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Protein

Lymphocyte activation gene 3 protein

Gene

Lag3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity).By similarity

GO - Molecular functioni

  • MHC class II protein binding Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • negative regulation of interleukin-2 biosynthetic process Source: MGI
  • negative regulation of T cell activation Source: MGI
  • positive regulation of natural killer cell mediated cytotoxicity Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte activation gene 3 protein
Short name:
LAG-3
Alternative name(s):
CD_antigen: CD223
Gene namesi
Name:Lag3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106588 Lag3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 442ExtracellularSequence analysisAdd BLAST420
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 521CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001463223 – 521Lymphocyte activation gene 3 proteinAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 156PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 235PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 327PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi363 ↔ 405PROSITE-ProRule annotation
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ61790
PaxDbiQ61790
PRIDEiQ61790

PTM databases

PhosphoSitePlusiQ61790

Miscellaneous databases

PMAP-CutDBiQ61790

Expressioni

Gene expression databases

BgeeiENSMUSG00000030124
CleanExiMM_LAG3
GenevisibleiQ61790 MM

Interactioni

GO - Molecular functioni

  • MHC class II protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032217

Structurei

3D structure databases

ProteinModelPortaliQ61790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 163Ig-like V-typeAdd BLAST127
Domaini165 – 246Ig-like C2-type 1Add BLAST82
Domaini258 – 341Ig-like C2-type 2Add BLAST84
Domaini345 – 412Ig-like C2-type 3Add BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni493 – 51813 X 2 AA tandem repeats of E-XAdd BLAST26

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPP Eukaryota
ENOG410Z3KP LUCA
GeneTreeiENSGT00390000017331
HOGENOMiHOG000113275
HOVERGENiHBG004952
InParanoidiQ61790
KOiK06565
OMAiGIHPPQA
OrthoDBiEOG091G0PJF
PhylomeDBiQ61790
TreeFamiTF335942

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR013151 Immunoglobulin
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREDLLLGFL LLGLLWEAPV VSSGPGKELP VVWAQEGAPV HLPCSLKSPN
60 70 80 90 100
LDPNFLRRGG VIWQHQPDSG QPTPIPALDL HQGMPSPRQP APGRYTVLSV
110 120 130 140 150
APGGLRSGRQ PLHPHVQLEE RGLQRGDFSL WLRPALRTDA GEYHATVRLP
160 170 180 190 200
NRALSCSLRL RVGQASMIAS PSGVLKLSDW VLLNCSFSRP DRPVSVHWFQ
210 220 230 240 250
GQNRVPVYNS PRHFLAETFL LLPQVSPLDS GTWGCVLTYR DGFNVSITYN
260 270 280 290 300
LKVLGLEPVA PLTVYAAEGS RVELPCHLPP GVGTPSLLIA KWTPPGGGPE
310 320 330 340 350
LPVAGKSGNF TLHLEAVGLA QAGTYTCSIH LQGQQLNATV TLAVITVTPK
360 370 380 390 400
SFGLPGSRGK LLCEVTPASG KERFVWRPLN NLSRSCPGPV LEIQEARLLA
410 420 430 440 450
ERWQCQLYEG QRLLGATVYA AESSSGAHSA RRISGDLKGG HLVLVLILGA
460 470 480 490 500
LSLFLLVAGA FGFHWWRKQL LLRRFSALEH GIQPFPAQRK IEELERELET
510 520
EMGQEPEPEP EPQLEPEPRQ L
Length:521
Mass (Da):56,978
Last modified:November 1, 1996 - v1
Checksum:i64C29C40EB780E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98113 mRNA Translation: CAA66794.1
BC120591 mRNA Translation: AAI20592.1
CCDSiCCDS20536.1
RefSeqiNP_032505.1, NM_008479.2
UniGeneiMm.4528

Genome annotation databases

EnsembliENSMUST00000032217; ENSMUSP00000032217; ENSMUSG00000030124
GeneIDi16768
KEGGimmu:16768
UCSCiuc009dsl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLAG3_MOUSE
AccessioniPrimary (citable) accession number: Q61790
Secondary accession number(s): Q0VBL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health