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Q61771

- KIF3B_MOUSE

UniProt

Q61771 - KIF3B_MOUSE

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Protein

Kinesin-like protein KIF3B

Gene
Kif3b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi96 – 1038ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. microtubule-based movement Source: InterPro
  2. spindle assembly involved in mitosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3B
Alternative name(s):
Microtubule plus end-directed kinesin motor 3B
Cleaved into the following chain:
Gene namesi
Name:Kif3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107688. Kif3b.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cilium Source: MGI
  3. cytosol Source: Reactome
  4. kinesin II complex Source: Ensembl
  5. microtubule Source: UniProtKB-KW
  6. midbody Source: Ensembl
  7. spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Kinesin-like protein KIF3BPRO_0000125396Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 747746Kinesin-like protein KIF3B, N-terminally processedPRO_0000424496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei2 – 21N-acetylserine; in Kinesin-like protein KIF3B, N-terminally processed By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ61771.
PaxDbiQ61771.
PRIDEiQ61771.

PTM databases

PhosphoSiteiQ61771.

Expressioni

Gene expression databases

ArrayExpressiQ61771.
BgeeiQ61771.
CleanExiMM_KIF3B.
GenevestigatoriQ61771.

Interactioni

Subunit structurei

Interacts with the SMC3 subunit of the cohesin complex By similarity. Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kif3aP287414EBI-6395332,EBI-6169413
Trim60Q8VI403EBI-6395332,EBI-6395249

Protein-protein interaction databases

BioGridi200942. 4 interactions.
IntActiQ61771. 3 interactions.
MINTiMINT-4997283.
STRINGi10090.ENSMUSP00000028977.

Structurei

3D structure databases

ProteinModelPortaliQ61771.
SMRiQ61771. Positions 7-358.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 340332Kinesin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni580 – 747168GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 579234 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi386 – 3938Poly-Gly
Compositional biasi394 – 40512Poly-GluAdd
BLAST
Compositional biasi723 – 7308Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00750000117465.
HOVERGENiHBG052255.
InParanoidiQ61771.
KOiK10394.
OMAiDNQQMMK.
OrthoDBiEOG7WX086.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61771-1 [UniParc]FASTAAdd to Basket

« Hide

MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTS    50
HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT 100
GKTYTMEGVR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE 150
EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN 200
RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE 250
RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL 300
LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP 350
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG 400
EEGEEDGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM 450
EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA 500
EQKRREREIQ QQMESRDEET LELKETYTSL QQEVDIKTKK LKKLFSKLQA 550
VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKNKIM 600
NRSFFDDEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR 650
PEPRYRAENI MLLELDMPSR TTRDYEGPAI SPKVQAALDA ALQDEDEIQV 700
DASSFESTAS RKPKARPKSG RKSGSSSSSS GNPASQFYPQ SRGLVPK 747
Length:747
Mass (Da):85,288
Last modified:November 1, 1996 - v1
Checksum:iFA369A4190EC8B47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26077 mRNA. Translation: BAA05070.1.
CCDSiCCDS16911.1.
PIRiA57107.
RefSeqiNP_032470.3. NM_008444.4.
UniGeneiMm.315560.

Genome annotation databases

EnsembliENSMUST00000028977; ENSMUSP00000028977; ENSMUSG00000027475.
GeneIDi16569.
KEGGimmu:16569.
UCSCiuc008nhp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26077 mRNA. Translation: BAA05070.1 .
CCDSi CCDS16911.1.
PIRi A57107.
RefSeqi NP_032470.3. NM_008444.4.
UniGenei Mm.315560.

3D structure databases

ProteinModelPortali Q61771.
SMRi Q61771. Positions 7-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200942. 4 interactions.
IntActi Q61771. 3 interactions.
MINTi MINT-4997283.
STRINGi 10090.ENSMUSP00000028977.

PTM databases

PhosphoSitei Q61771.

Proteomic databases

MaxQBi Q61771.
PaxDbi Q61771.
PRIDEi Q61771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028977 ; ENSMUSP00000028977 ; ENSMUSG00000027475 .
GeneIDi 16569.
KEGGi mmu:16569.
UCSCi uc008nhp.2. mouse.

Organism-specific databases

CTDi 9371.
MGIi MGI:107688. Kif3b.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00750000117465.
HOVERGENi HBG052255.
InParanoidi Q61771.
KOi K10394.
OMAi DNQQMMK.
OrthoDBi EOG7WX086.
TreeFami TF105223.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_199117. Kinesins.

Miscellaneous databases

NextBioi 290077.
PROi Q61771.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61771.
Bgeei Q61771.
CleanExi MM_KIF3B.
Genevestigatori Q61771.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport."
    Yamazaki H., Nakata T., Okada Y., Hirokawa N.
    J. Cell Biol. 130:1387-1399(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia."
    Baker S.A., Freeman K., Luby-Phelps K., Pazour G.J., Besharse J.C.
    J. Biol. Chem. 278:34211-34218(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFT20.

Entry informationi

Entry nameiKIF3B_MOUSE
AccessioniPrimary (citable) accession number: Q61771
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi