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Q61895

- Q61895_MOUSE

UniProt

Q61895 - Q61895_MOUSE

Protein
Submitted name:

mRNA

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.SAAS annotation

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
    3. defense response to bacterium Source: MGI
    4. immune response Source: InterPro
    5. inner ear development Source: MGI
    6. positive regulation of T cell mediated cytotoxicity Source: MGI

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    mRNAImported
    Gene namesi
    Name:H2-K1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95904. H2-K1.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC ISAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020 PotentialImportedAdd
    BLAST
    Chaini21 – 368348 PotentialImportedPRO_5000143470Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiQ61895.

    Expressioni

    Gene expression databases

    GenevestigatoriQ61895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61895.
    SMRiQ61895. Positions 22-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class I family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG016709.
    InParanoidiQ61895.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61895-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPCMLLLLL AAALAPTQTR AGPHSLRYFE TAVSRPGLGK PRYMEVGYVD    50
    DTEFVRFDSD AENPRYEPRA PWMEQVEPEY WEEQTQIAKG NEQRSRVNLR 100
    TALRYYNQSA GGSHTIQRMS GCDVGSDWRL LRGYEQVAYD GRDYIALNED 150
    LKTWTAADMA ALITKHKWEQ AGAAERRRAY LEGTCVEWLR RYLELGNATL 200
    LRTDSPKAHV THHSRPEDKA TLRCWALGFY PADITLTWQL NGEELTQDME 250
    LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS 300
    TVSNTVIIAV LVVLGAAIVT GAVVAFVMRR RRNTGGKGGD YALAPGSQTS 350
    DLSLPDCKVM VHNPHSLA 368
    Length:368
    Mass (Da):41,326
    Last modified:November 1, 1996 - v1
    Checksum:i8DE9BACB428CD8A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69071 mRNA. Translation: AAA39742.1.
    UniGeneiMm.422886.
    Mm.439675.
    Mm.440940.
    Mm.466882.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69071 mRNA. Translation: AAA39742.1 .
    UniGenei Mm.422886.
    Mm.439675.
    Mm.440940.
    Mm.466882.

    3D structure databases

    ProteinModelPortali Q61895.
    SMRi Q61895. Positions 22-296.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q61895.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95904. H2-K1.

    Phylogenomic databases

    HOVERGENi HBG016709.
    InParanoidi Q61895.

    Miscellaneous databases

    ChiTaRSi H2-K1. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q61895.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural diversity of the classical H-2 genes: K, D, and L."
      Pullen J.K., Horton R.M., Cai Z., Pease L.R.
      J. Immunol. 148:953-967(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10.RIIIImported.
      Tissue: SpleenImported.

    Entry informationi

    Entry nameiQ61895_MOUSE
    AccessioniPrimary (citable) accession number: Q61895
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)