Q61835 (FXYD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 3

Alternative name(s):
Chloride conductance inducer protein Mat-8
Mammary tumor 8 kDa protein
Phospholemman-like

Gene names

Name:	Fxyd3
Synonyms:	Mat8, Plml

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	88 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in a subset of murine breast tumors.
Miscellaneous	Marker of a cell type preferentially transformed by neu or ras oncoprotein.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of catalytic activity Inferred from direct assay. Source: MGI
Cellular component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum membrane Inferred from direct assay. Source: MGI microsome Inferred from direct assay. Source: MGI
Molecular function	ATPase binding Inferred from physical interaction. Source: MGI chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 88	68	FXYD domain-containing ion transport regulator 3		PRO_0000010363
Regions
	Topological domain	21 – 38	18	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 88	29	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q61835 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9CD61684B856E35D	FASTA	88	9,526
	10 20 30 40 50 60 MQEVVLSLLV LLAGLPTLDA NDPENKNDPF YYDWYSLRVG GLICAGILCA LGIIVLMSGK 70 80 CKCKFRQKPS HRPGEGPPLI TPGSAHNC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors." Morrison B.W., Leder P. Oncogene 9:3417-3426(1994) [PubMed: 7970700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: FVB/N. Tissue: Mammary gland.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
[3]	"Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes." Morrison B.W., Moorman J.R., Kowdley G.C., Kobayashi Y.M., Jones L.R., Leder P. J. Biol. Chem. 270:2176-2182(1995) [PubMed: 7836447] [Abstract] Cited for: EXPRESSION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X93038 mRNA. Translation: CAA63606.1. BC002039 mRNA. Translation: AAH02039.1. BC056223 mRNA. Translation: AAH56223.1.
IPI	IPI00126190.
PIR	S61552.
RefSeq	NP_032583.1. NM_008557.2.
UniGene	Mm.263847. Mm.389870.
3D structure databases
ProteinModelPortal	Q61835.
SMR	Q61835. Positions 21-87.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61835.
Protein family/group databases
TCDB	1.A.27.1.2. phospholemman (PLM) family.
Proteomic databases
PRIDE	Q61835.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000167369; ENSMUSP00000130245; ENSMUSG00000057092.
GeneID	17178.
KEGG	mmu:17178.
Organism-specific databases
CTD	5349.
MGI	MGI:107497. Fxyd3.
Phylogenomic databases
HOGENOM	HBG444253.
HOVERGEN	HBG008212.
InParanoid	Q61835.
OMA	PGSAHNC.
OrthoDB	EOG4W0XFT.
PhylomeDB	Q61835.
Gene expression databases
ArrayExpress	Q61835.
Bgee	Q61835.
CleanEx	MM_FXYD3.
Genevestigator	Q61835.
GermOnline	ENSMUSG00000057092. Mus musculus.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K13361.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291486.
SOURCE	Search...

Entry information

Entry name

FXYD3_MOUSE

Accession

Primary (citable) accession number: Q61835

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program