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Protein

Lymphocyte activation gene 3 protein

Gene

Lag3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity).By similarity

GO - Molecular functioni

  • MHC class II protein binding Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • negative regulation of interleukin-2 biosynthetic process Source: MGI
  • negative regulation of T cell activation Source: MGI
  • positive regulation of natural killer cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte activation gene 3 protein
Short name:
LAG-3
Alternative name(s):
CD_antigen: CD223
Gene namesi
Name:Lag3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106588. Lag3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 442ExtracellularSequence analysisAdd BLAST420
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 521CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001463223 – 521Lymphocyte activation gene 3 proteinAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 156PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi185 ↔ 235PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi276 ↔ 327PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi337N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi363 ↔ 405PROSITE-ProRule annotation
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ61790.
PaxDbiQ61790.
PRIDEiQ61790.

PTM databases

iPTMnetiQ61790.
PhosphoSitePlusiQ61790.

Miscellaneous databases

PMAP-CutDBQ61790.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030124.
CleanExiMM_LAG3.
GenevisibleiQ61790. MM.

Interactioni

GO - Molecular functioni

  • MHC class II protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032217.

Structurei

3D structure databases

ProteinModelPortaliQ61790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 163Ig-like V-typeAdd BLAST127
Domaini165 – 246Ig-like C2-type 1Add BLAST82
Domaini258 – 341Ig-like C2-type 2Add BLAST84
Domaini345 – 412Ig-like C2-type 3Add BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni493 – 51813 X 2 AA tandem repeats of E-XAdd BLAST26

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPP. Eukaryota.
ENOG410Z3KP. LUCA.
GeneTreeiENSGT00390000017331.
HOGENOMiHOG000113275.
HOVERGENiHBG004952.
InParanoidiQ61790.
KOiK06565.
OMAiERFVWSP.
OrthoDBiEOG091G0PJF.
PhylomeDBiQ61790.
TreeFamiTF335942.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREDLLLGFL LLGLLWEAPV VSSGPGKELP VVWAQEGAPV HLPCSLKSPN
60 70 80 90 100
LDPNFLRRGG VIWQHQPDSG QPTPIPALDL HQGMPSPRQP APGRYTVLSV
110 120 130 140 150
APGGLRSGRQ PLHPHVQLEE RGLQRGDFSL WLRPALRTDA GEYHATVRLP
160 170 180 190 200
NRALSCSLRL RVGQASMIAS PSGVLKLSDW VLLNCSFSRP DRPVSVHWFQ
210 220 230 240 250
GQNRVPVYNS PRHFLAETFL LLPQVSPLDS GTWGCVLTYR DGFNVSITYN
260 270 280 290 300
LKVLGLEPVA PLTVYAAEGS RVELPCHLPP GVGTPSLLIA KWTPPGGGPE
310 320 330 340 350
LPVAGKSGNF TLHLEAVGLA QAGTYTCSIH LQGQQLNATV TLAVITVTPK
360 370 380 390 400
SFGLPGSRGK LLCEVTPASG KERFVWRPLN NLSRSCPGPV LEIQEARLLA
410 420 430 440 450
ERWQCQLYEG QRLLGATVYA AESSSGAHSA RRISGDLKGG HLVLVLILGA
460 470 480 490 500
LSLFLLVAGA FGFHWWRKQL LLRRFSALEH GIQPFPAQRK IEELERELET
510 520
EMGQEPEPEP EPQLEPEPRQ L
Length:521
Mass (Da):56,978
Last modified:November 1, 1996 - v1
Checksum:i64C29C40EB780E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98113 mRNA. Translation: CAA66794.1.
BC120591 mRNA. Translation: AAI20592.1.
CCDSiCCDS20536.1.
RefSeqiNP_032505.1. NM_008479.2.
UniGeneiMm.4528.

Genome annotation databases

EnsembliENSMUST00000032217; ENSMUSP00000032217; ENSMUSG00000030124.
GeneIDi16768.
KEGGimmu:16768.
UCSCiuc009dsl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98113 mRNA. Translation: CAA66794.1.
BC120591 mRNA. Translation: AAI20592.1.
CCDSiCCDS20536.1.
RefSeqiNP_032505.1. NM_008479.2.
UniGeneiMm.4528.

3D structure databases

ProteinModelPortaliQ61790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032217.

PTM databases

iPTMnetiQ61790.
PhosphoSitePlusiQ61790.

Proteomic databases

EPDiQ61790.
PaxDbiQ61790.
PRIDEiQ61790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032217; ENSMUSP00000032217; ENSMUSG00000030124.
GeneIDi16768.
KEGGimmu:16768.
UCSCiuc009dsl.2. mouse.

Organism-specific databases

CTDi3902.
MGIiMGI:106588. Lag3.

Phylogenomic databases

eggNOGiENOG410IFPP. Eukaryota.
ENOG410Z3KP. LUCA.
GeneTreeiENSGT00390000017331.
HOGENOMiHOG000113275.
HOVERGENiHBG004952.
InParanoidiQ61790.
KOiK06565.
OMAiERFVWSP.
OrthoDBiEOG091G0PJF.
PhylomeDBiQ61790.
TreeFamiTF335942.

Miscellaneous databases

PMAP-CutDBQ61790.
PROiQ61790.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030124.
CleanExiMM_LAG3.
GenevisibleiQ61790. MM.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAG3_MOUSE
AccessioniPrimary (citable) accession number: Q61790
Secondary accession number(s): Q0VBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.