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Q61827 (MAFK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor MafK
Alternative name(s):
Erythroid transcription factor NF-E2 p18 subunit
Gene names
Name:Mafk
Synonyms:Nfe2u
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

Subunit structure

Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells.

Sequence similarities

Belongs to the bZIP family. Maf subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Transcription factor MafK
PRO_0000076504

Regions

Domain51 – 11464bZIP
Region51 – 7626Basic motif By similarity
Region79 – 9315Leucine-zipper By similarity

Amino acid modifications

Modified residue251Phosphoserine By similarity

Experimental info

Sequence conflict36 – 372EL → DV in AAC52132. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61827 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 39F98F8A257F46CB

FASTA15617,537
        10         20         30         40         50         60 
MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT RLKQRRRTLK 

        70         80         90        100        110        120 
NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM RLELDALRSK YEALQTFART 

       130        140        150 
VARGPVTPTK VATTSVITIV KSAELSSTSV PFSAAS 

« Hide

References

« Hide 'large scale' references
[1]"Activity and expression of murine small Maf family protein MafK."
Igarashi K., Itoh K., Motohashi H., Hayashi N., Matuzaki Y., Nakauchi H., Nishizawa M., Yamamoto M.
J. Biol. Chem. 270:7615-7624(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene."
Andrews N.C., Kotkow K.J., Ney P.A., Erdjument-Bromage H., Tempst P., Orkin S.H.
Proc. Natl. Acad. Sci. U.S.A. 90:11488-11492(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA.
Tissue: Hematopoietic.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D42124 mRNA. Translation: BAA07704.1.
U01036 mRNA. Translation: AAC52132.1.
BC014295 mRNA. Translation: AAH14295.1.
CCDSCCDS19814.1.
PIRA49391.
A56124.
RefSeqNP_034887.1. NM_010757.2.
XP_006504716.1. XM_006504653.1.
UniGeneMm.157313.

3D structure databases

ProteinModelPortalQ61827.
SMRQ61827. Positions 24-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201284. 5 interactions.
DIPDIP-46345N.

PTM databases

PhosphoSiteQ61827.

Proteomic databases

PRIDEQ61827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018287; ENSMUSP00000018287; ENSMUSG00000018143.
ENSMUST00000110836; ENSMUSP00000106460; ENSMUSG00000018143.
GeneID17135.
KEGGmmu:17135.
UCSCuc009ahd.1. mouse.

Organism-specific databases

CTD7975.
MGIMGI:99951. Mafk.

Phylogenomic databases

eggNOGNOG236209.
GeneTreeENSGT00550000074549.
HOGENOMHOG000045475.
HOVERGENHBG001725.
InParanoidQ61827.
KOK09037.
OMANASMRLE.
OrthoDBEOG7BGHMQ.
PhylomeDBQ61827.
TreeFamTF325689.

Enzyme and pathway databases

ReactomeREACT_224553. Hemostasis.

Gene expression databases

ArrayExpressQ61827.
BgeeQ61827.
GenevestigatorQ61827.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
InterProIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR028574. MafK.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF26. PTHR10129:SF26. 1 hit.
PfamPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291344.
PROQ61827.
SOURCESearch...

Entry information

Entry nameMAFK_MOUSE
AccessionPrimary (citable) accession number: Q61827
Secondary accession number(s): Q60600
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot