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Protein

Macrophage mannose receptor 1

Gene

Mrc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.1 Publication

GO - Molecular functioni

  • cargo receptor activity Source: UniProtKB
  • mannose binding Source: MGI
  • signaling receptor activity Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cellular response to interferon-gamma Source: MGI
  • cellular response to interleukin-4 Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • receptor-mediated endocytosis Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium, Lectin

Enzyme and pathway databases

ReactomeiR-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage mannose receptor 1
Short name:
MMR
Alternative name(s):
CD_antigen: CD206
Gene namesi
Name:Mrc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97142 Mrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1388ExtracellularSequence analysisAdd BLAST1369
Transmembranei1389 – 1409HelicalSequence analysisAdd BLAST21
Topological domaini1410 – 1456CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001754920 – 1456Macrophage mannose receptor 1Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 49
Disulfide bondi74 ↔ 91
Disulfide bondi102 ↔ 149
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 194By similarity
Disulfide bondi182 ↔ 209By similarity
Disulfide bondi247 ↔ 340By similarity
Disulfide bondi316 ↔ 332By similarity
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi391 ↔ 486By similarity
Disulfide bondi463 ↔ 478By similarity
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi532 ↔ 625By similarity
Disulfide bondi600 ↔ 617By similarity
Disulfide bondi680 ↔ 777By similarity
Disulfide bondi753 ↔ 769By similarity
Disulfide bondi828 ↔ 922By similarity
Disulfide bondi899 ↔ 914By similarity
Glycosylationi926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi930N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi976 ↔ 1078By similarity
Disulfide bondi1051 ↔ 1070By similarity
Disulfide bondi1122 ↔ 1211By similarity
Glycosylationi1159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1189 ↔ 1203By similarity
Glycosylationi1204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1262 ↔ 1354By similarity
Disulfide bondi1331 ↔ 1346By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61830
PaxDbiQ61830
PRIDEiQ61830

PTM databases

PhosphoSitePlusiQ61830

Expressioni

Tissue specificityi

Detected in macrophages.1 Publication

Inductioni

Down-regulated by interferon gamma.1 Publication

Gene expression databases

BgeeiENSMUSG00000026712
CleanExiMM_MRC1
ExpressionAtlasiQ61830 baseline and differential
GenevisibleiQ61830 MM

Interactioni

Protein-protein interaction databases

IntActiQ61830, 2 interactors
MINTiQ61830
STRINGi10090.ENSMUSP00000028045

Structurei

Secondary structure

11456
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 29Combined sources3
Turni30 – 33Combined sources4
Beta strandi34 – 40Combined sources7
Beta strandi43 – 48Combined sources6
Helixi54 – 56Combined sources3
Beta strandi58 – 64Combined sources7
Beta strandi66 – 68Combined sources3
Turni69 – 72Combined sources4
Beta strandi73 – 76Combined sources4
Beta strandi78 – 80Combined sources3
Beta strandi87 – 89Combined sources3
Helixi96 – 98Combined sources3
Beta strandi100 – 102Combined sources3
Beta strandi107 – 110Combined sources4
Beta strandi116 – 118Combined sources3
Helixi121 – 123Combined sources3
Beta strandi128 – 131Combined sources4
Helixi135 – 137Combined sources3
Beta strandi144 – 147Combined sources4
Helixi148 – 151Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DQGX-ray1.70A20-154[»]
1DQOX-ray2.20A20-154[»]
1FWUX-ray1.90A21-154[»]
1FWVX-ray2.20A21-154[»]
ProteinModelPortaliQ61830
SMRiQ61830
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61830

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 142Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST121
Domaini163 – 211Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini225 – 341C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini369 – 487C-type lectin 2PROSITE-ProRule annotationAdd BLAST119
Domaini511 – 626C-type lectin 3PROSITE-ProRule annotationAdd BLAST116
Domaini655 – 778C-type lectin 4PROSITE-ProRule annotationAdd BLAST124
Domaini807 – 923C-type lectin 5PROSITE-ProRule annotationAdd BLAST117
Domaini951 – 1079C-type lectin 6PROSITE-ProRule annotationAdd BLAST129
Domaini1101 – 1212C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1240 – 1355C-type lectin 8PROSITE-ProRule annotationAdd BLAST116

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS47 Eukaryota
ENOG410XRS3 LUCA
GeneTreeiENSGT00720000108514
HOGENOMiHOG000113647
HOVERGENiHBG107130
InParanoidiQ61830
KOiK06560
OMAiPNFANED
OrthoDBiEOG091G0EGC
TreeFamiTF316663

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
PF00652 Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 6 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLLLLAFI SVIPVSVQLL DARQFLIYNE DHKRCVDALS AISVQTATCN
60 70 80 90 100
PEAESQKFRW VSDSQIMSVA FKLCLGVPSK TDWASVTLYA CDSKSEYQKW
110 120 130 140 150
ECKNDTLFGI KGTELYFNYG NRQEKNIKLY KGSGLWSRWK VYGTTDDLCS
160 170 180 190 200
RGYEAMYSLL GNANGAVCAF PFKFENKWYA DCTSAGRSDG WLWCGTTTDY
210 220 230 240 250
DKDKLFGFCP LHFEGSERLW NKDPLTGILY QINSKSALTW HQARASCKQQ
260 270 280 290 300
NADLLSVTEI HEQMYLTGLT SSLSSGLWIG LNSLSVRSGW QWAGGSPFRY
310 320 330 340 350
LNWLPGSPSS EPGKSCVSLN PGKNAKWENL ECVQKLGYIC KKGNNTLNPF
360 370 380 390 400
IIPSASDVPT GCPNQWWPYA GHCYRIHREE KKIQKYALQA CRKEGGDLAS
410 420 430 440 450
IHSIEEFDFI FSQLGYEPND ELWIGLNDIK IQMYFEWSDG TPVTFTKWLP
460 470 480 490 500
GEPSHENNRQ EDCVVMKGKD GYWADRACEQ PLGYICKMVS QSHAVVPEGA
510 520 530 540 550
DKGCRKGWKR HGFYCYLIGS TLSTFTDANH TCTNEKAYLT TVEDRYEQAF
560 570 580 590 600
LTSLVGLRPE KYFWTGLSDV QNKGTFRWTV DEQVQFTHWN ADMPGRKAGC
610 620 630 640 650
VAMKTGVAGG LWDVLSCEEK AKFVCKHWAE GVTRPPEPTT TPEPKCPENW
660 670 680 690 700
GTTSKTSMCF KLYAKGKHEK KTWFESRDFC KAIGGELASI KSKDEQQVIW
710 720 730 740 750
RLITSSGSYH ELFWLGLTYG SPSEGFTWSD GSPVSYENWA YGEPNNYQNV
760 770 780 790 800
EYCGELKGDP GMSWNDINCE HLNNWICQIQ KGKTLLPEPT PAPQDNPPVT
810 820 830 840 850
ADGWVIYKDY QYYFSKEKET MDNARAFCKK NFGDLATIKS ESEKKFLWKY
860 870 880 890 900
INKNGGQSPY FIGMLISMDK KFIWMDGSKV DFVAWATGEP NFANDDENCV
910 920 930 940 950
TMYTNSGFWN DINCGYPNNF ICQRHNSSIN ATAMPTTPTT PGGCKEGWHL
960 970 980 990 1000
YKNKCFKIFG FANEEKKSWQ DARQACKGLK GNLVSIENAQ EQAFVTYHMR
1010 1020 1030 1040 1050
DSTFNAWTGL NDINAEHMFL WTAGQGVHYT NWGKGYPGGR RSSLSYEDAD
1060 1070 1080 1090 1100
CVVVIGGNSR EAGTWMDDTC DSKQGYICQT QTDPSLPVSP TTTPKDGFVT
1110 1120 1130 1140 1150
YGKSSYSLMK LKLPWHEAET YCKDHTSLLA SILDPYSNAF AWMKMHPFNV
1160 1170 1180 1190 1200
PIWIALNSNL TNNEYTWTDR WRVRYTNWGA DEPKLKSACV YMDVDGYWRT
1210 1220 1230 1240 1250
SYCNESFYFL CKKSDEIPAT EPPQLPGKCP ESEQTAWIPF YGHCYYFESS
1260 1270 1280 1290 1300
FTRSWGQASL ECLRMGASLV SIETAAESSF LSYRVEPLKS KTNFWIGMFR
1310 1320 1330 1340 1350
NVEGKWLWLN DNPVSFVNWK TGDPSGERND CVVLASSSGL WNNIHCSSYK
1360 1370 1380 1390 1400
GFICKMPKII DPVTTHSSIT TKADQRKMDP QPKGSSKAAG VVTVVLLIVI
1410 1420 1430 1440 1450
GAGVAAYFFY KKRHALHIPQ EATFENTLYF NSNLSPGTSD TKDLMGNIEQ

NEHAII
Length:1,456
Mass (Da):164,981
Last modified:July 27, 2011 - v2
Checksum:iFD568C1B812214D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti826A → R in CAA78028 (PubMed:1421407).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11974 mRNA Translation: CAA78028.1
AL845290 Genomic DNA No translation available.
AL845434 Genomic DNA No translation available.
AK079897 mRNA Translation: BAC37778.1
CCDSiCCDS15700.1
PIRiA48925
RefSeqiNP_032651.2, NM_008625.2
UniGeneiMm.2019

Genome annotation databases

EnsembliENSMUST00000028045; ENSMUSP00000028045; ENSMUSG00000026712
GeneIDi17533
KEGGimmu:17533
UCSCiuc008ikk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMRC1_MOUSE
AccessioniPrimary (citable) accession number: Q61830
Secondary accession number(s): Q8C502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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