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Protein

Myelin-oligodendrocyte glycoprotein

Gene

Mog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-oligodendrocyte glycoprotein
Gene namesi
Name:Mog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97435. Mog.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 156ExtracellularSequence analysisAdd BLAST128
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 209CytoplasmicSequence analysisAdd BLAST32
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 246ExtracellularSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001488929 – 246Myelin-oligodendrocyte glycoproteinAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 126PROSITE-ProRule annotation1 Publication
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61885.
PaxDbiQ61885.
PRIDEiQ61885.

PTM databases

PhosphoSitePlusiQ61885.
SwissPalmiQ61885.

Expressioni

Tissue specificityi

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. Reduced expression levels are observed in jimpy and quacking dysmyelinating mutant mice.1 Publication

Gene expression databases

CleanExiMM_MOG.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi201465. 2 interactors.
IntActiQ61885. 4 interactors.
MINTiMINT-1176800.
STRINGi10090.ENSMUSP00000099726.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 34Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi48 – 56Combined sources9
Beta strandi63 – 72Combined sources10
Beta strandi75 – 80Combined sources6
Helixi86 – 88Combined sources3
Helixi91 – 93Combined sources3
Turni94 – 96Combined sources3
Beta strandi97 – 100Combined sources4
Helixi104 – 106Combined sources3
Beta strandi108 – 115Combined sources8
Helixi118 – 120Combined sources3
Beta strandi122 – 130Combined sources9
Beta strandi133 – 144Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PY9X-ray1.80A30-145[»]
ProteinModelPortaliQ61885.
SMRiQ61885.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 144Ig-like V-typeAdd BLAST114

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKW. Eukaryota.
ENOG41119UE. LUCA.
HOVERGENiHBG004565.
InParanoidiQ61885.
KOiK17270.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLWSFSWP SCFLSLLLLL LQLSCSYAGQ FRVIGPGYPI RALVGDEAEL
60 70 80 90 100
PCRISPGKNA TGMEVGWYRS PFSRVVHLYR NGKDQDAEQA PEYRGRTELL
110 120 130 140 150
KETISEGKVT LRIQNVRFSD EGGYTCFFRD HSYQEEAAME LKVEDPFYWV
160 170 180 190 200
NPGVLTLIAL VPTILLQVPV GLVFLFLQHR LRGKLRAEVE NLHRTFDPHF
210 220 230 240
LRVPCWKITL FVIVPVLGPL VALIICYNWL HRRLAGQFLE ELRNPF
Length:246
Mass (Da):28,271
Last modified:November 1, 1997 - v1
Checksum:i1F1A8A4A0D5CFB89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21L → LL (Ref. 2) Curated1
Sequence conflicti32R → G AA sequence (PubMed:1373175).Curated1
Sequence conflicti95G → E (PubMed:8367453).Curated1
Sequence conflicti169P → S in AAB08096 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29503
, L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
U64572 mRNA. Translation: AAB08096.1.
L20942 mRNA. Translation: AAA03180.1.
PIRiA55717.
RefSeqiNP_034944.2. NM_010814.2.
UniGeneiMm.210857.

Genome annotation databases

GeneIDi17441.
KEGGimmu:17441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29503
, L29498, L29500, L29501, L29499, L29502 Genomic DNA. Translation: AAC42023.1.
U64572 mRNA. Translation: AAB08096.1.
L20942 mRNA. Translation: AAA03180.1.
PIRiA55717.
RefSeqiNP_034944.2. NM_010814.2.
UniGeneiMm.210857.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PY9X-ray1.80A30-145[»]
ProteinModelPortaliQ61885.
SMRiQ61885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201465. 2 interactors.
IntActiQ61885. 4 interactors.
MINTiMINT-1176800.
STRINGi10090.ENSMUSP00000099726.

PTM databases

PhosphoSitePlusiQ61885.
SwissPalmiQ61885.

Proteomic databases

MaxQBiQ61885.
PaxDbiQ61885.
PRIDEiQ61885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17441.
KEGGimmu:17441.

Organism-specific databases

CTDi4340.
MGIiMGI:97435. Mog.

Phylogenomic databases

eggNOGiENOG410IKKW. Eukaryota.
ENOG41119UE. LUCA.
HOVERGENiHBG004565.
InParanoidiQ61885.
KOiK17270.

Miscellaneous databases

EvolutionaryTraceiQ61885.
PROiQ61885.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MOG.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOG_MOUSE
AccessioniPrimary (citable) accession number: Q61885
Secondary accession number(s): P70364, Q62003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.