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Protein

C-type natriuretic peptide

Gene

Nppc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3.2 Publications

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI
  2. receptor binding Source: MGI

GO - Biological processi

  1. cGMP biosynthetic process Source: UniProtKB
  2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
  3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
  4. negative regulation of cell proliferation Source: Ensembl
  5. negative regulation of DNA metabolic process Source: Ensembl
  6. negative regulation of meiotic cell cycle Source: MGI
  7. negative regulation of oocyte maturation Source: MGI
  8. organ development Source: MGI
  9. ossification Source: UniProtKB-KW
  10. positive regulation of cGMP biosynthetic process Source: Ensembl
  11. positive regulation of osteoblast differentiation Source: Ensembl
  12. positive regulation of vasodilation Source: Ensembl
  13. post-embryonic development Source: MGI
  14. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  15. regulation of blood vessel size Source: UniProtKB-KW
  16. regulation of cAMP metabolic process Source: MGI
  17. regulation of cGMP metabolic process Source: MGI
  18. regulation of multicellular organism growth Source: MGI
  19. regulation of smooth muscle cell proliferation Source: Ensembl
  20. response to drug Source: Ensembl
  21. response to ethanol Source: Ensembl
  22. response to hypoxia Source: Ensembl
  23. single organism reproductive process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:Nppc
Synonyms:Cnp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97369. Nppc.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
  3. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable perinatally but less than half survive postnatally due to skeletal abnormalities. They display severe dwarfism which is the consequence of a defect in endochondral ossification.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 7350PRO_0000001557Add
BLAST
Peptidei74 – 12653CNP-53By similarityPRO_0000001558Add
BLAST
Peptidei98 – 12629CNP-29By similarityPRO_0000001559Add
BLAST
Peptidei105 – 12622CNP-22PRO_0000001560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ61839.

Expressioni

Gene expression databases

BgeeiQ61839.
CleanExiMM_CNP.
MM_NPPC.
ExpressionAtlasiQ61839. baseline.
GenevestigatoriQ61839.

Interactioni

Protein-protein interaction databases

BioGridi201829. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61839.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43160.
GeneTreeiENSGT00390000015492.
HOGENOMiHOG000010304.
HOVERGENiHBG004229.
InParanoidiQ61839.
KOiK12336.
OMAiTPPGEEV.
OrthoDBiEOG79CZ1S.
PhylomeDBiQ61839.
TreeFamiTF106305.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL ADSQAAGGNQ
60 70 80 90 100
KKGDKTPGSG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG
110 120
GNKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,320
Last modified:November 1, 1996 - v1
Checksum:i8F65B1C4E82F0ACB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28873 Genomic DNA. Translation: BAA06028.1.
U62939 Genomic DNA. Translation: AAB61717.1.
CCDSiCCDS15123.1.
PIRiA55688.
RefSeqiNP_035063.1. NM_010933.5.
UniGeneiMm.12802.
Mm.488919.

Genome annotation databases

EnsembliENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241.
GeneIDi18159.
KEGGimmu:18159.
UCSCiuc007bvt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28873 Genomic DNA. Translation: BAA06028.1.
U62939 Genomic DNA. Translation: AAB61717.1.
CCDSiCCDS15123.1.
PIRiA55688.
RefSeqiNP_035063.1. NM_010933.5.
UniGeneiMm.12802.
Mm.488919.

3D structure databases

ProteinModelPortaliQ61839.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201829. 1 interaction.

Proteomic databases

PRIDEiQ61839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241.
GeneIDi18159.
KEGGimmu:18159.
UCSCiuc007bvt.2. mouse.

Organism-specific databases

CTDi4880.
MGIiMGI:97369. Nppc.

Phylogenomic databases

eggNOGiNOG43160.
GeneTreeiENSGT00390000015492.
HOGENOMiHOG000010304.
HOVERGENiHBG004229.
InParanoidiQ61839.
KOiK12336.
OMAiTPPGEEV.
OrthoDBiEOG79CZ1S.
PhylomeDBiQ61839.
TreeFamiTF106305.

Miscellaneous databases

NextBioi293428.
PROiQ61839.
SOURCEiSearch...

Gene expression databases

BgeeiQ61839.
CleanExiMM_CNP.
MM_NPPC.
ExpressionAtlasiQ61839. baseline.
GenevestigatoriQ61839.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)."
    Ogawa Y., Itoh H., Yoshitake Y., Inoue M., Yoshimasa T., Serikawa T., Nakao K.
    Genomics 24:383-387(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "Isolation, mapping, and regulated expression of the gene encoding mouse C-type natriuretic peptide."
    Huang H., Acuff C.G., Steinhelper M.E.
    Am. J. Physiol. 271:H1565-H1575(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling."
    Madhani M., Scotland R.S., MacAllister R.J., Hobbs A.J.
    Br. J. Pharmacol. 139:1289-1296(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiANFC_MOUSE
AccessioniPrimary (citable) accession number: Q61839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.