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Protein

Keratin, type I cuticular Ha3-II

Gene

Krt33b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3
Keratin, type I cuticular Ha3
Keratin-33B
Short name:
K33B
Gene namesi
Name:Krt33b
Synonyms:Hka3, Krt1-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1309991 Krt33b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636901 – 404Keratin, type I cuticular Ha3-IIAdd BLAST404

Proteomic databases

MaxQBiQ61897
PaxDbiQ61897
PeptideAtlasiQ61897
PRIDEiQ61897

PTM databases

PhosphoSitePlusiQ61897

Expressioni

Tissue specificityi

Expressed strongly in cortex cells in newborn back skin and in the central unit of the lingual filiform papillae.1 Publication

Gene expression databases

BgeeiENSMUSG00000057723
CleanExiMM_KRT33B
GenevisibleiQ61897 MM

Interactioni

Protein-protein interaction databases

BioGridi201026, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ61897
SMRiQ61897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 48Cys-richAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ61897
KOiK07604
OMAiQCEINTY
OrthoDBiEOG091G087I
PhylomeDBiQ61897
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNERETM QFLNDRLASY MEKVRQLERE NAELECKIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCG KSENGRLVVQ IDNAKLAADD FRTKYESELS
160 170 180 190 200
LRQLVESDLN GLRRILDELT LCKSDLEAQV ESLRQELLCL KQNHEEEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH SMRNSLENTL
310 320 330 340 350
AESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVTNPC VTRSRCGPCN

SFGC
Length:404
Mass (Da):45,864
Last modified:March 3, 2009 - v2
Checksum:i0734BC6D69D820BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87K → R in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti120G → S in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti125G → A in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti132D → E in CAA53305 (PubMed:7514534).Curated1
Sequence conflicti153 – 154QL → HV in CAA53305 (PubMed:7514534).Curated2
Sequence conflicti204Q → R in CAA53305 (PubMed:7514534).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592545 Genomic DNA Translation: CAM22479.1
CH466662 Genomic DNA Translation: EDL02591.1
X75650 mRNA Translation: CAA53305.1
CCDSiCCDS48928.1
PIRiI48667
RefSeqiNP_038598.1, NM_013570.1
UniGeneiMm.439738

Genome annotation databases

EnsembliENSMUST00000073890; ENSMUSP00000073552; ENSMUSG00000057723
GeneIDi16671
KEGGimmu:16671
UCSCiuc007lkb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKT33B_MOUSE
AccessioniPrimary (citable) accession number: Q61897
Secondary accession number(s): A2A5X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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