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Protein

Transcription factor MafK

Gene

Mafk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafK
Alternative name(s):
Erythroid transcription factor NF-E2 p18 subunit
Gene namesi
Name:Mafk
Synonyms:Nfe2u
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99951 Mafk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765041 – 156Transcription factor MafKAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei25PhosphoserineCombined sources1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei60N6-acetyllysineBy similarity1
Modified residuei71N6-acetyllysineBy similarity1
Modified residuei76N6-acetyllysineBy similarity1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61827
MaxQBiQ61827
PaxDbiQ61827
PRIDEiQ61827

PTM databases

iPTMnetiQ61827
PhosphoSitePlusiQ61827

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells.

Gene expression databases

BgeeiENSMUSG00000018143
ExpressionAtlasiQ61827 baseline and differential
GenevisibleiQ61827 MM

Interactioni

Subunit structurei

Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Bach1P973025EBI-15740843,EBI-2552417

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201284, 6 interactors
DIPiDIP-46345N
IntActiQ61827, 2 interactors
STRINGi10090.ENSMUSP00000018287

Structurei

3D structure databases

ProteinModelPortaliQ61827
SMRiQ61827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISHX Eukaryota
ENOG4111MYK LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000045475
HOVERGENiHBG001725
InParanoidiQ61827
KOiK09037
OMAiLQCFART
OrthoDBiEOG091G0H46
PhylomeDBiQ61827
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR028574 MafK
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF26 PTHR10129:SF26, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q61827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM
110 120 130 140 150
RLELDALRSK YEALQTFART VARGPVTPTK VATTSVITIV KSAELSSTSV

PFSAAS
Length:156
Mass (Da):17,537
Last modified:November 1, 1997 - v1
Checksum:i39F98F8A257F46CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37EL → DV in AAC52132 (PubMed:8265578).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42124 mRNA Translation: BAA07704.1
U01036 mRNA Translation: AAC52132.1
BC014295 mRNA Translation: AAH14295.1
CCDSiCCDS19814.1
PIRiA49391
A56124
RefSeqiNP_034887.1, NM_010757.2
XP_006504716.1, XM_006504653.3
UniGeneiMm.157313

Genome annotation databases

EnsembliENSMUST00000018287; ENSMUSP00000018287; ENSMUSG00000018143
ENSMUST00000110836; ENSMUSP00000106460; ENSMUSG00000018143
GeneIDi17135
KEGGimmu:17135
UCSCiuc009ahd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMAFK_MOUSE
AccessioniPrimary (citable) accession number: Q61827
Secondary accession number(s): Q60600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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