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Protein

Lipopolysaccharide-binding protein

Gene

Lbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872).By similarity2 Publications

GO - Molecular functioni

  • lipopeptide binding Source: MGI
  • lipopolysaccharide binding Source: MGI
  • lipoteichoic acid binding Source: MGI
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: UniProtKB
  • cellular response to lipoteichoic acid Source: MGI
  • defense response to Gram-negative bacterium Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: BHF-UCL
  • detection of molecule of bacterial origin Source: MGI
  • innate immune response Source: BHF-UCL
  • leukocyte chemotaxis involved in inflammatory response Source: MGI
  • lipopolysaccharide-mediated signaling pathway Source: MGI
  • lipopolysaccharide transport Source: MGI
  • macromolecule localization Source: MGI
  • macrophage activation involved in immune response Source: BHF-UCL
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • opsonization Source: BHF-UCL
  • positive regulation of chemokine production Source: MGI
  • positive regulation of cytolysis Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of interleukin-8 production Source: MGI
  • positive regulation of macrophage activation Source: MGI
  • positive regulation of neutrophil chemotaxis Source: MGI
  • positive regulation of respiratory burst involved in inflammatory response Source: BHF-UCL
  • positive regulation of toll-like receptor 4 signaling pathway Source: MGI
  • positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  • positive regulation of tumor necrosis factor production Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
R-MMU-166020 Transfer of LPS from LBP carrier to CD14
R-MMU-5686938 Regulation of TLR by endogenous ligand

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-binding protein
Short name:
LBP
Gene namesi
Name:Lbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1098776 Lbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001715925 – 481Lipopolysaccharide-binding proteinAdd BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi159 ↔ 198Combined sources1 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61805
PaxDbiQ61805
PeptideAtlasiQ61805
PRIDEiQ61805

PTM databases

iPTMnetiQ61805
PhosphoSitePlusiQ61805

Expressioni

Gene expression databases

BgeeiENSMUSG00000016024
CleanExiMM_LBP
ExpressionAtlasiQ61805 baseline and differential
GenevisibleiQ61805 MM

Interactioni

Subunit structurei

When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.By similarity

GO - Molecular functioni

  • signaling receptor binding Source: BHF-UCL

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016168

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 35Combined sources7
Helixi36 – 54Combined sources19
Beta strandi62 – 68Combined sources7
Turni69 – 71Combined sources3
Beta strandi72 – 87Combined sources16
Beta strandi91 – 96Combined sources6
Turni97 – 99Combined sources3
Beta strandi100 – 119Combined sources20
Beta strandi127 – 146Combined sources20
Beta strandi152 – 162Combined sources11
Beta strandi166 – 170Combined sources5
Helixi175 – 184Combined sources10
Helixi186 – 207Combined sources22
Helixi209 – 213Combined sources5
Beta strandi218 – 221Combined sources4
Beta strandi223 – 225Combined sources3
Beta strandi227 – 229Combined sources3
Beta strandi232 – 235Combined sources4
Beta strandi240 – 247Combined sources8
Beta strandi254 – 256Combined sources3
Beta strandi274 – 281Combined sources8
Beta strandi285 – 287Combined sources3
Beta strandi300 – 304Combined sources5
Helixi305 – 307Combined sources3
Beta strandi310 – 312Combined sources3
Turni318 – 320Combined sources3
Turni322 – 324Combined sources3
Helixi328 – 331Combined sources4
Beta strandi336 – 345Combined sources10
Beta strandi350 – 352Combined sources3
Beta strandi355 – 358Combined sources4
Beta strandi361 – 369Combined sources9
Beta strandi373 – 394Combined sources22
Beta strandi397 – 417Combined sources21
Helixi421 – 434Combined sources14
Helixi436 – 446Combined sources11
Beta strandi456 – 465Combined sources10
Beta strandi467 – 478Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M4DX-ray2.91A/B25-481[»]
ProteinModelPortaliQ61805
SMRiQ61805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110583
HOGENOMiHOG000231250
HOVERGENiHBG002797
InParanoidiQ61805
KOiK05399
OMAiGHYEFHS
OrthoDBiEOG091G08NV
TreeFamiTF315617

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR030180 LBP
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF66 PTHR10504:SF66, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF002417 Lipid_binding_protein, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
PROSITEiView protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAGTGPLLS TLLGLLFLSI QGTGGVNPGV VARITDKGLA YAAKEGLVAL
60 70 80 90 100
QRELYKITLP DFSGDFKIKA VGRGQYEFHS LEIQNCELRG SSLKLLPGQG
110 120 130 140 150
LSLAISDSSI GVRGKWKVRK SFLKLHGSFD LDVKGVTISV DLLLGMDPSG
160 170 180 190 200
RPTVSASGCS SRICDLDVHI SGNVGWLLNL FHNQIESKLQ KVLENKVCEM
210 220 230 240 250
IQKSVTSDLQ PYLQTLPVTA EIDNVLGIDY SLVAAPQAKA QVLDVMFKGE
260 270 280 290 300
IFNRNHRSPV ATPTPTMSLP EDSKQMVYFA ISDYAFNIAS RVYHQAGYLN
310 320 330 340 350
FSITDDMLPH DSGIRLNTKA FRPFTPQIYK KYPDMKLELL GTVVSAPILN
360 370 380 390 400
VSPGNLSLAP QMEIEGFVIL PTSAREPVFR LGVVTNVFAS LTFNNSKVTG
410 420 430 440 450
MLHPDKAQVR LIESKVGMFN VNLFQAFLNY YLLNSLYPDV NAELAQGFPL
460 470 480
PLPRHIQLHD LDFQIRKDFL YLGANVQYMR V
Length:481
Mass (Da):53,055
Last modified:July 27, 2011 - v2
Checksum:iAC1D3FC2DA87FE9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → C in CAA67727 (PubMed:9144073).Curated1
Sequence conflicti51Q → K in CAA67727 (PubMed:9144073).Curated1
Sequence conflicti102S → R in CAA67727 (PubMed:9144073).Curated1
Sequence conflicti280A → S in AAH04795 (Ref. 3) Curated1
Sequence conflicti284Y → H in CAA67727 (PubMed:9144073).Curated1
Sequence conflicti284Y → H in AAH04795 (Ref. 3) Curated1
Sequence conflicti310H → P in AAH04795 (Ref. 3) Curated1
Sequence conflicti313G → S in AAH04795 (Ref. 3) Curated1
Sequence conflicti341G → R in CAA67727 (PubMed:9144073).Curated1
Sequence conflicti382G → S in CAA67727 (PubMed:9144073).Curated1
Sequence conflicti395 – 396NS → TR in CAA67727 (PubMed:9144073).Curated2
Sequence conflicti418M → I in CAA67727 (PubMed:9144073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99347 mRNA Translation: CAA67727.1
AL663063 Genomic DNA Translation: CAM23528.1
CH466551 Genomic DNA Translation: EDL06262.1
BC004795 mRNA Translation: AAH04795.1
CCDSiCCDS16988.1
RefSeqiNP_032515.2, NM_008489.2
UniGeneiMm.218846

Genome annotation databases

EnsembliENSMUST00000016168; ENSMUSP00000016168; ENSMUSG00000016024
GeneIDi16803
KEGGimmu:16803
UCSCiuc008npz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLBP_MOUSE
AccessioniPrimary (citable) accession number: Q61805
Secondary accession number(s): A2AC66, Q99KA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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