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Reviewed, UniProtKB/Swiss-Prot Q61790 (LAG3_MOUSE)

Last modified November 3, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Lymphocyte activation gene 3 protein
      Short name=LAG-3
Alternative name(s):
    CD_antigen=CD223
Gene names
Name: Lag3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in lymphocyte activation. Binds to HLA class-II antigens By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 521499Lymphocyte activation gene 3 protein
PRO_0000014632

Regions

Topological domain23 – 442420Extracellular Potential
Transmembrane443 – 46321 Potential
Topological domain464 – 52158Cytoplasmic Potential
Domain37 – 163127Ig-like V-type
Domain165 – 24682Ig-like C2-type 1
Domain258 – 34184Ig-like C2-type 2
Domain345 – 41268Ig-like C2-type 3
Region493 – 5182613 X 2 AA tandem repeats of E-X

Amino acid modifications

Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 156 Potential
Disulfide bond185 ↔ 235 Potential
Disulfide bond276 ↔ 327 Potential
Disulfide bond363 ↔ 405 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q61790-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 64C29C40EB780E48

FASTA52156,978
        10         20         30         40         50         60 
MREDLLLGFL LLGLLWEAPV VSSGPGKELP VVWAQEGAPV HLPCSLKSPN LDPNFLRRGG 

        70         80         90        100        110        120 
VIWQHQPDSG QPTPIPALDL HQGMPSPRQP APGRYTVLSV APGGLRSGRQ PLHPHVQLEE 

       130        140        150        160        170        180 
RGLQRGDFSL WLRPALRTDA GEYHATVRLP NRALSCSLRL RVGQASMIAS PSGVLKLSDW 

       190        200        210        220        230        240 
VLLNCSFSRP DRPVSVHWFQ GQNRVPVYNS PRHFLAETFL LLPQVSPLDS GTWGCVLTYR 

       250        260        270        280        290        300 
DGFNVSITYN LKVLGLEPVA PLTVYAAEGS RVELPCHLPP GVGTPSLLIA KWTPPGGGPE 

       310        320        330        340        350        360 
LPVAGKSGNF TLHLEAVGLA QAGTYTCSIH LQGQQLNATV TLAVITVTPK SFGLPGSRGK 

       370        380        390        400        410        420 
LLCEVTPASG KERFVWRPLN NLSRSCPGPV LEIQEARLLA ERWQCQLYEG QRLLGATVYA 

       430        440        450        460        470        480 
AESSSGAHSA RRISGDLKGG HLVLVLILGA LSLFLLVAGA FGFHWWRKQL LLRRFSALEH 

       490        500        510        520 
GIQPFPAQRK IEELERELET EMGQEPEPEP EPQLEPEPRQ L

« Hide

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References

« Hide 'large scale' references
[1]"Cloning of murine LAG-3 by magnetic bead bound homologous probes and PCR (gene-capture PCR)."
Mastrangeli R., Micangeli E., Donini S.
Anal. Biochem. 241:93-102(1996) [PubMed: 8921170] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Thymus.
[2]"Independent modes of natural killing distinguished in mice lacking Lag3."
Miyazaki T., Dierich A., Benoist C., Mathis D.
Science 272:405-408(1996) [PubMed: 8602528] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X98113 mRNA. Translation: CAA66794.1.
BC120591 mRNA. Translation: AAI20592.1.
IPIIPI00125089.
RefSeqNP_032505.1.
UniGeneMm.4528

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ61790.

Proteomic databases

PRIDEQ61790.

Genome annotation databases

EnsemblENSMUST00000032217; ENSMUSP00000032217; ENSMUSG00000030124; Mus musculus. [Genome view]
GeneID16768.
KEGGmmu:16768.
UCSCuc009dsl.1. mouse.

Organism-specific databases

CTD16768.
MGIMGI:106588. Lag3.

Phylogenomic databases

HOGENOMQ61790.
HOVERGENQ61790.
OMAAGDNGNF.

Gene expression databases

ArrayExpressQ61790.
BgeeQ61790.
CleanExMM_LAG3.
GenevestigatorQ61790.
GermOnlineENSMUSG00000030124. Mus musculus.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015621. IL1-receptor.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 2 hits.
PANTHERPTHR11890. IL1-receptor. 1 hit.
PfamPF07686. V-set. 2 hits.
[Graphical view]
SMARTSM00409. IG. 3 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio290590.
PMAP-CutDBQ61790.
SOURCESearch...

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Entry information

Entry nameLAG3_MOUSE
AccessionPrimary (citable) accession number: Q61790
Secondary accession number(s): Q0VBL2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 3, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents