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Q61772

- EPHA7_MOUSE

UniProt

Q61772 - EPHA7_MOUSE

Protein

Ephrin type-A receptor 7

Gene

Epha7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.3 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei665 – 6651ATPPROSITE-ProRule annotation
    Active sitei758 – 7581Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi639 – 6479ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. axon guidance receptor activity Source: UniProtKB
    3. chemorepellent activity Source: MGI
    4. GPI-linked ephrin receptor activity Source: UniProtKB
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. branching morphogenesis of a nerve Source: MGI
    3. ephrin receptor signaling pathway Source: UniProtKB
    4. negative chemotaxis Source: GOC
    5. phosphorylation Source: UniProtKB
    6. positive regulation of neuron apoptotic process Source: MGI
    7. regulation of cell-cell adhesion Source: UniProtKB
    8. regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    9. regulation of ERK1 and ERK2 cascade Source: UniProtKB
    10. regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    11. regulation of protein autophosphorylation Source: UniProtKB
    12. retinal ganglion cell axon guidance Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Apoptosis, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin type-A receptor 7 (EC:2.7.10.1)
    Alternative name(s):
    Developmental kinase 1
    Short name:
    mDK-1
    EPH homology kinase 3
    Short name:
    EHK-3
    Embryonic brain kinase
    Short name:
    EBK
    Gene namesi
    Name:Epha7
    Synonyms:Ebk, Ehk3, Mdk1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95276. Epha7.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. integral component of plasma membrane Source: UniProtKB
    3. neuromuscular junction Source: Ensembl
    4. neuronal cell body Source: Ensembl
    5. postsynaptic membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice are viable, fertile and show no gross morphological or behavioral defects. However, topographic targeting errors of nasal and temporal retinal axons appear during development of the retinocollicular projections in the visual system. 10 percent of the embryos also display exencephalic overgrowth of forebrain tissues which might be the result of reduced apoptosis.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 998971Ephrin type-A receptor 7PRO_0000016819Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Modified residuei608 – 6081Phosphotyrosine; by autocatalysisSequence Analysis
    Modified residuei614 – 6141Phosphotyrosine; by autocatalysisSequence Analysis
    Modified residuei791 – 7911Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei940 – 9401Phosphotyrosine; by autocatalysisSequence Analysis

    Post-translational modificationi

    Phosphorylated. Isoform 4 inhibits isoform 1 phosphorylation and may regulate its function in adhesion.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ61772.
    PRIDEiQ61772.

    PTM databases

    PhosphoSiteiQ61772.

    Expressioni

    Tissue specificityi

    Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen.

    Developmental stagei

    During visual system development, expressed in an anterior to posterior decreasing gradient stretching through the entire midbrain. This gradient has the reverse orientation to the one defined by the expression of ephrins. Isoform 4 and isoform 5 are expressed at the edges of the embryonic cranial neural fold.2 Publications

    Gene expression databases

    ArrayExpressiQ61772.
    BgeeiQ61772.
    CleanExiMM_EPHA7.
    GenevestigatoriQ61772.

    Interactioni

    Subunit structurei

    Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses By similarity. Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain).By similarity1 Publication

    Protein-protein interaction databases

    BioGridi199474. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61772.
    SMRiQ61772. Positions 30-899, 919-989.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 555528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini577 – 998422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei556 – 57621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 210179Eph LBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini331 – 441111Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini442 – 53796Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini633 – 894262Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini923 – 98765SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi996 – 9983PDZ-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi192 – 328137Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117255.
    HOGENOMiHOG000233856.
    HOVERGENiHBG062180.
    InParanoidiQ8BSU8.
    KOiK05108.
    OMAiENSPKMH.
    OrthoDBiEOG7VTDM6.
    TreeFamiTF315608.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view]
    PfamiPF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q61772-1) [UniParc]FASTAAdd to Basket

    Also known as: MDK1, EPHA7-FL

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVVQTRFPSW IILCYIWLLG FAHTGEAQAA KEVLLLDSKA QQTELEWISS    50
    PPSGWEEISG LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV 100
    ELKFTLRDCN SLPGVLGTCK ETFNLYYYET DYDTGRNIRE NLYVKIDTIA 150
    ADESFTQGDL GERKMKLNTE VREIGPLSKK GFYLAFQDVG ACIALVSVKV 200
    YYKKCWSIVE NLAVFPDTVT GSEFSSLVEV RGTCVSSAEE EAENSPRMHC 250
    SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RRFYKSSSQD LQCSRCPTHS 300
    FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE 350
    WSPPADNGGR NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV 400
    TVMDLLAHAN YTFEVEAVNG VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM 450
    KERVLQRSVQ LSWQEPEHPN GVITEYEIKY YEKDQRERTY STLKTKSTSA 500
    SINNLKPGTV YVFQIRAVTA AGYGNYSPRL DVATLEEASG KMFEATAVSS 550
    EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 600
    KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG 650
    RLKLPGKRDV AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV 700
    VTRGKPVMIV IEFMENGALD AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA 750
    DMGYVHRDLA ARNILVNSNL VCKVSDFGLS RVIEDDPEAV YTTTGGKIPV 800
    RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVIKAIE 850
    EGYRLPAPMD CPAGLHQLML DCWQKDRAER PKFEQIVGIL DKMIRNPSSL 900
    KTPLGTCSRP LSPLLDQSTP DFTAFCSVGE WLQAIKMERY KDNFTAAGYN 950
    SLESVARMTI DDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV 998
    Length:998
    Mass (Da):111,860
    Last modified:July 27, 2011 - v2
    Checksum:iFCA1E83490E746E1
    GO
    Isoform 2 (identifier: Q61772-2) [UniParc]FASTAAdd to Basket

    Also known as: MDK1-1, Ebk-td1

    The sequence of this isoform differs from the canonical sequence as follows:
         540-544: Missing.

    Show »
    Length:993
    Mass (Da):111,268
    Checksum:i2D1C811BCD1FA937
    GO
    Isoform 3 (identifier: Q61772-3) [UniParc]FASTAAdd to Basket

    Also known as: MDK1-2

    The sequence of this isoform differs from the canonical sequence as follows:
         601-604: Missing.

    Show »
    Length:994
    Mass (Da):111,431
    Checksum:i25ADED280A8D9FBF
    GO
    Isoform 4 (identifier: Q61772-4) [UniParc]FASTAAdd to Basket

    Also known as: MDK1-T1, EPHA7-T1

    The sequence of this isoform differs from the canonical sequence as follows:
         600-610: FKFPGTKTYID → SLVTNEHLSVL
         611-998: Missing.

    Note: Truncated receptor lacking the kinase domain.

    Show »
    Length:610
    Mass (Da):68,286
    Checksum:iE61310A72FE1E739
    GO
    Isoform 5 (identifier: Q61772-5) [UniParc]FASTAAdd to Basket

    Also known as: MDK1-T2, EPHA7-T2

    The sequence of this isoform differs from the canonical sequence as follows:
         600-626: FKFPGTKTYIDPETYEDPNRAVHQFAK → SLYRERGDGMEKTQHNKKWMIASCSRL
         627-998: Missing.

    Note: Truncated receptor lacking the kinase domain.

    Show »
    Length:626
    Mass (Da):70,300
    Checksum:iF929755DC75B5664
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti207 – 2071S → T in CAA55687. (PubMed:7824284)Curated
    Sequence conflicti207 – 2071S → T in CAA55688. (PubMed:7824284)Curated
    Sequence conflicti207 – 2071S → T in CAA55689. (PubMed:7824284)Curated
    Sequence conflicti480 – 4801Y → H in CAA57224. (PubMed:8541219)Curated
    Sequence conflicti657 – 6571K → Q in CAA55687. (PubMed:7824284)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei540 – 5445Missing in isoform 2. 1 PublicationVSP_003006
    Alternative sequencei600 – 62627FKFPG…HQFAK → SLYRERGDGMEKTQHNKKWM IASCSRL in isoform 5. CuratedVSP_003010Add
    BLAST
    Alternative sequencei600 – 61011FKFPGTKTYID → SLVTNEHLSVL in isoform 4. CuratedVSP_003008Add
    BLAST
    Alternative sequencei601 – 6044Missing in isoform 3. CuratedVSP_003007
    Alternative sequencei611 – 998388Missing in isoform 4. CuratedVSP_003009Add
    BLAST
    Alternative sequencei627 – 998372Missing in isoform 5. CuratedVSP_003011Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79082 mRNA. Translation: CAA55687.1.
    X79083 mRNA. Translation: CAA55688.1.
    X79084 mRNA. Translation: CAA55689.1.
    AK030480 mRNA. Translation: BAC26982.1.
    BX000989 Genomic DNA. Translation: CAM21483.1.
    CH466538 Genomic DNA. Translation: EDL05518.1.
    X81466 mRNA. Translation: CAA57224.1.
    CCDSiCCDS18013.1. [Q61772-1]
    CCDS51132.1. [Q61772-4]
    CCDS71353.1. [Q61772-3]
    PIRiI48612.
    I48614.
    JC5672.
    RefSeqiNP_001277363.1. NM_001290434.1.
    NP_034271.3. NM_010141.4. [Q61772-1]
    XP_006537669.1. XM_006537606.1. [Q61772-2]
    XP_006537670.1. XM_006537607.1. [Q61772-5]
    UniGeneiMm.257266.

    Genome annotation databases

    EnsembliENSMUST00000029964; ENSMUSP00000029964; ENSMUSG00000028289. [Q61772-1]
    ENSMUST00000080934; ENSMUSP00000079735; ENSMUSG00000028289. [Q61772-4]
    ENSMUST00000108194; ENSMUSP00000103829; ENSMUSG00000028289. [Q61772-5]
    GeneIDi13841.
    KEGGimmu:13841.
    UCSCiuc008sen.2. mouse. [Q61772-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79082 mRNA. Translation: CAA55687.1 .
    X79083 mRNA. Translation: CAA55688.1 .
    X79084 mRNA. Translation: CAA55689.1 .
    AK030480 mRNA. Translation: BAC26982.1 .
    BX000989 Genomic DNA. Translation: CAM21483.1 .
    CH466538 Genomic DNA. Translation: EDL05518.1 .
    X81466 mRNA. Translation: CAA57224.1 .
    CCDSi CCDS18013.1. [Q61772-1 ]
    CCDS51132.1. [Q61772-4 ]
    CCDS71353.1. [Q61772-3 ]
    PIRi I48612.
    I48614.
    JC5672.
    RefSeqi NP_001277363.1. NM_001290434.1.
    NP_034271.3. NM_010141.4. [Q61772-1 ]
    XP_006537669.1. XM_006537606.1. [Q61772-2 ]
    XP_006537670.1. XM_006537607.1. [Q61772-5 ]
    UniGenei Mm.257266.

    3D structure databases

    ProteinModelPortali Q61772.
    SMRi Q61772. Positions 30-899, 919-989.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199474. 1 interaction.

    PTM databases

    PhosphoSitei Q61772.

    Proteomic databases

    PaxDbi Q61772.
    PRIDEi Q61772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029964 ; ENSMUSP00000029964 ; ENSMUSG00000028289 . [Q61772-1 ]
    ENSMUST00000080934 ; ENSMUSP00000079735 ; ENSMUSG00000028289 . [Q61772-4 ]
    ENSMUST00000108194 ; ENSMUSP00000103829 ; ENSMUSG00000028289 . [Q61772-5 ]
    GeneIDi 13841.
    KEGGi mmu:13841.
    UCSCi uc008sen.2. mouse. [Q61772-1 ]

    Organism-specific databases

    CTDi 2045.
    MGIi MGI:95276. Epha7.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117255.
    HOGENOMi HOG000233856.
    HOVERGENi HBG062180.
    InParanoidi Q8BSU8.
    KOi K05108.
    OMAi ENSPKMH.
    OrthoDBi EOG7VTDM6.
    TreeFami TF315608.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 3474.

    Miscellaneous databases

    ChiTaRSi EPHA7. mouse.
    NextBioi 284676.
    PROi Q61772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61772.
    Bgeei Q61772.
    CleanExi MM_EPHA7.
    Genevestigatori Q61772.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view ]
    Pfami PF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system."
      Ciossek T., Millauer B., Ullrich A.
      Oncogene 10:97-108(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
      Strain: BALB/c.
      Tissue: Brain.
    2. "A novel truncated variant form of Ebk/MDK1 receptor tyrosine kinase is expressed in embryonic mouse brain."
      Talukder A.H., Muramatsu T., Kaneda N.
      Cell Struct. Funct. 22:477-485(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pituitary.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 431-998 (ISOFORM 1).
      Tissue: Brain.
    7. "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands."
      Torres R., Firestein B.L., Dong H., Staudinger J., Olson E.N., Huganir R.L., Bredt D.S., Gale N.W., Yancopoulos G.D.
      Neuron 21:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRIP1 AND PICK1, IDENTIFICATION OF PDZ-BINDING MOTIF.
    8. "Regulation of repulsion versus adhesion by different splice forms of an Eph receptor."
      Holmberg J., Clarke D.L., Frisen J.
      Nature 408:203-206(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL ADHESION AND REPULSION (ISOFORMS 1 AND 4), EFNA5 LIGAND-BINDING, PHOSPHORYLATION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    9. "Ephrin signalling controls brain size by regulating apoptosis of neural progenitors."
      Depaepe V., Suarez-Gonzalez N., Dufour A., Passante L., Gorski J.A., Jones K.R., Ledent C., Vanderhaeghen P.
      Nature 435:1244-1250(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN APOPTOSIS.
    10. "Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system."
      Rashid T., Upton A.L., Blentic A., Ciossek T., Knoell B., Thompson I.D., Drescher U.
      Neuron 47:57-69(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN TOPOGRAPHIC MAPPING, DEVELOPMENTAL STAGE.
    11. "Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism."
      Torii M., Levitt P.
      Neuron 48:563-575(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CORTICOTHALAMIC AXON GUIDANCE.

    Entry informationi

    Entry nameiEPHA7_MOUSE
    AccessioniPrimary (citable) accession number: Q61772
    Secondary accession number(s): Q61505
    , Q61773, Q61774, Q8BSU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3