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Q61827

- MAFK_MOUSE

UniProt

Q61827 - MAFK_MOUSE

Protein

Transcription factor MafK

Gene

Mafk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: BHF-UCL
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. nervous system development Source: Ensembl
    2. regulation of transcription, DNA-templated Source: MGI
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor MafK
    Alternative name(s):
    Erythroid transcription factor NF-E2 p18 subunit
    Gene namesi
    Name:Mafk
    Synonyms:Nfe2u
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:99951. Mafk.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Transcription factor MafKPRO_0000076504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ61827.

    PTM databases

    PhosphoSiteiQ61827.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells.

    Gene expression databases

    ArrayExpressiQ61827.
    BgeeiQ61827.
    GenevestigatoriQ61827.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201284. 5 interactions.
    DIPiDIP-46345N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61827.
    SMRiQ61827. Positions 24-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 11464bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 7626Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni79 – 9315Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Maf subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG236209.
    GeneTreeiENSGT00550000074549.
    HOGENOMiHOG000045475.
    HOVERGENiHBG001725.
    InParanoidiQ61827.
    KOiK09037.
    OMAiNASMRLE.
    OrthoDBiEOG7BGHMQ.
    PhylomeDBiQ61827.
    TreeFamiTF325689.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR028574. MafK.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view]
    PANTHERiPTHR10129. PTHR10129. 1 hit.
    PTHR10129:SF26. PTHR10129:SF26. 1 hit.
    PfamiPF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61827-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT    50
    RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM 100
    RLELDALRSK YEALQTFART VARGPVTPTK VATTSVITIV KSAELSSTSV 150
    PFSAAS 156
    Length:156
    Mass (Da):17,537
    Last modified:November 1, 1997 - v1
    Checksum:i39F98F8A257F46CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 372EL → DV in AAC52132. (PubMed:8265578)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42124 mRNA. Translation: BAA07704.1.
    U01036 mRNA. Translation: AAC52132.1.
    BC014295 mRNA. Translation: AAH14295.1.
    CCDSiCCDS19814.1.
    PIRiA49391.
    A56124.
    RefSeqiNP_034887.1. NM_010757.2.
    XP_006504716.1. XM_006504653.1.
    UniGeneiMm.157313.

    Genome annotation databases

    EnsembliENSMUST00000018287; ENSMUSP00000018287; ENSMUSG00000018143.
    ENSMUST00000110836; ENSMUSP00000106460; ENSMUSG00000018143.
    GeneIDi17135.
    KEGGimmu:17135.
    UCSCiuc009ahd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42124 mRNA. Translation: BAA07704.1 .
    U01036 mRNA. Translation: AAC52132.1 .
    BC014295 mRNA. Translation: AAH14295.1 .
    CCDSi CCDS19814.1.
    PIRi A49391.
    A56124.
    RefSeqi NP_034887.1. NM_010757.2.
    XP_006504716.1. XM_006504653.1.
    UniGenei Mm.157313.

    3D structure databases

    ProteinModelPortali Q61827.
    SMRi Q61827. Positions 24-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201284. 5 interactions.
    DIPi DIP-46345N.

    PTM databases

    PhosphoSitei Q61827.

    Proteomic databases

    PRIDEi Q61827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018287 ; ENSMUSP00000018287 ; ENSMUSG00000018143 .
    ENSMUST00000110836 ; ENSMUSP00000106460 ; ENSMUSG00000018143 .
    GeneIDi 17135.
    KEGGi mmu:17135.
    UCSCi uc009ahd.1. mouse.

    Organism-specific databases

    CTDi 7975.
    MGIi MGI:99951. Mafk.

    Phylogenomic databases

    eggNOGi NOG236209.
    GeneTreei ENSGT00550000074549.
    HOGENOMi HOG000045475.
    HOVERGENi HBG001725.
    InParanoidi Q61827.
    KOi K09037.
    OMAi NASMRLE.
    OrthoDBi EOG7BGHMQ.
    PhylomeDBi Q61827.
    TreeFami TF325689.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 291344.
    PROi Q61827.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61827.
    Bgeei Q61827.
    Genevestigatori Q61827.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR028574. MafK.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view ]
    PANTHERi PTHR10129. PTHR10129. 1 hit.
    PTHR10129:SF26. PTHR10129:SF26. 1 hit.
    Pfami PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene."
      Andrews N.C., Kotkow K.J., Ney P.A., Erdjument-Bromage H., Tempst P., Orkin S.H.
      Proc. Natl. Acad. Sci. U.S.A. 90:11488-11492(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA.
      Tissue: Hematopoietic.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiMAFK_MOUSE
    AccessioniPrimary (citable) accession number: Q61827
    Secondary accession number(s): Q60600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3