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Protein

Potassium voltage-gated channel subfamily A member 6

Gene

Kcna6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (By similarity). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
MK1.6
Voltage-gated potassium channel subunit Kv1.6
Gene namesi
Name:Kcna6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96663. Kcna6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 171CytoplasmicBy similarityAdd BLAST171
Transmembranei172 – 193Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini194 – 262ExtracellularBy similarityAdd BLAST69
Transmembranei263 – 284Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini285 – 295CytoplasmicBy similarityAdd BLAST11
Transmembranei296 – 316Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini317 – 337ExtracellularBy similarityAdd BLAST21
Transmembranei338 – 358Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini359 – 373CytoplasmicBy similarityAdd BLAST15
Transmembranei374 – 395Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini396 – 409ExtracellularBy similarityAdd BLAST14
Intramembranei410 – 421Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei422 – 429By similarity8
Topological domaini430 – 436ExtracellularBy similarity7
Transmembranei437 – 465Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini466 – 529CytoplasmicBy similarityAdd BLAST64

GO - Cellular componenti

  • axon Source: UniProtKB
  • axon terminus Source: UniProtKB
  • integral component of membrane Source: GO_Central
  • integral component of plasma membrane Source: UniProtKB
  • potassium channel complex Source: UniProtKB
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539911 – 529Potassium voltage-gated channel subfamily A member 6Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1
Lipidationi285S-palmitoyl cysteineSequence analysis1
Modified residuei511Phosphoserine; by PKACurated1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ61923.
PaxDbiQ61923.
PeptideAtlasiQ61923.
PRIDEiQ61923.

PTM databases

iPTMnetiQ61923.
PhosphoSitePlusiQ61923.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038077.
GenevisibleiQ61923. MM.

Interactioni

Subunit structurei

Homotetramer and heterotetramer of potassium channel proteins (Probable). Interacts with KCNAB1 and KCNAB2 (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036872.

Structurei

3D structure databases

ProteinModelPortaliQ61923.
SMRiQ61923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni360 – 373S4-S5 linkerBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi422 – 427Selectivity filterBy similarity6
Motifi527 – 529PDZ-bindingSequence analysis3

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ61923.
KOiK04879.
OMAiGKPEFSE.
OrthoDBiEOG091G10NU.
PhylomeDBiQ61923.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL
60 70 80 90 100
RFETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY
110 120 130 140 150
QSGGRLRRPV NVPLDIFMEE IRFYQLGEEA LAAFREDEGC LPEGGEDEKP
160 170 180 190 200
LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR
210 220 230 240 250
ADGRGGSNEG SGTRLSPASR SHEEEDEDED SYAFPGSIPS GGLGTGGTSS
260 270 280 290 300
LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKAA FFRNIMNIID
310 320 330 340 350
LVAIFPYFIT LGTELVQRHE QQSVSGGSGQ NGQQAMSLAI LRVIRLVRVF
360 370 380 390 400
RIFKLSRHSK GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD
410 420 430 440 450
DVDSLFPSIP DAFWWAVVTM TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI
460 470 480 490 500
ALPVPVIVSN FNYFYHRETE QEEQGQYTHV TCGQPTPDLK ATDNGLGKPD
510 520
FAEASRERRP SYLPTPHRAY AEKRMLTEV
Length:529
Mass (Da):58,674
Last modified:November 1, 1996 - v1
Checksum:i336D78C069ABEADD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96688 mRNA. Translation: AAA39772.1.
BC048782 mRNA. Translation: AAH48782.1.
BC054804 mRNA. Translation: AAH54804.1.
CCDSiCCDS20556.1.
PIRiS09043.
RefSeqiNP_038596.1. NM_013568.6.
XP_006505701.1. XM_006505638.3.
XP_006505702.1. XM_006505639.3.
XP_011239530.1. XM_011241228.2.
UniGeneiMm.62535.

Genome annotation databases

EnsembliENSMUST00000040751; ENSMUSP00000036872; ENSMUSG00000038077.
ENSMUST00000112242; ENSMUSP00000107861; ENSMUSG00000038077.
ENSMUST00000185333; ENSMUSP00000139481; ENSMUSG00000038077.
GeneIDi16494.
KEGGimmu:16494.
UCSCiuc009dvd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96688 mRNA. Translation: AAA39772.1.
BC048782 mRNA. Translation: AAH48782.1.
BC054804 mRNA. Translation: AAH54804.1.
CCDSiCCDS20556.1.
PIRiS09043.
RefSeqiNP_038596.1. NM_013568.6.
XP_006505701.1. XM_006505638.3.
XP_006505702.1. XM_006505639.3.
XP_011239530.1. XM_011241228.2.
UniGeneiMm.62535.

3D structure databases

ProteinModelPortaliQ61923.
SMRiQ61923.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036872.

PTM databases

iPTMnetiQ61923.
PhosphoSitePlusiQ61923.

Proteomic databases

MaxQBiQ61923.
PaxDbiQ61923.
PeptideAtlasiQ61923.
PRIDEiQ61923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040751; ENSMUSP00000036872; ENSMUSG00000038077.
ENSMUST00000112242; ENSMUSP00000107861; ENSMUSG00000038077.
ENSMUST00000185333; ENSMUSP00000139481; ENSMUSG00000038077.
GeneIDi16494.
KEGGimmu:16494.
UCSCiuc009dvd.2. mouse.

Organism-specific databases

CTDi3742.
MGIiMGI:96663. Kcna6.

Phylogenomic databases

eggNOGiKOG1545. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ61923.
KOiK04879.
OMAiGKPEFSE.
OrthoDBiEOG091G10NU.
PhylomeDBiQ61923.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ61923.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038077.
GenevisibleiQ61923. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNA6_MOUSE
AccessioniPrimary (citable) accession number: Q61923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.