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Q61839

- ANFC_MOUSE

UniProt

Q61839 - ANFC_MOUSE

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Protein

C-type natriuretic peptide

Gene
Nppc, Cnp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3.2 Publications

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI
  2. receptor binding Source: MGI

GO - Biological processi

  1. cGMP biosynthetic process Source: UniProtKB
  2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
  3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
  4. negative regulation of cell proliferation Source: Ensembl
  5. negative regulation of DNA metabolic process Source: Ensembl
  6. negative regulation of meiotic cell cycle Source: MGI
  7. negative regulation of oocyte maturation Source: MGI
  8. organ development Source: MGI
  9. ossification Source: UniProtKB-KW
  10. positive regulation of cGMP biosynthetic process Source: Ensembl
  11. positive regulation of osteoblast differentiation Source: Ensembl
  12. positive regulation of vasodilation Source: Ensembl
  13. post-embryonic development Source: MGI
  14. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  15. regulation of blood vessel size Source: UniProtKB-KW
  16. regulation of multicellular organism growth Source: MGI
  17. regulation of smooth muscle cell proliferation Source: Ensembl
  18. response to drug Source: Ensembl
  19. response to ethanol Source: Ensembl
  20. response to hypoxia Source: Ensembl
  21. single organism reproductive process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:Nppc
Synonyms:Cnp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:97369. Nppc.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
  3. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable perinatally but less than half survive postnatally due to skeletal abnormalities. They display severe dwarfism which is the consequence of a defect in endochondral ossification.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Propeptidei24 – 7350PRO_0000001557Add
BLAST
Peptidei74 – 12653CNP-53 By similarityPRO_0000001558Add
BLAST
Peptidei98 – 12629CNP-29 By similarityPRO_0000001559Add
BLAST
Peptidei105 – 12622CNP-22PRO_0000001560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 126 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ61839.

Expressioni

Gene expression databases

BgeeiQ61839.
CleanExiMM_CNP.
MM_NPPC.
GenevestigatoriQ61839.

Interactioni

Protein-protein interaction databases

BioGridi201829. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61839.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43160.
GeneTreeiENSGT00390000015492.
HOGENOMiHOG000010304.
HOVERGENiHBG004229.
InParanoidiQ61839.
KOiK12336.
OMAiHKMDRIG.
OrthoDBiEOG79CZ1S.
PhylomeDBiQ61839.
TreeFamiTF106305.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61839-1 [UniParc]FASTAAdd to Basket

« Hide

MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL ADSQAAGGNQ    50
KKGDKTPGSG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG 100
GNKKGLSKGC FGLKLDRIGS MSGLGC 126
Length:126
Mass (Da):13,320
Last modified:November 1, 1996 - v1
Checksum:i8F65B1C4E82F0ACB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28873 Genomic DNA. Translation: BAA06028.1.
U62939 Genomic DNA. Translation: AAB61717.1.
CCDSiCCDS15123.1.
PIRiA55688.
RefSeqiNP_035063.1. NM_010933.5.
UniGeneiMm.12802.
Mm.488919.

Genome annotation databases

EnsembliENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241.
GeneIDi18159.
KEGGimmu:18159.
UCSCiuc007bvt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28873 Genomic DNA. Translation: BAA06028.1 .
U62939 Genomic DNA. Translation: AAB61717.1 .
CCDSi CCDS15123.1.
PIRi A55688.
RefSeqi NP_035063.1. NM_010933.5.
UniGenei Mm.12802.
Mm.488919.

3D structure databases

ProteinModelPortali Q61839.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201829. 1 interaction.

Proteomic databases

PRIDEi Q61839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027449 ; ENSMUSP00000027449 ; ENSMUSG00000026241 .
GeneIDi 18159.
KEGGi mmu:18159.
UCSCi uc007bvt.2. mouse.

Organism-specific databases

CTDi 4880.
MGIi MGI:97369. Nppc.

Phylogenomic databases

eggNOGi NOG43160.
GeneTreei ENSGT00390000015492.
HOGENOMi HOG000010304.
HOVERGENi HBG004229.
InParanoidi Q61839.
KOi K12336.
OMAi HKMDRIG.
OrthoDBi EOG79CZ1S.
PhylomeDBi Q61839.
TreeFami TF106305.

Miscellaneous databases

NextBioi 293428.
PROi Q61839.
SOURCEi Search...

Gene expression databases

Bgeei Q61839.
CleanExi MM_CNP.
MM_NPPC.
Genevestigatori Q61839.

Family and domain databases

InterProi IPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view ]
Pfami PF00212. ANP. 1 hit.
[Graphical view ]
PRINTSi PR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTi SM00183. NAT_PEP. 1 hit.
[Graphical view ]
PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)."
    Ogawa Y., Itoh H., Yoshitake Y., Inoue M., Yoshimasa T., Serikawa T., Nakao K.
    Genomics 24:383-387(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "Isolation, mapping, and regulated expression of the gene encoding mouse C-type natriuretic peptide."
    Huang H., Acuff C.G., Steinhelper M.E.
    Am. J. Physiol. 271:H1565-H1575(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling."
    Madhani M., Scotland R.S., MacAllister R.J., Hobbs A.J.
    Br. J. Pharmacol. 139:1289-1296(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiANFC_MOUSE
AccessioniPrimary (citable) accession number: Q61839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi