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Protein

Forkhead box protein C2

Gene

Foxc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 16192Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  • sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • artery morphogenesis Source: MGI
  • blood vessel development Source: MGI
  • blood vessel remodeling Source: MGI
  • camera-type eye development Source: MGI
  • cardiac muscle cell proliferation Source: MGI
  • cell proliferation Source: MGI
  • collagen fibril organization Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic heart tube development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • embryonic viscerocranium morphogenesis Source: MGI
  • glomerular endothelium development Source: MGI
  • glomerular mesangial cell development Source: MGI
  • glomerular visceral epithelial cell differentiation Source: MGI
  • heart development Source: MGI
  • heart morphogenesis Source: MGI
  • insulin receptor signaling pathway Source: UniProtKB
  • kidney development Source: MGI
  • lymphangiogenesis Source: UniProtKB
  • lymph vessel development Source: MGI
  • metanephros development Source: MGI
  • negative regulation of apoptotic process involved in outflow tract morphogenesis Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • neural crest cell development Source: MGI
  • Notch signaling pathway Source: MGI
  • ossification Source: MGI
  • paraxial mesodermal cell fate commitment Source: MGI
  • paraxial mesoderm formation Source: MGI
  • patterning of blood vessels Source: MGI
  • positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
  • positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
  • positive regulation of endothelial cell migration Source: BHF-UCL
  • positive regulation of integrin activation Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of vascular wound healing Source: BHF-UCL
  • regulation of blood vessel size Source: MGI
  • regulation of organ growth Source: MGI
  • response to hormone Source: UniProtKB
  • skeletal system development Source: MGI
  • somitogenesis Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: GOC
  • ureteric bud development Source: MGI
  • vascular endothelial growth factor receptor signaling pathway Source: MGI
  • ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein C2
Alternative name(s):
Brain factor 3
Short name:
BF-3
Forkhead-related protein FKHL14
Mesenchyme fork head protein 1
Short name:
MFH-1 protein
Transcription factor FKH-14
Gene namesi
Name:Foxc2
Synonyms:Fkh14, Fkhl14, Mfh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347481. Foxc2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Forkhead box protein C2PRO_0000091809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141PhosphoserineBy similarity
Modified residuei218 – 2181PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei246 – 2461PhosphothreonineBy similarity
Modified residuei250 – 2501PhosphoserineBy similarity
Modified residuei280 – 2801PhosphoserineBy similarity
Modified residuei287 – 2871PhosphoserineBy similarity
Modified residuei366 – 3661PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61850.
PRIDEiQ61850.

PTM databases

PhosphoSiteiQ61850.

Expressioni

Developmental stagei

Expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head and limbs.

Gene expression databases

BgeeiQ61850.
CleanExiMM_FOXC2.
ExpressionAtlasiQ61850. baseline and differential.
GenevisibleiQ61850. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055290.

Structurei

3D structure databases

ProteinModelPortaliQ61850.
SMRiQ61850. Positions 69-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1665Poly-Arg
Compositional biasi386 – 39510His-rich
Compositional biasi396 – 41116Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ61850.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ61850.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA
60 70 80 90 100
GMGRSYAPYH HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF
110 120 130 140 150
IMDRFPFYRE NKQGWQNSIR HNLSLNECFV KVPRDDKKPG KGSYWTLDPD
160 170 180 190 200
SYNMFENGSF LRRRRRFKKK DVPKDKEERA HLKEPPSTTA KGAPTGTPVA
210 220 230 240 250
DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP RSASSTPAGS
260 270 280 290 300
PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL
310 320 330 340 350
ALPYAAAPPA AYTQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP
360 370 380 390 400
PALDEALSDH PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HGHLHPQAPP
410 420 430 440 450
PAPQPPPAPQ PATQATSWYL NHGGDLSHLP GHTFATQQQT FPNVREMFNS
460 470 480 490
HRLGLDNSSL GESQVSNASC QLPYRATPSL YRHAAPYSYD CTKY
Length:494
Mass (Da):52,874
Last modified:July 15, 1998 - v2
Checksum:i232C0D6FA64320A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132AL → V in CAA63244 (PubMed:8674414).Curated
Sequence conflicti182 – 1821L → I in BAC36298 (PubMed:16141072).Curated
Sequence conflicti388 – 3881H → Q in BAC36298 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92499 mRNA. Translation: CAA63244.1.
Y08222 Genomic DNA. Translation: CAA69399.1.
X74040 mRNA. Translation: CAA52192.1.
AK076319 mRNA. Translation: BAC36298.1.
S63607 mRNA. Translation: AAB27463.1.
CCDSiCCDS40499.1.
PIRiS34472.
RefSeqiNP_038547.2. NM_013519.2.
UniGeneiMm.14092.

Genome annotation databases

EnsembliENSMUST00000054691; ENSMUSP00000055290; ENSMUSG00000046714.
GeneIDi14234.
KEGGimmu:14234.
UCSCiuc012glx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92499 mRNA. Translation: CAA63244.1.
Y08222 Genomic DNA. Translation: CAA69399.1.
X74040 mRNA. Translation: CAA52192.1.
AK076319 mRNA. Translation: BAC36298.1.
S63607 mRNA. Translation: AAB27463.1.
CCDSiCCDS40499.1.
PIRiS34472.
RefSeqiNP_038547.2. NM_013519.2.
UniGeneiMm.14092.

3D structure databases

ProteinModelPortaliQ61850.
SMRiQ61850. Positions 69-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055290.

PTM databases

PhosphoSiteiQ61850.

Proteomic databases

MaxQBiQ61850.
PRIDEiQ61850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054691; ENSMUSP00000055290; ENSMUSG00000046714.
GeneIDi14234.
KEGGimmu:14234.
UCSCiuc012glx.1. mouse.

Organism-specific databases

CTDi2303.
MGIiMGI:1347481. Foxc2.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ61850.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ61850.
TreeFamiTF316127.

Miscellaneous databases

NextBioi285515.
PROiQ61850.
SOURCEiSearch...

Gene expression databases

BgeeiQ61850.
CleanExiMM_FOXC2.
ExpressionAtlasiQ61850. baseline and differential.
GenevisibleiQ61850. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development."
    Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlondorff J., Mincheva A., Lichter P., Schuetz G.
    Development 122:1751-1758(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  2. "Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures."
    Miura N., Iida K., Kakinuma H., Yang X.-L., Sugiyama T.
    Genomics 41:489-492(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION.
    Strain: 129 and ICR.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  4. "MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme."
    Miura N., Wanaka A., Tohyama M., Tanaka K.
    FEBS Lett. 326:171-176(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-494.

Entry informationi

Entry nameiFOXC2_MOUSE
AccessioniPrimary (citable) accession number: Q61850
Secondary accession number(s): P97948, Q63869, Q8C694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: June 24, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.