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Protein

Keratin, type I cytoskeletal 14

Gene

Krt14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei370Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-446107 Type I hemidesmosome assembly
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 14
Alternative name(s):
Cytokeratin-14
Short name:
CK-14
Keratin-14
Short name:
K14
Gene namesi
Name:Krt14
Synonyms:Krt1-14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96688 Krt14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636541 – 484Keratin, type I cytoskeletal 14Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi373Interchain1 Publication
Modified residuei447PhosphoserineCombined sources1

Post-translational modificationi

A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.
Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61781
PaxDbiQ61781
PeptideAtlasiQ61781
PRIDEiQ61781

PTM databases

iPTMnetiQ61781
PhosphoSitePlusiQ61781

Expressioni

Tissue specificityi

Basal cells of epidermis and other stratified epithelia.

Gene expression databases

BgeeiENSMUSG00000045545
CleanExiMM_KRT14
GenevisibleiQ61781 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. disulfide-linked keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins. Interacts with EPPK1 (PubMed:18285451). Interacts with KLHL24 (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi201019, 6 interactors
IntActiQ61781, 1 interactor
STRINGi10090.ENSMUSP00000007272

Structurei

3D structure databases

ProteinModelPortaliQ61781
SMRiQ61781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 432IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 120HeadAdd BLAST120
Regioni121 – 156Coil 1AAdd BLAST36
Regioni157 – 174Linker 1Add BLAST18
Regioni175 – 266Coil 1BAdd BLAST92
Regioni267 – 289Linker 12Add BLAST23
Regioni290 – 428Coil 2Add BLAST139
Regioni429 – 484TailAdd BLAST56
Regioni431 – 484Interaction with Type I keratins and keratin filamentsBy similarityAdd BLAST54

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ61781
KOiK07604
OMAiSYASNGL
OrthoDBiEOG091G087I
PhylomeDBiQ61781
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCSRQFTS SSSMKGSCGI GGGSSRMSSI LAGGSCRAPS TYGGMSVTSS
60 70 80 90 100
RFSSGGACGI GGGYGGSFSS SSFGGGLGSG FGGRFDGFGG GFGGGLGGGF
110 120 130 140 150
GGGLGGGLGG GIGDGLLVGS EKVTMQNLND RLATYLDKVR ALEEANTELE
160 170 180 190 200
VKIRDWYQRQ RPTEIKDYSP YFKTIEDLKS KILAATVDNA NVLLQIDNAR
210 220 230 240 250
LAADDFRTKF ETEQSLRMSV EADINGLRRV LDELTLARAD LEMQIESLKE
260 270 280 290 300
ELAYLKKNHE EEMASMRGQV GGDVNVEMDA APGVDLSRIL NEMRDQYEKM
310 320 330 340 350
AEKNRKDAEE WFFSKTEELN REVATNSELV QSGKSEISEL RRTMQNLEIE
360 370 380 390 400
LQSQLSMKAS LENNLEETKG RYCMQLAQIQ EMIGSVEEQL AQLRCEMEQQ
410 420 430 440 450
NQEYKILLDV KTRLEQEIAT YRRLLEGEDA HLSSSQFSSS SQFSSGSQSS
460 470 480
RDVTSTNRQI RTKVMDVHDG KVVSTHEQVL RTKN
Length:484
Mass (Da):52,867
Last modified:July 25, 2003 - v2
Checksum:iA9B6BA66B2F46668
GO

Sequence cautioni

The sequence AAH03325 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590873 Genomic DNA No translation available.
BC003325 mRNA Translation: AAH03325.1 Different initiation.
BC011074 mRNA Translation: AAH11074.1
M13806 mRNA Translation: AAA39392.1
CCDSiCCDS25413.1
PIRiB26135
RefSeqiNP_001300886.1, NM_001313957.1
NP_058654.1, NM_016958.2
UniGeneiMm.439898

Genome annotation databases

EnsembliENSMUST00000007272; ENSMUSP00000007272; ENSMUSG00000045545
GeneIDi16664
KEGGimmu:16664
UCSCiuc007lko.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1C14_MOUSE
AccessioniPrimary (citable) accession number: Q61781
Secondary accession number(s): A2A4G4, Q91VQ4, Q99LE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 25, 2003
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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