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Q61885

- MOG_MOUSE

UniProt

Q61885 - MOG_MOUSE

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Protein
Myelin-oligodendrocyte glycoprotein
Gene
Mog
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.1 Publication

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-oligodendrocyte glycoprotein
Gene namesi
Name:Mog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97435. Mog.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 156128Extracellular Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Reviewed prediction
Add
BLAST
Topological domaini178 – 20932Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei210 – 23021Helical; Reviewed prediction
Add
BLAST
Topological domaini231 – 24616Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 Publication
Add
BLAST
Chaini29 – 246218Myelin-oligodendrocyte glycoprotein
PRO_0000014889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 1261 Publication
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61885.
PaxDbiQ61885.
PRIDEiQ61885.

PTM databases

PhosphoSiteiQ61885.

Expressioni

Tissue specificityi

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Gene expression databases

CleanExiMM_MOG.
GenevestigatoriQ61885.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi201465. 2 interactions.
IntActiQ61885. 4 interactions.
MINTiMINT-1176800.
STRINGi10090.ENSMUSP00000099726.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 343
Beta strandi40 – 434
Beta strandi48 – 569
Beta strandi63 – 7210
Beta strandi75 – 806
Helixi86 – 883
Helixi91 – 933
Turni94 – 963
Beta strandi97 – 1004
Helixi104 – 1063
Beta strandi108 – 1158
Helixi118 – 1203
Beta strandi122 – 1309
Beta strandi133 – 14412

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PY9X-ray1.80A30-145[»]
ProteinModelPortaliQ61885.
SMRiQ61885. Positions 30-145.

Miscellaneous databases

EvolutionaryTraceiQ61885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 144114Ig-like V-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146805.
HOVERGENiHBG004565.
InParanoidiQ61885.
KOiK17270.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61885-1 [UniParc]FASTAAdd to Basket

« Hide

MACLWSFSWP SCFLSLLLLL LQLSCSYAGQ FRVIGPGYPI RALVGDEAEL    50
PCRISPGKNA TGMEVGWYRS PFSRVVHLYR NGKDQDAEQA PEYRGRTELL 100
KETISEGKVT LRIQNVRFSD EGGYTCFFRD HSYQEEAAME LKVEDPFYWV 150
NPGVLTLIAL VPTILLQVPV GLVFLFLQHR LRGKLRAEVE NLHRTFDPHF 200
LRVPCWKITL FVIVPVLGPL VALIICYNWL HRRLAGQFLE ELRNPF 246
Length:246
Mass (Da):28,271
Last modified:November 1, 1997 - v1
Checksum:i1F1A8A4A0D5CFB89
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211L → LL1 Publication
Sequence conflicti32 – 321R → G AA sequence 1 Publication
Sequence conflicti95 – 951G → E1 Publication
Sequence conflicti169 – 1691P → S in AAB08096. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29503
, L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
U64572 mRNA. Translation: AAB08096.1.
L20942 mRNA. Translation: AAA03180.1.
PIRiA55717.
RefSeqiNP_034944.2. NM_010814.2.
UniGeneiMm.210857.

Genome annotation databases

GeneIDi17441.
KEGGimmu:17441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29503
, L29498 , L29500 , L29501 , L29499 , L29502 Genomic DNA. Translation: AAC42023.1 .
U64572 mRNA. Translation: AAB08096.1 .
L20942 mRNA. Translation: AAA03180.1 .
PIRi A55717.
RefSeqi NP_034944.2. NM_010814.2.
UniGenei Mm.210857.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PY9 X-ray 1.80 A 30-145 [» ]
ProteinModelPortali Q61885.
SMRi Q61885. Positions 30-145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201465. 2 interactions.
IntActi Q61885. 4 interactions.
MINTi MINT-1176800.
STRINGi 10090.ENSMUSP00000099726.

PTM databases

PhosphoSitei Q61885.

Proteomic databases

MaxQBi Q61885.
PaxDbi Q61885.
PRIDEi Q61885.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 17441.
KEGGi mmu:17441.

Organism-specific databases

CTDi 4340.
MGIi MGI:97435. Mog.

Phylogenomic databases

eggNOGi NOG146805.
HOVERGENi HBG004565.
InParanoidi Q61885.
KOi K17270.

Miscellaneous databases

EvolutionaryTracei Q61885.
NextBioi 292076.
PROi Q61885.
SOURCEi Search...

Gene expression databases

CleanExi MM_MOG.
Genevestigatori Q61885.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
PIRSFi PIRSF016522. MOG. 1 hit.
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene."
    Daubas P., Pham-Dinh D., Dautigny A.
    Genomics 23:36-41(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Murine and human MOG are highly conserved: cDNA analysis."
    Gardinier M.V., Matthieu J.-M.
    Trans. Am. Soc. Neurochem. 24:234-234(1993)
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex."
    Pham-Dinh D., Mattei M.-G., Nussbaum J.-L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., Dautigny A.
    Proc. Natl. Acad. Sci. U.S.A. 90:7990-7994(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-246.
    Strain: BALB/c.
    Tissue: Brain.
  4. "Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein."
    Amiguet P., Gardinier M.V., Zanetta J.-P., Matthieu J.-M.
    J. Neurochem. 58:1676-1682(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-54.
    Strain: BALB/c.
    Tissue: Brain.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 33-53; 81-94; 97-101; 118-142; 185-194 AND 234-246, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis."
    Clements C.S., Reid H.H., Beddoe T., Tynan F.E., Perugini M.A., Johns T.G., Bernard C.C., Rossjohn J.
    Proc. Natl. Acad. Sci. U.S.A. 100:11059-11064(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-145, SUBUNIT, FUNCTION, DISULFIDE BOND.

Entry informationi

Entry nameiMOG_MOUSE
AccessioniPrimary (citable) accession number: Q61885
Secondary accession number(s): P70364, Q62003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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