SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61805

- LBP_MOUSE

UniProt

Q61805 - LBP_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Lipopolysaccharide-binding protein
Gene
Lbp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide By similarity.1 Publication

GO - Molecular functioni

  1. lipopolysaccharide binding Source: MGI
  2. lipoteichoic acid binding Source: Ensembl
  3. receptor binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. acute-phase response Source: BHF-UCL
  2. cellular response to lipoteichoic acid Source: Ensembl
  3. defense response to Gram-negative bacterium Source: BHF-UCL
  4. defense response to Gram-positive bacterium Source: BHF-UCL
  5. detection of molecule of bacterial origin Source: Ensembl
  6. innate immune response Source: BHF-UCL
  7. leukocyte chemotaxis involved in inflammatory response Source: MGI
  8. lipopolysaccharide transport Source: Ensembl
  9. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  10. macrophage activation involved in immune response Source: BHF-UCL
  11. negative regulation of growth of symbiont in host Source: MGI
  12. negative regulation of tumor necrosis factor production Source: Ensembl
  13. opsonization Source: BHF-UCL
  14. positive regulation of chemokine production Source: MGI
  15. positive regulation of interleukin-6 production Source: Ensembl
  16. positive regulation of interleukin-8 production Source: Ensembl
  17. positive regulation of macrophage activation Source: Ensembl
  18. positive regulation of neutrophil chemotaxis Source: MGI
  19. positive regulation of respiratory burst involved in inflammatory response Source: BHF-UCL
  20. positive regulation of toll-like receptor 4 signaling pathway Source: Ensembl
  21. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  22. positive regulation of tumor necrosis factor production Source: BHF-UCL
  23. response to lipopolysaccharide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity, Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-binding protein
Short name:
LBP
Gene namesi
Name:Lbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1098776. Lbp.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 481457Lipopolysaccharide-binding protein
PRO_0000017159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi159 ↔ 1981 Publication
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61805.
PaxDbiQ61805.
PRIDEiQ61805.

PTM databases

PhosphoSiteiQ61805.

Expressioni

Gene expression databases

ArrayExpressiQ61805.
BgeeiQ61805.
CleanExiMM_LBP.
GenevestigatoriQ61805.

Interactioni

Subunit structurei

When bound to LPS, interacts (via C-terminus) with soluble CD14 By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 357
Helixi36 – 5419
Beta strandi62 – 687
Turni69 – 713
Beta strandi72 – 8716
Beta strandi91 – 966
Turni97 – 993
Beta strandi100 – 11920
Beta strandi127 – 14620
Beta strandi152 – 16211
Beta strandi166 – 1705
Helixi175 – 18410
Helixi186 – 20722
Helixi209 – 2135
Beta strandi218 – 2214
Beta strandi223 – 2253
Beta strandi227 – 2293
Beta strandi232 – 2354
Beta strandi240 – 2478
Beta strandi254 – 2563
Beta strandi274 – 2818
Beta strandi285 – 2873
Beta strandi300 – 3045
Helixi305 – 3073
Beta strandi310 – 3123
Turni318 – 3203
Turni322 – 3243
Helixi328 – 3314
Beta strandi336 – 34510
Beta strandi350 – 3523
Beta strandi355 – 3584
Beta strandi361 – 3699
Beta strandi373 – 39422
Beta strandi397 – 41721
Helixi421 – 43414
Helixi436 – 44611
Beta strandi456 – 46510
Beta strandi467 – 47812

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4M4DX-ray2.91A/B25-481[»]
ProteinModelPortaliQ61805.
SMRiQ61805. Positions 26-480.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG262970.
GeneTreeiENSGT00730000110583.
HOGENOMiHOG000231250.
HOVERGENiHBG002797.
InParanoidiA2AC66.
KOiK05399.
OMAiRNHRSPV.
OrthoDBiEOG76739B.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61805-1 [UniParc]FASTAAdd to Basket

« Hide

MKAGTGPLLS TLLGLLFLSI QGTGGVNPGV VARITDKGLA YAAKEGLVAL    50
QRELYKITLP DFSGDFKIKA VGRGQYEFHS LEIQNCELRG SSLKLLPGQG 100
LSLAISDSSI GVRGKWKVRK SFLKLHGSFD LDVKGVTISV DLLLGMDPSG 150
RPTVSASGCS SRICDLDVHI SGNVGWLLNL FHNQIESKLQ KVLENKVCEM 200
IQKSVTSDLQ PYLQTLPVTA EIDNVLGIDY SLVAAPQAKA QVLDVMFKGE 250
IFNRNHRSPV ATPTPTMSLP EDSKQMVYFA ISDYAFNIAS RVYHQAGYLN 300
FSITDDMLPH DSGIRLNTKA FRPFTPQIYK KYPDMKLELL GTVVSAPILN 350
VSPGNLSLAP QMEIEGFVIL PTSAREPVFR LGVVTNVFAS LTFNNSKVTG 400
MLHPDKAQVR LIESKVGMFN VNLFQAFLNY YLLNSLYPDV NAELAQGFPL 450
PLPRHIQLHD LDFQIRKDFL YLGANVQYMR V 481
Length:481
Mass (Da):53,055
Last modified:July 27, 2011 - v2
Checksum:iAC1D3FC2DA87FE9A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → C in CAA67727. 1 Publication
Sequence conflicti51 – 511Q → K in CAA67727. 1 Publication
Sequence conflicti102 – 1021S → R in CAA67727. 1 Publication
Sequence conflicti280 – 2801A → S in AAH04795. 1 Publication
Sequence conflicti284 – 2841Y → H in CAA67727. 1 Publication
Sequence conflicti284 – 2841Y → H in AAH04795. 1 Publication
Sequence conflicti310 – 3101H → P in AAH04795. 1 Publication
Sequence conflicti313 – 3131G → S in AAH04795. 1 Publication
Sequence conflicti341 – 3411G → R in CAA67727. 1 Publication
Sequence conflicti382 – 3821G → S in CAA67727. 1 Publication
Sequence conflicti395 – 3962NS → TR in CAA67727. 1 Publication
Sequence conflicti418 – 4181M → I in CAA67727. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99347 mRNA. Translation: CAA67727.1.
AL663063 Genomic DNA. Translation: CAM23528.1.
CH466551 Genomic DNA. Translation: EDL06262.1.
BC004795 mRNA. Translation: AAH04795.1.
CCDSiCCDS16988.1.
RefSeqiNP_032515.2. NM_008489.2.
UniGeneiMm.218846.

Genome annotation databases

EnsembliENSMUST00000016168; ENSMUSP00000016168; ENSMUSG00000016024.
GeneIDi16803.
KEGGimmu:16803.
UCSCiuc008npz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99347 mRNA. Translation: CAA67727.1 .
AL663063 Genomic DNA. Translation: CAM23528.1 .
CH466551 Genomic DNA. Translation: EDL06262.1 .
BC004795 mRNA. Translation: AAH04795.1 .
CCDSi CCDS16988.1.
RefSeqi NP_032515.2. NM_008489.2.
UniGenei Mm.218846.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4M4D X-ray 2.91 A/B 25-481 [» ]
ProteinModelPortali Q61805.
SMRi Q61805. Positions 26-480.
ModBasei Search...

PTM databases

PhosphoSitei Q61805.

Proteomic databases

MaxQBi Q61805.
PaxDbi Q61805.
PRIDEi Q61805.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016168 ; ENSMUSP00000016168 ; ENSMUSG00000016024 .
GeneIDi 16803.
KEGGi mmu:16803.
UCSCi uc008npz.1. mouse.

Organism-specific databases

CTDi 3929.
MGIi MGI:1098776. Lbp.

Phylogenomic databases

eggNOGi NOG262970.
GeneTreei ENSGT00730000110583.
HOGENOMi HOG000231250.
HOVERGENi HBG002797.
InParanoidi A2AC66.
KOi K05399.
OMAi RNHRSPV.
OrthoDBi EOG76739B.
TreeFami TF315617.

Miscellaneous databases

ChiTaRSi LBP. mouse.
NextBioi 290688.
PROi Q61805.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61805.
Bgeei Q61805.
CleanExi MM_LBP.
Genevestigatori Q61805.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
SMARTi SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and Gram-negative bacteria."
    Lengacher S., Jongeneel C.V., le Roy D., Lee J.D., Kravchenko V., Ulevitch R.J., Glauser M.P., Heumann D.
    J. Inflamm. 47:165-172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity."
    Eckert J.K., Kim Y.J., Kim J.I., Guertler K., Oh D.Y., Sur S., Lundvall L., Hamann L., van der Ploeg A., Pickkers P., Giamarellos-Bourboulis E., Kubarenko A.V., Weber A.N., Kabesch M., Kumpf O., An H.J., Lee J.O., Schumann R.R.
    Immunity 39:647-660(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS), FUNCTION, DISULFIDE BOND.

Entry informationi

Entry nameiLBP_MOUSE
AccessioniPrimary (citable) accession number: Q61805
Secondary accession number(s): A2AC66, Q99KA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi