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Q61909

- MTG8_MOUSE

UniProt

Q61909 - MTG8_MOUSE

Protein

Protein CBFA2T1

Gene

Runx1t1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri488 – 52437MYND-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. protein homodimerization activity Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. fat cell differentiation Source: MGI
    2. negative regulation of neuron projection development Source: UniProtKB
    3. regulation of DNA binding Source: MGI
    4. regulation of transcription, DNA-templated Source: MGI
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CBFA2T1
    Alternative name(s):
    Protein MTG8
    Gene namesi
    Name:Runx1t1
    Synonyms:Cbfa2t1, Cbfa2t1h, Mtg8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:104793. Runx1t1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation
    Note: Colocalizes with ATN1 in discrete nuclear dots.By similarity

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577Protein CBFA2T1PRO_0000218300Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphoserineBy similarity
    Modified residuei390 – 3901PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ61909.
    PRIDEiQ61909.

    PTM databases

    PhosphoSiteiQ61909.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61909.
    BgeeiQ61909.
    GenevestigatoriQ61909.

    Interactioni

    Subunit structurei

    Homotetramer By similarity. Heterotetramer with CBFA2T2 and CBFA2T3 By similarity. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198520. 7 interactions.
    IntActiQ61909. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61909.
    SMRiQ61909. Positions 92-189, 314-373, 410-440, 478-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 18896TAFHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni310 – 35647Important for oligomerizationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 334Poly-Pro
    Compositional biasi75 – 817Poly-Ser
    Compositional biasi263 – 2708Poly-Pro
    Compositional biasi380 – 3867Poly-Ser

    Domaini

    The TAFH domain mediates interaction with transcription regulators.By similarity

    Sequence similaritiesi

    Belongs to the CBFA2T family.Curated
    Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
    Contains 1 TAFH (NHR1) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri488 – 52437MYND-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG79810.
    GeneTreeiENSGT00390000013479.
    HOGENOMiHOG000049245.
    HOVERGENiHBG000169.
    KOiK10053.

    Family and domain databases

    InterProiIPR013289. ETO.
    IPR013290. MTG8.
    IPR014896. NHR2.
    IPR003894. TAFH_NHR1.
    IPR002893. Znf_MYND.
    [Graphical view]
    PANTHERiPTHR10379:SF5. PTHR10379:SF5. 1 hit.
    PfamiPF08788. NHR2. 1 hit.
    PF07531. TAFH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view]
    PRINTSiPR01875. ETOFAMILY.
    PR01876. MTG8PROTEIN.
    SMARTiSM00549. TAFH. 1 hit.
    [Graphical view]
    PROSITEiPS51119. TAFH. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61909-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDRTEKHST MPDSPVDVKT QSRLTPPAMP PPPTTQGAPR TSSFTPTTLT    50
    NGTSHSPTAL NGAPSPPNGF SNGPSSSSSS SLANQQLPPA CGARQLSKLK 100
    RFLTTLQQFG NDISPEIGER VRTLVLGLVN STLTIEEFHS KLQEATNFPL 150
    RPFVIPFLKA NLPLLQRELL HCARLAKQNP AQYLAQHEQL LLDASTTSPV 200
    DSSELLLDVN ENGKRRTPDR TKENGFDREP LHSEHPSKRP CTISPGQRYS 250
    PNNGLSYQPN GLPHPTPPPP QHYRLDDMAI AHHYRDSYRH PSHRDLRDRN 300
    RPMGLHGTRQ EEMIDHRLTD REWAEEWKHL DHLLNCIMDM VEKTRRSLTV 350
    LRRCQEADRE ELNYWIRRYS DAEDLKKGGS SSSSHSRQQS PVNPDPVALD 400
    AHREFLHRPA SGYVPEEIWK KAEEAVNEVK RQAMTELQKA VSEAERKAHD 450
    MITTERAKME RTVAEAKRQA AEDALAVINQ QEDSSESCWN CGRKASETCS 500
    GCNTARYCGS FCQHKDWEKH HHICGQTLQA PQQGDTPAVS SSVTPSSGAG 550
    SPMDTPPAAT PRSTTPGTPS TIETTPR 577
    Length:577
    Mass (Da):64,338
    Last modified:November 1, 1996 - v1
    Checksum:i2656F185318C4B11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D32007 mRNA. Translation: BAA06774.1.
    CCDSiCCDS17978.1.
    RefSeqiNP_033952.1. NM_009822.3.
    UniGeneiMm.470961.
    Mm.4909.

    Genome annotation databases

    EnsembliENSMUST00000098256; ENSMUSP00000095856; ENSMUSG00000006586.
    GeneIDi12395.
    KEGGimmu:12395.
    UCSCiuc008sax.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D32007 mRNA. Translation: BAA06774.1 .
    CCDSi CCDS17978.1.
    RefSeqi NP_033952.1. NM_009822.3.
    UniGenei Mm.470961.
    Mm.4909.

    3D structure databases

    ProteinModelPortali Q61909.
    SMRi Q61909. Positions 92-189, 314-373, 410-440, 478-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198520. 7 interactions.
    IntActi Q61909. 2 interactions.

    PTM databases

    PhosphoSitei Q61909.

    Proteomic databases

    MaxQBi Q61909.
    PRIDEi Q61909.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098256 ; ENSMUSP00000095856 ; ENSMUSG00000006586 .
    GeneIDi 12395.
    KEGGi mmu:12395.
    UCSCi uc008sax.2. mouse.

    Organism-specific databases

    CTDi 862.
    MGIi MGI:104793. Runx1t1.

    Phylogenomic databases

    eggNOGi NOG79810.
    GeneTreei ENSGT00390000013479.
    HOGENOMi HOG000049245.
    HOVERGENi HBG000169.
    KOi K10053.

    Miscellaneous databases

    NextBioi 281144.
    PROi Q61909.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61909.
    Bgeei Q61909.
    Genevestigatori Q61909.

    Family and domain databases

    InterProi IPR013289. ETO.
    IPR013290. MTG8.
    IPR014896. NHR2.
    IPR003894. TAFH_NHR1.
    IPR002893. Znf_MYND.
    [Graphical view ]
    PANTHERi PTHR10379:SF5. PTHR10379:SF5. 1 hit.
    Pfami PF08788. NHR2. 1 hit.
    PF07531. TAFH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view ]
    PRINTSi PR01875. ETOFAMILY.
    PR01876. MTG8PROTEIN.
    SMARTi SM00549. TAFH. 1 hit.
    [Graphical view ]
    PROSITEi PS51119. TAFH. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia."
      Niwa-Kawakita M., Miyoshi H., Gotoh O., Matsushima Y., Nishimura M., Shisa H., Ohki M.
      Genomics 29:755-759(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.

    Entry informationi

    Entry nameiMTG8_MOUSE
    AccessioniPrimary (citable) accession number: Q61909
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3