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Q61850 (FOXC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein C2
Alternative name(s):
Brain factor 3
Short name=BF-3
Forkhead-related protein FKHL14
Mesenchyme fork head protein 1
Short name=MFH-1 protein
Transcription factor FKH-14
Gene names
Name:Foxc2
Synonyms:Fkh14, Fkhl14, Mfh1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Ref.2

Subcellular location

Nucleus By similarity.

Developmental stage

Expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head and limbs.

Post-translational modification

Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin By similarity.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from genetic interaction PubMed 11562355. Source: MGI

artery morphogenesis

Inferred from mutant phenotype PubMed 10479458PubMed 9409679. Source: MGI

blood vessel development

Inferred from genetic interaction PubMed 16678147. Source: MGI

blood vessel remodeling

Inferred from genetic interaction PubMed 11562355PubMed 16678147. Source: MGI

camera-type eye development

Inferred from mutant phenotype PubMed 10767326. Source: MGI

cardiac muscle cell proliferation

Inferred from genetic interaction PubMed 16839542. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 10364424PubMed 9106663. Source: MGI

collagen fibril organization

Inferred from mutant phenotype PubMed 10767326. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 9106663. Source: MGI

embryonic heart tube development

Inferred from genetic interaction PubMed 16678147. Source: MGI

embryonic skeletal system morphogenesis

Inferred from mutant phenotype PubMed 9409679. Source: MGI

embryonic viscerocranium morphogenesis

Inferred from mutant phenotype PubMed 9409679. Source: MGI

glomerular endothelium development

Inferred from mutant phenotype PubMed 16498405. Source: MGI

glomerular mesangial cell development

Inferred from mutant phenotype PubMed 16498405. Source: MGI

glomerular visceral epithelial cell differentiation

Inferred from mutant phenotype PubMed 16498405. Source: MGI

heart development

Inferred from mutant phenotype PubMed 10479458. Source: MGI

heart morphogenesis

Inferred from genetic interaction PubMed 16839542. Source: MGI

insulin receptor signaling pathway

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

kidney development

Inferred from mutant phenotype PubMed 10704385. Source: MGI

lymph vessel development

Inferred from genetic interaction PubMed 16678147. Source: MGI

lymphangiogenesis

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

metanephros development

Inferred from mutant phenotype PubMed 16498405. Source: MGI

negative regulation of apoptotic process involved in outflow tract morphogenesis

Inferred from genetic interaction PubMed 16839542. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

neural crest cell development

Inferred from genetic interaction PubMed 16839542. Source: MGI

ossification

Inferred from mutant phenotype PubMed 9106663. Source: MGI

paraxial mesoderm formation

Inferred from genetic interaction PubMed 11562355. Source: MGI

paraxial mesodermal cell fate commitment

Inferred from mutant phenotype PubMed 9106663. Source: MGI

patterning of blood vessels

Inferred from genetic interaction PubMed 15664398. Source: MGI

positive regulation of cell adhesion mediated by integrin

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

positive regulation of cell migration involved in sprouting angiogenesis

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

positive regulation of endothelial cell migration

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

positive regulation of integrin activation

Inferred by curator PubMed 18579532. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.2. Source: UniProtKB

positive regulation of vascular wound healing

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

regulation of blood vessel size

Inferred from genetic interaction PubMed 16678147. Source: MGI

regulation of organ growth

Inferred from genetic interaction PubMed 16839542. Source: MGI

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to hormone

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

skeletal system development

Inferred from mutant phenotype PubMed 10364424. Source: MGI

somitogenesis

Inferred from genetic interaction PubMed 11562355. Source: UniProtKB

transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 16678147. Source: GOC

ureteric bud development

Inferred from mutant phenotype PubMed 10704385. Source: MGI

vascular endothelial growth factor receptor signaling pathway

Inferred from genetic interaction PubMed 16678147. Source: MGI

ventricular cardiac muscle tissue morphogenesis

Inferred from genetic interaction PubMed 16839542. Source: MGI

   Cellular_componentnucleus

Inferred by curator Ref.2. Source: UniProtKB

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from direct assay Ref.4. Source: MGI

DNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from genetic interaction PubMed 16678147. Source: MGI

chromatin DNA binding

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region DNA binding

Inferred from direct assay PubMed 18579532. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Forkhead box protein C2
PRO_0000091809

Regions

DNA binding70 – 16192Fork-head
Compositional bias162 – 1665Poly-Arg
Compositional bias386 – 39510His-rich
Compositional bias396 – 41116Pro-rich

Amino acid modifications

Modified residue2141Phosphoserine By similarity
Modified residue2181Phosphoserine By similarity
Modified residue2311Phosphoserine By similarity
Modified residue2391Phosphoserine By similarity
Modified residue2461Phosphothreonine By similarity
Modified residue2501Phosphoserine By similarity
Modified residue2801Phosphoserine By similarity
Modified residue2871Phosphoserine By similarity
Modified residue3661Phosphoserine By similarity

Experimental info

Sequence conflict12 – 132AL → V in CAA63244. Ref.1
Sequence conflict1821L → I in BAC36298. Ref.3
Sequence conflict3881H → Q in BAC36298. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61850 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 232C0D6FA64320A6

FASTA49452,874
        10         20         30         40         50         60 
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA GMGRSYAPYH 

        70         80         90        100        110        120 
HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF IMDRFPFYRE NKQGWQNSIR 

       130        140        150        160        170        180 
HNLSLNECFV KVPRDDKKPG KGSYWTLDPD SYNMFENGSF LRRRRRFKKK DVPKDKEERA 

       190        200        210        220        230        240 
HLKEPPSTTA KGAPTGTPVA DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP 

       250        260        270        280        290        300 
RSASSTPAGS PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL 

       310        320        330        340        350        360 
ALPYAAAPPA AYTQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP PALDEALSDH 

       370        380        390        400        410        420 
PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HGHLHPQAPP PAPQPPPAPQ PATQATSWYL 

       430        440        450        460        470        480 
NHGGDLSHLP GHTFATQQQT FPNVREMFNS HRLGLDNSSL GESQVSNASC QLPYRATPSL 

       490 
YRHAAPYSYD CTKY 

« Hide

References

« Hide 'large scale' references
[1]"Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development."
Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlondorff J., Mincheva A., Lichter P., Schuetz G.
Development 122:1751-1758(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Embryo.
[2]"Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures."
Miura N., Iida K., Kakinuma H., Yang X.-L., Sugiyama T.
Genomics 41:489-492(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION.
Strain: 129 and ICR.
Tissue: Embryo.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Skin.
[4]"MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme."
Miura N., Wanaka A., Tohyama M., Tanaka K.
FEBS Lett. 326:171-176(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-494.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92499 mRNA. Translation: CAA63244.1.
Y08222 Genomic DNA. Translation: CAA69399.1.
X74040 mRNA. Translation: CAA52192.1.
AK076319 mRNA. Translation: BAC36298.1.
S63607 mRNA. Translation: AAB27463.1.
CCDSCCDS40499.1.
PIRS34472.
RefSeqNP_038547.2. NM_013519.2.
UniGeneMm.14092.

3D structure databases

ProteinModelPortalQ61850.
SMRQ61850. Positions 69-161.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ61850.

Proteomic databases

PRIDEQ61850.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054691; ENSMUSP00000055290; ENSMUSG00000046714.
GeneID14234.
KEGGmmu:14234.
UCSCuc012glx.1. mouse.

Organism-specific databases

CTD2303.
MGIMGI:1347481. Foxc2.

Phylogenomic databases

eggNOGCOG5025.
GeneTreeENSGT00740000114928.
HOGENOMHOG000007939.
HOVERGENHBG051640.
InParanoidQ61850.
KOK09396.
OMALNHLPGH.
OrthoDBEOG7C8GHD.
PhylomeDBQ61850.
TreeFamTF316127.

Gene expression databases

BgeeQ61850.
CleanExMM_FOXC2.
GenevestigatorQ61850.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285515.
PROQ61850.
SOURCESearch...

Entry information

Entry nameFOXC2_MOUSE
AccessionPrimary (citable) accession number: Q61850
Secondary accession number(s): P97948, Q63869, Q8C694
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot