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Q61846

- MELK_MOUSE

UniProt

Q61846 - MELK_MOUSE

Protein

Maternal embryonic leucine zipper kinase

Gene

Melk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.2 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation
    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by autophosphorylation of the T-loop at Thr-167 and Ser-171: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-167 is not mediated by STK11/LKB1 but via autophosphorylation instead. Inhibited by calcium-binding. Kinase activity is also regulated by reducing agents: dithiothreitol (DTT) or reduced glutathione are required for kinase activity in vitro; such dependence is however not due to the presence of disulfide bonds By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401ATPPROSITE-ProRule annotation
    Active sitei132 – 1321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: UniProtKB
    3. lipid binding Source: UniProtKB-KW
    4. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. protein kinase activity Source: MGI
    7. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. cell cycle Source: UniProtKB-KW
    3. cell proliferation Source: UniProtKB
    4. hemopoiesis Source: UniProtKB
    5. intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
    6. neural precursor cell proliferation Source: UniProtKB
    7. peptidyl-tyrosine phosphorylation Source: GOC
    8. positive regulation of apoptotic process Source: UniProtKB
    9. protein autophosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Cell cycle

    Keywords - Ligandi

    ATP-binding, Calcium, Lipid-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Maternal embryonic leucine zipper kinase (EC:2.7.11.1)
    Alternative name(s):
    Protein kinase PK38
    Short name:
    mPK38
    Tyrosine-protein kinase MELK (EC:2.7.10.2)
    Gene namesi
    Name:Melk
    Synonyms:Kiaa0175, Pk38
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:106924. Melk.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB
    2. cytoplasm Source: MGI
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi40 – 401K → R: Loss of kinase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Maternal embryonic leucine zipper kinasePRO_0000086324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561Phosphothreonine; by autocatalysisBy similarity
    Modified residuei163 – 1631Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei167 – 1671Phosphothreonine; by autocatalysisBy similarity
    Modified residuei171 – 1711Phosphoserine; by autocatalysisBy similarity
    Modified residuei253 – 2531Phosphoserine; by autocatalysisBy similarity
    Modified residuei336 – 3361Phosphoserine; by autocatalysisBy similarity
    Modified residuei343 – 3431Phosphoserine; by autocatalysisBy similarity
    Modified residuei352 – 3521Phosphoserine; by autocatalysisBy similarity
    Modified residuei399 – 3991Phosphoserine; by autocatalysisBy similarity
    Modified residuei423 – 4231Phosphoserine; by autocatalysisBy similarity
    Modified residuei486 – 4861Phosphothreonine; by autocatalysisBy similarity
    Modified residuei490 – 4901PhosphoserineBy similarity
    Modified residuei497 – 4971Phosphoserine; by autocatalysisBy similarity
    Modified residuei510 – 5101PhosphothreonineBy similarity
    Modified residuei521 – 5211Phosphoserine; alternate2 Publications
    Modified residuei521 – 5211Phosphoserine; by autocatalysis; alternate2 Publications
    Modified residuei531 – 5311Phosphothreonine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ61846.
    PRIDEiQ61846.

    PTM databases

    PhosphoSiteiQ61846.

    Expressioni

    Tissue specificityi

    Expressed in testis, ovary, thymus, spleen and T-cell. Expressed by neural progenitors: highly enriched in cultures containing multipotent progenitors.3 Publications

    Developmental stagei

    Expressed in the 2-cell-stage embryo, followed by a strong expression at 8-cell-stage.1 Publication

    Gene expression databases

    ArrayExpressiQ61846.
    BgeeiQ61846.
    CleanExiMM_MELK.
    GenevestigatoriQ61846.

    Interactioni

    Subunit structurei

    Monomer. Interacts with ZNF622 and PPP1R8 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201390. 9 interactions.

    Structurei

    Secondary structure

    1
    643
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 75
    Turni8 – 103
    Beta strandi11 – 199
    Beta strandi21 – 3010
    Turni31 – 333
    Beta strandi36 – 438
    Helixi44 – 474
    Helixi48 – 514
    Helixi52 – 6211
    Beta strandi72 – 776
    Beta strandi79 – 879
    Helixi94 – 1018
    Helixi106 – 12520
    Helixi135 – 1373
    Beta strandi138 – 1403
    Beta strandi146 – 1483
    Helixi172 – 1743
    Helixi177 – 1793
    Helixi188 – 20417
    Helixi214 – 22310
    Helixi234 – 24310
    Turni248 – 2503
    Helixi254 – 2585
    Helixi261 – 2644
    Helixi284 – 29411
    Helixi298 – 3058
    Helixi312 – 32615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BFMX-ray2.35A1-326[»]
    ProteinModelPortaliQ61846.
    SMRiQ61846. Positions 2-312, 546-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 263253Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini594 – 64350KA1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni282 – 32140UBA-likeBy similarityAdd
    BLAST
    Regioni326 – 643318Autoinhibitory regionBy similarityAdd
    BLAST

    Domaini

    The KA1 domain mediates binding to phospholipids and targeting to membranes.By similarity

    Sequence similaritiesi

    Contains 1 KA1 (kinase-associated) domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000115114.
    HOGENOMiHOG000233023.
    HOVERGENiHBG106273.
    InParanoidiQ3TPU1.
    KOiK08799.
    OMAiWQSKNPF.
    OrthoDBiEOG7CK36C.
    TreeFamiTF314032.

    Family and domain databases

    Gene3Di3.30.310.80. 1 hit.
    InterProiIPR028375. KA1/Ssp2_C.
    IPR001772. KA1_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF02149. KA1. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF103243. SSF103243. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50032. KA1. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61846-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDYDELLKY YELYETIGTG GFAKVKLACH VLTGEMVAIK IMDKNALGSD    50
    LPRVKTEIDA LKSLRHQHIC QLYHVLETKN KIFMVLEYCP GGELFDYIIS 100
    QDRLSEEETR VVFRQILSAV AYVHSQGYAH RDLKPENLLF DENHKLKLID 150
    FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA DVWSMGILLY 200
    VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSPSSILLL QQMLQVDPKK 250
    RISMRNLLNH PWVMQDYSCP VEWQSKTPLT HLDEDCVTEL SVHHRSSRQT 300
    MEDLISSWQY DHLTATYLLL LAKKARGKPA RLQLLSFSCG TASTTPKSKN 350
    LSLEDMSTSD DNCVAGLIDY ELCEDKLLAP KTPQVTKHLA ESNHAASKSP 400
    APGVRRAVAN KLMDKENVCT PKSSVKNEEQ FVFSEPKIPV SKNQYKREIP 450
    ASPTRFPTPA KARAQCLREA PVRTPGNSAG ADTLTTGVIS PERRCRSMDV 500
    DLNQAHMEDT PKKKGTNVFG SLERGLDKVL TALTRNKKKG SARDGPRKRK 550
    LHYNVTTTRL VNPDQLLSEI MAILPKKNVD FVQKGYTLKC QTQSDFGKVT 600
    MQFELEVCQL QRPDVVGIRR QRLKGDAWVY KRLVEDILSG CKM 643
    Length:643
    Mass (Da):72,729
    Last modified:July 27, 2011 - v2
    Checksum:i5637D2A4E8CFA216
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti335 – 3351L → P in CAA64641. (PubMed:9136115)Curated
    Sequence conflicti335 – 3351L → P in BAC97886. (PubMed:14621295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76158 mRNA. Translation: AAB72030.1.
    X95351 mRNA. Translation: CAA64641.1.
    AK011932 mRNA. Translation: BAB27923.1.
    AK145316 mRNA. Translation: BAE26362.1.
    AK164138 mRNA. Translation: BAE37644.1.
    AK129076 mRNA. Translation: BAC97886.1.
    AL805952, AL807399 Genomic DNA. Translation: CAM14393.1.
    AL807399, AL805952 Genomic DNA. Translation: CAM22652.1.
    CCDSiCCDS18124.1.
    RefSeqiNP_034920.2. NM_010790.2.
    UniGeneiMm.268668.

    Genome annotation databases

    EnsembliENSMUST00000045607; ENSMUSP00000043806; ENSMUSG00000035683.
    GeneIDi17279.
    KEGGimmu:17279.
    UCSCiuc008srv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76158 mRNA. Translation: AAB72030.1 .
    X95351 mRNA. Translation: CAA64641.1 .
    AK011932 mRNA. Translation: BAB27923.1 .
    AK145316 mRNA. Translation: BAE26362.1 .
    AK164138 mRNA. Translation: BAE37644.1 .
    AK129076 mRNA. Translation: BAC97886.1 .
    AL805952 , AL807399 Genomic DNA. Translation: CAM14393.1 .
    AL807399 , AL805952 Genomic DNA. Translation: CAM22652.1 .
    CCDSi CCDS18124.1.
    RefSeqi NP_034920.2. NM_010790.2.
    UniGenei Mm.268668.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BFM X-ray 2.35 A 1-326 [» ]
    ProteinModelPortali Q61846.
    SMRi Q61846. Positions 2-312, 546-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201390. 9 interactions.

    PTM databases

    PhosphoSitei Q61846.

    Proteomic databases

    PaxDbi Q61846.
    PRIDEi Q61846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045607 ; ENSMUSP00000043806 ; ENSMUSG00000035683 .
    GeneIDi 17279.
    KEGGi mmu:17279.
    UCSCi uc008srv.1. mouse.

    Organism-specific databases

    CTDi 9833.
    MGIi MGI:106924. Melk.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000115114.
    HOGENOMi HOG000233023.
    HOVERGENi HBG106273.
    InParanoidi Q3TPU1.
    KOi K08799.
    OMAi WQSKNPF.
    OrthoDBi EOG7CK36C.
    TreeFami TF314032.

    Miscellaneous databases

    NextBioi 291778.
    PROi Q61846.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61846.
    Bgeei Q61846.
    CleanExi MM_MELK.
    Genevestigatori Q61846.

    Family and domain databases

    Gene3Di 3.30.310.80. 1 hit.
    InterProi IPR028375. KA1/Ssp2_C.
    IPR001772. KA1_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF02149. KA1. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103243. SSF103243. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50032. KA1. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells."
      Gil M., Yang Y., Lee Y., Choi I., Ha H.
      Gene 195:295-301(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Keratinocyte.
    2. "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo."
      Heyer B.S., Warsowe J., Solter D., Knowles B.B., Ackerman S.L.
      Mol. Reprod. Dev. 47:148-156(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6 X DBA/2.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Spinal cord.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Cited for: FUNCTION, TISSUE SPECIFICITY.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation."
      Jung H., Seong H.A., Ha H.
      J. Biol. Chem. 283:34541-34553(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF MAP3K5, MUTAGENESIS OF LYS-40.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMELK_MOUSE
    AccessioniPrimary (citable) accession number: Q61846
    Secondary accession number(s): Q3TPU1, Q61804, Q6ZQH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3