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Q61885

- MOG_MOUSE

UniProt

Q61885 - MOG_MOUSE

Protein

Myelin-oligodendrocyte glycoprotein

Gene

Mog

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.1 Publication

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin-oligodendrocyte glycoprotein
    Gene namesi
    Name:Mog
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97435. Mog.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 246218Myelin-oligodendrocyte glycoproteinPRO_0000014889Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 1261 PublicationPROSITE-ProRule annotation
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61885.
    PaxDbiQ61885.
    PRIDEiQ61885.

    PTM databases

    PhosphoSiteiQ61885.

    Expressioni

    Tissue specificityi

    Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

    Gene expression databases

    CleanExiMM_MOG.
    GenevestigatoriQ61885.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi201465. 2 interactions.
    IntActiQ61885. 4 interactions.
    MINTiMINT-1176800.
    STRINGi10090.ENSMUSP00000099726.

    Structurei

    Secondary structure

    1
    246
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi32 – 343
    Beta strandi40 – 434
    Beta strandi48 – 569
    Beta strandi63 – 7210
    Beta strandi75 – 806
    Helixi86 – 883
    Helixi91 – 933
    Turni94 – 963
    Beta strandi97 – 1004
    Helixi104 – 1063
    Beta strandi108 – 1158
    Helixi118 – 1203
    Beta strandi122 – 1309
    Beta strandi133 – 14412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PY9X-ray1.80A30-145[»]
    ProteinModelPortaliQ61885.
    SMRiQ61885. Positions 30-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ61885.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 156128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20932CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24616ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei157 – 17721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 144114Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146805.
    HOVERGENiHBG004565.
    InParanoidiQ61885.
    KOiK17270.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR016663. Myelin-oligodendrocyte_glycop.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016522. MOG. 1 hit.
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61885-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACLWSFSWP SCFLSLLLLL LQLSCSYAGQ FRVIGPGYPI RALVGDEAEL    50
    PCRISPGKNA TGMEVGWYRS PFSRVVHLYR NGKDQDAEQA PEYRGRTELL 100
    KETISEGKVT LRIQNVRFSD EGGYTCFFRD HSYQEEAAME LKVEDPFYWV 150
    NPGVLTLIAL VPTILLQVPV GLVFLFLQHR LRGKLRAEVE NLHRTFDPHF 200
    LRVPCWKITL FVIVPVLGPL VALIICYNWL HRRLAGQFLE ELRNPF 246
    Length:246
    Mass (Da):28,271
    Last modified:November 1, 1997 - v1
    Checksum:i1F1A8A4A0D5CFB89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211L → LL1 PublicationCurated
    Sequence conflicti32 – 321R → G AA sequence (PubMed:1373175)Curated
    Sequence conflicti95 – 951G → E(PubMed:8367453)Curated
    Sequence conflicti169 – 1691P → S in AAB08096. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29503
    , L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
    U64572 mRNA. Translation: AAB08096.1.
    L20942 mRNA. Translation: AAA03180.1.
    PIRiA55717.
    RefSeqiNP_034944.2. NM_010814.2.
    UniGeneiMm.210857.

    Genome annotation databases

    GeneIDi17441.
    KEGGimmu:17441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29503
    , L29498 , L29500 , L29501 , L29499 , L29502 Genomic DNA. Translation: AAC42023.1 .
    U64572 mRNA. Translation: AAB08096.1 .
    L20942 mRNA. Translation: AAA03180.1 .
    PIRi A55717.
    RefSeqi NP_034944.2. NM_010814.2.
    UniGenei Mm.210857.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PY9 X-ray 1.80 A 30-145 [» ]
    ProteinModelPortali Q61885.
    SMRi Q61885. Positions 30-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201465. 2 interactions.
    IntActi Q61885. 4 interactions.
    MINTi MINT-1176800.
    STRINGi 10090.ENSMUSP00000099726.

    PTM databases

    PhosphoSitei Q61885.

    Proteomic databases

    MaxQBi Q61885.
    PaxDbi Q61885.
    PRIDEi Q61885.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17441.
    KEGGi mmu:17441.

    Organism-specific databases

    CTDi 4340.
    MGIi MGI:97435. Mog.

    Phylogenomic databases

    eggNOGi NOG146805.
    HOVERGENi HBG004565.
    InParanoidi Q61885.
    KOi K17270.

    Miscellaneous databases

    EvolutionaryTracei Q61885.
    NextBioi 292076.
    PROi Q61885.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MOG.
    Genevestigatori Q61885.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR016663. Myelin-oligodendrocyte_glycop.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016522. MOG. 1 hit.
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene."
      Daubas P., Pham-Dinh D., Dautigny A.
      Genomics 23:36-41(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    2. "Murine and human MOG are highly conserved: cDNA analysis."
      Gardinier M.V., Matthieu J.-M.
      Trans. Am. Soc. Neurochem. 24:234-234(1993)
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex."
      Pham-Dinh D., Mattei M.-G., Nussbaum J.-L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., Dautigny A.
      Proc. Natl. Acad. Sci. U.S.A. 90:7990-7994(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-246.
      Strain: BALB/c.
      Tissue: Brain.
    4. "Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein."
      Amiguet P., Gardinier M.V., Zanetta J.-P., Matthieu J.-M.
      J. Neurochem. 58:1676-1682(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-54.
      Strain: BALB/c.
      Tissue: Brain.
    5. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 33-53; 81-94; 97-101; 118-142; 185-194 AND 234-246, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    6. "The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis."
      Clements C.S., Reid H.H., Beddoe T., Tynan F.E., Perugini M.A., Johns T.G., Bernard C.C., Rossjohn J.
      Proc. Natl. Acad. Sci. U.S.A. 100:11059-11064(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-145, SUBUNIT, FUNCTION, DISULFIDE BOND.

    Entry informationi

    Entry nameiMOG_MOUSE
    AccessioniPrimary (citable) accession number: Q61885
    Secondary accession number(s): P70364, Q62003
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3