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Q61771 (KIF3B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF3B
Alternative name(s):
Microtubule plus end-directed kinesin motor 3B
Gene names
Name:Kif3b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length747 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro By similarity.

Subunit structure

Interacts with the SMC3 subunit of the cohesin complex By similarity. Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20. Ref.2

Subcellular location

Cytoplasmcytoskeleton Probable.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.

Contains 1 kinesin motor domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 747747Kinesin-like protein KIF3B
PRO_0000125396
Initiator methionine11Removed; alternate By similarity
Chain2 – 747746Kinesin-like protein KIF3B, N-terminally processed
PRO_0000424496

Regions

Domain9 – 340332Kinesin motor
Nucleotide binding96 – 1038ATP By similarity
Region580 – 747168Globular
Coiled coil346 – 579234 Potential
Compositional bias386 – 3938Poly-Gly
Compositional bias394 – 40512Poly-Glu
Compositional bias723 – 7308Poly-Ser

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue21N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processed By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61771 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FA369A4190EC8B47

FASTA74785,288
        10         20         30         40         50         60 
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS HEMPKTFTFD 

        70         80         90        100        110        120 
AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGVR GDPEKRGVIP 

       130        140        150        160        170        180 
NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS 

       190        200        210        220        230        240 
SFVTKSVKEI EHVMNVGNQN RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK 

       250        260        270        280        290        300 
LNLVDLAGSE RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL 

       310        320        330        340        350        360 
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP KDALLREFQE 

       370        380        390        400        410        420 
EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG EEGEEDGDDK DDYWREQQEK 

       430        440        450        460        470        480 
LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM EDLRREKDAA EMLGAKIKAM ESKLLVGGKN 

       490        500        510        520        530        540 
IVDHTNEQQK ILEQKRQEIA EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK 

       550        560        570        580        590        600 
LKKLFSKLQA VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM 

       610        620        630        640        650        660 
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR PEPRYRAENI 

       670        680        690        700        710        720 
MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV DASSFESTAS RKPKARPKSG 

       730        740 
RKSGSSSSSS GNPASQFYPQ SRGLVPK 

« Hide

References

[1]"KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport."
Yamazaki H., Nakata T., Okada Y., Hirokawa N.
J. Cell Biol. 130:1387-1399(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Brain.
[2]"IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia."
Baker S.A., Freeman K., Luby-Phelps K., Pazour G.J., Besharse J.C.
J. Biol. Chem. 278:34211-34218(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH IFT20.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26077 mRNA. Translation: BAA05070.1.
CCDSCCDS16911.1.
PIRA57107.
RefSeqNP_032470.3. NM_008444.4.
UniGeneMm.315560.

3D structure databases

ProteinModelPortalQ61771.
SMRQ61771. Positions 7-358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200942. 4 interactions.
IntActQ61771. 3 interactions.
MINTMINT-4997283.
STRING10090.ENSMUSP00000028977.

PTM databases

PhosphoSiteQ61771.

Proteomic databases

MaxQBQ61771.
PaxDbQ61771.
PRIDEQ61771.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475.
GeneID16569.
KEGGmmu:16569.
UCSCuc008nhp.2. mouse.

Organism-specific databases

CTD9371.
MGIMGI:107688. Kif3b.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00750000117465.
HOVERGENHBG052255.
InParanoidQ61771.
KOK10394.
OMADNQQMMK.
OrthoDBEOG7WX086.
TreeFamTF105223.

Enzyme and pathway databases

ReactomeREACT_147847. Translocation of Glut4 to the Plasma Membrane.
REACT_209837. Membrane Trafficking.
REACT_224553. Hemostasis.

Gene expression databases

ArrayExpressQ61771.
BgeeQ61771.
CleanExMM_KIF3B.
GenevestigatorQ61771.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290077.
PROQ61771.
SOURCESearch...

Entry information

Entry nameKIF3B_MOUSE
AccessionPrimary (citable) accession number: Q61771
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot