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Q61923

- KCNA6_MOUSE

UniProt

Q61923 - KCNA6_MOUSE

Protein

Potassium voltage-gated channel subfamily A member 6

Gene

Kcna6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 6
    Alternative name(s):
    MK1.6
    Voltage-gated potassium channel subunit Kv1.6
    Gene namesi
    Name:Kcna6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96663. Kcna6.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Potassium voltage-gated channel subfamily A member 6PRO_0000053991Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Lipidationi285 – 2851S-palmitoyl cysteineSequence Analysis
    Modified residuei511 – 5111Phosphoserine; by PKACurated

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiQ61923.
    PRIDEiQ61923.

    PTM databases

    PhosphoSiteiQ61923.

    Expressioni

    Gene expression databases

    BgeeiQ61923.
    GenevestigatoriQ61923.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000036872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61923.
    SMRiQ61923. Positions 41-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei175 – 19319Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28422Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi422 – 4276Selectivity filterBy similarity
    Motifi527 – 5293PDZ-bindingSequence Analysis

    Domaini

    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115256.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    InParanoidiQ61923.
    KOiK04879.
    OMAiDDSYTFH.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiQ61923.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004053. K_chnl_volt-dep_Kv1.6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01513. KV16CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q61923-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL    50
    RFETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY 100
    QSGGRLRRPV NVPLDIFMEE IRFYQLGEEA LAAFREDEGC LPEGGEDEKP 150
    LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR 200
    ADGRGGSNEG SGTRLSPASR SHEEEDEDED SYAFPGSIPS GGLGTGGTSS 250
    LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKAA FFRNIMNIID 300
    LVAIFPYFIT LGTELVQRHE QQSVSGGSGQ NGQQAMSLAI LRVIRLVRVF 350
    RIFKLSRHSK GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD 400
    DVDSLFPSIP DAFWWAVVTM TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI 450
    ALPVPVIVSN FNYFYHRETE QEEQGQYTHV TCGQPTPDLK ATDNGLGKPD 500
    FAEASRERRP SYLPTPHRAY AEKRMLTEV 529
    Length:529
    Mass (Da):58,674
    Last modified:November 1, 1996 - v1
    Checksum:i336D78C069ABEADD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96688 mRNA. Translation: AAA39772.1.
    BC048782 mRNA. Translation: AAH48782.1.
    BC054804 mRNA. Translation: AAH54804.1.
    CCDSiCCDS20556.1.
    PIRiS09043.
    RefSeqiNP_038596.1. NM_013568.6.
    XP_006505701.1. XM_006505638.1.
    XP_006505702.1. XM_006505639.1.
    UniGeneiMm.62535.

    Genome annotation databases

    EnsembliENSMUST00000040751; ENSMUSP00000036872; ENSMUSG00000038077.
    ENSMUST00000112242; ENSMUSP00000107861; ENSMUSG00000038077.
    GeneIDi16494.
    KEGGimmu:16494.
    UCSCiuc009dvd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96688 mRNA. Translation: AAA39772.1 .
    BC048782 mRNA. Translation: AAH48782.1 .
    BC054804 mRNA. Translation: AAH54804.1 .
    CCDSi CCDS20556.1.
    PIRi S09043.
    RefSeqi NP_038596.1. NM_013568.6.
    XP_006505701.1. XM_006505638.1.
    XP_006505702.1. XM_006505639.1.
    UniGenei Mm.62535.

    3D structure databases

    ProteinModelPortali Q61923.
    SMRi Q61923. Positions 41-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000036872.

    PTM databases

    PhosphoSitei Q61923.

    Proteomic databases

    PaxDbi Q61923.
    PRIDEi Q61923.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040751 ; ENSMUSP00000036872 ; ENSMUSG00000038077 .
    ENSMUST00000112242 ; ENSMUSP00000107861 ; ENSMUSG00000038077 .
    GeneIDi 16494.
    KEGGi mmu:16494.
    UCSCi uc009dvd.2. mouse.

    Organism-specific databases

    CTDi 3742.
    MGIi MGI:96663. Kcna6.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115256.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    InParanoidi Q61923.
    KOi K04879.
    OMAi DDSYTFH.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi Q61923.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 289803.
    PROi Q61923.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61923.
    Genevestigatori Q61923.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004053. K_chnl_volt-dep_Kv1.6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01513. KV16CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequence and chromosomal localization of MK1.6, a murine potassium channel gene."
      Migeon M.B., Street V.A., Demas V.P., Tempel B.L.
      Epilepsy Res. Suppl. 9:173-180(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Eye.

    Entry informationi

    Entry nameiKCNA6_MOUSE
    AccessioniPrimary (citable) accession number: Q61923
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3