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Q61909

- MTG8_MOUSE

UniProt

Q61909 - MTG8_MOUSE

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Protein

Protein CBFA2T1

Gene

Runx1t1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri488 – 52437MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein homodimerization activity Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. fat cell differentiation Source: MGI
  2. negative regulation of neuron projection development Source: UniProtKB
  3. regulation of DNA binding Source: MGI
  4. regulation of transcription, DNA-templated Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T1
Alternative name(s):
Protein MTG8
Gene namesi
Name:Runx1t1
Synonyms:Cbfa2t1, Cbfa2t1h, Mtg8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:104793. Runx1t1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation
Note: Colocalizes with ATN1 in discrete nuclear dots.By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Protein CBFA2T1PRO_0000218300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei390 – 3901PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61909.
PRIDEiQ61909.

PTM databases

PhosphoSiteiQ61909.

Expressioni

Gene expression databases

BgeeiQ61909.
ExpressionAtlasiQ61909. baseline and differential.
GenevestigatoriQ61909.

Interactioni

Subunit structurei

Homotetramer (By similarity). Heterotetramer with CBFA2T2 and CBFA2T3 (By similarity). Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression (By similarity).By similarity

Protein-protein interaction databases

BioGridi198520. 7 interactions.
IntActiQ61909. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61909.
SMRiQ61909. Positions 92-189, 314-373, 410-440, 478-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 18896TAFHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni310 – 35647Important for oligomerizationBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 334Poly-Pro
Compositional biasi75 – 817Poly-Ser
Compositional biasi263 – 2708Poly-Pro
Compositional biasi380 – 3867Poly-Ser

Domaini

The TAFH domain mediates interaction with transcription regulators.By similarity

Sequence similaritiesi

Belongs to the CBFA2T family.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 1 TAFH (NHR1) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri488 – 52437MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG79810.
GeneTreeiENSGT00390000013479.
HOGENOMiHOG000049245.
HOVERGENiHBG000169.
InParanoidiQ61909.
KOiK10053.

Family and domain databases

InterProiIPR013289. ETO.
IPR013290. MTG8.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PANTHERiPTHR10379:SF5. PTHR10379:SF5. 1 hit.
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01876. MTG8PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDRTEKHST MPDSPVDVKT QSRLTPPAMP PPPTTQGAPR TSSFTPTTLT
60 70 80 90 100
NGTSHSPTAL NGAPSPPNGF SNGPSSSSSS SLANQQLPPA CGARQLSKLK
110 120 130 140 150
RFLTTLQQFG NDISPEIGER VRTLVLGLVN STLTIEEFHS KLQEATNFPL
160 170 180 190 200
RPFVIPFLKA NLPLLQRELL HCARLAKQNP AQYLAQHEQL LLDASTTSPV
210 220 230 240 250
DSSELLLDVN ENGKRRTPDR TKENGFDREP LHSEHPSKRP CTISPGQRYS
260 270 280 290 300
PNNGLSYQPN GLPHPTPPPP QHYRLDDMAI AHHYRDSYRH PSHRDLRDRN
310 320 330 340 350
RPMGLHGTRQ EEMIDHRLTD REWAEEWKHL DHLLNCIMDM VEKTRRSLTV
360 370 380 390 400
LRRCQEADRE ELNYWIRRYS DAEDLKKGGS SSSSHSRQQS PVNPDPVALD
410 420 430 440 450
AHREFLHRPA SGYVPEEIWK KAEEAVNEVK RQAMTELQKA VSEAERKAHD
460 470 480 490 500
MITTERAKME RTVAEAKRQA AEDALAVINQ QEDSSESCWN CGRKASETCS
510 520 530 540 550
GCNTARYCGS FCQHKDWEKH HHICGQTLQA PQQGDTPAVS SSVTPSSGAG
560 570
SPMDTPPAAT PRSTTPGTPS TIETTPR
Length:577
Mass (Da):64,338
Last modified:November 1, 1996 - v1
Checksum:i2656F185318C4B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32007 mRNA. Translation: BAA06774.1.
CCDSiCCDS17978.1.
RefSeqiNP_033952.1. NM_009822.3.
UniGeneiMm.470961.
Mm.4909.

Genome annotation databases

EnsembliENSMUST00000098256; ENSMUSP00000095856; ENSMUSG00000006586.
GeneIDi12395.
KEGGimmu:12395.
UCSCiuc008sax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32007 mRNA. Translation: BAA06774.1 .
CCDSi CCDS17978.1.
RefSeqi NP_033952.1. NM_009822.3.
UniGenei Mm.470961.
Mm.4909.

3D structure databases

ProteinModelPortali Q61909.
SMRi Q61909. Positions 92-189, 314-373, 410-440, 478-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198520. 7 interactions.
IntActi Q61909. 2 interactions.

PTM databases

PhosphoSitei Q61909.

Proteomic databases

MaxQBi Q61909.
PRIDEi Q61909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098256 ; ENSMUSP00000095856 ; ENSMUSG00000006586 .
GeneIDi 12395.
KEGGi mmu:12395.
UCSCi uc008sax.2. mouse.

Organism-specific databases

CTDi 862.
MGIi MGI:104793. Runx1t1.

Phylogenomic databases

eggNOGi NOG79810.
GeneTreei ENSGT00390000013479.
HOGENOMi HOG000049245.
HOVERGENi HBG000169.
InParanoidi Q61909.
KOi K10053.

Miscellaneous databases

NextBioi 281144.
PROi Q61909.
SOURCEi Search...

Gene expression databases

Bgeei Q61909.
ExpressionAtlasi Q61909. baseline and differential.
Genevestigatori Q61909.

Family and domain databases

InterProi IPR013289. ETO.
IPR013290. MTG8.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view ]
PANTHERi PTHR10379:SF5. PTHR10379:SF5. 1 hit.
Pfami PF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PRINTSi PR01875. ETOFAMILY.
PR01876. MTG8PROTEIN.
SMARTi SM00549. TAFH. 1 hit.
[Graphical view ]
PROSITEi PS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia."
    Niwa-Kawakita M., Miyoshi H., Gotoh O., Matsushima Y., Nishimura M., Shisa H., Ohki M.
    Genomics 29:755-759(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.

Entry informationi

Entry nameiMTG8_MOUSE
AccessioniPrimary (citable) accession number: Q61909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3