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Q61839

- ANFC_MOUSE

UniProt

Q61839 - ANFC_MOUSE

Protein

C-type natriuretic peptide

Gene

Nppc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3.2 Publications

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI
    2. receptor binding Source: MGI

    GO - Biological processi

    1. cGMP biosynthetic process Source: UniProtKB
    2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
    3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
    4. negative regulation of cell proliferation Source: Ensembl
    5. negative regulation of DNA metabolic process Source: Ensembl
    6. negative regulation of meiotic cell cycle Source: MGI
    7. negative regulation of oocyte maturation Source: MGI
    8. organ development Source: MGI
    9. ossification Source: UniProtKB-KW
    10. positive regulation of cGMP biosynthetic process Source: Ensembl
    11. positive regulation of osteoblast differentiation Source: Ensembl
    12. positive regulation of vasodilation Source: Ensembl
    13. post-embryonic development Source: MGI
    14. receptor guanylyl cyclase signaling pathway Source: UniProtKB
    15. regulation of blood vessel size Source: UniProtKB-KW
    16. regulation of multicellular organism growth Source: MGI
    17. regulation of smooth muscle cell proliferation Source: Ensembl
    18. response to drug Source: Ensembl
    19. response to ethanol Source: Ensembl
    20. response to hypoxia Source: Ensembl
    21. single organism reproductive process Source: MGI

    Keywords - Molecular functioni

    Hormone, Vasoactive

    Keywords - Biological processi

    Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type natriuretic peptide
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Nppc
    Synonyms:Cnp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:97369. Nppc.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: Ensembl
    3. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice are viable perinatally but less than half survive postnatally due to skeletal abnormalities. They display severe dwarfism which is the consequence of a defect in endochondral ossification.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 7350PRO_0000001557Add
    BLAST
    Peptidei74 – 12653CNP-53By similarityPRO_0000001558Add
    BLAST
    Peptidei98 – 12629CNP-29By similarityPRO_0000001559Add
    BLAST
    Peptidei105 – 12622CNP-22PRO_0000001560Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 126By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ61839.

    Expressioni

    Gene expression databases

    BgeeiQ61839.
    CleanExiMM_CNP.
    MM_NPPC.
    GenevestigatoriQ61839.

    Interactioni

    Protein-protein interaction databases

    BioGridi201829. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61839.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the natriuretic peptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43160.
    GeneTreeiENSGT00390000015492.
    HOGENOMiHOG000010304.
    HOVERGENiHBG004229.
    InParanoidiQ61839.
    KOiK12336.
    OMAiHKMDRIG.
    OrthoDBiEOG79CZ1S.
    PhylomeDBiQ61839.
    TreeFamiTF106305.

    Family and domain databases

    InterProiIPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view]
    PfamiPF00212. ANP. 1 hit.
    [Graphical view]
    PRINTSiPR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTiSM00183. NAT_PEP. 1 hit.
    [Graphical view]
    PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61839-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL ADSQAAGGNQ    50
    KKGDKTPGSG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG 100
    GNKKGLSKGC FGLKLDRIGS MSGLGC 126
    Length:126
    Mass (Da):13,320
    Last modified:November 1, 1996 - v1
    Checksum:i8F65B1C4E82F0ACB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28873 Genomic DNA. Translation: BAA06028.1.
    U62939 Genomic DNA. Translation: AAB61717.1.
    CCDSiCCDS15123.1.
    PIRiA55688.
    RefSeqiNP_035063.1. NM_010933.5.
    UniGeneiMm.12802.
    Mm.488919.

    Genome annotation databases

    EnsembliENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241.
    GeneIDi18159.
    KEGGimmu:18159.
    UCSCiuc007bvt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28873 Genomic DNA. Translation: BAA06028.1 .
    U62939 Genomic DNA. Translation: AAB61717.1 .
    CCDSi CCDS15123.1.
    PIRi A55688.
    RefSeqi NP_035063.1. NM_010933.5.
    UniGenei Mm.12802.
    Mm.488919.

    3D structure databases

    ProteinModelPortali Q61839.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201829. 1 interaction.

    Proteomic databases

    PRIDEi Q61839.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027449 ; ENSMUSP00000027449 ; ENSMUSG00000026241 .
    GeneIDi 18159.
    KEGGi mmu:18159.
    UCSCi uc007bvt.2. mouse.

    Organism-specific databases

    CTDi 4880.
    MGIi MGI:97369. Nppc.

    Phylogenomic databases

    eggNOGi NOG43160.
    GeneTreei ENSGT00390000015492.
    HOGENOMi HOG000010304.
    HOVERGENi HBG004229.
    InParanoidi Q61839.
    KOi K12336.
    OMAi HKMDRIG.
    OrthoDBi EOG79CZ1S.
    PhylomeDBi Q61839.
    TreeFami TF106305.

    Miscellaneous databases

    NextBioi 293428.
    PROi Q61839.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61839.
    CleanExi MM_CNP.
    MM_NPPC.
    Genevestigatori Q61839.

    Family and domain databases

    InterProi IPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view ]
    Pfami PF00212. ANP. 1 hit.
    [Graphical view ]
    PRINTSi PR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTi SM00183. NAT_PEP. 1 hit.
    [Graphical view ]
    PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)."
      Ogawa Y., Itoh H., Yoshitake Y., Inoue M., Yoshimasa T., Serikawa T., Nakao K.
      Genomics 24:383-387(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    2. "Isolation, mapping, and regulated expression of the gene encoding mouse C-type natriuretic peptide."
      Huang H., Acuff C.G., Steinhelper M.E.
      Am. J. Physiol. 271:H1565-H1575(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. "Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling."
      Madhani M., Scotland R.S., MacAllister R.J., Hobbs A.J.
      Br. J. Pharmacol. 139:1289-1296(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiANFC_MOUSE
    AccessioniPrimary (citable) accession number: Q61839
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3