Q61885 (MOG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin-oligodendrocyte glycoprotein

Gene names

Name:

Mog

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Ref.7
Subunit structure	Homodimer. Ref.7
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Involvement in disease	Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.
Sequence similarities	Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Caution	Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Ref.4

Chain

29 – 246

218

Myelin-oligodendrocyte glycoprotein

PRO_0000014889

Regions

Topological domain

29 – 156

128

Extracellular Potential

Transmembrane

157 – 177

21

Helical; Potential

Topological domain

178 – 209

32

Cytoplasmic Potential

Transmembrane

210 – 230

21

Helical; Potential

Topological domain

231 – 246

16

Extracellular Potential

Domain

31 – 144

114

Ig-like V-type

Amino acid modifications

Modified residue

124

1

Phosphotyrosine Ref.6

Glycosylation

59

1

N-linked (GlcNAc...) Potential

Disulfide bond

52 ↔ 126

Ref.7

Experimental info

Sequence conflict

21

1

L → LL Ref.2

Sequence conflict

32

1

R → G AA sequence Ref.4

Sequence conflict

95

1

G → E Ref.3

Sequence conflict

169

1

P → S in AAB08096. Ref.2

Secondary structure

1

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246

Helix Strand Turn

Details...

Beta strand

32 – 34

3

Beta strand

40 – 43

4

Beta strand

48 – 56

9

Beta strand

63 – 72

10

Beta strand

75 – 80

6

Helix

86 – 88

3

Helix

91 – 93

3

Turn

94 – 96

3

Beta strand

97 – 100

4

Helix

104 – 106

3

Beta strand

108 – 115

8

Helix

118 – 120

3

Beta strand

122 – 130

9

Beta strand

133 – 144

12

Sequences

	Sequence		Length	Mass (Da)
	Q61885 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1F1A8A4A0D5CFB89	FASTA	246	28,271
	10 20 30 40 50 60 MACLWSFSWP SCFLSLLLLL LQLSCSYAGQ FRVIGPGYPI RALVGDEAEL PCRISPGKNA 70 80 90 100 110 120 TGMEVGWYRS PFSRVVHLYR NGKDQDAEQA PEYRGRTELL KETISEGKVT LRIQNVRFSD 130 140 150 160 170 180 EGGYTCFFRD HSYQEEAAME LKVEDPFYWV NPGVLTLIAL VPTILLQVPV GLVFLFLQHR 190 200 210 220 230 240 LRGKLRAEVE NLHRTFDPHF LRVPCWKITL FVIVPVLGPL VALIICYNWL HRRLAGQFLE ELRNPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene." Daubas P., Pham-Dinh D., Dautigny A. Genomics 23:36-41(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[2]	"Murine and human MOG are highly conserved: cDNA analysis." Gardinier M.V., Matthieu J.-M. Trans. Am. Soc. Neurochem. 24:234-234(1993) Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex." Pham-Dinh D., Mattei M.-G., Nussbaum J.-L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., Dautigny A. Proc. Natl. Acad. Sci. U.S.A. 90:7990-7994(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-246. Strain: BALB/c. Tissue: Brain.
[4]	"Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein." Amiguet P., Gardinier M.V., Zanetta J.-P., Matthieu J.-M. J. Neurochem. 58:1676-1682(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-54. Strain: BALB/c. Tissue: Brain.
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 33-53; 81-94; 97-101; 118-142; 185-194 AND 234-246, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[6]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-124, MASS SPECTROMETRY. Tissue: Brain.
[7]	"The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis." Clements C.S., Reid H.H., Beddoe T., Tynan F.E., Perugini M.A., Johns T.G., Bernard C.C., Rossjohn J. Proc. Natl. Acad. Sci. U.S.A. 100:11059-11064(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-145, SUBUNIT, FUNCTION, DISULFIDE BOND.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L29503 , L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
U64572 mRNA. Translation: AAB08096.1.
L20942 mRNA. Translation: AAA03180.1.

IPI

IPI00126405.

PIR

A55717.

RefSeq

NP_034944.2. NM_010814.2.

UniGene

Mm.210857.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PY9	X-ray	1.80	A	30-145	[»]

ProteinModelPortal

Q61885.

SMR

Q61885. Positions 30-195.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q61885. 3 interactions.

MINT

MINT-1176800.

STRING

10090.ENSMUSP00000099726.

PTM databases

PhosphoSite

Q61885.

Proteomic databases

PaxDb

Q61885.

PRIDE

Q61885.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

17441.

KEGG

mmu:17441.

Organism-specific databases

CTD

4340.

MGI

MGI:97435. Mog.

Phylogenomic databases

eggNOG

NOG146805.

HOVERGEN

HBG004565.

InParanoid

Q61885.

OrthoDB

EOG4W6NWX.

Gene expression databases

CleanEx

MM_MOG.

Genevestigator

Q61885.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

PIRSF

PIRSF016522. MOG. 1 hit.

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q61885.

NextBio

292076.

SOURCE

Search...

Entry information

Entry name

MOG_MOUSE

Accession

Primary (citable) accession number: Q61885
Secondary accession number(s): P70364, Q62003

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program