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Q61923

- KCNA6_MOUSE

UniProt

Q61923 - KCNA6_MOUSE

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Protein

Potassium voltage-gated channel subfamily A member 6

Gene

Kcna6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
MK1.6
Voltage-gated potassium channel subunit Kv1.6
Gene namesi
Name:Kcna6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96663. Kcna6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei175 – 19319Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei263 – 28422Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei296 – 31621Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei340 – 36021Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei376 – 39621Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei437 – 45721Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Potassium voltage-gated channel subfamily A member 6PRO_0000053991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Lipidationi285 – 2851S-palmitoyl cysteineSequence Analysis
Modified residuei511 – 5111Phosphoserine; by PKACurated

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ61923.
PaxDbiQ61923.
PRIDEiQ61923.

PTM databases

PhosphoSiteiQ61923.

Expressioni

Gene expression databases

BgeeiQ61923.
GenevestigatoriQ61923.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036872.

Structurei

3D structure databases

ProteinModelPortaliQ61923.
SMRiQ61923. Positions 41-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi422 – 4276Selectivity filterBy similarity
Motifi527 – 5293PDZ-bindingSequence Analysis

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ61923.
KOiK04879.
OMAiDDSYTFH.
OrthoDBiEOG7M0NRD.
PhylomeDBiQ61923.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61923-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL
60 70 80 90 100
RFETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY
110 120 130 140 150
QSGGRLRRPV NVPLDIFMEE IRFYQLGEEA LAAFREDEGC LPEGGEDEKP
160 170 180 190 200
LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR
210 220 230 240 250
ADGRGGSNEG SGTRLSPASR SHEEEDEDED SYAFPGSIPS GGLGTGGTSS
260 270 280 290 300
LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKAA FFRNIMNIID
310 320 330 340 350
LVAIFPYFIT LGTELVQRHE QQSVSGGSGQ NGQQAMSLAI LRVIRLVRVF
360 370 380 390 400
RIFKLSRHSK GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD
410 420 430 440 450
DVDSLFPSIP DAFWWAVVTM TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI
460 470 480 490 500
ALPVPVIVSN FNYFYHRETE QEEQGQYTHV TCGQPTPDLK ATDNGLGKPD
510 520
FAEASRERRP SYLPTPHRAY AEKRMLTEV
Length:529
Mass (Da):58,674
Last modified:November 1, 1996 - v1
Checksum:i336D78C069ABEADD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96688 mRNA. Translation: AAA39772.1.
BC048782 mRNA. Translation: AAH48782.1.
BC054804 mRNA. Translation: AAH54804.1.
CCDSiCCDS20556.1.
PIRiS09043.
RefSeqiNP_038596.1. NM_013568.6.
XP_006505701.1. XM_006505638.1.
XP_006505702.1. XM_006505639.1.
UniGeneiMm.62535.

Genome annotation databases

EnsembliENSMUST00000040751; ENSMUSP00000036872; ENSMUSG00000038077.
ENSMUST00000112242; ENSMUSP00000107861; ENSMUSG00000038077.
ENSMUST00000185333; ENSMUSP00000139481; ENSMUSG00000038077.
GeneIDi16494.
KEGGimmu:16494.
UCSCiuc009dvd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96688 mRNA. Translation: AAA39772.1 .
BC048782 mRNA. Translation: AAH48782.1 .
BC054804 mRNA. Translation: AAH54804.1 .
CCDSi CCDS20556.1.
PIRi S09043.
RefSeqi NP_038596.1. NM_013568.6.
XP_006505701.1. XM_006505638.1.
XP_006505702.1. XM_006505639.1.
UniGenei Mm.62535.

3D structure databases

ProteinModelPortali Q61923.
SMRi Q61923. Positions 41-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000036872.

PTM databases

PhosphoSitei Q61923.

Proteomic databases

MaxQBi Q61923.
PaxDbi Q61923.
PRIDEi Q61923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040751 ; ENSMUSP00000036872 ; ENSMUSG00000038077 .
ENSMUST00000112242 ; ENSMUSP00000107861 ; ENSMUSG00000038077 .
ENSMUST00000185333 ; ENSMUSP00000139481 ; ENSMUSG00000038077 .
GeneIDi 16494.
KEGGi mmu:16494.
UCSCi uc009dvd.2. mouse.

Organism-specific databases

CTDi 3742.
MGIi MGI:96663. Kcna6.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi Q61923.
KOi K04879.
OMAi DDSYTFH.
OrthoDBi EOG7M0NRD.
PhylomeDBi Q61923.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289803.
PROi Q61923.
SOURCEi Search...

Gene expression databases

Bgeei Q61923.
Genevestigatori Q61923.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequence and chromosomal localization of MK1.6, a murine potassium channel gene."
    Migeon M.B., Street V.A., Demas V.P., Tempel B.L.
    Epilepsy Res. Suppl. 9:173-180(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiKCNA6_MOUSE
AccessioniPrimary (citable) accession number: Q61923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3