Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cuticular Ha3-II

Gene

Krt33b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3
Keratin, type I cuticular Ha3
Keratin-33B
Short name:
K33B
Gene namesi
Name:Krt33b
Synonyms:Hka3, Krt1-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1309991. Krt33b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-IIPRO_0000063690Add
BLAST

Proteomic databases

MaxQBiQ61897.
PaxDbiQ61897.
PRIDEiQ61897.

PTM databases

PhosphoSiteiQ61897.

Expressioni

Tissue specificityi

Expressed strongly in cortex cells in newborn back skin and in the central unit of the lingual filiform papillae.1 Publication

Gene expression databases

BgeeiQ61897.
CleanExiMM_KRT33B.
GenevisibleiQ61897. MM.

Interactioni

Protein-protein interaction databases

BioGridi201026. 1 interaction.
STRINGi10090.ENSMUSP00000073552.

Structurei

3D structure databases

ProteinModelPortaliQ61897.
SMRiQ61897. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656HeadAdd
BLAST
Regioni57 – 363307RodAdd
BLAST
Regioni57 – 9135Coil 1AAdd
BLAST
Regioni92 – 10211Linker 1Add
BLAST
Regioni103 – 203101Coil 1BAdd
BLAST
Regioni204 – 21916Linker 12Add
BLAST
Regioni220 – 363144Coil 2Add
BLAST
Regioni364 – 40441TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 4844Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61897.
KOiK07604.
OMAiVEINRRE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ61897.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNERETM QFLNDRLASY MEKVRQLERE NAELECKIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCG KSENGRLVVQ IDNAKLAADD FRTKYESELS
160 170 180 190 200
LRQLVESDLN GLRRILDELT LCKSDLEAQV ESLRQELLCL KQNHEEEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH SMRNSLENTL
310 320 330 340 350
AESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVTNPC VTRSRCGPCN

SFGC
Length:404
Mass (Da):45,864
Last modified:March 3, 2009 - v2
Checksum:i0734BC6D69D820BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871K → R in CAA53305 (PubMed:7514534).Curated
Sequence conflicti120 – 1201G → S in CAA53305 (PubMed:7514534).Curated
Sequence conflicti125 – 1251G → A in CAA53305 (PubMed:7514534).Curated
Sequence conflicti132 – 1321D → E in CAA53305 (PubMed:7514534).Curated
Sequence conflicti153 – 1542QL → HV in CAA53305 (PubMed:7514534).Curated
Sequence conflicti204 – 2041Q → R in CAA53305 (PubMed:7514534).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592545 Genomic DNA. Translation: CAM22479.1.
CH466662 Genomic DNA. Translation: EDL02591.1.
X75650 mRNA. Translation: CAA53305.1.
CCDSiCCDS48928.1.
PIRiI48667.
RefSeqiNP_038598.1. NM_013570.1.
UniGeneiMm.439738.

Genome annotation databases

EnsembliENSMUST00000073890; ENSMUSP00000073552; ENSMUSG00000057723.
GeneIDi16671.
KEGGimmu:16671.
UCSCiuc007lkb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592545 Genomic DNA. Translation: CAM22479.1.
CH466662 Genomic DNA. Translation: EDL02591.1.
X75650 mRNA. Translation: CAA53305.1.
CCDSiCCDS48928.1.
PIRiI48667.
RefSeqiNP_038598.1. NM_013570.1.
UniGeneiMm.439738.

3D structure databases

ProteinModelPortaliQ61897.
SMRiQ61897. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201026. 1 interaction.
STRINGi10090.ENSMUSP00000073552.

PTM databases

PhosphoSiteiQ61897.

Proteomic databases

MaxQBiQ61897.
PaxDbiQ61897.
PRIDEiQ61897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073890; ENSMUSP00000073552; ENSMUSG00000057723.
GeneIDi16671.
KEGGimmu:16671.
UCSCiuc007lkb.2. mouse.

Organism-specific databases

CTDi3884.
MGIiMGI:1309991. Krt33b.

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61897.
KOiK07604.
OMAiVEINRRE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ61897.
TreeFamiTF332742.

Miscellaneous databases

ChiTaRSiKrt33b. mouse.
NextBioi290399.
PROiQ61897.
SOURCEiSearch...

Gene expression databases

BgeeiQ61897.
CleanExiMM_KRT33B.
GenevisibleiQ61897. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Sequence and expression of murine type I hair keratins mHa2 and mHa3."
    Winter H., Siry P., Tobiasch E., Schweizer J.
    Exp. Cell Res. 212:190-200(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-404, TISSUE SPECIFICITY.
    Strain: NMRI.
    Tissue: Tail epidermis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiKT33B_MOUSE
AccessioniPrimary (citable) accession number: Q61897
Secondary accession number(s): A2A5X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.