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Protein

Myelin-oligodendrocyte glycoprotein

Gene

Mog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.1 Publication

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-oligodendrocyte glycoprotein
Gene namesi
Name:Mog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97435. Mog.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 156128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence AnalysisAdd
BLAST
Topological domaini178 – 20932CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence AnalysisAdd
BLAST
Topological domaini231 – 24616ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 246218Myelin-oligodendrocyte glycoproteinPRO_0000014889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 126PROSITE-ProRule annotation1 Publication
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61885.
PaxDbiQ61885.
PRIDEiQ61885.

PTM databases

PhosphoSiteiQ61885.

Expressioni

Tissue specificityi

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Gene expression databases

CleanExiMM_MOG.
GenevestigatoriQ61885.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi201465. 2 interactions.
IntActiQ61885. 4 interactions.
MINTiMINT-1176800.
STRINGi10090.ENSMUSP00000099726.

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 343Combined sources
Beta strandi40 – 434Combined sources
Beta strandi48 – 569Combined sources
Beta strandi63 – 7210Combined sources
Beta strandi75 – 806Combined sources
Helixi86 – 883Combined sources
Helixi91 – 933Combined sources
Turni94 – 963Combined sources
Beta strandi97 – 1004Combined sources
Helixi104 – 1063Combined sources
Beta strandi108 – 1158Combined sources
Helixi118 – 1203Combined sources
Beta strandi122 – 1309Combined sources
Beta strandi133 – 14412Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PY9X-ray1.80A30-145[»]
ProteinModelPortaliQ61885.
SMRiQ61885. Positions 30-145.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 144114Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146805.
HOVERGENiHBG004565.
InParanoidiQ61885.
KOiK17270.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLWSFSWP SCFLSLLLLL LQLSCSYAGQ FRVIGPGYPI RALVGDEAEL
60 70 80 90 100
PCRISPGKNA TGMEVGWYRS PFSRVVHLYR NGKDQDAEQA PEYRGRTELL
110 120 130 140 150
KETISEGKVT LRIQNVRFSD EGGYTCFFRD HSYQEEAAME LKVEDPFYWV
160 170 180 190 200
NPGVLTLIAL VPTILLQVPV GLVFLFLQHR LRGKLRAEVE NLHRTFDPHF
210 220 230 240
LRVPCWKITL FVIVPVLGPL VALIICYNWL HRRLAGQFLE ELRNPF
Length:246
Mass (Da):28,271
Last modified:November 1, 1997 - v1
Checksum:i1F1A8A4A0D5CFB89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211L → LL (Ref. 2) Curated
Sequence conflicti32 – 321R → G AA sequence (PubMed:1373175).Curated
Sequence conflicti95 – 951G → E (PubMed:8367453).Curated
Sequence conflicti169 – 1691P → S in AAB08096 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29503
, L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
U64572 mRNA. Translation: AAB08096.1.
L20942 mRNA. Translation: AAA03180.1.
PIRiA55717.
RefSeqiNP_034944.2. NM_010814.2.
UniGeneiMm.210857.

Genome annotation databases

GeneIDi17441.
KEGGimmu:17441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29503
, L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
U64572 mRNA. Translation: AAB08096.1.
L20942 mRNA. Translation: AAA03180.1.
PIRiA55717.
RefSeqiNP_034944.2. NM_010814.2.
UniGeneiMm.210857.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PY9X-ray1.80A30-145[»]
ProteinModelPortaliQ61885.
SMRiQ61885. Positions 30-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201465. 2 interactions.
IntActiQ61885. 4 interactions.
MINTiMINT-1176800.
STRINGi10090.ENSMUSP00000099726.

PTM databases

PhosphoSiteiQ61885.

Proteomic databases

MaxQBiQ61885.
PaxDbiQ61885.
PRIDEiQ61885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17441.
KEGGimmu:17441.

Organism-specific databases

CTDi4340.
MGIiMGI:97435. Mog.

Phylogenomic databases

eggNOGiNOG146805.
HOVERGENiHBG004565.
InParanoidiQ61885.
KOiK17270.

Miscellaneous databases

EvolutionaryTraceiQ61885.
NextBioi292076.
PROiQ61885.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MOG.
GenevestigatoriQ61885.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene."
    Daubas P., Pham-Dinh D., Dautigny A.
    Genomics 23:36-41(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Murine and human MOG are highly conserved: cDNA analysis."
    Gardinier M.V., Matthieu J.-M.
    Trans. Am. Soc. Neurochem. 24:234-234(1992)
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex."
    Pham-Dinh D., Mattei M.-G., Nussbaum J.-L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., Dautigny A.
    Proc. Natl. Acad. Sci. U.S.A. 90:7990-7994(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-246.
    Strain: BALB/c.
    Tissue: Brain.
  4. "Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein."
    Amiguet P., Gardinier M.V., Zanetta J.-P., Matthieu J.-M.
    J. Neurochem. 58:1676-1682(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-54.
    Strain: BALB/c.
    Tissue: Brain.
  5. Lubec G., Kang S.U.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 33-53; 81-94; 97-101; 118-142; 185-194 AND 234-246, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis."
    Clements C.S., Reid H.H., Beddoe T., Tynan F.E., Perugini M.A., Johns T.G., Bernard C.C., Rossjohn J.
    Proc. Natl. Acad. Sci. U.S.A. 100:11059-11064(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-145, SUBUNIT, FUNCTION, DISULFIDE BOND.

Entry informationi

Entry nameiMOG_MOUSE
AccessioniPrimary (citable) accession number: Q61885
Secondary accession number(s): P70364, Q62003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.