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Protein

Melanoma-derived growth regulatory protein

Gene

Mia

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.By similarity

GO - Biological processi

  • cell-matrix adhesion Source: MGI
  • extracellular matrix organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-derived growth regulatory protein
Alternative name(s):
Cartilage-derived retinoic acid-sensitive protein
Short name:
CD-RAP
Melanoma inhibitory activity protein
Gene namesi
Name:Mia
Synonyms:Cdrap, Mia1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109615. Mia.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 130108Melanoma-derived growth regulatory proteinPRO_0000019029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 40By similarity
Disulfide bondi58 ↔ 129By similarity

Post-translational modificationi

May possess two intramolecular disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ61865.
PRIDEiQ61865.

PTM databases

PhosphoSiteiQ61865.

Expressioni

Tissue specificityi

All malignant melanoma cell lines tested and infrequently in glioma cell lines.

Gene expression databases

BgeeiQ61865.
CleanExiMM_MIA1.
ExpressionAtlasiQ61865. baseline and differential.
GenevisibleiQ61865. MM.

Interactioni

Subunit structurei

Interacts with FASLG.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071876.

Structurei

3D structure databases

ProteinModelPortaliQ61865.
SMRiQ61865. Positions 26-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11271SH3Add
BLAST

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IVZ6. Eukaryota.
ENOG411207U. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ61865.
KOiK16655.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWSPVLLGI VVLSVFSGPS RADRAMPKLA DWKLCADEEC SHPISMAVAL
60 70 80 90 100
QDYVAPDCRF LTIYRGQVVY VFSKLKGRGR LFWGGSVQGG YYGDLAARLG
110 120 130
YFPSSIVRED LTLKPGKIDM KTDQWDFYCQ
Length:130
Mass (Da):14,593
Last modified:February 21, 2001 - v2
Checksum:i16C957459C5BB5F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1132TL → NS in CAA63983 (PubMed:7923218).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94322 mRNA. Translation: CAA63983.1.
U85612 Genomic DNA. Translation: AAB42082.1.
X97965 Genomic DNA. Translation: CAA66608.1.
CCDSiCCDS21013.1.
RefSeqiNP_062267.2. NM_019394.3.
UniGeneiMm.262447.

Genome annotation databases

EnsembliENSMUST00000071986; ENSMUSP00000071876; ENSMUSG00000089661.
GeneIDi12587.
KEGGimmu:12587.
UCSCiuc009fvf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94322 mRNA. Translation: CAA63983.1.
U85612 Genomic DNA. Translation: AAB42082.1.
X97965 Genomic DNA. Translation: CAA66608.1.
CCDSiCCDS21013.1.
RefSeqiNP_062267.2. NM_019394.3.
UniGeneiMm.262447.

3D structure databases

ProteinModelPortaliQ61865.
SMRiQ61865. Positions 26-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071876.

PTM databases

PhosphoSiteiQ61865.

Proteomic databases

PaxDbiQ61865.
PRIDEiQ61865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071986; ENSMUSP00000071876; ENSMUSG00000089661.
GeneIDi12587.
KEGGimmu:12587.
UCSCiuc009fvf.2. mouse.

Organism-specific databases

CTDi8190.
MGIiMGI:109615. Mia.

Phylogenomic databases

eggNOGiENOG410IVZ6. Eukaryota.
ENOG411207U. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ61865.
KOiK16655.

Miscellaneous databases

NextBioi281726.
PROiQ61865.
SOURCEiSearch...

Gene expression databases

BgeeiQ61865.
CleanExiMM_MIA1.
ExpressionAtlasiQ61865. baseline and differential.
GenevisibleiQ61865. MM.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA."
    Blesch A., Bosserhoff A.-K., Apfel R., Behl C., Hessdoerfer B., Schmitt A., Jachimczak P., Lottspeich F., Buettner R., Bogdahn U.
    Cancer Res. 54:5695-5701(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "Mouse CD-RAP/MIA gene: structure, chromosomal localization, and expression in cartilage and chondrosarcoma."
    Bosserhoff A.K., Kondo S., Moser M., Dietz U., Copeland N.G., Gilbert D.J., Jenkins N.A., Buettner R., Sandell L.J.
    Dev. Dyn. 208:516-525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiMIA_MOUSE
AccessioniPrimary (citable) accession number: Q61865
Secondary accession number(s): O09086, P97495
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2001
Last modified: November 11, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.