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Q61839 (ANFC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type natriuretic peptide

Cleaved into the following 3 chains:

  1. CNP-22
  2. CNP-29
  3. CNP-53
Gene names
Name:Nppc
Synonyms:Cnp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Ref.3 Ref.4

Subcellular location

Secreted.

Disruption phenotype

Mice are viable perinatally but less than half survive postnatally due to skeletal abnormalities. They display severe dwarfism which is the consequence of a defect in endochondral ossification. Ref.3

Sequence similarities

Belongs to the natriuretic peptide family.

Ontologies

Keywords
   Biological processOsteogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
Vasoactive
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcGMP biosynthetic process

Inferred from mutant phenotype Ref.3. Source: UniProtKB

growth plate cartilage chondrocyte differentiation

Inferred from mutant phenotype Ref.3. Source: UniProtKB

growth plate cartilage chondrocyte proliferation

Inferred from mutant phenotype Ref.3. Source: UniProtKB

negative regulation of DNA metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of meiotic cell cycle

Inferred from mutant phenotype PubMed 20947764. Source: MGI

negative regulation of oocyte maturation

Inferred from mutant phenotype PubMed 20947764. Source: MGI

organ development

Inferred from mutant phenotype PubMed 17439653. Source: MGI

ossification

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cGMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from mutant phenotype PubMed 17439653. Source: MGI

receptor guanylyl cyclase signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of blood vessel size

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 17439653. Source: MGI

regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

single organism reproductive process

Inferred from mutant phenotype PubMed 20947764. Source: MGI

   Cellular_componentextracellular region

Traceable author statement Ref.1. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionneuropeptide hormone activity

Traceable author statement Ref.2. Source: MGI

receptor binding

Inferred from direct assay PubMed 14514678. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 7350
PRO_0000001557
Peptide74 – 12653CNP-53 By similarity
PRO_0000001558
Peptide98 – 12629CNP-29 By similarity
PRO_0000001559
Peptide105 – 12622CNP-22
PRO_0000001560

Amino acid modifications

Disulfide bond110 ↔ 126 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61839 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8F65B1C4E82F0ACB

FASTA12613,320
        10         20         30         40         50         60 
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL ADSQAAGGNQ KKGDKTPGSG 

        70         80         90        100        110        120 
GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS 


MSGLGC 

« Hide

References

[1]"Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)."
Ogawa Y., Itoh H., Yoshitake Y., Inoue M., Yoshimasa T., Serikawa T., Nakao K.
Genomics 24:383-387(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[2]"Isolation, mapping, and regulated expression of the gene encoding mouse C-type natriuretic peptide."
Huang H., Acuff C.G., Steinhelper M.E.
Am. J. Physiol. 271:H1565-H1575(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"Dwarfism and early death in mice lacking C-type natriuretic peptide."
Chusho H., Tamura N., Ogawa Y., Yasoda A., Suda M., Miyazawa T., Nakamura K., Nakao K., Kurihara T., Komatsu Y., Itoh H., Tanaka K., Saito Y., Katsuki M., Nakao K.
Proc. Natl. Acad. Sci. U.S.A. 98:4016-4021(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[4]"Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling."
Madhani M., Scotland R.S., MacAllister R.J., Hobbs A.J.
Br. J. Pharmacol. 139:1289-1296(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D28873 Genomic DNA. Translation: BAA06028.1.
U62939 Genomic DNA. Translation: AAB61717.1.
CCDSCCDS15123.1.
PIRA55688.
RefSeqNP_035063.1. NM_010933.5.
UniGeneMm.12802.
Mm.488919.

3D structure databases

ProteinModelPortalQ61839.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201829. 1 interaction.

Proteomic databases

PRIDEQ61839.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241.
GeneID18159.
KEGGmmu:18159.
UCSCuc007bvt.2. mouse.

Organism-specific databases

CTD4880.
MGIMGI:97369. Nppc.

Phylogenomic databases

eggNOGNOG43160.
GeneTreeENSGT00390000015492.
HOGENOMHOG000010304.
HOVERGENHBG004229.
InParanoidQ61839.
KOK12336.
OMAHKMDRIG.
OrthoDBEOG79CZ1S.
PhylomeDBQ61839.
TreeFamTF106305.

Gene expression databases

BgeeQ61839.
CleanExMM_CNP.
MM_NPPC.
GenevestigatorQ61839.

Family and domain databases

InterProIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view]
PfamPF00212. ANP. 1 hit.
[Graphical view]
PRINTSPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293428.
PROQ61839.
SOURCESearch...

Entry information

Entry nameANFC_MOUSE
AccessionPrimary (citable) accession number: Q61839
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot