Q61771 (KIF3B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF3B

Alternative name(s):
Microtubule plus end-directed kinesin motor 3B

Gene names

Name:

Kif3b

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro By similarity.
Subunit structure	Interacts with the SMC3 subunit of the cohesin complex By similarity. Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20. Ref.2
Subcellular location	Cytoplasm › cytoskeleton Probable.
Sequence similarities	Belongs to the kinesin-like protein family. Kinesin II subfamily. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro spindle assembly involved in mitosis Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Traceable author statement. Source: Reactome kinesin II complex Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 747	747	Kinesin-like protein KIF3B		PRO_0000125396
Regions
	Domain	1 – 345	345	Kinesin-motor
	Nucleotide binding	96 – 103	8	ATP By similarity
	Region	580 – 747	168	Globular
	Coiled coil	346 – 579	234	Potential
	Compositional bias	386 – 393	8	Poly-Gly
	Compositional bias	394 – 405	12	Poly-Glu
	Compositional bias	723 – 730	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q61771 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FA369A4190EC8B47	FASTA	747	85,288
	10 20 30 40 50 60 MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS HEMPKTFTFD 70 80 90 100 110 120 AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGVR GDPEKRGVIP 130 140 150 160 170 180 NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS 190 200 210 220 230 240 SFVTKSVKEI EHVMNVGNQN RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK 250 260 270 280 290 300 LNLVDLAGSE RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL 310 320 330 340 350 360 LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP KDALLREFQE 370 380 390 400 410 420 EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG EEGEEDGDDK DDYWREQQEK 430 440 450 460 470 480 LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM EDLRREKDAA EMLGAKIKAM ESKLLVGGKN 490 500 510 520 530 540 IVDHTNEQQK ILEQKRQEIA EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK 550 560 570 580 590 600 LKKLFSKLQA VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM 610 620 630 640 650 660 NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR PEPRYRAENI 670 680 690 700 710 720 MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV DASSFESTAS RKPKARPKSG 730 740 RKSGSSSSSS GNPASQFYPQ SRGLVPK

References

[1]	"KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport." Yamazaki H., Nakata T., Okada Y., Hirokawa N. J. Cell Biol. 130:1387-1399(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Brain.
[2]	"IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia." Baker S.A., Freeman K., Luby-Phelps K., Pazour G.J., Besharse J.C. J. Biol. Chem. 278:34211-34218(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IFT20.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D26077 mRNA. Translation: BAA05070.1.
IPI	IPI00465809.
PIR	A57107.
RefSeq	NP_032470.3. NM_008444.4.
UniGene	Mm.315560.
3D structure databases
ProteinModelPortal	Q61771.
SMR	Q61771. Positions 7-358.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4997283.
STRING	10090.ENSMUSP00000028977.
PTM databases
PhosphoSite	Q61771.
Proteomic databases
PaxDb	Q61771.
PRIDE	Q61771.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475.
GeneID	16569.
KEGG	mmu:16569.
UCSC	uc008nhp.2. mouse.
Organism-specific databases
CTD	9371.
MGI	MGI:107688. Kif3b.
Phylogenomic databases
eggNOG	COG5059.
GeneTree	ENSGT00690000101932.
HOVERGEN	HBG052255.
InParanoid	Q61771.
KO	K10394.
OMA	EIYMEEL.
OrthoDB	EOG4J3WGM.
Enzyme and pathway databases
Reactome	REACT_147847. Translocation of Glut4 to the Plasma Membrane. REACT_88307. Membrane Trafficking. REACT_89750. Hemostasis.
Gene expression databases
ArrayExpress	Q61771.
Bgee	Q61771.
CleanEx	MM_KIF3B.
Genevestigator	Q61771.
GermOnline	ENSMUSG00000027475. Mus musculus.
Family and domain databases
Gene3D	3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290077.
SOURCE	Search...

Entry information

Entry name

KIF3B_MOUSE

Accession

Primary (citable) accession number: Q61771

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program