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Protein

FXYD domain-containing ion transport regulator 3

Gene

Fxyd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell (PubMed:15743908). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity).By similarity1 Publication

Miscellaneous

Marker of a cell type preferentially transformed by neu or ras oncoprotein.

GO - Molecular functioni

  • ATPase binding Source: MGI
  • ion channel activity Source: InterPro
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi1.A.27.1.2. the phospholemman (plm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 3
Alternative name(s):
Chloride conductance inducer protein Mat-8
Mammary tumor 8 kDa protein
Phospholemman-like
Sodium/potassium-transporting ATPase subunit FXYD3Curated
Gene namesi
Name:Fxyd3
Synonyms:Mat8, Plml
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107497. Fxyd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 88CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5V → N: Does not lead to glycosylation, suggesting that the non-cleavable signal sequence remains partly or entirely embedded in the membrane. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000103631 – 88FXYD domain-containing ion transport regulator 3Add BLAST88
Signal peptidei1 – 20Not cleaved1 PublicationAdd BLAST20

Post-translational modificationi

Glutathionylated.By similarity

Keywords - PTMi

Glutathionylation

Proteomic databases

PaxDbiQ61835.
PRIDEiQ61835.

PTM databases

PhosphoSitePlusiQ61835.

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and liver with low levels of expression in breast, brain, lung, stomach and colon (PubMed:7836447). In the gastric gland, mainly expressed in the mucus cells forming the upper part of the gland and is absent from the parietal cells (PubMed:15743908).2 Publications

Gene expression databases

BgeeiENSMUSG00000057092.
CleanExiMM_FXYD3.
ExpressionAtlasiQ61835. baseline and differential.
GenevisibleiQ61835. MM.

Interactioni

Subunit structurei

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (PubMed:15743908). Interacts with catalytic alpha subunit ATP1A1 (PubMed:15743908). Also interacts with non-catalytic beta subunit ATP1B1 (PubMed:15743908). Interacts with the ATP1A1-ATP1B1, ATP1A2-ATP1B1 and ATP1A3-ATP1B1 NKA isozymes (By similarity).By similarity1 Publication

GO - Molecular functioni

  • ATPase binding Source: MGI

Protein-protein interaction databases

BioGridi201318. 2 interactors.
STRINGi10090.ENSMUSP00000130245.

Structurei

3D structure databases

ProteinModelPortaliQ61835.
SMRiQ61835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ61835.
KOiK13361.
OMAiKPSHRPG.
OrthoDBiEOG091G14HJ.
PhylomeDBiQ61835.
TreeFamiTF333443.

Family and domain databases

InterProiView protein in InterPro
IPR000272. Ion-transport_regulator_FXYD.
PfamiView protein in Pfam
PF02038. ATP1G1_PLM_MAT8. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989. PD005989. 1 hit.
PROSITEiView protein in PROSITE
PS01310. FXYD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEVVLSLLV LLAGLPTLDA NDPENKNDPF YYDWYSLRVG GLICAGILCA
60 70 80
LGIIVLMSGK CKCKFRQKPS HRPGEGPPLI TPGSAHNC
Length:88
Mass (Da):9,526
Last modified:November 1, 1996 - v1
Checksum:i9CD61684B856E35D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93038 mRNA. Translation: CAA63606.1.
BC002039 mRNA. Translation: AAH02039.1.
BC056223 mRNA. Translation: AAH56223.1.
CCDSiCCDS21125.1.
PIRiS61552.
RefSeqiNP_032583.1. NM_008557.2.
UniGeneiMm.263847.

Genome annotation databases

EnsembliENSMUST00000167369; ENSMUSP00000130245; ENSMUSG00000057092.
GeneIDi17178.
KEGGimmu:17178.
UCSCiuc009gia.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiFXYD3_MOUSE
AccessioniPrimary (citable) accession number: Q61835
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families