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Q61850

- FOXC2_MOUSE

UniProt

Q61850 - FOXC2_MOUSE

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Protein

Forkhead box protein C2

Gene

Foxc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 16192Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: UniProtKB
  2. DNA binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  5. sequence-specific DNA binding Source: UniProtKB
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  7. transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. blood vessel development Source: MGI
  3. blood vessel remodeling Source: MGI
  4. camera-type eye development Source: MGI
  5. cardiac muscle cell proliferation Source: MGI
  6. cell proliferation Source: MGI
  7. collagen fibril organization Source: MGI
  8. embryonic cranial skeleton morphogenesis Source: MGI
  9. embryonic heart tube development Source: MGI
  10. embryonic skeletal system morphogenesis Source: MGI
  11. embryonic viscerocranium morphogenesis Source: MGI
  12. glomerular endothelium development Source: MGI
  13. glomerular mesangial cell development Source: MGI
  14. glomerular visceral epithelial cell differentiation Source: MGI
  15. heart development Source: MGI
  16. heart morphogenesis Source: MGI
  17. insulin receptor signaling pathway Source: UniProtKB
  18. kidney development Source: MGI
  19. lymphangiogenesis Source: UniProtKB
  20. lymph vessel development Source: MGI
  21. metanephros development Source: MGI
  22. negative regulation of apoptotic process involved in outflow tract morphogenesis Source: MGI
  23. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  24. neural crest cell development Source: MGI
  25. Notch signaling pathway Source: MGI
  26. ossification Source: MGI
  27. paraxial mesodermal cell fate commitment Source: MGI
  28. paraxial mesoderm formation Source: MGI
  29. patterning of blood vessels Source: MGI
  30. positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
  31. positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
  32. positive regulation of endothelial cell migration Source: BHF-UCL
  33. positive regulation of integrin activation Source: BHF-UCL
  34. positive regulation of transcription, DNA-templated Source: UniProtKB
  35. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  36. positive regulation of vascular wound healing Source: BHF-UCL
  37. regulation of blood vessel size Source: MGI
  38. regulation of organ growth Source: MGI
  39. response to hormone Source: UniProtKB
  40. skeletal system development Source: MGI
  41. somitogenesis Source: UniProtKB
  42. transcription from RNA polymerase II promoter Source: GOC
  43. ureteric bud development Source: MGI
  44. vascular endothelial growth factor receptor signaling pathway Source: MGI
  45. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein C2
Alternative name(s):
Brain factor 3
Short name:
BF-3
Forkhead-related protein FKHL14
Mesenchyme fork head protein 1
Short name:
MFH-1 protein
Transcription factor FKH-14
Gene namesi
Name:Foxc2
Synonyms:Fkh14, Fkhl14, Mfh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1347481. Foxc2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Forkhead box protein C2PRO_0000091809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141PhosphoserineBy similarity
Modified residuei218 – 2181PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei246 – 2461PhosphothreonineBy similarity
Modified residuei250 – 2501PhosphoserineBy similarity
Modified residuei280 – 2801PhosphoserineBy similarity
Modified residuei287 – 2871PhosphoserineBy similarity
Modified residuei366 – 3661PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61850.
PRIDEiQ61850.

PTM databases

PhosphoSiteiQ61850.

Expressioni

Developmental stagei

Expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head and limbs.

Gene expression databases

BgeeiQ61850.
CleanExiMM_FOXC2.
ExpressionAtlasiQ61850. differential.
GenevestigatoriQ61850.

Structurei

3D structure databases

ProteinModelPortaliQ61850.
SMRiQ61850. Positions 69-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1665Poly-Arg
Compositional biasi386 – 39510His-rich
Compositional biasi396 – 41116Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ61850.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ61850.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61850 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA
60 70 80 90 100
GMGRSYAPYH HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF
110 120 130 140 150
IMDRFPFYRE NKQGWQNSIR HNLSLNECFV KVPRDDKKPG KGSYWTLDPD
160 170 180 190 200
SYNMFENGSF LRRRRRFKKK DVPKDKEERA HLKEPPSTTA KGAPTGTPVA
210 220 230 240 250
DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP RSASSTPAGS
260 270 280 290 300
PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL
310 320 330 340 350
ALPYAAAPPA AYTQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP
360 370 380 390 400
PALDEALSDH PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HGHLHPQAPP
410 420 430 440 450
PAPQPPPAPQ PATQATSWYL NHGGDLSHLP GHTFATQQQT FPNVREMFNS
460 470 480 490
HRLGLDNSSL GESQVSNASC QLPYRATPSL YRHAAPYSYD CTKY
Length:494
Mass (Da):52,874
Last modified:July 15, 1998 - v2
Checksum:i232C0D6FA64320A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132AL → V in CAA63244. (PubMed:8674414)Curated
Sequence conflicti182 – 1821L → I in BAC36298. (PubMed:16141072)Curated
Sequence conflicti388 – 3881H → Q in BAC36298. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92499 mRNA. Translation: CAA63244.1.
Y08222 Genomic DNA. Translation: CAA69399.1.
X74040 mRNA. Translation: CAA52192.1.
AK076319 mRNA. Translation: BAC36298.1.
S63607 mRNA. Translation: AAB27463.1.
CCDSiCCDS40499.1.
PIRiS34472.
RefSeqiNP_038547.2. NM_013519.2.
UniGeneiMm.14092.

Genome annotation databases

EnsembliENSMUST00000054691; ENSMUSP00000055290; ENSMUSG00000046714.
GeneIDi14234.
KEGGimmu:14234.
UCSCiuc012glx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92499 mRNA. Translation: CAA63244.1 .
Y08222 Genomic DNA. Translation: CAA69399.1 .
X74040 mRNA. Translation: CAA52192.1 .
AK076319 mRNA. Translation: BAC36298.1 .
S63607 mRNA. Translation: AAB27463.1 .
CCDSi CCDS40499.1.
PIRi S34472.
RefSeqi NP_038547.2. NM_013519.2.
UniGenei Mm.14092.

3D structure databases

ProteinModelPortali Q61850.
SMRi Q61850. Positions 69-161.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61850.

Proteomic databases

MaxQBi Q61850.
PRIDEi Q61850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054691 ; ENSMUSP00000055290 ; ENSMUSG00000046714 .
GeneIDi 14234.
KEGGi mmu:14234.
UCSCi uc012glx.1. mouse.

Organism-specific databases

CTDi 2303.
MGIi MGI:1347481. Foxc2.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118904.
HOGENOMi HOG000007939.
HOVERGENi HBG051640.
InParanoidi Q61850.
KOi K09396.
OMAi LNHLPGH.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q61850.
TreeFami TF316127.

Miscellaneous databases

NextBioi 285515.
PROi Q61850.
SOURCEi Search...

Gene expression databases

Bgeei Q61850.
CleanExi MM_FOXC2.
ExpressionAtlasi Q61850. differential.
Genevestigatori Q61850.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development."
    Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlondorff J., Mincheva A., Lichter P., Schuetz G.
    Development 122:1751-1758(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  2. "Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures."
    Miura N., Iida K., Kakinuma H., Yang X.-L., Sugiyama T.
    Genomics 41:489-492(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION.
    Strain: 129 and ICR.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  4. "MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme."
    Miura N., Wanaka A., Tohyama M., Tanaka K.
    FEBS Lett. 326:171-176(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-494.

Entry informationi

Entry nameiFOXC2_MOUSE
AccessioniPrimary (citable) accession number: Q61850
Secondary accession number(s): P97948, Q63869, Q8C694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3