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Q61850

- FOXC2_MOUSE

UniProt

Q61850 - FOXC2_MOUSE

Protein

Forkhead box protein C2

Gene

Foxc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi70 – 16192Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin DNA binding Source: UniProtKB
    2. DNA binding Source: MGI
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    5. sequence-specific DNA binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    7. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. artery morphogenesis Source: MGI
    2. blood vessel development Source: MGI
    3. blood vessel remodeling Source: MGI
    4. camera-type eye development Source: MGI
    5. cardiac muscle cell proliferation Source: MGI
    6. cell proliferation Source: MGI
    7. collagen fibril organization Source: MGI
    8. embryonic cranial skeleton morphogenesis Source: MGI
    9. embryonic heart tube development Source: MGI
    10. embryonic skeletal system morphogenesis Source: MGI
    11. embryonic viscerocranium morphogenesis Source: MGI
    12. glomerular endothelium development Source: MGI
    13. glomerular mesangial cell development Source: MGI
    14. glomerular visceral epithelial cell differentiation Source: MGI
    15. heart development Source: MGI
    16. heart morphogenesis Source: MGI
    17. insulin receptor signaling pathway Source: UniProtKB
    18. kidney development Source: MGI
    19. lymphangiogenesis Source: UniProtKB
    20. lymph vessel development Source: MGI
    21. metanephros development Source: MGI
    22. negative regulation of apoptotic process involved in outflow tract morphogenesis Source: MGI
    23. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    24. neural crest cell development Source: MGI
    25. Notch signaling pathway Source: MGI
    26. ossification Source: MGI
    27. paraxial mesodermal cell fate commitment Source: MGI
    28. paraxial mesoderm formation Source: MGI
    29. patterning of blood vessels Source: MGI
    30. positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
    31. positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
    32. positive regulation of endothelial cell migration Source: BHF-UCL
    33. positive regulation of integrin activation Source: BHF-UCL
    34. positive regulation of transcription, DNA-templated Source: UniProtKB
    35. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    36. positive regulation of vascular wound healing Source: BHF-UCL
    37. regulation of blood vessel size Source: MGI
    38. regulation of organ growth Source: MGI
    39. response to hormone Source: UniProtKB
    40. skeletal system development Source: MGI
    41. somitogenesis Source: UniProtKB
    42. transcription from RNA polymerase II promoter Source: GOC
    43. ureteric bud development Source: MGI
    44. vascular endothelial growth factor receptor signaling pathway Source: MGI
    45. ventricular cardiac muscle tissue morphogenesis Source: MGI

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein C2
    Alternative name(s):
    Brain factor 3
    Short name:
    BF-3
    Forkhead-related protein FKHL14
    Mesenchyme fork head protein 1
    Short name:
    MFH-1 protein
    Transcription factor FKH-14
    Gene namesi
    Name:Foxc2
    Synonyms:Fkh14, Fkhl14, Mfh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1347481. Foxc2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Forkhead box protein C2PRO_0000091809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei214 – 2141PhosphoserineBy similarity
    Modified residuei218 – 2181PhosphoserineBy similarity
    Modified residuei231 – 2311PhosphoserineBy similarity
    Modified residuei239 – 2391PhosphoserineBy similarity
    Modified residuei246 – 2461PhosphothreonineBy similarity
    Modified residuei250 – 2501PhosphoserineBy similarity
    Modified residuei280 – 2801PhosphoserineBy similarity
    Modified residuei287 – 2871PhosphoserineBy similarity
    Modified residuei366 – 3661PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ61850.

    PTM databases

    PhosphoSiteiQ61850.

    Expressioni

    Developmental stagei

    Expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head and limbs.

    Gene expression databases

    BgeeiQ61850.
    CleanExiMM_FOXC2.
    GenevestigatoriQ61850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61850.
    SMRiQ61850. Positions 69-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi162 – 1665Poly-Arg
    Compositional biasi386 – 39510His-rich
    Compositional biasi396 – 41116Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00740000114928.
    HOGENOMiHOG000007939.
    HOVERGENiHBG051640.
    InParanoidiQ61850.
    KOiK09396.
    OMAiLNHLPGH.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ61850.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA    50
    GMGRSYAPYH HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF 100
    IMDRFPFYRE NKQGWQNSIR HNLSLNECFV KVPRDDKKPG KGSYWTLDPD 150
    SYNMFENGSF LRRRRRFKKK DVPKDKEERA HLKEPPSTTA KGAPTGTPVA 200
    DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP RSASSTPAGS 250
    PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL 300
    ALPYAAAPPA AYTQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP 350
    PALDEALSDH PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HGHLHPQAPP 400
    PAPQPPPAPQ PATQATSWYL NHGGDLSHLP GHTFATQQQT FPNVREMFNS 450
    HRLGLDNSSL GESQVSNASC QLPYRATPSL YRHAAPYSYD CTKY 494
    Length:494
    Mass (Da):52,874
    Last modified:July 15, 1998 - v2
    Checksum:i232C0D6FA64320A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 132AL → V in CAA63244. (PubMed:8674414)Curated
    Sequence conflicti182 – 1821L → I in BAC36298. (PubMed:16141072)Curated
    Sequence conflicti388 – 3881H → Q in BAC36298. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92499 mRNA. Translation: CAA63244.1.
    Y08222 Genomic DNA. Translation: CAA69399.1.
    X74040 mRNA. Translation: CAA52192.1.
    AK076319 mRNA. Translation: BAC36298.1.
    S63607 mRNA. Translation: AAB27463.1.
    CCDSiCCDS40499.1.
    PIRiS34472.
    RefSeqiNP_038547.2. NM_013519.2.
    UniGeneiMm.14092.

    Genome annotation databases

    EnsembliENSMUST00000054691; ENSMUSP00000055290; ENSMUSG00000046714.
    GeneIDi14234.
    KEGGimmu:14234.
    UCSCiuc012glx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92499 mRNA. Translation: CAA63244.1 .
    Y08222 Genomic DNA. Translation: CAA69399.1 .
    X74040 mRNA. Translation: CAA52192.1 .
    AK076319 mRNA. Translation: BAC36298.1 .
    S63607 mRNA. Translation: AAB27463.1 .
    CCDSi CCDS40499.1.
    PIRi S34472.
    RefSeqi NP_038547.2. NM_013519.2.
    UniGenei Mm.14092.

    3D structure databases

    ProteinModelPortali Q61850.
    SMRi Q61850. Positions 69-161.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61850.

    Proteomic databases

    PRIDEi Q61850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054691 ; ENSMUSP00000055290 ; ENSMUSG00000046714 .
    GeneIDi 14234.
    KEGGi mmu:14234.
    UCSCi uc012glx.1. mouse.

    Organism-specific databases

    CTDi 2303.
    MGIi MGI:1347481. Foxc2.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00740000114928.
    HOGENOMi HOG000007939.
    HOVERGENi HBG051640.
    InParanoidi Q61850.
    KOi K09396.
    OMAi LNHLPGH.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q61850.
    TreeFami TF316127.

    Miscellaneous databases

    NextBioi 285515.
    PROi Q61850.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61850.
    CleanExi MM_FOXC2.
    Genevestigatori Q61850.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development."
      Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlondorff J., Mincheva A., Lichter P., Schuetz G.
      Development 122:1751-1758(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Embryo.
    2. "Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures."
      Miura N., Iida K., Kakinuma H., Yang X.-L., Sugiyama T.
      Genomics 41:489-492(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION.
      Strain: 129 and ICR.
      Tissue: Embryo.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    4. "MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme."
      Miura N., Wanaka A., Tohyama M., Tanaka K.
      FEBS Lett. 326:171-176(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-494.

    Entry informationi

    Entry nameiFOXC2_MOUSE
    AccessioniPrimary (citable) accession number: Q61850
    Secondary accession number(s): P97948, Q63869, Q8C694
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3