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Protein

Meiotic recombination protein DMC1/LIM15 homolog

Gene

Dmc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ssDNA or dsDNABy similarity
Binding sitei233 – 2331ssDNABy similarity
Binding sitei236 – 2361ssDNA or dsDNABy similarity
Binding sitei242 – 2421ssDNA or dsDNABy similarity
Binding sitei311 – 3111ssDNABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi126 – 1338ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • DNA recombinase assembly Source: GO_Central
  • gamete generation Source: MGI
  • male meiosis I Source: MGI
  • mitotic recombination Source: GO_Central
  • oocyte maturation Source: MGI
  • ovarian follicle development Source: MGI
  • reciprocal meiotic recombination Source: GO_Central
  • response to ionizing radiation Source: GO_Central
  • spermatid development Source: MGI
  • spermatogenesis Source: MGI
  • strand invasion Source: GO_Central
  • synapsis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Meiosis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-912446. Meiotic recombination.
R-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein DMC1/LIM15 homolog
Gene namesi
Name:Dmc1
Synonyms:Dmc1h, Lim15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:105393. Dmc1.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB
  • chromosome, telomeric region Source: MGI
  • condensed nuclear chromosome Source: MGI
  • nucleoplasm Source: GO_Central
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Meiotic recombination protein DMC1/LIM15 homologPRO_0000122919Add
BLAST

Proteomic databases

PaxDbiQ61880.
PRIDEiQ61880.

PTM databases

PhosphoSiteiQ61880.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSMUSG00000022429.
ExpressionAtlasiQ61880. baseline and differential.
GenevisibleiQ61880. MM.

Interactioni

Subunit structurei

Double stacked ring-shaped homooctamer (By similarity). Interacts with the MND1-PSMC3IP heterodimer. Interacts with BRCA2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023065.

Structurei

3D structure databases

ProteinModelPortaliQ61880.
SMRiQ61880. Positions 24-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. DMC1 subfamily.Curated
Contains 1 HhH domain.Curated

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00760000119398.
HOGENOMiHOG000227426.
HOVERGENiHBG001504.
InParanoidiQ61880.
KOiK10872.
OMAiINMADIK.
OrthoDBiEOG091G09QY.
PhylomeDBiQ61880.
TreeFamiTF300698.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011940. DMC1_rcmbase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02238. recomb_DMC1. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDQVVQEE SGFQDDEESL FQDIDLLQKH GINMADIKKL KSVGICTIKG
60 70 80 90 100
IQMTTRRALC NVKGLSEAKV EKIKEAANKL IEPGFLTAFQ YSERRKMVFH
110 120 130 140 150
ITTGSQEFDK LLGGGIESMA ITEAFGEFRT GKTQLSHTLC VTAQLPGTGG
160 170 180 190 200
YSGGKIIFID TENTFRPDRL RDIADRFNVD HEAVLDNVLY ARAYTSEHQM
210 220 230 240 250
ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA ERQQKLAQML
260 270 280 290 300
SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR
310 320 330 340
ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE
Length:340
Mass (Da):37,821
Last modified:November 1, 1997 - v1
Checksum:i23EAB08D6E668637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D58419 mRNA. Translation: BAA09590.1.
D64107 mRNA. Translation: BAA10969.1.
CCDSiCCDS27644.1.
PIRiJC4191.
RefSeqiNP_034189.1. NM_010059.3.
UniGeneiMm.2524.

Genome annotation databases

EnsembliENSMUST00000023065; ENSMUSP00000023065; ENSMUSG00000022429.
GeneIDi13404.
KEGGimmu:13404.
UCSCiuc007wtu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D58419 mRNA. Translation: BAA09590.1.
D64107 mRNA. Translation: BAA10969.1.
CCDSiCCDS27644.1.
PIRiJC4191.
RefSeqiNP_034189.1. NM_010059.3.
UniGeneiMm.2524.

3D structure databases

ProteinModelPortaliQ61880.
SMRiQ61880. Positions 24-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023065.

PTM databases

PhosphoSiteiQ61880.

Proteomic databases

PaxDbiQ61880.
PRIDEiQ61880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023065; ENSMUSP00000023065; ENSMUSG00000022429.
GeneIDi13404.
KEGGimmu:13404.
UCSCiuc007wtu.2. mouse.

Organism-specific databases

CTDi11144.
MGIiMGI:105393. Dmc1.

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00760000119398.
HOGENOMiHOG000227426.
HOVERGENiHBG001504.
InParanoidiQ61880.
KOiK10872.
OMAiINMADIK.
OrthoDBiEOG091G09QY.
PhylomeDBiQ61880.
TreeFamiTF300698.

Enzyme and pathway databases

ReactomeiR-MMU-912446. Meiotic recombination.
R-MMU-912497. Meiotic Recombination.

Miscellaneous databases

PROiQ61880.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022429.
ExpressionAtlasiQ61880. baseline and differential.
GenevisibleiQ61880. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011940. DMC1_rcmbase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02238. recomb_DMC1. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMC1_MOUSE
AccessioniPrimary (citable) accession number: Q61880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.