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Protein

FXYD domain-containing ion transport regulator 3

Gene

Fxyd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

GO - Molecular functioni

  • ATPase binding Source: MGI
  • chloride channel activity Source: UniProtKB-KW
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi1.A.27.1.2. the phospholemman (plm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 3
Alternative name(s):
Chloride conductance inducer protein Mat-8
Mammary tumor 8 kDa protein
Phospholemman-like
Gene namesi
Name:Fxyd3
Synonyms:Mat8, Plml
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107497. Fxyd3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 38ExtracellularSequence analysisAdd BLAST18
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 88CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001036321 – 88FXYD domain-containing ion transport regulator 3Add BLAST68

Proteomic databases

PaxDbiQ61835.
PRIDEiQ61835.

PTM databases

PhosphoSitePlusiQ61835.

Expressioni

Tissue specificityi

Expressed in a subset of murine breast tumors.

Gene expression databases

BgeeiENSMUSG00000057092.
CleanExiMM_FXYD3.
ExpressionAtlasiQ61835. baseline and differential.
GenevisibleiQ61835. MM.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: MGI

Protein-protein interaction databases

BioGridi201318. 2 interactors.
STRINGi10090.ENSMUSP00000130245.

Structurei

3D structure databases

ProteinModelPortaliQ61835.
SMRiQ61835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ61835.
KOiK13361.
OMAiKPSHRPG.
OrthoDBiEOG091G14HJ.
PhylomeDBiQ61835.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEVVLSLLV LLAGLPTLDA NDPENKNDPF YYDWYSLRVG GLICAGILCA
60 70 80
LGIIVLMSGK CKCKFRQKPS HRPGEGPPLI TPGSAHNC
Length:88
Mass (Da):9,526
Last modified:November 1, 1996 - v1
Checksum:i9CD61684B856E35D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93038 mRNA. Translation: CAA63606.1.
BC002039 mRNA. Translation: AAH02039.1.
BC056223 mRNA. Translation: AAH56223.1.
CCDSiCCDS21125.1.
PIRiS61552.
RefSeqiNP_032583.1. NM_008557.2.
UniGeneiMm.263847.

Genome annotation databases

EnsembliENSMUST00000167369; ENSMUSP00000130245; ENSMUSG00000057092.
GeneIDi17178.
KEGGimmu:17178.
UCSCiuc009gia.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93038 mRNA. Translation: CAA63606.1.
BC002039 mRNA. Translation: AAH02039.1.
BC056223 mRNA. Translation: AAH56223.1.
CCDSiCCDS21125.1.
PIRiS61552.
RefSeqiNP_032583.1. NM_008557.2.
UniGeneiMm.263847.

3D structure databases

ProteinModelPortaliQ61835.
SMRiQ61835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201318. 2 interactors.
STRINGi10090.ENSMUSP00000130245.

Protein family/group databases

TCDBi1.A.27.1.2. the phospholemman (plm) family.

PTM databases

PhosphoSitePlusiQ61835.

Proteomic databases

PaxDbiQ61835.
PRIDEiQ61835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167369; ENSMUSP00000130245; ENSMUSG00000057092.
GeneIDi17178.
KEGGimmu:17178.
UCSCiuc009gia.2. mouse.

Organism-specific databases

CTDi5349.
MGIiMGI:107497. Fxyd3.

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ61835.
KOiK13361.
OMAiKPSHRPG.
OrthoDBiEOG091G14HJ.
PhylomeDBiQ61835.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiFxyd3. mouse.
PROiQ61835.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057092.
CleanExiMM_FXYD3.
ExpressionAtlasiQ61835. baseline and differential.
GenevisibleiQ61835. MM.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXYD3_MOUSE
AccessioniPrimary (citable) accession number: Q61835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Marker of a cell type preferentially transformed by neu or ras oncoprotein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.