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Q61771

- KIF3B_MOUSE

UniProt

Q61771 - KIF3B_MOUSE

Protein

Kinesin-like protein KIF3B

Gene

Kif3b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi96 – 1038ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. microtubule-based movement Source: InterPro
    2. spindle assembly involved in mitosis Source: Ensembl

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199054. Translocation of GLUT4 to the plasma membrane.
    REACT_199117. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF3B
    Alternative name(s):
    Microtubule plus end-directed kinesin motor 3B
    Cleaved into the following chain:
    Gene namesi
    Name:Kif3b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107688. Kif3b.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: MGI
    2. cilium Source: MGI
    3. cytosol Source: Reactome
    4. kinesin II complex Source: MGI
    5. microtubule Source: UniProtKB-KW
    6. midbody Source: Ensembl
    7. spindle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 747747Kinesin-like protein KIF3BPRO_0000125396Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 747746Kinesin-like protein KIF3B, N-terminally processedPRO_0000424496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processedBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ61771.
    PaxDbiQ61771.
    PRIDEiQ61771.

    PTM databases

    PhosphoSiteiQ61771.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61771.
    BgeeiQ61771.
    CleanExiMM_KIF3B.
    GenevestigatoriQ61771.

    Interactioni

    Subunit structurei

    Interacts with the SMC3 subunit of the cohesin complex By similarity. Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kif3aP287414EBI-6395332,EBI-6169413
    Trim60Q8VI403EBI-6395332,EBI-6395249

    Protein-protein interaction databases

    BioGridi200942. 4 interactions.
    IntActiQ61771. 3 interactions.
    MINTiMINT-4997283.
    STRINGi10090.ENSMUSP00000028977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61771.
    SMRiQ61771. Positions 7-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 340332Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni580 – 747168GlobularAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili346 – 579234Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi386 – 3938Poly-Gly
    Compositional biasi394 – 40512Poly-GluAdd
    BLAST
    Compositional biasi723 – 7308Poly-Ser

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00750000117465.
    HOVERGENiHBG052255.
    InParanoidiQ61771.
    KOiK10394.
    OMAiDNQQMMK.
    OrthoDBiEOG7WX086.
    TreeFamiTF105223.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61771-1 [UniParc]FASTAAdd to Basket

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    MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS    50
    HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT 100
    GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE 150
    EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN 200
    RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE 250
    RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL 300
    LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP 350
    KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG 400
    EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM 450
    EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA 500
    EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA 550
    VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM 600
    NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR 650
    PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV 700
    DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK 747
    Length:747
    Mass (Da):85,288
    Last modified:November 1, 1996 - v1
    Checksum:iFA369A4190EC8B47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26077 mRNA. Translation: BAA05070.1.
    CCDSiCCDS16911.1.
    PIRiA57107.
    RefSeqiNP_032470.3. NM_008444.4.
    UniGeneiMm.315560.

    Genome annotation databases

    EnsembliENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475.
    GeneIDi16569.
    KEGGimmu:16569.
    UCSCiuc008nhp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26077 mRNA. Translation: BAA05070.1 .
    CCDSi CCDS16911.1.
    PIRi A57107.
    RefSeqi NP_032470.3. NM_008444.4.
    UniGenei Mm.315560.

    3D structure databases

    ProteinModelPortali Q61771.
    SMRi Q61771. Positions 7-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200942. 4 interactions.
    IntActi Q61771. 3 interactions.
    MINTi MINT-4997283.
    STRINGi 10090.ENSMUSP00000028977.

    PTM databases

    PhosphoSitei Q61771.

    Proteomic databases

    MaxQBi Q61771.
    PaxDbi Q61771.
    PRIDEi Q61771.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028977 ; ENSMUSP00000028977 ; ENSMUSG00000027475 .
    GeneIDi 16569.
    KEGGi mmu:16569.
    UCSCi uc008nhp.2. mouse.

    Organism-specific databases

    CTDi 9371.
    MGIi MGI:107688. Kif3b.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00750000117465.
    HOVERGENi HBG052255.
    InParanoidi Q61771.
    KOi K10394.
    OMAi DNQQMMK.
    OrthoDBi EOG7WX086.
    TreeFami TF105223.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199054. Translocation of GLUT4 to the plasma membrane.
    REACT_199117. Kinesins.

    Miscellaneous databases

    NextBioi 290077.
    PROi Q61771.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61771.
    Bgeei Q61771.
    CleanExi MM_KIF3B.
    Genevestigatori Q61771.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport."
      Yamazaki H., Nakata T., Okada Y., Hirokawa N.
      J. Cell Biol. 130:1387-1399(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    2. "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia."
      Baker S.A., Freeman K., Luby-Phelps K., Pazour G.J., Besharse J.C.
      J. Biol. Chem. 278:34211-34218(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IFT20.

    Entry informationi

    Entry nameiKIF3B_MOUSE
    AccessioniPrimary (citable) accession number: Q61771
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3