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Protein

Transcription factor MafK

Gene

Mafk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafK
Alternative name(s):
Erythroid transcription factor NF-E2 p18 subunit
Gene namesi
Name:Mafk
Synonyms:Nfe2u
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99951. Mafk.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Transcription factor MafKPRO_0000076504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ61827.

PTM databases

PhosphoSiteiQ61827.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells.

Gene expression databases

BgeeiQ61827.
ExpressionAtlasiQ61827. baseline and differential.
GenevisibleiQ61827. MM.

Interactioni

Subunit structurei

Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201284. 6 interactions.
DIPiDIP-46345N.
STRINGi10090.ENSMUSP00000018287.

Structurei

3D structure databases

ProteinModelPortaliQ61827.
SMRiQ61827. Positions 24-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 11464bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 7626Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni79 – 9315Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG236209.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiQ61827.
KOiK09037.
OMAiGPIAPTK.
OrthoDBiEOG7BGHMQ.
PhylomeDBiQ61827.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR028574. MafK.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF26. PTHR10129:SF26. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM
110 120 130 140 150
RLELDALRSK YEALQTFART VARGPVTPTK VATTSVITIV KSAELSSTSV

PFSAAS
Length:156
Mass (Da):17,537
Last modified:November 1, 1997 - v1
Checksum:i39F98F8A257F46CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 372EL → DV in AAC52132 (PubMed:8265578).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42124 mRNA. Translation: BAA07704.1.
U01036 mRNA. Translation: AAC52132.1.
BC014295 mRNA. Translation: AAH14295.1.
CCDSiCCDS19814.1.
PIRiA49391.
A56124.
RefSeqiNP_034887.1. NM_010757.2.
XP_006504716.1. XM_006504653.2.
UniGeneiMm.157313.

Genome annotation databases

EnsembliENSMUST00000018287; ENSMUSP00000018287; ENSMUSG00000018143.
ENSMUST00000110836; ENSMUSP00000106460; ENSMUSG00000018143.
GeneIDi17135.
KEGGimmu:17135.
UCSCiuc009ahd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42124 mRNA. Translation: BAA07704.1.
U01036 mRNA. Translation: AAC52132.1.
BC014295 mRNA. Translation: AAH14295.1.
CCDSiCCDS19814.1.
PIRiA49391.
A56124.
RefSeqiNP_034887.1. NM_010757.2.
XP_006504716.1. XM_006504653.2.
UniGeneiMm.157313.

3D structure databases

ProteinModelPortaliQ61827.
SMRiQ61827. Positions 24-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201284. 6 interactions.
DIPiDIP-46345N.
STRINGi10090.ENSMUSP00000018287.

PTM databases

PhosphoSiteiQ61827.

Proteomic databases

PRIDEiQ61827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018287; ENSMUSP00000018287; ENSMUSG00000018143.
ENSMUST00000110836; ENSMUSP00000106460; ENSMUSG00000018143.
GeneIDi17135.
KEGGimmu:17135.
UCSCiuc009ahd.1. mouse.

Organism-specific databases

CTDi7975.
MGIiMGI:99951. Mafk.

Phylogenomic databases

eggNOGiNOG236209.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiQ61827.
KOiK09037.
OMAiGPIAPTK.
OrthoDBiEOG7BGHMQ.
PhylomeDBiQ61827.
TreeFamiTF325689.

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi291344.
PROiQ61827.
SOURCEiSearch...

Gene expression databases

BgeeiQ61827.
ExpressionAtlasiQ61827. baseline and differential.
GenevisibleiQ61827. MM.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR028574. MafK.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF26. PTHR10129:SF26. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene."
    Andrews N.C., Kotkow K.J., Ney P.A., Erdjument-Bromage H., Tempst P., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:11488-11492(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA.
    Tissue: Hematopoietic.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiMAFK_MOUSE
AccessioniPrimary (citable) accession number: Q61827
Secondary accession number(s): Q60600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.