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Protein
Submitted name:

mRNA

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • defense response to bacterium Source: MGI
  • immune response Source: InterPro
  • inner ear development Source: MGI
  • positive regulation of T cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
mRNAImported
Gene namesi
Name:H2-K1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95904. H2-K1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 368348 PotentialImportedPRO_5000143470Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ61895.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025181.

Structurei

3D structure databases

ProteinModelPortaliQ61895.
SMRiQ61895. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPCMLLLLL AAALAPTQTR AGPHSLRYFE TAVSRPGLGK PRYMEVGYVD
60 70 80 90 100
DTEFVRFDSD AENPRYEPRA PWMEQVEPEY WEEQTQIAKG NEQRSRVNLR
110 120 130 140 150
TALRYYNQSA GGSHTIQRMS GCDVGSDWRL LRGYEQVAYD GRDYIALNED
160 170 180 190 200
LKTWTAADMA ALITKHKWEQ AGAAERRRAY LEGTCVEWLR RYLELGNATL
210 220 230 240 250
LRTDSPKAHV THHSRPEDKA TLRCWALGFY PADITLTWQL NGEELTQDME
260 270 280 290 300
LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS
310 320 330 340 350
TVSNTVIIAV LVVLGAAIVT GAVVAFVMRR RRNTGGKGGD YALAPGSQTS
360
DLSLPDCKVM VHNPHSLA
Length:368
Mass (Da):41,326
Last modified:November 1, 1996 - v1
Checksum:i8DE9BACB428CD8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69071 mRNA. Translation: AAA39742.1.
UniGeneiMm.422886.
Mm.439675.
Mm.440940.
Mm.466882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69071 mRNA. Translation: AAA39742.1.
UniGeneiMm.422886.
Mm.439675.
Mm.440940.
Mm.466882.

3D structure databases

ProteinModelPortaliQ61895.
SMRiQ61895. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025181.

Proteomic databases

PRIDEiQ61895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95904. H2-K1.

Phylogenomic databases

HOVERGENiHBG016709.

Miscellaneous databases

ChiTaRSiH2-K1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structural diversity of the classical H-2 genes: K, D, and L."
    Pullen J.K., Horton R.M., Cai Z., Pease L.R.
    J. Immunol. 148:953-967(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.RIIIImported.
    Tissue: SpleenImported.

Entry informationi

Entry nameiQ61895_MOUSE
AccessioniPrimary (citable) accession number: Q61895
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.