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Protein

C-type natriuretic peptide

Gene

Nppc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3.2 Publications

GO - Molecular functioni

  • hormone receptor binding Source: MGI
  • neuropeptide hormone activity Source: MGI
  • peptide hormone receptor binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • signaling receptor binding Source: MGI

GO - Biological processi

  • animal organ development Source: MGI
  • cGMP biosynthetic process Source: MGI
  • growth plate cartilage chondrocyte differentiation Source: UniProtKB
  • growth plate cartilage chondrocyte proliferation Source: UniProtKB
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of DNA metabolic process Source: Ensembl
  • negative regulation of meiotic cell cycle Source: MGI
  • negative regulation of oocyte maturation Source: MGI
  • ossification Source: UniProtKB-KW
  • positive regulation of blood vessel diameter Source: Ensembl
  • positive regulation of cGMP biosynthetic process Source: Ensembl
  • positive regulation of osteoblast differentiation Source: Ensembl
  • post-embryonic development Source: MGI
  • protein folding Source: MGI
  • receptor guanylyl cyclase signaling pathway Source: UniProtKB
  • regulation of cAMP metabolic process Source: MGI
  • regulation of cGMP metabolic process Source: MGI
  • regulation of multicellular organism growth Source: MGI
  • regulation of smooth muscle cell proliferation Source: Ensembl
  • reproductive process Source: MGI
  • response to ethanol Source: Ensembl
  • response to hypoxia Source: Ensembl

Keywordsi

Molecular functionHormone, Vasoactive
Biological processOsteogenesis

Enzyme and pathway databases

ReactomeiR-MMU-5578768 Physiological factors

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:Nppc
Synonyms:Cnp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97369 Nppc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable perinatally but less than half survive postnatally due to skeletal abnormalities. They display severe dwarfism which is the consequence of a defect in endochondral ossification.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000155724 – 73Add BLAST50
PeptideiPRO_000000155874 – 126CNP-53By similarityAdd BLAST53
PeptideiPRO_000000155998 – 126CNP-29By similarityAdd BLAST29
PeptideiPRO_0000001560105 – 126CNP-22Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ61839
PRIDEiQ61839

PTM databases

PhosphoSitePlusiQ61839
SwissPalmiQ61839

Expressioni

Gene expression databases

BgeeiENSMUSG00000026241
CleanExiMM_CNP
MM_NPPC
ExpressionAtlasiQ61839 baseline and differential
GenevisibleiQ61839 MM

Interactioni

GO - Molecular functioni

  • hormone receptor binding Source: MGI
  • neuropeptide hormone activity Source: MGI
  • peptide hormone receptor binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

BioGridi201829, 1 interactor
STRINGi10090.ENSMUSP00000027449

Structurei

3D structure databases

ProteinModelPortaliQ61839
SMRiQ61839
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBQ Eukaryota
ENOG410YUR4 LUCA
GeneTreeiENSGT00390000015492
HOGENOMiHOG000010304
HOVERGENiHBG004229
InParanoidiQ61839
KOiK12336
OMAiGMWARLL
OrthoDBiEOG091G14FZ
PhylomeDBiQ61839
TreeFamiTF106305

Family and domain databases

InterProiView protein in InterPro
IPR002406 C_natriurtcpep
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00713 CNATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL ADSQAAGGNQ
60 70 80 90 100
KKGDKTPGSG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG
110 120
GNKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,320
Last modified:November 1, 1996 - v1
Checksum:i8F65B1C4E82F0ACB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28873 Genomic DNA Translation: BAA06028.1
U62939 Genomic DNA Translation: AAB61717.1
CCDSiCCDS15123.1
PIRiA55688
RefSeqiNP_035063.1, NM_010933.5
UniGeneiMm.12802
Mm.488919

Genome annotation databases

EnsembliENSMUST00000027449; ENSMUSP00000027449; ENSMUSG00000026241
GeneIDi18159
KEGGimmu:18159
UCSCiuc007bvt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiANFC_MOUSE
AccessioniPrimary (citable) accession number: Q61839
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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