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Protein

Meiotic recombination protein DMC1/LIM15 homolog

Gene

Dmc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230ssDNA or dsDNABy similarity1
Binding sitei233ssDNABy similarity1
Binding sitei236ssDNA or dsDNABy similarity1
Binding sitei242ssDNA or dsDNABy similarity1
Binding sitei311ssDNABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi126 – 133ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • DNA recombinase assembly Source: GO_Central
  • gamete generation Source: MGI
  • male meiosis I Source: MGI
  • mitotic recombination Source: GO_Central
  • oocyte maturation Source: MGI
  • ovarian follicle development Source: MGI
  • reciprocal meiotic recombination Source: GO_Central
  • response to ionizing radiation Source: GO_Central
  • spermatid development Source: MGI
  • spermatogenesis Source: MGI
  • strand invasion Source: GO_Central
  • synapsis Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Meiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiotic recombination protein DMC1/LIM15 homolog
Gene namesi
Name:Dmc1
Synonyms:Dmc1h, Lim15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:105393. Dmc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229191 – 340Meiotic recombination protein DMC1/LIM15 homologAdd BLAST340

Proteomic databases

PaxDbiQ61880.
PRIDEiQ61880.

PTM databases

iPTMnetiQ61880.
PhosphoSitePlusiQ61880.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSMUSG00000022429.
ExpressionAtlasiQ61880. baseline and differential.
GenevisibleiQ61880. MM.

Interactioni

Subunit structurei

Double stacked ring-shaped homooctamer (By similarity). Interacts with the MND1-PSMC3IP heterodimer. Interacts with BRCA2 (By similarity).By similarity

Protein-protein interaction databases

CORUMiQ61880.
STRINGi10090.ENSMUSP00000023065.

Structurei

3D structure databases

ProteinModelPortaliQ61880.
SMRiQ61880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. DMC1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00760000119398.
HOGENOMiHOG000227426.
HOVERGENiHBG001504.
InParanoidiQ61880.
KOiK10872.
OMAiCTVKGIQ.
OrthoDBiEOG091G09QY.
PhylomeDBiQ61880.
TreeFamiTF300698.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011940. DMC1_rcmbase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
PfamiView protein in Pfam
PF08423. Rad51. 1 hit.
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02238. recomb_DMC1. 1 hit.
PROSITEiView protein in PROSITE
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDQVVQEE SGFQDDEESL FQDIDLLQKH GINMADIKKL KSVGICTIKG
60 70 80 90 100
IQMTTRRALC NVKGLSEAKV EKIKEAANKL IEPGFLTAFQ YSERRKMVFH
110 120 130 140 150
ITTGSQEFDK LLGGGIESMA ITEAFGEFRT GKTQLSHTLC VTAQLPGTGG
160 170 180 190 200
YSGGKIIFID TENTFRPDRL RDIADRFNVD HEAVLDNVLY ARAYTSEHQM
210 220 230 240 250
ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA ERQQKLAQML
260 270 280 290 300
SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR
310 320 330 340
ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE
Length:340
Mass (Da):37,821
Last modified:November 1, 1997 - v1
Checksum:i23EAB08D6E668637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D58419 mRNA. Translation: BAA09590.1.
D64107 mRNA. Translation: BAA10969.1.
CCDSiCCDS27644.1.
PIRiJC4191.
RefSeqiNP_034189.1. NM_010059.3.
UniGeneiMm.2524.

Genome annotation databases

EnsembliENSMUST00000023065; ENSMUSP00000023065; ENSMUSG00000022429.
GeneIDi13404.
KEGGimmu:13404.
UCSCiuc007wtu.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiDMC1_MOUSE
AccessioniPrimary (citable) accession number: Q61880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families