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Q61909 (MTG8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CBFA2T1
Alternative name(s):
Protein MTG8
Gene names
Name:Runx1t1
Synonyms:Cbfa2t1, Cbfa2t1h, Mtg8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12 By similarity.

Subunit structure

Homotetramer By similarity. Heterotetramer with CBFA2T2 and CBFA2T3 By similarity. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression By similarity.

Subcellular location

Nucleus By similarity. Note: Colocalizes with ATN1 in discrete nuclear dots By similarity.

Domain

The TAFH domain mediates interaction with transcription regulators By similarity.

Sequence similarities

Belongs to the CBFA2T family.

Contains 1 MYND-type zinc finger.

Contains 1 TAFH (NHR1) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 577577Protein CBFA2T1
PRO_0000218300

Regions

Domain93 – 18896TAFH
Zinc finger488 – 52437MYND-type
Region310 – 35647Important for oligomerization By similarity
Compositional bias30 – 334Poly-Pro
Compositional bias75 – 817Poly-Ser
Compositional bias263 – 2708Poly-Pro
Compositional bias380 – 3867Poly-Ser

Amino acid modifications

Modified residue141Phosphoserine By similarity
Modified residue3901Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61909 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2656F185318C4B11

FASTA57764,338
        10         20         30         40         50         60 
MPDRTEKHST MPDSPVDVKT QSRLTPPAMP PPPTTQGAPR TSSFTPTTLT NGTSHSPTAL 

        70         80         90        100        110        120 
NGAPSPPNGF SNGPSSSSSS SLANQQLPPA CGARQLSKLK RFLTTLQQFG NDISPEIGER 

       130        140        150        160        170        180 
VRTLVLGLVN STLTIEEFHS KLQEATNFPL RPFVIPFLKA NLPLLQRELL HCARLAKQNP 

       190        200        210        220        230        240 
AQYLAQHEQL LLDASTTSPV DSSELLLDVN ENGKRRTPDR TKENGFDREP LHSEHPSKRP 

       250        260        270        280        290        300 
CTISPGQRYS PNNGLSYQPN GLPHPTPPPP QHYRLDDMAI AHHYRDSYRH PSHRDLRDRN 

       310        320        330        340        350        360 
RPMGLHGTRQ EEMIDHRLTD REWAEEWKHL DHLLNCIMDM VEKTRRSLTV LRRCQEADRE 

       370        380        390        400        410        420 
ELNYWIRRYS DAEDLKKGGS SSSSHSRQQS PVNPDPVALD AHREFLHRPA SGYVPEEIWK 

       430        440        450        460        470        480 
KAEEAVNEVK RQAMTELQKA VSEAERKAHD MITTERAKME RTVAEAKRQA AEDALAVINQ 

       490        500        510        520        530        540 
QEDSSESCWN CGRKASETCS GCNTARYCGS FCQHKDWEKH HHICGQTLQA PQQGDTPAVS 

       550        560        570 
SSVTPSSGAG SPMDTPPAAT PRSTTPGTPS TIETTPR 

« Hide

References

[1]"Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia."
Niwa-Kawakita M., Miyoshi H., Gotoh O., Matsushima Y., Nishimura M., Shisa H., Ohki M.
Genomics 29:755-759(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D32007 mRNA. Translation: BAA06774.1.
RefSeqNP_033952.1. NM_009822.3.
UniGeneMm.470961.
Mm.4909.

3D structure databases

ProteinModelPortalQ61909.
SMRQ61909. Positions 92-189, 314-373, 410-440, 478-524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198520. 7 interactions.
IntActQ61909. 2 interactions.

PTM databases

PhosphoSiteQ61909.

Proteomic databases

PRIDEQ61909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098256; ENSMUSP00000095856; ENSMUSG00000006586.
GeneID12395.
KEGGmmu:12395.
UCSCuc008sax.2. mouse.

Organism-specific databases

CTD862.
MGIMGI:104793. Runx1t1.

Phylogenomic databases

eggNOGNOG79810.
GeneTreeENSGT00390000013479.
HOGENOMHOG000049245.
HOVERGENHBG000169.
KOK10053.

Gene expression databases

ArrayExpressQ61909.
BgeeQ61909.
GenevestigatorQ61909.

Family and domain databases

InterProIPR013289. ETO.
IPR013290. MTG8.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PANTHERPTHR10379:SF5. PTHR10379:SF5. 1 hit.
PfamPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSPR01875. ETOFAMILY.
PR01876. MTG8PROTEIN.
SMARTSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281144.
PROQ61909.
SOURCESearch...

Entry information

Entry nameMTG8_MOUSE
AccessionPrimary (citable) accession number: Q61909
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot