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Protein

Keratin, type I cuticular Ha3-II

Gene

Krt33b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3
Keratin, type I cuticular Ha3
Keratin-33B
Short name:
K33B
Gene namesi
Name:Krt33b
Synonyms:Hka3, Krt1-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1309991. Krt33b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636901 – 404Keratin, type I cuticular Ha3-IIAdd BLAST404

Proteomic databases

MaxQBiQ61897.
PaxDbiQ61897.
PeptideAtlasiQ61897.
PRIDEiQ61897.

PTM databases

PhosphoSitePlusiQ61897.

Expressioni

Tissue specificityi

Expressed strongly in cortex cells in newborn back skin and in the central unit of the lingual filiform papillae.1 Publication

Gene expression databases

BgeeiENSMUSG00000057723.
CleanExiMM_KRT33B.
GenevisibleiQ61897. MM.

Interactioni

Protein-protein interaction databases

BioGridi201026. 1 interactor.
STRINGi10090.ENSMUSP00000073552.

Structurei

3D structure databases

ProteinModelPortaliQ61897.
SMRiQ61897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 363RodAdd BLAST307
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 48Cys-richAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61897.
KOiK07604.
OMAiVEINRRE.
OrthoDBiEOG091G087I.
PhylomeDBiQ61897.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNERETM QFLNDRLASY MEKVRQLERE NAELECKIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCG KSENGRLVVQ IDNAKLAADD FRTKYESELS
160 170 180 190 200
LRQLVESDLN GLRRILDELT LCKSDLEAQV ESLRQELLCL KQNHEEEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH SMRNSLENTL
310 320 330 340 350
AESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVTNPC VTRSRCGPCN

SFGC
Length:404
Mass (Da):45,864
Last modified:March 3, 2009 - v2
Checksum:i0734BC6D69D820BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87K → R in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti120G → S in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti125G → A in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti132D → E in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti153 – 154QL → HV in CAA53305 (PubMed:7514534).Curated2
Sequence conflicti204Q → R in CAA53305 (PubMed:7514534).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592545 Genomic DNA. Translation: CAM22479.1.
CH466662 Genomic DNA. Translation: EDL02591.1.
X75650 mRNA. Translation: CAA53305.1.
CCDSiCCDS48928.1.
PIRiI48667.
RefSeqiNP_038598.1. NM_013570.1.
UniGeneiMm.439738.

Genome annotation databases

EnsembliENSMUST00000073890; ENSMUSP00000073552; ENSMUSG00000057723.
GeneIDi16671.
KEGGimmu:16671.
UCSCiuc007lkb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592545 Genomic DNA. Translation: CAM22479.1.
CH466662 Genomic DNA. Translation: EDL02591.1.
X75650 mRNA. Translation: CAA53305.1.
CCDSiCCDS48928.1.
PIRiI48667.
RefSeqiNP_038598.1. NM_013570.1.
UniGeneiMm.439738.

3D structure databases

ProteinModelPortaliQ61897.
SMRiQ61897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201026. 1 interactor.
STRINGi10090.ENSMUSP00000073552.

PTM databases

PhosphoSitePlusiQ61897.

Proteomic databases

MaxQBiQ61897.
PaxDbiQ61897.
PeptideAtlasiQ61897.
PRIDEiQ61897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073890; ENSMUSP00000073552; ENSMUSG00000057723.
GeneIDi16671.
KEGGimmu:16671.
UCSCiuc007lkb.2. mouse.

Organism-specific databases

CTDi3884.
MGIiMGI:1309991. Krt33b.

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61897.
KOiK07604.
OMAiVEINRRE.
OrthoDBiEOG091G087I.
PhylomeDBiQ61897.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiKrt33b. mouse.
PROiQ61897.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057723.
CleanExiMM_KRT33B.
GenevisibleiQ61897. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKT33B_MOUSE
AccessioniPrimary (citable) accession number: Q61897
Secondary accession number(s): A2A5X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.