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Protein

Kinesin-like protein KIF3B

Gene

Kif3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi96 – 1038ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_302653. Translocation of GLUT4 to the plasma membrane.
REACT_316383. MHC class II antigen presentation.
REACT_342780. Kinesins.
REACT_361683. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3B
Alternative name(s):
Microtubule plus end-directed kinesin motor 3B
Cleaved into the following chain:
Gene namesi
Name:Kif3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107688. Kif3b.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cilium Source: MGI
  • cytosol Source: Reactome
  • extracellular exosome Source: MGI
  • kinesin II complex Source: MGI
  • membrane Source: MGI
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: MGI
  • midbody Source: Ensembl
  • spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Kinesin-like protein KIF3BPRO_0000125396Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 747746Kinesin-like protein KIF3B, N-terminally processedPRO_0000424496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ61771.
PaxDbiQ61771.
PRIDEiQ61771.

PTM databases

PhosphoSiteiQ61771.

Expressioni

Gene expression databases

BgeeiQ61771.
CleanExiMM_KIF3B.
ExpressionAtlasiQ61771. baseline and differential.
GenevisibleiQ61771. MM.

Interactioni

Subunit structurei

Interacts with the SMC3 subunit of the cohesin complex (By similarity). Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kif3aP287414EBI-6395332,EBI-6169413
Trim60Q8VI403EBI-6395332,EBI-6395249

Protein-protein interaction databases

BioGridi200942. 4 interactions.
IntActiQ61771. 3 interactions.
MINTiMINT-4997283.
STRINGi10090.ENSMUSP00000028977.

Structurei

3D structure databases

ProteinModelPortaliQ61771.
SMRiQ61771. Positions 7-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 340332Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni580 – 747168GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 579234Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi386 – 3938Poly-Gly
Compositional biasi394 – 40512Poly-GluAdd
BLAST
Compositional biasi723 – 7308Poly-Ser

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052255.
InParanoidiQ61771.
KOiK10394.
OMAiSEFIMSK.
OrthoDBiEOG7WX086.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS
60 70 80 90 100
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT
110 120 130 140 150
GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE
160 170 180 190 200
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN
210 220 230 240 250
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE
260 270 280 290 300
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
310 320 330 340 350
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
360 370 380 390 400
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG
410 420 430 440 450
EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM
460 470 480 490 500
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA
510 520 530 540 550
EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA
560 570 580 590 600
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM
610 620 630 640 650
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
660 670 680 690 700
PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV
710 720 730 740
DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK
Length:747
Mass (Da):85,288
Last modified:November 1, 1996 - v1
Checksum:iFA369A4190EC8B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26077 mRNA. Translation: BAA05070.1.
CCDSiCCDS16911.1.
PIRiA57107.
RefSeqiNP_032470.3. NM_008444.4.
UniGeneiMm.315560.

Genome annotation databases

EnsembliENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475.
GeneIDi16569.
KEGGimmu:16569.
UCSCiuc008nhp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26077 mRNA. Translation: BAA05070.1.
CCDSiCCDS16911.1.
PIRiA57107.
RefSeqiNP_032470.3. NM_008444.4.
UniGeneiMm.315560.

3D structure databases

ProteinModelPortaliQ61771.
SMRiQ61771. Positions 7-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200942. 4 interactions.
IntActiQ61771. 3 interactions.
MINTiMINT-4997283.
STRINGi10090.ENSMUSP00000028977.

PTM databases

PhosphoSiteiQ61771.

Proteomic databases

MaxQBiQ61771.
PaxDbiQ61771.
PRIDEiQ61771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475.
GeneIDi16569.
KEGGimmu:16569.
UCSCiuc008nhp.2. mouse.

Organism-specific databases

CTDi9371.
MGIiMGI:107688. Kif3b.

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052255.
InParanoidiQ61771.
KOiK10394.
OMAiSEFIMSK.
OrthoDBiEOG7WX086.
TreeFamiTF105223.

Enzyme and pathway databases

ReactomeiREACT_302653. Translocation of GLUT4 to the plasma membrane.
REACT_316383. MHC class II antigen presentation.
REACT_342780. Kinesins.
REACT_361683. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiKif3b. mouse.
NextBioi290077.
PROiQ61771.
SOURCEiSearch...

Gene expression databases

BgeeiQ61771.
CleanExiMM_KIF3B.
ExpressionAtlasiQ61771. baseline and differential.
GenevisibleiQ61771. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport."
    Yamazaki H., Nakata T., Okada Y., Hirokawa N.
    J. Cell Biol. 130:1387-1399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia."
    Baker S.A., Freeman K., Luby-Phelps K., Pazour G.J., Besharse J.C.
    J. Biol. Chem. 278:34211-34218(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFT20.

Entry informationi

Entry nameiKIF3B_MOUSE
AccessioniPrimary (citable) accession number: Q61771
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.