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Q61895

- Q61895_MOUSE

UniProt

Q61895 - Q61895_MOUSE

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Protein
Submitted name:

mRNA

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Molecular functioni

  1. peptide antigen binding Source: MGI

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  3. defense response to bacterium Source: MGI
  4. immune response Source: InterPro
  5. inner ear development Source: MGI
  6. positive regulation of T cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
mRNAImported
Gene namesi
Name:H2-K1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95904. H2-K1.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. MHC class I protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 368348 PotentialImportedPRO_5000143470Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ61895.

Expressioni

Gene expression databases

GenevestigatoriQ61895.

Structurei

3D structure databases

ProteinModelPortaliQ61895.
SMRiQ61895. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61895-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPCMLLLLL AAALAPTQTR AGPHSLRYFE TAVSRPGLGK PRYMEVGYVD
60 70 80 90 100
DTEFVRFDSD AENPRYEPRA PWMEQVEPEY WEEQTQIAKG NEQRSRVNLR
110 120 130 140 150
TALRYYNQSA GGSHTIQRMS GCDVGSDWRL LRGYEQVAYD GRDYIALNED
160 170 180 190 200
LKTWTAADMA ALITKHKWEQ AGAAERRRAY LEGTCVEWLR RYLELGNATL
210 220 230 240 250
LRTDSPKAHV THHSRPEDKA TLRCWALGFY PADITLTWQL NGEELTQDME
260 270 280 290 300
LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS
310 320 330 340 350
TVSNTVIIAV LVVLGAAIVT GAVVAFVMRR RRNTGGKGGD YALAPGSQTS
360
DLSLPDCKVM VHNPHSLA
Length:368
Mass (Da):41,326
Last modified:November 1, 1996 - v1
Checksum:i8DE9BACB428CD8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69071 mRNA. Translation: AAA39742.1.
UniGeneiMm.422886.
Mm.439675.
Mm.440940.
Mm.466882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69071 mRNA. Translation: AAA39742.1 .
UniGenei Mm.422886.
Mm.439675.
Mm.440940.
Mm.466882.

3D structure databases

ProteinModelPortali Q61895.
SMRi Q61895. Positions 22-296.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q61895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95904. H2-K1.

Phylogenomic databases

HOVERGENi HBG016709.

Miscellaneous databases

ChiTaRSi H2-K1. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q61895.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural diversity of the classical H-2 genes: K, D, and L."
    Pullen J.K., Horton R.M., Cai Z., Pease L.R.
    J. Immunol. 148:953-967(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.RIIIImported.
    Tissue: SpleenImported.

Entry informationi

Entry nameiQ61895_MOUSE
AccessioniPrimary (citable) accession number: Q61895
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)