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Q61923 (KCNA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
MK1.6
Voltage-gated potassium channel subunit Kv1.6
Gene names
Name:Kcna6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Potassium voltage-gated channel subfamily A member 6
PRO_0000053991

Regions

Transmembrane175 – 19319Helical; Name=Segment S1; Potential
Transmembrane263 – 28422Helical; Name=Segment S2; Potential
Transmembrane296 – 31621Helical; Name=Segment S3; Potential
Transmembrane340 – 36021Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane376 – 39621Helical; Name=Segment S5; Potential
Transmembrane437 – 45721Helical; Name=Segment S6; Potential
Motif422 – 4276Selectivity filter By similarity
Motif527 – 5293PDZ-binding Potential

Amino acid modifications

Modified residue81Phosphothreonine Ref.3
Modified residue5111Phosphoserine; by PKA Probable
Lipidation2851S-palmitoyl cysteine Potential
Glycosylation461N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q61923 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 336D78C069ABEADD

FASTA52958,674
        10         20         30         40         50         60 
MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL RFETQLRTLS 

        70         80         90        100        110        120 
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFMEE 

       130        140        150        160        170        180 
IRFYQLGEEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 

       190        200        210        220        230        240 
VLVILISIVI FCLETLPQFR ADGRGGSNEG SGTRLSPASR SHEEEDEDED SYAFPGSIPS 

       250        260        270        280        290        300 
GGLGTGGTSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKAA FFRNIMNIID 

       310        320        330        340        350        360 
LVAIFPYFIT LGTELVQRHE QQSVSGGSGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 

       370        380        390        400        410        420 
GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DVDSLFPSIP DAFWWAVVTM 

       430        440        450        460        470        480 
TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 

       490        500        510        520 
TCGQPTPDLK ATDNGLGKPD FAEASRERRP SYLPTPHRAY AEKRMLTEV

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequence and chromosomal localization of MK1.6, a murine potassium channel gene."
Migeon M.B., Street V.A., Demas V.P., Tempel B.L.
Epilepsy Res. Suppl. 9:173-180(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Eye.
[3]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8, MASS SPECTROMETRY.
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M96688 mRNA. Translation: AAA39772.1.
BC048782 mRNA. Translation: AAH48782.1.
BC054804 mRNA. Translation: AAH54804.1.
IPIIPI00127368.
PIRS09043.
RefSeqNP_038596.1. NM_013568.6.
UniGeneMm.62535.

3D structure databases

ProteinModelPortalQ61923.
SMRQ61923. Positions 41-469.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000036872.

PTM databases

PhosphoSiteQ61923.

Proteomic databases

PaxDbQ61923.
PRIDEQ61923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040751; ENSMUSP00000036872; ENSMUSG00000038077.
ENSMUST00000112242; ENSMUSP00000107861; ENSMUSG00000038077.
GeneID16494.
KEGGmmu:16494.
UCSCuc009dvd.2. mouse.

Organism-specific databases

CTD3742.
MGIMGI:96663. Kcna6.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00560000076957.
HOGENOMHOG000231015.
HOVERGENHBG052230.
InParanoidQ61923.
KOK04879.
OMAGKPEFSE.
OrthoDBEOG43JC4R.

Gene expression databases

BgeeQ61923.
GenevestigatorQ61923.
GermOnlineENSMUSG00000038077. Mus musculus.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR027359. K_channel_four-helix_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio289803.
SOURCESearch...

Entry information

Entry nameKCNA6_MOUSE
AccessionPrimary (citable) accession number: Q61923
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents