008940.2.
    XP_006540971.1. XM_006540908.1.
    UniGenei Mm.458023.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NPM X-ray 2.10 A/B 33-257 [» ]
    ProteinModelPortali Q61955.
    SMRi Q61955. Positions 33-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234416. 1 interaction.
    STRINGi 10090.ENSMUSP00000082588.

    Protein family/group databases

    MEROPSi S01.244.

    PTM databases

    PhosphoSitei Q61955.

    Proteomic databases

    PaxDbi Q61955.
    PRIDEi Q61955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085461 ; ENSMUSP00000082588 ; ENSMUSG00000064023 .
    GeneIDi 259277.
    KEGGi mmu:259277.
    UCSCi uc009gns.1. mouse.

    Organism-specific databases

    CTDi 11202.
    MGIi MGI:1343327. Klk8.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117409.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q61955.
    KOi K08650.
    OMAi TKLYAEN.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q61955.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.118. 3474.

    Miscellaneous databases

    EvolutionaryTracei Q61955.
    NextBioi 392031.
    PROi Q61955.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61955.
    CleanExi MM_KLK8.
    Genevestigatori Q61955.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus."
      Chen Z.-L., Yoshida S., Kato K., Momota Y., Suzuki J., Tanaka T., Ito J., Nishino H., Aimoto S., Kiyama H., Shiosaka S.
      J. Neurosci. 15:5088-5097(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Hippocampus.
    2. "Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization."
      Yoshida S., Hirata A., Inoue N., Shiosaka S.
      Cytogenet. Cell Genet. 88:97-98(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    4. "Characterization of recombinant and brain neuropsin, a plasticity-related serine protease."
      Shimizu C., Yoshida S., Shibata M., Kato K., Momota Y., Matsumoto K., Shiosaka T., Midorikawa R., Kamachi T., Kawabe A., Shiosaka S.
      J. Biol. Chem. 273:11189-11196(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
      Strain: BALB/c.
      Tissue: Brain.
    5. "Estrogen-independent expression of neuropsin, a serine protease in the vagina of mice exposed neonatally to diethylstilbestrol."
      Katsu Y., Takasu E., Iguchi T.
      Mol. Cell. Endocrinol. 195:99-107(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-260, TISSUE SPECIFICITY.
      Strain: C57BL/6.
    6. "Ontogeny of neuropsin mRNA expression in the mouse brain."
      Suzuki J., Yoshida S., Chen Z.-L., Momota Y., Kato K., Hirata A., Shiosaka S.
      Neurosci. Res. 23:345-351(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    7. Cited for: INDUCTION.
    8. "Effects of oxidative stress on the expression of limbic-specific protease neuropsin and avoidance learning in mice."
      Akita H., Matsuyama T., Iso H., Sugita M., Yoshida S.
      Brain Res. 769:86-96(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy."
      Momota Y., Yoshida S., Ito J., Shibata M., Kato K., Sakurai K., Matsumoto K., Shiosaka S.
      Eur. J. Neurosci. 10:760-764(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    10. "Expression of neuropsin in the keratinizing epithelial tissue - immunohistochemical analysis of wild-type and nude mice."
      Inoue N., Kuwae K., Ishida-Yamamoto A., Iizuka H., Shibata M., Yoshida S., Kato K., Shiosaka S.
      J. Invest. Dermatol. 110:923-931(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin."
      Kitayoshi H., Inoue N., Kuwae K., Chen Z.-L., Sato H., Ohta T., Hosokawa K., Itami S., Yoshikawa K., Yoshida S., Shiosaka S.
      Arch. Dermatol. Res. 291:333-338(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    12. "Injury induces neuropsin mRNA in the central nervous system."
      Tomizawa K., He X.-P., Yamanaka H., Shiosaka S., Yoshida S.
      Brain Res. 824:308-311(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    13. "Neuropsin regulates an early phase of Schaffer-collateral long-term potentiation in the murine hippocampus."
      Komai S., Matsuyama T., Matsumoto K., Kato K., Kobayashi M., Imamura K., Yoshida S., Ugawa S., Shiosaka S.
      Eur. J. Neurosci. 12:1479-1486(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity."
      Davies B., Kearns I.R., Ure J., Davies C.H., Lathe R.
      J. Neurosci. 21:6993-7000(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    15. Cited for: DISRUPTION PHENOTYPE.
    16. "Expression of neuropsin in oligodendrocytes after injury to the CNS."
      He X.-P., Shiosaka S., Yoshida S.
      Neurosci. Res. 39:455-462(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    17. "Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture."
      Oka T., Akisada M., Okabe A., Sakurai K., Shiosaka S., Kato K.
      Neurosci. Lett. 321:141-144(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    18. "Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice."
      Kirihara T., Matsumoto-Miyai K., Nakamura Y., Sadayama T., Yoshida S., Shiosaka S.
      Br. J. Dermatol. 149:700-706(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, DISRUPTION PHENOTYPE.
    19. "NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin."
      Matsumoto-Miyai K., Ninomiya A., Yamasaki H., Tamura H., Nakamura Y., Shiosaka S.
      J. Neurosci. 23:7727-7736(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons."
      Nakamura Y., Tamura H., Horinouchi K., Shiosaka S.
      J. Cell Sci. 119:1341-1349(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    21. "Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo."
      Tamura H., Ishikawa Y., Hino N., Maeda M., Yoshida S., Kaku S., Shiosaka S.
      J. Physiol. (Lond.) 570:541-551(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    22. "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
      Scott F.L., Sun J., Whisstock J.C., Kato K., Bird P.I.
      J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    23. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    24. "Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury."
      Terayama R., Bando Y., Murakami K., Kato K., Kishibe M., Yoshida S.
      Neuroscience 148:175-187(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
    25. "Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis."
      Kishi T., Kato M., Shimizu T., Kato K., Matsumoto K., Yoshida S., Shiosaka S., Hakoshima T.
      J. Biol. Chem. 274:4220-4224(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-257.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiKLK8_MOUSE
    AccessioniPrimary (citable) accession number: Q61955
    Secondary accession number(s): Q8K5D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3